Play around with it Kal. Run some scenarios in the app. Then decide what variables are hard to change, such as ambient room temp, and adjust the other 2 parameters in the calculator.
If you look at this that I posted for Azi you can see at the bottom what your targets are for the stage of the grow you are in.
Leaf temp is the tricky one. If you raise room temp it will also raise leaf temp but if both go up 1 degree not much difference is noticed. Like this
raising both did raise VPD but if room temp stayed at 90 and you only raised leaf temp by 1 degree you would get this
which is a much greater rise in VPD.
To raise leaf temps to close the gap on air temps, you add more light and the radiation in the light excites molecules in the leaf just as exercise does in our muscles, and heat is formed.
You need to be careful you don't light burn the leaves so don't get carried away, but once you calibrate your PPFD app you can guard against that.
A healthy plant under optimal conditions will try to get to 2 degrees under room temp after 10 hours of lights on. That is where optimal transpiration occurs.
It's important that you take your readings late in the plants day as they are all over the place in the mornings. You want readings from when the plant is working it's hardest or you may end up over revving your plants late in the day. Never react to earlier readings. Always from the 10 hour mark.
Then there is RH. Once your light is set properly to your room temp you can speed up or slow down the plant by lowering or raising RH.
It's not as complicated as it sounds if you run some scenarios in the app before you start actually adjusting things in the grow room.
Right now in my grow when the plants stretch and PPFD hits 1100 the leaf temp differential is 2 degrees, and when I drop it back to 950-1000 PPFD it goes to a 3.5 degree differential which tells me she may be able to handle 1100 PPFD, but I will wait until stretch finishes and she stops growing taller before I sneak in on that one, as I don't want to burn my leaves or yield and quality will suffer.
VPD is an extremely powerful tool. It's actually the difference between outdoors and indoors. Outdoors you get what nature dictates.
It surprises me that it isn't followed and used by everyone. We all have lights and nutes, so environment is all thats left.
And as always, the proof is in the pudding so lets look at the pudding. We have all read/heard numerous times that in flower 76F is the ideal temp, and most would say that after stretch 48RH is perfect. Well if you toss 76 and 48 into the calculator with a 2 degree spread you get this...
and 1.4 is perfect VPD for flower after stretch. The plants are working hard but not too hard and you still have buffer room if conditions fluctuate.
So here is the warning. If you raise VPD too high the atmosphere will suck too hard on the plant and draw water in too fast at the roots. The water coming in will not contain adequate food as it's getting sucked in too fast, and a deficiency will occur, so try to stay under 1.5 always, and 1.4 in late flower is plenty.
Don't get greedy here. Over 1.4 and you are one RH drop or temp spike away from screwing up your grow for a few days until it recovers, and possibly damaging leaves that won't recover. That comes out in yield.
In a nutshell, it's the throttle for the grow.