SweetSue's Cannabis Oil Study Hall

No keltic, I hadn't seen this. Exciting eh? Gave me goosebumps and sent me running for the iPad. Lol!

Nutr Healthy Aging. 2016 Oct 27;4(1):73-80. doi: 10.3233/NHA-160008.


Dietary olive oil induces cannabinoid CB2 receptor expression in adipose tissue of ApcMin/+ transgenic mice.
Notarnicola M1, Tutino V1, Tafaro A2, Bianco G2, Guglielmi E1, Caruso MG1.

Abstract
BACKGROUND: Cannabinoid- 2 (CB2) receptor is known for its anti-obesity effects silencing the activated immune cells that are key drivers of metabolic syndrome and inflammation. Nutritional interventions in experimental models of carcinogenesis have been demonstrated to modulate tissue inflammation state and proliferation.

OBJECTIVE: Aim of this study was to test, in ApcMin/+ mice, whether a diet enriched with olive oil, omega- 3 and omega-6- PUFAs affects the adipose tissue inflammation status.

METHODS: Four groups of animal were studied: ST group, receiving a standard diet; OO group, receiving the standard diet in which soybean oil (source of fats) was replaced with olive oil; OM-3 group, receiving the standard diet in which soybean oil was replaced with salmon oil; OM-6 group, receiving the standard diet in which soybean oil was replaced with oenothera oil. Gene and protein expression, in adipose tissue, were evaluated by RT-PCR and Western Blotting, respectively. Enzymatic activities were assayed by fluorescent and radiometric method, where appropriated.

RESULTS: The diet enriched with olive oil significantly induced CB2 receptor expression and it was able to control inflammatory and proliferative activity of mice adipose tissue.

CONCLUSIONS: The present findings open opportunities for developing novel nutritional strategies considering olive oil a key ingredient of a healthy dietary pattern.

AKgramma, I'd be looking for ways to sneak it into the diet. I developed a taste for it in brownies, but I suspect that disparate mix of flavors might be more than a little off-putting to some. At the very least you might want to consider making your capsules with an infused olive oil rather than your preferred cannabudder.
 
Ha ha almost a cross post with sue.

So for fun I looked at other articles from one of the authors, and 90+ came up. So I take that to be a real in action researcher and many different subjects. So I feel good about the info.

Here is a copy and paste of another I found on CB1, I have not reviewed this one in depth not sure what it says.

[h=3]Abstract[/h][h=4]BACKGROUND:[/h]Cannabinoid type 1 receptor (CB1-R) is a key mediator in the control of food intake and is linked to obesity.
[h=4]AIM:[/h]To evaluate the relationship between CB1-R gene polymorphism and dietary macronutrient intake in elderly subjects.
[h=4]METHODS:[/h]This study included 118 subjects (60 males, 58 females) from a population survey carried out in southern Italy in 1992-1993 who were older than 65 years and previously characterized for CB1-R polymorphism (75 with GG wild-type genotype, 41 with heterozygous polymorphic allele AG, and 2 with genotype AA). All subjects completed a validated semi-quantitative food frequency questionnaire. Statistical methods included multiple logistic regression to model macronutrient intake to genotype, controlling for potential confounders.
[h=4]RESULTS:[/h]When controlled for age, gender, and body mass index, the intake of dietary cholesterol and saturated fats corrected for calories was inversely associated with the CB1-R 1359 G/A polymorphism, while the intake of starchy carbohydrates was directly associated with this polymorphism.
[h=4]CONCLUSION:[/h]In our unselected elderly population, the 1359 G/A polymorphism is linked with a specific macronutrient intake. This could be explained by the role of the cannabinoid system as a determinant of food intake and eating behavior.
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kelticblue said:
it is a study from italy, i am not the best with all the acronyms but in summary the anti inflammatory properties seem to be what they talk about from the olive oil, and some from omega 3 and 6.
Not sure what info can be transferred to other oils.
:scratchinghead:
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Omega-6 promotes inflammatory response, where omega-3 counteracts inflammation. The typical American diet is so far off the mark it's breathtaking that we continue to procreate. The body runs on a balance of omega fatty acids, in a 1:1. We have developed a national diet closer to 20:1, with omega-6 fatty acids the unfortunate choice of imbalance. Inflammation is our big enemy, and dietary control as a national awareness would benefit everyone.

If you have the delight of sharing internal space with tumor cells, that omeg-6 is working against your chances of survival in a big, big way, particularly if it's breast or prostate cancer.

I believe it may be time to get that thread on supporting the ECS up and running.
 
I just needed to stop for a big hug. I have such a difficult time studying the fatty acids. I keep flashing back to the visit with Dale's cardiologist. Dale had been taking the omega-3 capsules on the advice of his PC for the two years following his most recent heart attack and this was the visit when the cardiologist cut him loose for once a year visits.

Then he paused and proceeded to explain how there were no definitive studies linking fish oil (omega-3) with any increased survival rates with the heart. So we could save ourselves the money and stop buying them.

So Dale did, and inflammation got out of control. He was dead in three years.

The arrogance of that moment in time, and the destruction caused by that arrogance stuns me. I take full responsibility for not being better informed, but I was also a wife trying desperately to keep my mate alive as he tumbled from one crisis to another.

It's just so hard to get past some days.
 
:laughtwo:

OK, apparently I've grown past grief. Lol! No sooner did I post that than Dale stepped in behind my ear and reminded me that everything happens for a purpose, and anyway, I was looking at death like it was something out of the ordinary.

I think I'm good now, if the laughter is any indication. I have some errands to run and then I'm tearing into a study of the lipids. I'll share what I learn later.
 
SweetSue said:
I just needed to stop for a big hug. I have such a difficult time studying the fatty acids. I keep flashing back to the visit with Dale's cardiologist. Dale had been taking the omega-3 capsules on the advice of his PC for the two years following his most recent heart attack and this was the visit when the cardiologist cut him loose for once a year visits.

Then he paused and proceeded to explain how there were no definitive studies linking fish oil (omega-3) with any increased survival rates with the heart. So we could save ourselves the money and stop buying them.

So Dale did, and inflammation got out of control. He was dead in three years.

The arrogance of that moment in time, and the destruction caused by that arrogance stuns me. I take full responsibility for not being better informed, but I was also a wife trying desperately to keep my mate alive as he tumbled from one crisis to another.

It's just so hard to get past some days.
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I know you feel better, but :hugs: :circle-of-love: for that anyway.

Every good thing I try to do for my parents (that they'll follow through on) is counteracted by the arrogance and ignorance of the medical community. Every. Freaking. Time. At this stage, I have virtually zero respect for the community as a whole. They've done too much hideous, hideous damage to me and my loved ones. This might be the angriest I ever get. :) I'll move past that, too....
 
SweetSue said:
I just needed to stop for a big hug. I have such a difficult time studying the fatty acids. I keep flashing back to the visit with Dale's cardiologist. Dale had been taking the omega-3 capsules on the advice of his PC for the two years following his most recent heart attack and this was the visit when the cardiologist cut him loose for once a year visits.

Then he paused and proceeded to explain how there were no definitive studies linking fish oil (omega-3) with any increased survival rates with the heart. So we could save ourselves the money and stop buying them.

So Dale did, and inflammation got out of control. He was dead in three years.

The arrogance of that moment in time, and the destruction caused by that arrogance stuns me. I take full responsibility for not being better informed, but I was also a wife trying desperately to keep my mate alive as he tumbled from one crisis to another.

It's just so hard to get past some days.
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:hugs::Love::hugs::Love: :hugs:
 
kelticBlue said:
.........complications of which killed my father, at 90.

Indeedy, no shite, Omega 6, Hmmmm... Interesting..... THX. :ciao:


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Obviously time for me to make that thread on supporting the ECS a priority post. I'll get to it before lipids. Right now, I'm making Callanetics my top priority after a really good buzz. :cheesygrinsmiley:

Thank you all for the hugs. You know how much they mean to me. :Love: :hugs::hugs::hugs::hugs::hugs: :Love:
 
SweetSue said:
I just needed to stop for a big hug. I have such a difficult time studying the fatty acids. I keep flashing back to the visit with Dale's cardiologist. Dale had been taking the omega-3 capsules on the advice of his PC for the two years following his most recent heart attack and this was the visit when the cardiologist cut him loose for once a year visits.

Then he paused and proceeded to explain how there were no definitive studies linking fish oil (omega-3) with any increased survival rates with the heart. So we could save ourselves the money and stop buying them.

So Dale did, and inflammation got out of control. He was dead in three years.

The arrogance of that moment in time, and the destruction caused by that arrogance stuns me. I take full responsibility for not being better informed, but I was also a wife trying desperately to keep my mate alive as he tumbled from one crisis to another.

It's just so hard to get past some days.
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This post really pisses me off! Doctors' advice is based on what they learned decades ago, learning that is outdated, and actually harmful, as you have found. Chemo is found to be much less than immunotherapy now. And we know that cannibus ingested in the correct doses KILLS cancer cells.

I have gotten to the point where I refuse tests that only lead to more unnecessary tests, some which are invasive. I had one (former) GP whose answer for everything was surgery. Well, I'm almost 70, and no way am I going to risk my life with anesthetics and surgery! The meds I take elevate my calcium levels, and so the Dr. looks for disease, rather than remove the offending medication. More $ from Medicare.

Sue, you cannot carry the guilt of not knowing that stopping Omega 3's killed your dear husband! Since then you have learned to take your own health into your own hands, and will fare far better than your husband did.

Just imagine this: years down the line oncologists will look back on the barbaric treatments for cancer of the 20th Century in horror, as so much useless suffering. It is illogical to poison the whole body to kill a few cells. it is far more logical to target the tumour cells themselves. If we can do that with cannabis, then no more losing hair, vomiting, weakness, and infections from a compromised immune system.:Namaste:
 
Regarding Dietary Olive oil: I assume this is Olive oil I can buy at the grocery store? What kind or brand do I look for, and how much per day should I use to regulate the inflammation (severe) and the weight gain (since I was 9 years old)?
 
Hi ya'll...am here in study hall for first, no really, 2nd time! First time was overwhelming, as I tried to start from the beginning!
Impossible, as Sue let me know!
I am ready to learn, am not as "up" on everything (or really ANYTHING) as you all are. I just know that I have BC and I need a plan of action! I have a MMJ card in NY, but don't think I could ever treat myself with the dosing they have prescribed for me. To qualify, I had to say I had pain; so this isn't meant to be curative, only palliative........I am ready to learn, but need a crash course!
 
AKgramma said:
Regarding Dietary Olive oil: I assume this is Olive oil I can buy at the grocery store? What kind or brand do I look for, and how much per day should I use to regulate the inflammation (severe) and the weight gain (since I was 9 years old)?
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really good question, Sue if ya see this, I forget but I thought there was some olive oil that was better, more pure, ?
My memory is weak at times but i remember some drama about fake olive oil?

I found myself reading through some of this info because I give my cat canna-infused coconut oil for the CBDs. just happened to catch my eye but I am sticking with coconut oil for my cat. 6 months no seizures.
 
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