SweetSue's Cannabis Oil Study Hall

[SweetSue]

Thank you, Kingston (and Sue).

My problem with a lot of this is that I'm not familiar with a lot of the cannabis-related terms. I'm not a stupid person but I have a hard time wrapping my head around everything when I'm still learning and I don't want to have to post multiple questions about what the terms mean. I wonder if there's a Marijuana for Dummies book available? I liked Sue's Coles Notes infographic on cannabinoids and terpenes although my LP doesn't list the cannabinoids for their products.

Heck, I don't even understand all the information about rheumatoid arthritis and its treatments and I've had RA for 12 years.

Kingston, I don't even know what C1, C2 (and C3 and C4) receptors are. I'm guessing they're something in the body that depending which one the cannabis comes in contact with determines how the body reacts but that's just a guess.

I think I know the website you're talking about for the strains. After 420 Magazine, it's my favourite cannabis-related website mainly because of all the great strain reviews.

I just love it when you make me go into teacher mode.

Receptors are, in essence, the keyhole that the cannabinoids (the key in this illustration) fits into. Every cell in your body has them, and each of the individual cannabinoids will have points where they attach. Some will share receptors, meaning they may compete for those receptors, and some receptors are exclusive to certain cannabinoids.

When the cannabinoids attach to a receptor it causes a cascade of chemical signals that inform the cell of the action it needs to take. For example, when cannabinoids attach to tumor cells they can trigger a number of different things to occur, from the cutting off of the blood supply to the tumor cell to the disruption of the mitochondrial wall, that energy factory at the center of every cell. Make that wall permeable and the cell falls apart. These are just two of the many things cannabinoids can signal in tumor cells alone.

There are signals generated by this type of activity that control every function in your body, including the personality expression we know as you.

We know for sure that there are the two receptors, CB1 and CB2. We know that THC and CBD attach to these receptors, depending on what the body needs to have happen. But there are many more cannabinoids than THC and CBD. The assumption is that there are more receptors that we simply haven't identified.

Prohibition set us back a few decades in research. We'll catch up somewhere along the line.

 

[SweetSue]

I'm dropping this here because I'm researching cannabis treatments for tinnitus for HashGirl.

"The prognosis of tinnitus depends on the type and severity of the cause.
Cannabis helps Tinnitus
One of the main theories of tinnitus is that it is a form of sensory epilepsy, sometimes arising from neuronal hyperactivity in the brainstem cochlear nucleus.

Antiepileptic drugs have therefore been explored as one potential treatment option.
Increasing evidence suggests that cannabinoid drugs can also have antiepileptic effects.
Recently, it has been reported that cannabinoid CB1, CB2 receptors, and the endogenous cannabinoid, 2-arachidonylglycerol (2-AG), are expressed in the cochlear nucleus.

CB1 receptors appear to negatively regulate the release of glutamate, and it is possible that their down-regulation during the development of tinnitus is responsible for the neuronal hyperactivity associated with the condition.

cannabinoid drugs might be useful in the treatment of tinnitus.

Previous studies in animals and humans have shown that, in some cases at least, anti-epileptic drugs can reduce the severity of tinnitus. Given that cannabinoid receptor agonists have been shown to exert anti-epileptic effects in some circumstances, we investigated whether two synthetic CB(1)/CB(2) receptor agonists, WIN55,212-2, and CP55,940, could inhibit the behavioral manifestations of salicylate-induced tinnitus in rats in a conditioned suppression task. We found that neither WIN55, 212-2 (3.0 mg/kg s.c) nor CP55, 940 (0.1 or 0.3 mg/kg s.c), significantly reduced conditioned behavior associated with tinnitus. However, both 3 mg/kg WIN55, 212-2 and 0.3 mg/kg CP55, 940 did significantly increase tinnitus-related behavior compared to the vehicle control groups.

These results suggest that cannabinoid receptor agonists may not be useful in the treatment of salicylate-induced tinnitus and that at certain doses; they could actually exacerbate the condition.

Cannabinoid CB1 receptors have not been systematically investigated in the brainstem cochlear nucleus, nor have they been investigated in relation to tinnitus. Using immunohistochemistry and cell counting, we showed that a large number of neurons in the rat cochlear nucleus possess cannabinoid CB1 receptors. Following salicylate injections that induced the behavioral manifestations of tinnitus, the number of principal neurons in the ventral cochlear nucleus expressing CB1 receptors significantly decreased, while the number of CB1-positive principal neurons in the dorsal cochlear nucleus did not change significantly.

These results suggest that CB1 receptors in the cochlear nucleus may be important for auditory function and that a down-regulation of CB1 receptors in the ventral cochlear nucleus may be related to the development of tinnitus.

One of the most important uses of cannabis is as a substitute for other, more dangerous or costly pharmaceutical drugs.

Many patients report substantial reductions in use of narcotics, non-steroidal anti-inflammatories, anti-depressants, tranquilizers, sleeping pills and other drugs once they started using cannabis medicine.
CBD is an anticonvulsant.
Cannabis is powerful medicine for mixed syndromes.

Use Indica’s with high CBD levels.
Use Indica dominant hybrid with high CBD levels."

I'll get back to this tomorrow. I'm beat guys. I had the book on the ECS organize itself today. Caught me a little off guard. I was doing something completely different and suddenly I was filling out cards and making notes like a mad-woman. An hour later, this is what I had in front of me.

The book has decided it's time to start the process. This fascinated me. I've never written a book before. Never even seriously considered doing so. When this process started it was as though I was just there, moving things around. Something much bigger than anything I've felt within me before is running this show.

I think we're in for some serious fun. See those two cards off by themselves on the left? That's the next two books.

Goodnight everyone. Tomorrow's another glorious day filled with opportunity.

 

[AngryBird]

I will be first in line buying your books

I was curious about the class canna/pregnancy, since I wasn't sure WHAT goes in the fetus and when you breast feed, what goes in the milk.
For a few years now, I am looking into the connection between a mother using, for example, morphine as pain killer (small doses) and the relation in making the child she carry a drug user (not talking about weed here at all) when he grows up.
Like as it is implanted in the fetus's DNA to me more vulnerable.

Since there is no addictive substance in cannabis. my thought was it should be safe.

 

[Chew]

I'm dropping this here because I'm researching cannabis treatments for tinnitus for HashGirl.

"The prognosis of tinnitus depends on the type and severity of the cause.
Cannabis helps Tinnitus
One of the main theories of tinnitus is that it is a form of sensory epilepsy, sometimes arising from neuronal hyperactivity in the brainstem cochlear nucleus.

Antiepileptic drugs have therefore been explored as one potential treatment option.
Increasing evidence suggests that cannabinoid drugs can also have antiepileptic effects.
Recently, it has been reported that cannabinoid CB1, CB2 receptors, and the endogenous cannabinoid, 2-arachidonylglycerol (2-AG), are expressed in the cochlear nucleus.

CB1 receptors appear to negatively regulate the release of glutamate, and it is possible that their down-regulation during the development of tinnitus is responsible for the neuronal hyperactivity associated with the condition.

cannabinoid drugs might be useful in the treatment of tinnitus.

Previous studies in animals and humans have shown that, in some cases at least, anti-epileptic drugs can reduce the severity of tinnitus. Given that cannabinoid receptor agonists have been shown to exert anti-epileptic effects in some circumstances, we investigated whether two synthetic CB(1)/CB(2) receptor agonists, WIN55,212-2, and CP55,940, could inhibit the behavioral manifestations of salicylate-induced tinnitus in rats in a conditioned suppression task. We found that neither WIN55, 212-2 (3.0 mg/kg s.c) nor CP55, 940 (0.1 or 0.3 mg/kg s.c), significantly reduced conditioned behavior associated with tinnitus. However, both 3 mg/kg WIN55, 212-2 and 0.3 mg/kg CP55, 940 did significantly increase tinnitus-related behavior compared to the vehicle control groups.

These results suggest that cannabinoid receptor agonists may not be useful in the treatment of salicylate-induced tinnitus and that at certain doses; they could actually exacerbate the condition.

Cannabinoid CB1 receptors have not been systematically investigated in the brainstem cochlear nucleus, nor have they been investigated in relation to tinnitus. Using immunohistochemistry and cell counting, we showed that a large number of neurons in the rat cochlear nucleus possess cannabinoid CB1 receptors. Following salicylate injections that induced the behavioral manifestations of tinnitus, the number of principal neurons in the ventral cochlear nucleus expressing CB1 receptors significantly decreased, while the number of CB1-positive principal neurons in the dorsal cochlear nucleus did not change significantly.

These results suggest that CB1 receptors in the cochlear nucleus may be important for auditory function and that a down-regulation of CB1 receptors in the ventral cochlear nucleus may be related to the development of tinnitus.

One of the most important uses of cannabis is as a substitute for other, more dangerous or costly pharmaceutical drugs.

Many patients report substantial reductions in use of narcotics, non-steroidal anti-inflammatories, anti-depressants, tranquilizers, sleeping pills and other drugs once they started using cannabis medicine.
CBD is an anticonvulsant.
Cannabis is powerful medicine for mixed syndromes.

Use Indica’s with high CBD levels.
Use Indica dominant hybrid with high CBD levels."

I'll get back to this tomorrow. I'm beat guys. I had the book on the ECS organize itself today. Caught me a little off guard. I was doing something completely different and suddenly I was filling out cards and making notes like a mad-woman. An hour later, this is what I had in front of me.

The book has decided it's time to start the process. This fascinated me. I've never written a book before. Never even seriously considered doing so. When this process started it was as though I was just there, moving things around. Something much bigger than anything I've felt within me before is running this show.

I think we're in for some serious fun. See those two cards off by themselves on the left? That's the next two books.

Goodnight everyone. Tomorrow's another glorious day filled with opportunity.

Tinnitus is one of reason I started using cannabis again after a 16 year break. It doesn't bother me much during the day but trying to sleep was extremely difficult. Until I discovered CO and caps

I'm intrigued to see what you discover

 

[SweetSue]

I had a friend who toked up a lot and I could hardly keep up. He ate a lot of junk food and eventually died from colon cancer. He used to call it an attitude adjustment when he smoked weed. Unfortunately he seemed grouchy when he did not.

From what I have learned here and now doing some self reflection, I think he may have actually damaged his ECS by over doing it. My body always tried to let me know when I was over doing it. I had to quit cigs and cannot drink in excess or smoke weed in excess etc thanks to my body ( ecs?) telling me or signalling me to slow down.

THis ECS theory of yours , Sue, may explain the therapeutic ability behind faith or meditation and the rise of religions etc. It's nice to put a face on the theory I guess but as with so many good things for the masses such as socialism or spiritualism or communication , ECS will ultimately be turned into something it is not meant to be in the name of power and wealth.

We're going to keep that from happening gudyul. I'm a force of nature. I'll refuse to let that control occur.

What struck me deeply as I considered this was how this message to think positive has been there all along, but now we can appreciate the biology that explains the necessity. It's much more than pie-in-the-sky or rosey-tinted glasses. It comes down to survival. Control of your emotional tone determines your level of homeostasis because you have an endocannabinoid system.

 

[SweetSue]

This tidbit is from Tune Out Tinnitus, based in the UK. The language is way less technical.

"Can Marijuana Use Alleviate Tinnitus?/B]

Tinnitus, or ringing in the ears, is a fairly mysterious condition. It doesn’t always appear as a phantom ringing– it can also show up as a whooshing sound, beeping, buzzing, or any number of other annoying noises. It can be caused by things as varied as wax buildup or foreign objects in the ear canal, allergies, neurological conditions, injuries, or what appears to be nothing– even people with no hearing can experience tinnitus. Unfortunately, since the sounds tinnitus sufferers hear don’t really exist and the causes of it are varied, there’s no objective test or foolproof cure for this condition.

medical-cannabis-tinnitus-relief

While tinnitus might seem like a mild annoyance to outsiders, people with severe tinnitus often find that it seriously disrupts their lifestyle. The sounds can make it hard to hear properly, sleep, or even go about their daily lives. As a result, there are any number of home remedies for the condition, some of them ranging from useless to downright dangerous.

Some people speculate that medicinal marijuana may help alleviate tinnitus symptoms. Since there’s no test to measure tinnitus and it’s often difficult to pinpoint a cause, getting a prescription for medicinal marijuana for it might be nearly impossible. However, that doesn’t mean that cannabis isn’t helpful.

A neurological tinnitus study

A 2009 study by Dr. Thanos Tzounopoulos found that mice with tinnitus exhibited exaggerated brain activity. In the past, Dr. Tzounopoulos found that endocannabinoid receptors affected brain plasticity. He drew comparisons between tinnitus and other neurological conditions, like chronic pain, which suggests that marijuana may be an effective treatment. However, there is also anecdotal evidence that marijuana may cause or exacerbate tinnitus for some sufferers.

Medicinal cannabis has been prescribed to help people cope with some of the conditions that can cause tinnitus, like cancer and allergies. In those cases, it’s easy to see how marijuana might help. Even among those people whose tinnitus doesn’t respond to marijuana, it may help alleviate some of the stress, anxiety, and insomnia that plague tinnitus sufferers.

One thing many people forget is that a marijuana prescription isn’t like a regular pharmaceutical prescription– it is effectively permission for an individual to experiment with medical-grade cannabis, and determine if it helps their symptoms. Some tinnitus sufferers may find that it does, while others may find that it worsens them. As medicinal marijuana prescriptions are currently not available for this condition, some patients opt to growing their own cannabis plants from seeds. While this legally puts patients in danger, the alleviation it causes makes it the most helpful tool in their search for relief. Hopefully, as people like. Dr. Tzounopoulos further tinnitus research, more concrete and clear evidence becomes available."

I'll keep digging. I want to see if I can discover, or reason out, which strains, or more precisely which ratios, are causing the aggravation of the condition. We have a level of understanding about cannabis in this group that many others don't. We go about this exploration in our own way. Let's use our insights and see if we can solve this one. I'm thinking it's too much THC causing excitability. It could be a blend of terpenes. Thinking about it casually, this popped into view. Terpenes determine cannabinoid expression.

 

[SweetSue]

I'm having bursts of clarity - the connection between the idea of Law of Attraction and the healthy ECS. I've accepted that Law of Attraction exists. The evidence is irrefutable. But I suddenly suspect that the out there, left field feel to this subject is unnecessary. Aren't we really talking about a healthy ECS?

Consider: You have a system at, or reasonably close to homeostasis. This would be expressed in a mostly optimistic approach to life. I'm convinced of this. This is simple biology, in my opinion, and I can't believe they haven't proven it yet. It's not even a far reach, IMO.

This optimistic nature allows you to see opportunity someone else wouldn't. A healthy personality has the confidence levels to take the big risks in life. Again, biology awaiting lab confirmation. That confidence helps you take appropriate action towards a goal you have no doubt you can achieve because you know you can do anything you set out to do, and there is no failure.

Fearlessness born out of a curious nature and a love of play. These are hallmarks of the healthiest brains among us, are they not? Even those confined by physical limitations manage to play through life, and that's where they find their inspiration - in moments of play.

It's not Law of Attraction, it's a healthier ECS allowing you to focus better and take action without fear.

Whew! This stuff writes itself guys. I've been collecting data nonstop for over a year now, and things are beginning to fall into place in the most amazing way. We need serious research money behind us.

OMG! A curriculum guide for elementary ed. I was not expecting that.

 

[SweetSue]

A grab from Wikipedia:

The endocannabinoid system has been studied using genetic and pharmacological methods. These studies have revealed that cannabinoids act as neuromodulators for a variety of processes, including motor learning, appetite, and pain sensation, among other cognitive and physical processes. The localization of the CB1 receptor in the endocannabinoid system has a very large degree of overlap with the orexinergic projection system, which mediates many of the same functions, both physical and cognitive. Moreover, CB1 is colocalized on orexin projection neurons in the lateral hypothalamus and many output structures of the orexin system, where the CB1 and orexin receptor 1 (OX1) receptors physically and functionally join together to form the CB1—OX1 receptor heterodimer.

**********​

The orexin system was initially suggested to be primarily involved in the stimulation of food intake, based on the finding that central administration of orexin-A and -B increased food intake. In addition, it stimulates wakefulness, regulates energy expenditure, and modulates visceral function.

..... There are approximately 70,000 orexin producing neurons in the human brain that project from the lateral hypothalamus to neurons and brain regions that modulate wakefulness. However, the axons from these neurons extend throughout the entire brain and spinal cord, where there are also receptors for orexin.

**********​

From the Cambridge University Press dictionary:

visceral adjective (EMOTIONAL) ​ literary based on deep feeling and emotional reactions rather than on reason or thought: visceral hatred/excitement. His approach to acting is visceral rather than intellectual.

What you feel, or more precisely, what you allow yourself to feel, takes on a whole new perspective.

I need to modify my message to include the fact that we only know of the receptors that we've been able to see through the testing processes we chose. Those searches were limited by the scope of what they were looking for, which to some extent determined the search parameters.

I suspect there are many more receptors than we consider possible, or that receptors can be shared. We have so much learning ahead of us in the molecular sciences it makes the head swim just to consider it.

But I can't go around saying there are ECS receptors on all of our cells like it's a matter of scientific fact. It's not, and I'll stop doing that.

 

[HashGirl]

I just love it when you make me go into teacher mode.

Receptors are, in essence, the keyhole that the cannabinoids (the key in this illustration) fits into. Every cell in your body has them, and each of the individual cannabinoids will have points where they attach. Some will share receptors, meaning they may compete for those receptors, and some receptors are exclusive to certain cannabinoids.

When the cannabinoids attach to a receptor it causes a cascade of chemical signals that inform the cell of the action it needs to take. For example, when cannabinoids attach to tumor cells they can trigger a number of different things to occur, from the cutting off of the blood supply to the tumor cell to the disruption of the mitochondrial wall, that energy factory at the center of every cell. Make that wall permeable and the cell falls apart. These are just two of the many things cannabinoids can signal in tumor cells alone.

There are signals generated by this type of activity that control every function in your body, including the personality expression we know as you.

We know for sure that there are the two receptors, CB1 and CB2. We know that THC and CBD attach to these receptors, depending on what the body needs to have happen. But there are many more cannabinoids than THC and CBD. The assumption is that there are more receptors that we simply haven't identified.

Prohibition set us back a few decades in research. We'll catch up somewhere along the line.

Thank you, Sue. I told my husband that it will be easier to learn all about these things once I'm retired. However, that said, I learn best from hands-on experience or from examples like the one you used above or from pictures like the infographic you used in your last response to my bewilderment. When faced with multiple paragraphs full of words I don't understand, I just find it overwhelming. For this thread, I love reading everyone else's experiences best.


On another note, I made more cannaoil today using a 10:1 ratio (oil:cannabis). I used sunflower oil this time but I forgot all about the lecithin. I'm not planning on putting this oil into capsules. I currently take 1/2 to 1 mg of cannaoil using a dosing syringe every night before bed and this oil will go into the empty bottle that used to hold my medicine from the LP.

 

[HashGirl]

Thanks, Sue, this article was definitely easier for me to understand.

And, I do think that cannabis does help me ignore it. It's not there all the time but often enough to be annoying but when I get high, I find it much easier to ignore. I'll have to monitor whether my CBD-based meds help it, too.

This tidbit is from Tune Out Tinnitus, based in the UK. The language is way less technical.

"Can Marijuana Use Alleviate Tinnitus?/B]

Tinnitus, or ringing in the ears, is a fairly mysterious condition. It doesn't always appear as a phantom ringing— it can also show up as a whooshing sound, beeping, buzzing, or any number of other annoying noises. It can be caused by things as varied as wax buildup or foreign objects in the ear canal, allergies, neurological conditions, injuries, or what appears to be nothing— even people with no hearing can experience tinnitus. Unfortunately, since the sounds tinnitus sufferers hear don't really exist and the causes of it are varied, there's no objective test or foolproof cure for this condition.

medical-cannabis-tinnitus-relief

While tinnitus might seem like a mild annoyance to outsiders, people with severe tinnitus often find that it seriously disrupts their lifestyle. The sounds can make it hard to hear properly, sleep, or even go about their daily lives. As a result, there are any number of home remedies for the condition, some of them ranging from useless to downright dangerous.

Some people speculate that medicinal marijuana may help alleviate tinnitus symptoms. Since there's no test to measure tinnitus and it's often difficult to pinpoint a cause, getting a prescription for medicinal marijuana for it might be nearly impossible. However, that doesn't mean that cannabis isn't helpful.

A neurological tinnitus study

A 2009 study by Dr. Thanos Tzounopoulos found that mice with tinnitus exhibited exaggerated brain activity. In the past, Dr. Tzounopoulos found that endocannabinoid receptors affected brain plasticity. He drew comparisons between tinnitus and other neurological conditions, like chronic pain, which suggests that marijuana may be an effective treatment. However, there is also anecdotal evidence that marijuana may cause or exacerbate tinnitus for some sufferers.

Medicinal cannabis has been prescribed to help people cope with some of the conditions that can cause tinnitus, like cancer and allergies. In those cases, it's easy to see how marijuana might help. Even among those people whose tinnitus doesn't respond to marijuana, it may help alleviate some of the stress, anxiety, and insomnia that plague tinnitus sufferers.

One thing many people forget is that a marijuana prescription isn't like a regular pharmaceutical prescription— it is effectively permission for an individual to experiment with medical-grade cannabis, and determine if it helps their symptoms. Some tinnitus sufferers may find that it does, while others may find that it worsens them. As medicinal marijuana prescriptions are currently not available for this condition, some patients opt to growing their own cannabis plants from seeds. While this legally puts patients in danger, the alleviation it causes makes it the most helpful tool in their search for relief. Hopefully, as people like. Dr. Tzounopoulos further tinnitus research, more concrete and clear evidence becomes available."

I'll keep digging. I want to see if I can discover, or reason out, which strains, or more precisely which ratios, are causing the aggravation of the condition. We have a level of understanding about cannabis in this group that many others don't. We go about this exploration in our own way. Let's use our insights and see if we can solve this one. I'm thinking it's too much THC causing excitability. It could be a blend of terpenes. Thinking about it casually, this popped into view. Terpenes determine cannabinoid expression.

 

[SweetSue]

Thanks, Sue, this article was definitely easier for me to understand.

And, I do think that cannabis does help me ignore it. It's not there all the time but often enough to be annoying but when I get high, I find it much easier to ignore. I'll have to monitor whether my CBD-based meds help it, too.

Im glad it helped some HashGirl, and thank you for sharing that you're more visually oriented. There are a number of members that share that challenge, and if I know that going in I modify my posting method. I'll do so for you in the future.

The first few times I made oils the lecithin got added later than at the very beginning. Lol! It's a learning process, helped along by a healthy sense of humor. I remind myself that life is a big science experiment anyway.

 

[SL2222]

A grab from Wikipedia:

The endocannabinoid system has been studied using genetic and pharmacological methods. These studies have revealed that cannabinoids act as neuromodulators for a variety of processes, including motor learning, appetite, and pain sensation, among other cognitive and physical processes. The localization of the CB1 receptor in the endocannabinoid system has a very large degree of overlap with the orexinergic projection system, which mediates many of the same functions, both physical and cognitive. Moreover, CB1 is colocalized on orexin projection neurons in the lateral hypothalamus and many output structures of the orexin system, where the CB1 and orexin receptor 1 (OX1) receptors physically and functionally join together to form the CB1–OX1 receptor heterodimer.

**********​

The orexin system was initially suggested to be primarily involved in the stimulation of food intake, based on the finding that central administration of orexin-A and -B increased food intake. In addition, it stimulates wakefulness, regulates energy expenditure, and modulates visceral function.

..... There are approximately 70,000 orexin producing neurons in the human brain that project from the lateral hypothalamus to neurons and brain regions that modulate wakefulness. However, the axons from these neurons extend throughout the entire brain and spinal cord, where there are also receptors for orexin.

**********​

From the Cambridge University Press dictionary:

visceral adjective (EMOTIONAL) ​ literary based on deep feeling and emotional reactions rather than on reason or thought: visceral hatred/excitement. His approach to acting is visceral rather than intellectual.

What you feel, or more precisely, what you allow yourself to feel, takes on a whole new perspective.

I need to modify my message to include the fact that we only know of the receptors that we've been able to see through the testing processes we chose. Those searches were limited by the scope of what they were looking for, which to some extent determined the search parameters.

I suspect there are many more receptors than we consider possible, or that receptors can be shared. We have so much learning ahead of us in the molecular sciences it makes the head swim just to consider it.

But I can't go around saying there are ECS receptors on all of our cells like it's a matter of scientific fact. It's not, and I'll stop doing that.

Interesting thought - before I got sick I had a very high pain threshold. But, really, it was more like I didn't feel pain so intensely that it knocked me out. I mean, not even so much as an ibuprofen after wisdom tooth removals, I tolerated period pains, I rarely even cared to take anything when I DID have pain, unless I had the flu or something awful. I managed it, and usually moved through it. Then I got sick - this is when everything changed - anxiety, hormones, immune system, etc., everything. Including my ability to deal with pain. EVERYTHING started to feel excruciating after that - like not only was the pain amplified exponentially, but it was penetrating my whole body, not just the site. I also began having very emotional responses to pain.

Learning about the endocannabinoid system is making everything that happened to me make SO much more sense - things that back then seemed so unrelated are now coming together.

 

[HashGirl]

I really do love you, Sue.

Im glad it helped some HashGirl, and thank you for sharing that you're more visually oriented. There are a number of members that share that challenge, and if I know that going in I modify my posting method. I'll do so for you in the future.

The first few times I made oils the lecithin got added later than at the very beginning. Lol! It's a learning process, helped along by a healthy sense of humor. I remind myself that life is a big science experiment anyway.

 

[SweetSue]

I really do love you, Sue.

The feeling is mutual HashGirl.

 

[SweetSue]

I went to bed last night intending to do a run of CCO this afternoon. Then I woke up, proclaiming my eagerness to engage the universe in play, and was slammed with the realization that I needed to rethink my process.

I live in a small apartment in a building with other renters of small apartments. We're a community without vent fans over our stoves and the outdoor temps are running 15 F at this moment. This doesn't make me want to throw the windows open, and evaporating outdoors would be an act of futility.

Suddenly I remembered Major PITA had developed a sweet technique for quickly converting plant material into dry-sift hash by freezing the plant material first. Reviewing this it struck me that I'm making a medicinal oil, and wouldn't it behoove me to learn to work for putity?

So I went into opportunistic mode, dashing off on a searching mission, to run smack-dab into Bubbleman's article in High Times magazine this month on his own technique, using just the right screens and a gentle hand over a longer period of time.

Almost 99% purity on trichome heads in his final product. Think of that! Whoa!!!! This is the material I want for my next oil run. Working with dry sift eliminates the need for more than drops of solvent. Using this process will also eliminate my need for a press, since working slow and steady will give me a product beyond that method, although I obviously give up speed.

I'll be finding another use for the frozen ounce of bud in my freezer right now. I'll be making some butter today. That might be a fun addition. My butters are usually made with leaves only. I think of it as a way to get a different nutrient mix in there with the cannabinoids. Butter that makes me high might be a interesting adventure.

 

[AngryBird]

interesting
Hi by the way

 

[Arctic Bowl]

gotta love da butter

 

[kelticBlue]

Not sure if anyone saw this.....
An increased intake of olive oil in mice increased the number of CB2 receptors.

Thought it might be of interest.


hard for me to figure links on my phone. Hope this is ok if not I am sorry.
A link.
Dietary olive oil induces cannabinoid CB2 receptor expression in adipose tissue of ApcMin/+ transgenic mice. - PubMed - NCBI

 

[AKgramma]

Not sure if anyone saw this.....
An increased intake of olive oil in mice increased the number of CB2 receptors.

Thought it might be of interest.


hard for me to figure links on my phone. Hope this is ok if not I am sorry.
A link.
Dietary olive oil induces cannabinoid CB2 receptor expression in adipose tissue ofÂ-ApcMin/+ transgenic mice. - PubMed - NCBI

What do you do if olive oil activates your gag reflex? I love black olives, but I cannot tolerate olive oil. :-(

 

[kelticBlue]

Not sure if anyone saw this.....
An increased intake of olive oil in mice increased the number of CB2 receptors.

Thought it might be of interest.


hard for me to figure links on my phone. Hope this is ok if not I am sorry.
A link.
Dietary olive oil induces cannabinoid CB2 receptor expression in adipose tissue ofÂ-ApcMin/+ transgenic mice. - PubMed - NCBI

It is a study from Italy, I am not the best with all the acronyms but in summary the anti inflammatory properties seem to be what they talk about from the Olive oil, and some from Omega 3 and 6.
Not sure what info can be transferred to other oils.