SweetSue's Class Notes
- Thread starter SweetSue
- Start date
- Thread starter
- #242
Lol! I have until the 29th before I can crack one open next. I'm trying to keep myself occupied until then.
overlord
Well-Known Member
- Thread starter
- #244
You poor girl, have a brownie..
I missed this bit of frivolity in all the cob ruckus. Lol! I did. More than one.
- Thread starter
- #245
- Thread starter
- #246
At 19:48 he explains why bile helps fats be absorbed. This is the same explaination for how lecithin works. Do you have any idea how excited it makes me to find something that matches up with what I'm trying to better understand?
I'm gaining a better understanding of how the biobombs are more bioavailable, why Cajun had us include liquid sunflower lecithin in the formulation.
Bile is more complex, but they both do essentially the same thing, which is to lovingly encircle the cannabinoids in a hug to help them slip through the stomach caldron undamaged.
You know, he simply wouldn't take the time to explain it to me. Couldn't be bothered. I'd have walked through walls for that man, and he didn't think I was worth the effort to help me understand something this important.
You know what? Part of why I keep at this is to kinda thumb my nose at him.
22:04 suppositories
25:34 - confirmation of what I learned at Green Flower about sublingual administration - people swallow! The bioavailability of the sublingual sprays is no better than oral administration.
29:18 It surprises me to find I know things the experts overlook. THCA may work for inflammation - at least in theory - in a cream, but it's so aggressively trying to convert to THC that you have to be careful about storage. Decarb is a function of time and temperature, and given either time or warm enough temps and the cream THCa will become THC.
Knowing that, why bother to add it to your creams? Decarb for maximum THC for the pain application and get the inflammatory help on a systemic level with edibles or suppositories.
No mention of the instability of THCa and its aggressive nature to convert. I think this is an important thing to know. I learned it at Green Flower Media. Made me glad I pay that price every month, though to be honest, it makes me feel good to support them. They certainly do a lot for us.
Back to the video.
At 31:35 he hit my favorite nerve, the reference to studies that show the developing brain effected enough by cannabis consumption as to cause structural changes
Does no one consider that those changes may have been for the better? The study in NZ ran for over 30 years and found no negative effects from continuious consumption of cannabis.
Case closed. Let's get on with the healing and leave the fear behind us, thank you very much.
If cannabis was that dangerous to the developing brain explain cannabinoids in breast milk. Explain how I can be surrounded by all this brilliance when so many of them started using cannabis to keep themselves level and sane when they were in their early teens.
Yeah...., this one gets me riled. Lol! Back to work woman!
33:52 He explains that the CBD molecule is a CBD molecule, despite its being derived from cannabis sativa or hemp. It's the accompanying components that will either enhance or detract from the effectiveness of the CBD molecules, the entourage effect. Hemp has fewer medicinally complementary components.
To which she says "So there's no difference between hemp CBD and marijuana CBD." He answers "Yes" and they move on.
*sigh*
~ 35:00 This stopped me: he mentions that if you don't produce enough bile - it's produced in the gall bladder, remember? That organ they said we don't really need, so we can remove it? Yeah, that one. Well, if you don't have one, or have one that can't keep up with your fat consumption, it's gonna be hard for you to absorb cannabinoids in edibles.
But he doesn't say anything about how this makes lecithin, and in particular liquid sunflower lecithin, an attractive additive for cannabis edibles.
I mean, sometimes it feels like they aren't even trying.
Finishing up at 1:30. Ok, I learned a couple things there, but I couldn't help wondering if this young man has ever used cannabis. Too much of what we learn is from people in research, working with animals or Petri dishes, but who've never used the plant in any way, haven't felt the touch of euphoria cannabis offers. That means they have a limited outlook, in great part flavored by the prohibitionary propaganda that effected all of us, in one way or another.
But I learned a thing or two from him, and for that I give thanks.
Thank you @overlord It's a pleasure working with you m'lord.
- Thread starter
- #247
Well.... there's that little matter of how much I love studying and sharing.
- Thread starter
- #248
with supporting graphics
At 19:48 he explains why bile helps fats be absorbed. This is the same explaination for how lecithin works. Do you have any idea how excited it makes me to find something that matches up with what I'm trying to better understand?
I'm gaining a better understanding of how the biobombs are more bioavailable, why Cajun had us include liquid sunflower lecithin in the formulation.
Bile is more complex, but they both do essentially the same thing, which is to lovingly encircle the cannabinoids in a hug to help them slip through the stomach caldron undamaged.
You know, he simply wouldn't take the time to explain it to me. Couldn't be bothered. I'd have walked through walls for that man, and he didn't think I was worth the effort to help me understand something this important.
You know what? Part of why I keep at this is to kinda thumb my nose at him.
22:04 suppositories
25:34 - confirmation of what I learned at Green Flower about sublingual administration - people swallow! The bioavailability of the sublingual sprays is no better than oral administration.
29:18 It surprises me to find I know things the experts overlook. THCA may work for inflammation - at least in theory - in a cream, but it's so aggressively trying to convert to THC that you have to be careful about storage. Decarb is a function of time and temperature, and given either time or warm enough temps and the cream THCa will become THC.
Knowing that, why bother to add it to your creams? Decarb for maximum THC for the pain application and get the inflammatory help on a systemic level with edibles or suppositories.
No mention of the instability of THCa and its aggressive nature to convert. I think this is an important thing to know. I learned it at Green Flower Media. Made me glad I pay that price every month, though to be honest, it makes me feel good to support them. They certainly do a lot for us.
Back to the video.
At 31:35 he hit my favorite nerve, the reference to studies that show the developing brain effected enough by cannabis consumption as to cause structural changes
Does no one consider that those changes may have been for the better? The study in NZ ran for over 30 years and found no negative effects from continuious consumption of cannabis.
Case closed. Let's get on with the healing and leave the fear behind us, thank you very much.
If cannabis was that dangerous to the developing brain explain cannabinoids in breast milk. Explain how I can be surrounded by all this brilliance when so many of them started using cannabis to keep themselves level and sane when they were in their early teens.
Yeah...., this one gets me riled. Lol! Back to work woman!
33:52 He explains that the CBD molecule is a CBD molecule, despite its being derived from cannabis sativa or hemp. It's the accompanying components that will either enhance or detract from the effectiveness of the CBD molecules, the entourage effect. Hemp has fewer medicinally complementary components.
To which she says "So there's no difference between hemp CBD and marijuana CBD." He answers "Yes" and they move on.
*sigh*
~ 35:00 This stopped me: he mentions that if you don't produce enough bile - it's produced in the gall bladder, remember? That organ they said we don't really need, so we can remove it? Yeah, that one. Well, if you don't have one, or have one that can't keep up with your fat consumption, it's gonna be hard for you to absorb cannabinoids in edibles.
But he doesn't say anything about how this makes lecithin, and in particular liquid sunflower lecithin, an attractive additive for cannabis edibles.
I mean, sometimes it feels like they aren't even trying.
Finishing up at 1:30. Ok, I learned a couple things there, but I couldn't help wondering if this young man has ever used cannabis. Too much of what we learn is from people in research, working with animals or Petri dishes, but who've never used the plant in any way, haven't felt the touch of euphoria cannabis offers. That means they have a limited outlook, in great part flavored by the prohibitionary propaganda that effected all of us, in one way or another.
But I learned a thing or two from him, and for that I give thanks.
No need to thank you again m'lord, but there it was anyway.
Maybe now I can stop and take this last hits.
At 19:48 he explains why bile helps fats be absorbed. This is the same explaination for how lecithin works. Do you have any idea how excited it makes me to find something that matches up with what I'm trying to better understand?
I'm gaining a better understanding of how the biobombs are more bioavailable, why Cajun had us include liquid sunflower lecithin in the formulation.
Bile is more complex, but they both do essentially the same thing, which is to lovingly encircle the cannabinoids in a hug to help them slip through the stomach caldron undamaged.
You know, he simply wouldn't take the time to explain it to me. Couldn't be bothered. I'd have walked through walls for that man, and he didn't think I was worth the effort to help me understand something this important.
You know what? Part of why I keep at this is to kinda thumb my nose at him.
22:04 suppositories
25:34 - confirmation of what I learned at Green Flower about sublingual administration - people swallow! The bioavailability of the sublingual sprays is no better than oral administration.
29:18 It surprises me to find I know things the experts overlook. THCA may work for inflammation - at least in theory - in a cream, but it's so aggressively trying to convert to THC that you have to be careful about storage. Decarb is a function of time and temperature, and given either time or warm enough temps and the cream THCa will become THC.
Knowing that, why bother to add it to your creams? Decarb for maximum THC for the pain application and get the inflammatory help on a systemic level with edibles or suppositories.
No mention of the instability of THCa and its aggressive nature to convert. I think this is an important thing to know. I learned it at Green Flower Media. Made me glad I pay that price every month, though to be honest, it makes me feel good to support them. They certainly do a lot for us.
Back to the video.
At 31:35 he hit my favorite nerve, the reference to studies that show the developing brain effected enough by cannabis consumption as to cause structural changes
Does no one consider that those changes may have been for the better? The study in NZ ran for over 30 years and found no negative effects from continuious consumption of cannabis.
Case closed. Let's get on with the healing and leave the fear behind us, thank you very much.
If cannabis was that dangerous to the developing brain explain cannabinoids in breast milk. Explain how I can be surrounded by all this brilliance when so many of them started using cannabis to keep themselves level and sane when they were in their early teens.
Yeah...., this one gets me riled. Lol! Back to work woman!
33:52 He explains that the CBD molecule is a CBD molecule, despite its being derived from cannabis sativa or hemp. It's the accompanying components that will either enhance or detract from the effectiveness of the CBD molecules, the entourage effect. Hemp has fewer medicinally complementary components.
To which she says "So there's no difference between hemp CBD and marijuana CBD." He answers "Yes" and they move on.
*sigh*
~ 35:00 This stopped me: he mentions that if you don't produce enough bile - it's produced in the gall bladder, remember? That organ they said we don't really need, so we can remove it? Yeah, that one. Well, if you don't have one, or have one that can't keep up with your fat consumption, it's gonna be hard for you to absorb cannabinoids in edibles.
But he doesn't say anything about how this makes lecithin, and in particular liquid sunflower lecithin, an attractive additive for cannabis edibles.
I mean, sometimes it feels like they aren't even trying.
Finishing up at 1:30. Ok, I learned a couple things there, but I couldn't help wondering if this young man has ever used cannabis. Too much of what we learn is from people in research, working with animals or Petri dishes, but who've never used the plant in any way, haven't felt the touch of euphoria cannabis offers. That means they have a limited outlook, in great part flavored by the prohibitionary propaganda that effected all of us, in one way or another.
But I learned a thing or two from him, and for that I give thanks.
No need to thank you again m'lord, but there it was anyway.
Maybe now I can stop and take this last hits.
- Thread starter
- #249
Well....this is disturbing.
- Thread starter
- #250
The daughter had another of those withdrawal experiences brought in by missing a single dose of Effexor. That’s the most frightening thing to watch, to be honest. Her brain glitches communications, brain zaps get in the way of breathing, she’s overtaken by debilitating vertigo, the distress is palpable. Time to get her off this fucking drug. Damn them anyway.
Tapering "How to" for Effexor -- Method 1
sweettooth said:11-30-2005 01:14 PM
Tapering "How to" for Effexor -- Method 1
sweettooth said:11-30-2005 01:14 PM
- Tapering "How to" for Effexor -- Method 1
If you are at the point that you, along with your doctor, have decided it is time to stop taking Effexor, here is some help in order to avoid overwhelming withdrawal symptons that often happens when someone tapers too much, too fast.
I have taken Effexor, my highest dose was 150mg XR/once a day (extended release capsules) for 1 1/2 years. I have been tapering for 10 months so far and I'm now at 25mg/for the day (using tablets). I have had minimal withdrawal to this point and I attribute that to the very slow tapering and cutting doseage's at a rate between 5-10% (and no more than that) each time.
I started using the tapering method below after my doctor cut my highest dose in half from 150mg to 75mg. He kept me there for a few months and then cut 75mg down to 37.50mg--withdrawal started. Then he did the other day routine with the 37.50--I was a mess! Then off--3 days later I CRASHED big time and had 95% of all withdrawal associated with Effexor.
My doctor put me back on 75mg of Effexor, but had no idea how to get me safely off. So I came up with the following regiment for myself and it has been very successful. I've been able to go about my responsibilities with little to no disruption in my routine or schedule. I hope it is a help and blessing to you.
Now for the how to's:
Instead of counting out granules (which really isn't accurate as granule capsule contents vary anywhere from 105 - 124 granules per capsule), use Effexor immediate release tablets (don't worry you won't feel any different than using the capsules---I switched from the capsules to the tablets). The only difference is that you will take one half of your tablet dose in the morning and twelve hours later take the second half of your dose.
THE GOOD NEWS: Effexor comes in tablets: 100mg, 75mg, 50mg, 37.50mg, and 25mg. You can purchase a "pill splitter" from any pharmacy--the cost about $4.00 (american money) and split your pills in half, quarters, and even eigths--(with a little practice for the 1/8s). Splitting tablets will enable you to have more control stepping done your medication. When I got to a dose that is in between one of the tablet sizes listed above, I respectfully requested from my doctor a prescription of two different amounts of tablets (for example 37.50mg tablet and 25mg tablet). When I was ready to step down from 37.50mg I did NOT want to go directly to 25mg--that is WAY TOO MUCH of a cut. Instead this is what I did:
---I cut a 37.50mg tablet into eights = 4.66mg/per eight and then cut a 25mg tablet in half = 12.50 mg. I would then take: one 4.66mg plus one 12.50 mg = 17.16mg (morning dose) and then do the same thing 12 hours later. 17.16mg + 17.16mg = 34.32mg for the day. I stayed at this new amount for a month.
Then I tapered to 31.24mg for the day. I got that by: cutting a 37.50 in quarters = 9.37mg and cutting a 25mg into quarters = 6.25mg. I then took 9.37mg + 6.25mg = 15.62mg in the morning and then same thing 12 hours later. 15.62mg + 15.62mg = 31.24mg for the day. I stayed at this amount for a month.
Then I tapered to 1/8 of a 37.50mg tablet = 4.66mg plus 1/4 of a 37.50mg tablet = 9.37mg. 4.66mg + 9.37mg = 14.03mg. 14.03mg + 14.03mg = 28.06mg for the day.
I am currently taking 25mg/per day. 12.50mg in the morning and 12.50mg twelve hours later (splitting the 25mg tablet in half).
You can see this is MUCH EASIER on your system than going from 37.50mg to 25mg.
By splitting any combination of the 100, 75, 50, 37.50 and 25mg, you can achieve your approx. needed dose.
WHEN CUTTING YOUR PILLS of differing milligrams, have some empty, clean, prescription bottles that are labeled (for example 4.66mg on one, 9.37mg on another, 6.25 mg on another, etc.) so that you don't get them mixed up. As you cut smaller amounts it gets harder to distinguish what is what--the labeled bottles will keep you straight. Just be sure to put the correct amounts in the correct bottles!
BE SURE once you step down on a doseage that you remain at that amount for at least 3 weeks, preferably 4 weeks. It will give your brain chemistry a time to adjust to the lower level of chemical serotonin.
DON'T BE SUPRISED as you get lower and lower on your dose that you may need more than 3-4 weeks to stablize; remember your brain is going through a HUGE change--give it the chance to even out. It's not important how long it takes to taper from dose to dose, it matters that you take your time!
ALWAYS take Effexor with food in your stomach and drink plenty of water.
Do NOT eat or drink anything containing GRAPFRUIT, it can create a serious toxic reaction.
NEVER, EVER take St. John's Wort or 5-HTP--they have a serotonin in them. Mixing them with an anti-depressant or taking then after you've been off of an anti-depressant for only a year of less can lead to SEROTONIN SYNDROME - a toxic and deadly condition.
Drugs that may induce serotonin syndrome when taken with antidepressants (not a complete list)
ecstasy
cocaine
lithium
St John's wort (Hypericum) - herbal antidepressant
diethylproprion - an amphetamine
dextromethorphan - found in many cough suppressants
Buspar (buspirone) - for anxiety
Selgene, Eldepryl (selegiline) - for Parkinson's Disease
anti-epileptics - Tegretol, Carbium, Teril (carbamazepine)
analgesics - pethidine, Fortral (pentazocine), Tramal (tramadol), fentanyl
anti-migraine drugs - Naramig (naratriptan), Imigran (sumatriptan), Zomig (zolmitriptan)
appetite suppressants - phentermine and fenfluramine
tryptophan - an amino acid
NEVER, EVER take Effexor or any anti-depressant every other day--withdrawal will start and you will never get back on an even keel. I know, I know your doctor told you to do this, but MOST doctors are truely ignorant of the hell they are about to put you through doing this. If you are currently on this program get back to taking your dose everyday and after you are stabilized you can start your tapering.
The best to everyone,
Sweettooth
- Thread starter
- #251
Put people on a drug you tell them they’ll never be able to stop taking. WTF????
- Thread starter
- #252
HOORA!!! Finally got this picked up and ready to go. I grabbed the comments section too, because OMG, there's a lot of info there. 
Super-Cooled Dry-Ice Cannabis Extraction
July 27, 2016
SUPER-COOLED QWET WASH FOR CANNABIS EXTRACTION USING DRY ICE
Making a great smokeable cannabis concentrate yourself at home, with good color, great taste, and unbelievable potency is easy but you must understand some basic fundamentals of how to keep the green out of the extraction.
Using ethanol for cannabis extraction is very effective, but has limitations due to its hydrophilic and polar nature. Meaning it likes to pick up polar and water based molecules and that’s not good for cannabis extraction. We don’t want polar, water based undesirables like chlorophyll, waxes, paraffin and fats in our extractions so we must take steps to limit the contamination.
To limit the uptake of undesirables we use a method called Quick Wash Ethanol (QWET). QWET involves freezing ethanol and cannabis separately before the extraction, controlling the duration the cannabis is exposed to ethanol in the wash, stopping it from turning green and instead producing a beautiful golden wash and amazing concentrate. In this blog I introduce the use of dry ice to super-cool and increase the effectiveness of the process and take QWET to the next level.
WHY FREEZE FOR THE WASH?
Performing a wash with ethanol and cannabis at room temperature allows the ethanol to quickly attach to polar undesirables in the cannabis and carry them into your extraction turning it green and unsuitable for making a quality vapable concentrate.
To avoid picking up undesirables in the wash, freeze the ethanol and cannabis separately overnight. Freezing cannabis immobilizes water based compounds making them difficult to pick up. Freezing ethanol also helps in two additional ways. First, it keeps the cannabis frozen during the wash cycle. Second, when ethanol is lowered to below freezing temperatures it’s pickup of soluble components is substantially slowed and the ability to attach to frozen water based components nearly eliminated. This is very useful because to make the best smokeable concentrate we have to eliminate undesirables and maximize the pick up of the soluble components we want like THC, CBD and terpenes.
Using a freezer to perform frozen QWET works with the general limitations of 10-min wash for flower and no more than 3-min for beat up trim. If executed with care, using quality buds broken up by hand with minimal cell wall damage it can be stretched to 20-minutes. For best results it’s very important to keep everything frozen the entire time and gently shake the mixture periodically to make sure a saturated boundary layer doesn’t form around the plant material.
There are two situations where this process has weaknesses. First, using beat up, chopped up trim with a lot of cell wall destruction still tends to leak green and quickly pick up a plant flavor. Bad trim can leak in as short as a 1-minute wash. Second, the temperature of a typical freezer will not keep the water elements immobile very long and will warm quickly once removed from the frozen environment. Dry ice can combat these weaknesses to enhance the immobilization of undesirables and slow pickup further.
COOLING WITH DRY ICE
The average recommended temperature setting for a freezer is 0°F compared to the surface temperature of dry ice being nearly -110°F. That large difference in temperature give us the margin necessary to hit the recommended wash temperature of -40°F, substantially colder than a freezer’s ability, providing absolute immobilization of water compounds and slowing pick-up to a crawl.
To use the dry ice method here is what you will need:
SUPER-COOLED WASH
When the cannabis and ethanol are suitably cooled combine them and keep the mixture in the dry ice environment for the duration of the wash. You must gently agitate the mixture every couple of minutes to move saturated ethanol away from the plant material and fresh ethanol in. If you’re using beat up trim use very light agitation only, but with quality flower a little stronger agitation is beneficial. Once the wash is finished continue with filtering, evaporation, and post processing as you normally would.
-DRY ICE WASH USING POOR QUALITY CHOPPY TRIM-
To test the dry ice wash tolerance for poor quality choppy trim I tested the difference between 3-min and 10-min washes. I like using inferior materials for process testing because it clearly gives the worst case scenario.
Both wash samples came from equal amounts of ethanol and 29g of poor quality Jack Frost trim. For separation and filtering I used a Buchner funnel under vacuum to separate the cannabis and ethanol as quickly as possible to minimize the risk of green leak. Both samples in the photo were approximately 10 fl oz with the lighter 3-min wash on the left and darker 10-min wash on the right. There’s an obvious color difference between the wash on the left and the one on the right.
After evaporating the alcohol at 102°f for about 3 hours using the Source by ExtractCraft the oil from both samples looked remarkably similar in every way except volume. The 10-min wash produced more volume and appeared to be of the same nature and characteristics as the 3-min wash with no apparent additional pick up of undesirables. That means the the difference in the washes was not a simple color difference but due to increased density of desirable component pickup.
Lastly, the oil was purged using a standard vacuum chamber and single stage pump operating between 90°F-100°F for 72 hours ending with very interesting results.
Both samples appeared identical in quality but weight was clearly a different story. Fully purged the 3-min wash sample was 0.9g and the 10-min wash sample came in at 1.4g, more than a 50% increase (yields are low as a consequence of using scrappy starting material). The 50% gain came with no discernible detrimental effects of the significantly longer super-cooled wash.
-DRY ICE WASH USING QUALITY FLOWER-
Using flower provides some distinct advantages. Flower has the best trichomes in the most concentrated areas and these are what we’re obviously most interested in targeting. Also, the layered fashion in which the buds grow make it easy to break up by hand without causing much cell wall damage and protecting the extraction from green leak. Breaking up buds by hand (don’t grind) is important to allow the ethanol access all surfaces and flow freely over the cannabis during the wash.
Compared to trim, flower can definitely stand up to extended ethanol exposure and slightly more robust agitation, both of which are instrumental in harvesting as much THC, CBD, and terpenes as possible.
For this experiment I used 14g of Bubba-Cross flower for each wash. Knowing flower can stand up to more aggressive treatment in the wash I started testing with a 15-min wash, and it came out beautifully. I then stretched it to 20-min, then 30-min then 1-hour. I was amazed the wash could be stretched to an hour, and could have easily gone even longer, but most importantly all the washes maintained the same color characteristics! The color characteristics are uniform however the density of pickup clearly increased with the longer washes (left to right: 15 min, 20 min, 30 min).
To process the extractions I used the Source Turbo by ExtractCraft (www.extractcraft.com) to make the strongest oil possible then finished in a vacuum oven at 90°F. In the photos below you can see the result of the 1-hour wash. On the left is the oil straight out of the Source Turbo and on the right is the finished purged product. That’s from a 1-HOUR WASH Y’ALL!
In terms of quality and yield it’s the same observation we had with the choppy trim results. Quality didn’t suffer in any real observable way but the yield increased tremendously. The yields from the 15-minute wash to the 30-minute wash increased from 11.5% to 15.5% providing a 35% increase in yield for the exact same material. The 1-hour wash showed a small increase in yield at 16% but the gains in yield seemed to be slowing.
CONSIDERATIONS AND TAKE AWAY
Dry ice defiantly makes cleaner QWET extraction possible and almost easy. The low temperatures used with a dry ice wash defiantly slows the absorption and collection of the desirable components as well as the undesirables. Some people contend that when using dry ice to wash good flower it loses some flavor and terpene profile. I don’t know to what extent this is true because I don’t have testing lab access, but to my experience I think it holds some merit. Dry ice extraction compared directly with freezer extraction from the same material has shown me a small decrease in flavor, but no apparent change in potency. Conversely, freezer QWET will sometimes have a slight plant taste while a good dry ice QWET never does. With everything we covered in mind, I think the take away is with trim absolutely use dry ice to make good trim into amazing smoke, decent trim into something very good, and throw away trim into something useful and valuable. With flower it’s debatable and you are going to have to experiment and try on your own to determine what is best for you because we all have very different preferences.
I have another blog that ties into this one that pits using the freezer against dry ice and compares the results. If you’d like you can check it out here Cannabis Oil QWET Extraction Battle of The Wash: Dry Ice vs. Freezer
CAVEATS:
STAY LIFTED, STAY FREE, STAY HEALTHY. LOVE YOU ALL AND HAPPY CRAFTING!!
25 THOUGHTS ON “SUPER-COOLED QWET WASH FOR CANNABIS EXTRACTION USING DRY ICE”
Super-Cooled Dry-Ice Cannabis Extraction
July 27, 2016
SUPER-COOLED QWET WASH FOR CANNABIS EXTRACTION USING DRY ICE
Making a great smokeable cannabis concentrate yourself at home, with good color, great taste, and unbelievable potency is easy but you must understand some basic fundamentals of how to keep the green out of the extraction.
Using ethanol for cannabis extraction is very effective, but has limitations due to its hydrophilic and polar nature. Meaning it likes to pick up polar and water based molecules and that’s not good for cannabis extraction. We don’t want polar, water based undesirables like chlorophyll, waxes, paraffin and fats in our extractions so we must take steps to limit the contamination.
To limit the uptake of undesirables we use a method called Quick Wash Ethanol (QWET). QWET involves freezing ethanol and cannabis separately before the extraction, controlling the duration the cannabis is exposed to ethanol in the wash, stopping it from turning green and instead producing a beautiful golden wash and amazing concentrate. In this blog I introduce the use of dry ice to super-cool and increase the effectiveness of the process and take QWET to the next level.
WHY FREEZE FOR THE WASH?
Performing a wash with ethanol and cannabis at room temperature allows the ethanol to quickly attach to polar undesirables in the cannabis and carry them into your extraction turning it green and unsuitable for making a quality vapable concentrate.
To avoid picking up undesirables in the wash, freeze the ethanol and cannabis separately overnight. Freezing cannabis immobilizes water based compounds making them difficult to pick up. Freezing ethanol also helps in two additional ways. First, it keeps the cannabis frozen during the wash cycle. Second, when ethanol is lowered to below freezing temperatures it’s pickup of soluble components is substantially slowed and the ability to attach to frozen water based components nearly eliminated. This is very useful because to make the best smokeable concentrate we have to eliminate undesirables and maximize the pick up of the soluble components we want like THC, CBD and terpenes.
Using a freezer to perform frozen QWET works with the general limitations of 10-min wash for flower and no more than 3-min for beat up trim. If executed with care, using quality buds broken up by hand with minimal cell wall damage it can be stretched to 20-minutes. For best results it’s very important to keep everything frozen the entire time and gently shake the mixture periodically to make sure a saturated boundary layer doesn’t form around the plant material.
There are two situations where this process has weaknesses. First, using beat up, chopped up trim with a lot of cell wall destruction still tends to leak green and quickly pick up a plant flavor. Bad trim can leak in as short as a 1-minute wash. Second, the temperature of a typical freezer will not keep the water elements immobile very long and will warm quickly once removed from the frozen environment. Dry ice can combat these weaknesses to enhance the immobilization of undesirables and slow pickup further.
COOLING WITH DRY ICE
The average recommended temperature setting for a freezer is 0°F compared to the surface temperature of dry ice being nearly -110°F. That large difference in temperature give us the margin necessary to hit the recommended wash temperature of -40°F, substantially colder than a freezer’s ability, providing absolute immobilization of water compounds and slowing pick-up to a crawl.
To use the dry ice method here is what you will need:
- Ethanol – 190-proof (95%)
- Cannabis
- Small cooler
- 2 ziplock freezer bags
- 2-4 lbs of dry ice.
SUPER-COOLED WASH
When the cannabis and ethanol are suitably cooled combine them and keep the mixture in the dry ice environment for the duration of the wash. You must gently agitate the mixture every couple of minutes to move saturated ethanol away from the plant material and fresh ethanol in. If you’re using beat up trim use very light agitation only, but with quality flower a little stronger agitation is beneficial. Once the wash is finished continue with filtering, evaporation, and post processing as you normally would.
-DRY ICE WASH USING POOR QUALITY CHOPPY TRIM-
To test the dry ice wash tolerance for poor quality choppy trim I tested the difference between 3-min and 10-min washes. I like using inferior materials for process testing because it clearly gives the worst case scenario.
Both wash samples came from equal amounts of ethanol and 29g of poor quality Jack Frost trim. For separation and filtering I used a Buchner funnel under vacuum to separate the cannabis and ethanol as quickly as possible to minimize the risk of green leak. Both samples in the photo were approximately 10 fl oz with the lighter 3-min wash on the left and darker 10-min wash on the right. There’s an obvious color difference between the wash on the left and the one on the right.
After evaporating the alcohol at 102°f for about 3 hours using the Source by ExtractCraft the oil from both samples looked remarkably similar in every way except volume. The 10-min wash produced more volume and appeared to be of the same nature and characteristics as the 3-min wash with no apparent additional pick up of undesirables. That means the the difference in the washes was not a simple color difference but due to increased density of desirable component pickup.
Lastly, the oil was purged using a standard vacuum chamber and single stage pump operating between 90°F-100°F for 72 hours ending with very interesting results.
Both samples appeared identical in quality but weight was clearly a different story. Fully purged the 3-min wash sample was 0.9g and the 10-min wash sample came in at 1.4g, more than a 50% increase (yields are low as a consequence of using scrappy starting material). The 50% gain came with no discernible detrimental effects of the significantly longer super-cooled wash.
-DRY ICE WASH USING QUALITY FLOWER-
Using flower provides some distinct advantages. Flower has the best trichomes in the most concentrated areas and these are what we’re obviously most interested in targeting. Also, the layered fashion in which the buds grow make it easy to break up by hand without causing much cell wall damage and protecting the extraction from green leak. Breaking up buds by hand (don’t grind) is important to allow the ethanol access all surfaces and flow freely over the cannabis during the wash.
Compared to trim, flower can definitely stand up to extended ethanol exposure and slightly more robust agitation, both of which are instrumental in harvesting as much THC, CBD, and terpenes as possible.
For this experiment I used 14g of Bubba-Cross flower for each wash. Knowing flower can stand up to more aggressive treatment in the wash I started testing with a 15-min wash, and it came out beautifully. I then stretched it to 20-min, then 30-min then 1-hour. I was amazed the wash could be stretched to an hour, and could have easily gone even longer, but most importantly all the washes maintained the same color characteristics! The color characteristics are uniform however the density of pickup clearly increased with the longer washes (left to right: 15 min, 20 min, 30 min).
To process the extractions I used the Source Turbo by ExtractCraft (www.extractcraft.com) to make the strongest oil possible then finished in a vacuum oven at 90°F. In the photos below you can see the result of the 1-hour wash. On the left is the oil straight out of the Source Turbo and on the right is the finished purged product. That’s from a 1-HOUR WASH Y’ALL!
In terms of quality and yield it’s the same observation we had with the choppy trim results. Quality didn’t suffer in any real observable way but the yield increased tremendously. The yields from the 15-minute wash to the 30-minute wash increased from 11.5% to 15.5% providing a 35% increase in yield for the exact same material. The 1-hour wash showed a small increase in yield at 16% but the gains in yield seemed to be slowing.
CONSIDERATIONS AND TAKE AWAY
Dry ice defiantly makes cleaner QWET extraction possible and almost easy. The low temperatures used with a dry ice wash defiantly slows the absorption and collection of the desirable components as well as the undesirables. Some people contend that when using dry ice to wash good flower it loses some flavor and terpene profile. I don’t know to what extent this is true because I don’t have testing lab access, but to my experience I think it holds some merit. Dry ice extraction compared directly with freezer extraction from the same material has shown me a small decrease in flavor, but no apparent change in potency. Conversely, freezer QWET will sometimes have a slight plant taste while a good dry ice QWET never does. With everything we covered in mind, I think the take away is with trim absolutely use dry ice to make good trim into amazing smoke, decent trim into something very good, and throw away trim into something useful and valuable. With flower it’s debatable and you are going to have to experiment and try on your own to determine what is best for you because we all have very different preferences.
I have another blog that ties into this one that pits using the freezer against dry ice and compares the results. If you’d like you can check it out here Cannabis Oil QWET Extraction Battle of The Wash: Dry Ice vs. Freezer
CAVEATS:
- “Super-Cooled” isn’t technically correct as far as science is concerned but it sounds so super-cool that I couldn’t resist taking some literary liberties and bending it to my own demanding cannabis needs.
- I’m no expert and still learning, so if you see something blatantly wrong or silly please point it out.
STAY LIFTED, STAY FREE, STAY HEALTHY. LOVE YOU ALL AND HAPPY CRAFTING!!
25 THOUGHTS ON “SUPER-COOLED QWET WASH FOR CANNABIS EXTRACTION USING DRY ICE”
- JAMES L
July 31, 2016 at 4:58 pm
Hi Ichiban, great site, I found it looking for more information on this exact process.
The different wash times was very interesting. I would imagine the 3 minute is a little more potent? Both look great, what’s the word on the consumer end, good taste? - Also, I’d be interested to see some item amounts/costs. How much alcohol per batch (29g) was used? What % of your alcohol are you reclaiming? How much dry ice was used?
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Reply- ICHIBANCRAFTER
July 31, 2016 at 5:29 pm
Hi James,
Thanks for checking out my stuff. Those are all great questions, and you may be disappointed to know that I don’t have perfect answers for most of those questions the answer is “It depends”. Having said that, I will share with you what I do know.
The 3-minute wash would in theory be more potent than and 1-minute wash and the 10-minute wash (assuming comparable clean wash) would be more potent yet. Because the end products are coming out visually comparable I have to contribute a lot of the yield difference to potency. With that said, a typical 3-minute was is said to remove 80% of the potential THC so how beneficial the extra time actually is isn’t proven yet, but appears beneficial. I would love to have access to test that, but, in colorado you can only test material if you have the applicable license. Unfortunately, I don’t have that license.
Considering my experimentations have been with low quality trim I think the taste has been pretty good. I actually took this process to the next level a couple days ago but running the wash through the Buchner Funnel with a slow feed filter three times then winterized it before evaporating. All I can say is WOW! Huge improvement. The oil came out smelling like it was a nug run. I highly reccomend taking the extra time to do this. Its never going to be as perfect as a nug run, but it was pretty dam good.
Alcohol per batch, it depends….. It varies depending on the starting material. For example, the cruddy trim I’m using is quite fluffy so it takes extra alcohol to fill the extra space, so I have to use around 10-12 oz of ethanol to wash 29g. On the other hand, if I use tight, dense bud I can use 6-8oz for 29g. Basically, you need the ethanol to cover the cannabis well and be able to work its way all around it. I’m currently trying to work out the exact saturation goings which I think is around 4g per 8oz of Ethanol but I need to consult someone who knows this well.
Reclaim is very consistent. Assuming proper eye-balling portions of Solvent covering plant material the absorption rate is around 30%. (you don’t want to try to improve this by squeezing the material to wring out more alcohol, all you end up doing is ruing your run with waxes, paraffins, and chlorophyll). Then using the Source I am able to reclaim about 95% of what would normally be lost to evaporation.
Dry Ice is going to depend on how much material you are going to use, how big the cooler is and how you put the material in. I have found using a smaller cooler, with the plant material and ethanol in ziplock provides the most surface exposure for cooling while using the least amount of space and requiring minimal dry ice. Doing 29g in a small cooler can use just a few pounds of dry ice.
Hope this helps!
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- ICHIBANCRAFTER
- CURIOUSSTONER89
November 11, 2016 at 5:54 pm
Hi just thinking “out loud” but wouldn’t it be beneficial to do 2-3 minute washes? If in fact it is more potent, get the 80% from the first wash keep it cooled and the remaining 20% from the second wash mix the alcohol cool together and then evaporate off the alcohol? (After filtration and warming to room temperature)
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Reply- ICHIBANCRAFTER
November 11, 2016 at 6:07 pm
Hi Curious!
For the most part that is standard operating procedure. What I found is that when I kept the temp at around -40f for the wash up to filtering, I found little change to no change in quality of the wash between 3min and 10min. But there was a large pickup in yield. Obviously, this requires a lot of care and any sloppy procedure is going to have tremendous negative effects with a 10 min wash.
Conversely, every time I have executed a second wash, like you are inquiring about, I always have a lot more green leak and plant smell/flavor. This will also be accompanied by a hight CBD and CBN ratio of that wash. For me that is not what I am looking for and would keep those two washes separate as the first wash would be more head high, and the second wash would produce a more sleepy and sedate affect. However, if you aren’t as particular to green leak, and you wanted an end result that is both head high and sedative in nature, what you are proposing may be a good option.
Great question, and thanks for asking!
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Reply- RANDY WISER
February 11, 2017 at 4:33 pm
Hi this is randy wiser (see above). I started using the dry ice after seeing it on YouTube. I have used up to 4 ten minute runs with the same material. Very low to no green leak. I also mixed all the runs together and placed in a countertop still from Nutrihome to reclaim as much as possible as I am using 200 proof ethanol from extractrahol. They also sell an organic 190. Available in gal, 5 gal, and 50 gal. Recently bought 200 5 gal that turned out to be less expensive then Everclear. I mix the resulting extract with MCT AT 1 gr to 1 oz, and use sublingually throughout the day for arthritis and pain. I mix in high CBD oil 1-1 for sleep.
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- RANDY WISER
- ICHIBANCRAFTER
- RANDY WISER
February 11, 2017 at 4:51 pm
Hey ICHIBANCRAFTER, thanks for the acknowledgement. Observation, are you concerned at all about using plastic bags? Especially since you are not able to have it tested. It seems risky to me. I have been storing and processing everything in mason jars, just don’t trust the big plastic companies for this use. I am concerned that the 190-200 ethanol will extract from the plastic as well. Also a hint, if you place your ethanol and dried material on the bottom of the cooler, and the ice on top it will freeze everything faster. I lay the jars on their sides and stack the slabs of ice on them.
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Reply- ICHIBANCRAFTER
February 11, 2017 at 4:54 pm
Plastic for an hour or two doesn’t bother me. Ice on top is a good idea.
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Reply - MALIQUE
October 25, 2017 at 1:41 am
are you not worried about the mason jars cracking with the dry ice on it?
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Reply- ICHIBANCRAFTER
October 25, 2017 at 1:45 am
Am I worried, yes. Have I had a problem yet, no. Most of the time I am using ziplock bags in with the dry Ice. They also now have reusable silicone ziplock type bags that can go in with the dry ice as well as in the oven.
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- ICHIBANCRAFTER
- ICHIBANCRAFTER
- FRANK
March 1, 2017 at 10:45 pm
just curious why there is an ever clear bottle in the pic? Are you using a denatured alcohol instead of pure 200proof ethanol?
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Reply- ICHIBANCRAFTER
March 1, 2017 at 11:02 pm
Used 95% ethanol, so in this case I was using Everclear
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- ICHIBANCRAFTER
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- OSCAR
October 7, 2017 at 11:23 pm
Great info. I did a quick freezer run without Vac Purging. Great product! Defiantly getting a vac though!
What do you think of using 200 Proof Ethenol (Extractohol)?
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Reply- ICHIBANCRAFTER
October 7, 2017 at 11:28 pm
Quite honestly I’m not sure. I haven’t used that brand but I hear good things. I haven’t really focused on 200-proof enough to give an opinion. That should definitely be on my list of things to do.
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- ICHIBANCRAFTER
- HESAIDGROW
December 4, 2017 at 6:57 am
Thanks for posting I enjoyed reading it. How about tossing the dry ice into the ethanol, cooling it to sub zero temps, and tossing in some fresh frozen nugs popcorns and sugar and letting it soak at sub zero agitating it around and letting the non polar part of the alcohol do its thing while the polar is frozen, conforming temps with a temp gun. Then straining it through some mesh into your distiller or apparatus of choice to evaporate. Strain while dry ice possibly still chunky to ensure sub Ero temeperayude. You should be left with some pristine oil. Oh and also do this in a stainless steel pot or rubber ice bucket to avoid breaking glass or plastic due to sub zero temps. Seems like the most fool proof way to avoid chlorophyll extracting. That stuff is kinda hard to digest as well as mentioned really harsh to inhale.
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Reply- ICHIBANCRAFTER
December 4, 2017 at 2:24 pm
Hi there! Thank you for your input, it is very much appreciated! May I ask if you have personally executed this process? I have wanted to experiment with this further but haven’t had the time to go back to it. I tried this process one time and it was so violent that the wash turned green even with the subzero temps because the plant material was bashed around so much by the hyper activity going on in the vessel I was using. If you have done this yourself and have any tips I what I may have been doing wrong please let me know. Thanks again!
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Reply- HESAIDGROW
December 4, 2017 at 3:34 pm
Hi. You are very welcome. i haven’t executed it yet though was going to attempt it pretty soon. Maybe you added too much dry ice too soon. I got the idea from a youtube video as well as reading about ethanol dry ice baths that are commonly used in laboratories. All that being said though, I still liked the idea and have been reading and reading about it and don’t see why it wouldn’t work. I am curious on the exact steps you took like what kind of vessel you used to perform the extraction. I have read that only stainless steel or rubber buckets should be used because the sub zero temps can crack glass or plastic. Feel free to share and I will do my best to video the process as well and provide data on how the extraction goes.
Loading... - ICHIBANCRAFTER
December 4, 2017 at 3:46 pm
I’d love to see how yours comes out. I am super busy on too many things to get back to this in any timely manner so your demo would be awesome. I just used a large mason jar, probably not the best choice, but it was just a quick and dirty experiment to see what would happen. I also used trim which would have been more susceptible to green leak with all the agitation. My main problem with the process is the lack of control and overly aggressive nature of the interaction between the ethanol and dry ice. I don’t really see any gain when you can super cool the ethanol, under controlled circumstance in about 60 minutes or so. If you come up with a great solution I will be very happy to see it, best of luck!
Loading... - AARONNORAA
December 7, 2017 at 9:42 pm
I have done it as Hesaidgrow outlined and it turned out fantastic.. I used 99% isopropyl rather than ethanol, filled up a vessel halfway with iso, tossed in a few large-ish chunks of dry ice and let it boil until it reached it’s lowest temperature at which time the boiling will suddenly reduce in intensity. While the alcohol was cooling, I had my material on top of another piece of dry ice that had been cooling for about an hour beforehand. While still in the freezer, added material to alcohol and stirred it in to where it wasn’t riding the surface and was swept up in the current from the boiling dry ice. Left it for 25 minutes to self-agitate and transferred it to pyrex baking dish after course straining then paper filtering. The filtering was a bit of a panic as the filters do not like passing liquid that is causing frozen condensation, plugging up the pores in the paper. I ended up having to use a needle to poke some small holes in the filter after the solids had settled to get it to drain, trying to do so before the solution rose in temperature to the point it would start pulling green. I would recommend using a fine mesh filter rather than paper as the final media to avoid the issue I had! After filtering, gently boiled off alcohol on a hotplate in a well ventilated room, on top of a catch pan to contain everything in case something went wrong such as the pyrex breaking and contents igniting.
Loading... - HESAIDGROW
December 8, 2017 at 2:10 am
awesome……. i was definitely planning on using a fine mesh / bubble bag… that sounds great though.. the only thing that has been on my mind is are there any temperatures that are too cold for extraction? freezing the alcohol and the material before hand and ensuring those are cold are important. and as far as dry ice goes., i would probably just approach it in not throwing a whole bunch of it in, but just enough to keep the temp below zero
Loading... - AARONNORAA
December 8, 2017 at 2:34 am
I’m not sure if there’s a temperature that’s too cold, but I can say that I left the dry ice in the alcohol for a good 30 or 40 min before starting and I’m quite certain that the alcohol was as cold as it could get in that dry ice.. almost appeared thick in consistency. Given that, the yield at 25 min soak time was excellent and the color was super light yellow liquid. Final result is blonde.
Loading... - HESAIDGROW
December 8, 2017 at 2:58 am
wowzas… so great to hear….. when i did only frozen (not dry ice), i got somewhat of an amber which was beautiful too, but blond is also good.. That was with dry material.> This time I am going to use Fresh Frozen.
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- HESAIDGROW
- ICHIBANCRAFTER
- MDC
December 6, 2017 at 4:27 pm
Since there is no decarb, I am new to this, using indy hemp and cbd extract, looks like combustion is the end delivery – so decarbed then.
What are good entry level ways to heat/consume this end product? Maybe what is your experienced favorite? ie best for longer term use?
Know this is a bit off topic…
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Reply- ICHIBANCRAFTER
December 6, 2017 at 4:35 pm
This end product will not be decarbed. The decarb happens when you smoke/vape. I use a vape/wax pen mostly. Many dab or make cartridges. Is that what you are asking?
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- ICHIBANCRAFTER
- Thread starter
- #253
Practical applications of cannabinoids and terpenes for chronic illnesses
Presentation by Mara Gordon at CannaCosta2015
Cannabinoids
The ECS is the reason cannabis functions as it does for as many different disease states.
B-caryophyllene, found in black pepper and other sources, may qualify as a cannabinoid, because it activates the CB2 receptors.
- It's not only cannabis that will stimulate the ECS, it's just that cannabis does so in so many ways as to set it apart from other sources of cannabinoids.
The euphoria caused by THC is a side benefit of all the other wonderful things the cannabinoid is doing for your healing body.
CBD doesn't offer any reported psychoactivity, but it does sometimes cause anxiety and sleepiness, which could be called psychoactivity of a different sort.
Terpenes are what you smell.
- They're involved in the entourage effect, the synergistic interplay of cannabinoids, terpenes, flavonoids, etc, the many components of cannabis sativa.
- Together they're greater than the sum of their parts.
- Full-plant extractions create very different physiological results than isolates.
Choose the terpenes you use carefully when developing medicines for particular disease states. All chemovars are not made alike.
For example, pinene is a good bronchial dialator, an anti-inflammatory, AIDS in memory function and is a good anti-bacterial, but it can also cause anxiety and allergic reaction in sensitive persons. Pine needles have high concentrations of pinene.
Limonene is very, very uplifting, is good for acid reflux, anxiety, and depression.
Linalool anti-convulsants, analgesic, and anti-anxiety. Lavender is high in linalool.
Beta-Caryophyllene has anti-inflammatory effects, is an analgesic, and will protect the cells lining the digestive tract. It's found in black pepper.
Myrcene contributes to the sedative effects of strong indicas, making it a powerful sleep aid, as well as a good muscle relaxer. It's also found in hops.
Eating a mango prior to ingesting cannabis demonstrates the importance of the entourage effect. The myrcene in the mango increases the absorbtion of the cannabinoids, thus improving bioavailibility. Myrcene has a very relaxing effect.
- When choosing your cannabis you're usually looking for something to slow you down or something to energize you. Slowing you down is what myrcene does.
- Myrcene is typically highest in the chemovars we refer to as indicas.
Sativas are used with PTSD, ADHD, Tourette's, some autism.
Indicas are preferred for chronic diseases like cancer, chronic pain, sleep disorder, etc.
Examples:
ACDC is an extremely high indica dominant chemovar bred specifically for high CBD It has little psychoactive effect for most people and is used (in conjunction with THC-rich chemovars) for epilepsy, cancer, and inflammatory disease.
Blue Dream is an extremely high THC sativa dominant chemovar that carried the Myrcene from an indica ?????? It's one of the most popular sativa dominant chemovars in the adult use market yet has ??????????? pain relief properties. Can't read the graphic and she didn't mention them.
Granddaddy Purple (GDP) is a high THC indica strain that is very relaxing and calming. Many patients choose it as a sleep aid.
The purpose of the ECS is to create homeostasis by balancing the CNS and the immune system. Disease is the lack of homeostasis.
- Cannabinoids and receptors in the ECS will do whatever they can to create a homeostatic environment.
THC has more medical applications in current clinical work (this was presented in 2015, and things have progressed) Without THC you're leaving the vast majority of diseases in most sick people without treatment.
Why is happiness and euphoria listed as a negative side effect? Reefer Madness, that's why.
THCa is becoming recognized as an important medicinal component.
- THCa is an anti-inflammatory, anti-prolific, and anti-epileptic. It's an important tool in the medicine box.
- Aunt Zelda's treats a lot of seizure disorder patients, either from epilepsy or some other condition like glioblastomas or metastatic cancers that've settled in the brain or other parts of the body.
Decarboxylation frees the carbon molecules from the acid cannabinoids so they can activate the receptors. With the carbon molecules attached they won't fit the receptors.
In treating epilepsy and CBD becomes less effective or isn't effective THCa is a viable substitute. You always need a small amount of THC.
CBD is being studies as an anti-psychotic, anti-epileptic, as useful in extreme inflammatory response.
- It's good for inflammation and pain.
- CBD will be effective in keeping cancer from returning. After cancer is in remission the maintenance dose can be dropped to low THC, high CBD (can be very high) so they can live more normal lives.
Pick up at 11:28. Can't see anymore tonight. Lol!
- Thread starter
- #254
The lock and key explanation of how cannabinoids and receptors work is outdated. Last year it was published that they now know cannabinoids will activate numerous receptors or act as allosteric modulators. I believe they also discovered that other components will somehow stimulate the GPRs.
- Thread starter
- #255
Endocannabinoids and liver damage
Concluding Remarks
The ECS is present in the liver and is involved in the control of various hepatic functions with important therapeutic implications. Increased CB1 activity contributes to the hemodynamic abnormalities and promotes fibrosis in liver cirrhosis, whereas CB1blockade attenuates and delays these changes. Endocannabinoids acting via hepatic CB1 receptors have emerged as mediators of both diet-induced and alcoholic fatty liver which, together, account for the majority of cirrhosis in Western societies. Additionally, hepatic CB1activation contributes to obesity-related insulin- and leptin-resistance and dyslipidemias. This provides strong rationale for the therapeutic use of CB1 antagonists in these conditions. Although neuropsychiatric side effects limit the therapeutic potential of brain-penetrant CB1antagonists, the recent emergence of second generation, peripherally-restricted CB1 antagonists may mitigate this problem. Additionally, non-psychoactive CB2 agonists may offer therapeutic benefit in attenuating liver injury and promoting tissue repair in the fibrotic liver.
The daughter apparently did more damage to her liver than we thought with the first suicide attempt 14 years ago.
My, how time flies.....
She took a bottle of Tylenol and waited an hour to tell anyone. The idea of grandma coming home and finding her dead was too much for her to deal with, so she called me instead and I called the ambulance.
They were pleased when they pumped her stomach and it looked like they got most of it because her stomach stopped digesting. Blood tests came back clean.
The cosmos interceded.
Now, all these years later she’s beginning to exhibit symptomology if early-stage cirrhosis, and the other day she had an ultrasound done that showed cysts on the liver.
Now she understands some of the other symptoms.
I’ve told her we’ll grow something high in CBD and make a specialized oil. Now the game begins of how much I can learn about cannabinoids and treating the liver.
Concluding Remarks
The ECS is present in the liver and is involved in the control of various hepatic functions with important therapeutic implications. Increased CB1 activity contributes to the hemodynamic abnormalities and promotes fibrosis in liver cirrhosis, whereas CB1blockade attenuates and delays these changes. Endocannabinoids acting via hepatic CB1 receptors have emerged as mediators of both diet-induced and alcoholic fatty liver which, together, account for the majority of cirrhosis in Western societies. Additionally, hepatic CB1activation contributes to obesity-related insulin- and leptin-resistance and dyslipidemias. This provides strong rationale for the therapeutic use of CB1 antagonists in these conditions. Although neuropsychiatric side effects limit the therapeutic potential of brain-penetrant CB1antagonists, the recent emergence of second generation, peripherally-restricted CB1 antagonists may mitigate this problem. Additionally, non-psychoactive CB2 agonists may offer therapeutic benefit in attenuating liver injury and promoting tissue repair in the fibrotic liver.
The daughter apparently did more damage to her liver than we thought with the first suicide attempt 14 years ago.
My, how time flies.....
She took a bottle of Tylenol and waited an hour to tell anyone. The idea of grandma coming home and finding her dead was too much for her to deal with, so she called me instead and I called the ambulance.
They were pleased when they pumped her stomach and it looked like they got most of it because her stomach stopped digesting. Blood tests came back clean.
The cosmos interceded.
Now, all these years later she’s beginning to exhibit symptomology if early-stage cirrhosis, and the other day she had an ultrasound done that showed cysts on the liver.
Now she understands some of the other symptoms.
I’ve told her we’ll grow something high in CBD and make a specialized oil. Now the game begins of how much I can learn about cannabinoids and treating the liver.
Derbybud
Well-Known Member
Well Sue if anybody can do it I think it's you. I hope you find what you need to help your daughter. Much hugs and love your way.
- Thread starter
- #257
Does Cannabis Treat Liver Disease?
PUBLISHED ON DECEMBER 21, 2015, BY GOOEY RABINSKI
When one hears the term “medical cannabis,” a variety of core diseases and conditions come to mind. Cancer, HIV/AIDS, arthritis, multiple sclerosis, and Crohn’s disease all gain significant benefit from the cannabinoids and terpenes contained in cannabis. A set of diseases not typically conjured are those of the liver. Recent research indicates that a lack of homeostasis (balance) in the body’s endocannabinoid system (what a medical professional would call “dysregulation”) can result in hepatitis, fibrosis, and cirrhosis.
Liver fibrosis, one of the most common forms of liver disease, afflicts more than 400,000 patients in the United States and is the tenth leading cause of death in the country. It occurs when the liver, the largest organ in the human body, experiences “excessive accumulation of scar tissue” that results from chronic inflammation and the death of liver cells. Dying cells are replaced by those that are regenerating, a process that produces abnormal areas of tough, fibrous tissue called nodules. As more nodules form, the liver begins to literally harden.
Cirrhosis is a situation in which the liver does not function properly, typically because of long-term damage. This damage is often inflicted during repeated alcohol binging and suffered by alcoholics. Like Alzheimer’s, cirrhosis reveals itself very slowly, typically over months or even years. It may result in patients being weak and tired and experiencing swelling of the calves and feet. They may also exhibit yellow skin and bruise easily. One of the most dangerous symptoms of cirrhosis is the accumulation of abdominal fluid, which may become very rapidly infected. Other possible outcomes include liver cancer and bleeding from the esophagus.
Much media attention is paid to the issue of alcohol versus cannabis for recreational use. It is fitting that cannabis offers not only a healthier euphoriant than whiskey or vodka, but also one that can help repair the damage imposed on the body, especially the liver, by an overabundance of the alcohol molecule — especially over the long term. A variety of cannabinoids battle inflammation, which is the root cause of many diseases, including cancer, arthritis, fibromyalgia, and liver disease.
Endocannabinoid System and Cirrhosis
Many theorize that conditions like cirrhosis and other diseases, especially those related to inflammation, are the result of an endocannabinoid deficiency, or basically being malnourished in terms of cannabinoids and terpenes. Why? It turns out that patients with active cirrhosis feature CB2 receptors in their liver cells, whereas those not suffering from the disease lack these receptors. CB1 and CB2 receptors are those targeted by cannabinoids like THC and CBD. It is only through the binding of these special molecules with the appropriate receptors that medical benefit is experienced by patients.
Is this expression of cannabinoid receptors, which is intended to reduce the fibrosis process, the diseased liver’s way — via the endocannabinoid system and its governance of the immune system — to be prepared to accept phytocannabinoids (those derived from plants like cannabis) with the goal of restoring health and homeostasis? Researchers have learned just enough to understand that this mechanism is very similar to how cannabinoids take control of cancer cells, basically reprogramming them to cease spreading or even self-destruct.
It is interesting to observe how these CB2 receptors are located in the liver cells of patients with active cirrhosis, but not in those people not suffering it. This observation appears to indicate that the endocannabinoid system plays a protective role in a variety of liver diseases and overall immune system function.
Fibrosis and Consumption Volumes
Some studies have shown that the volume of cannabis consumed by a patient or lifestyle user determines the efficacy gained. For example, a 2004 analysis study in France regarding the development of fibrosis in hepatitis C patients found a “high progression rate” for fibrosis in those who daily consumed both cannabis and 30 grams of alcohol. For those who consumed cannabis moderately, however, no effect was found on the development of fibrosis (it neither increased or decreased).
A 2005 study conducted at Hebrew University Medical School concluded that endocannabinoids — the body’s own internally-produced cannabinoids that are intimately involved in regulation of the immune system and nervous system — help control things like vascular changes and the modulation of inflammation. In addition, it found these endocannabinoids to be critical to proper neurological function and helpful for those suffering from liver diseases like fibrosis and cirrhosis.
A 2011 study published in the journal Cell Death and Disease revealed that CBD causes malignant cells in liver fibrosis to commit suicide, a process called “induced apoptosis.” The study concluded: “Collectively, these results, coupled with the excellent safety and tolerability profile of cannabidiol in humans, strongly suggest that it may have great therapeutic potential…” The researchers suggested that CBD may be an effective treatment for:
PUBLISHED ON DECEMBER 21, 2015, BY GOOEY RABINSKI
When one hears the term “medical cannabis,” a variety of core diseases and conditions come to mind. Cancer, HIV/AIDS, arthritis, multiple sclerosis, and Crohn’s disease all gain significant benefit from the cannabinoids and terpenes contained in cannabis. A set of diseases not typically conjured are those of the liver. Recent research indicates that a lack of homeostasis (balance) in the body’s endocannabinoid system (what a medical professional would call “dysregulation”) can result in hepatitis, fibrosis, and cirrhosis.
Liver fibrosis, one of the most common forms of liver disease, afflicts more than 400,000 patients in the United States and is the tenth leading cause of death in the country. It occurs when the liver, the largest organ in the human body, experiences “excessive accumulation of scar tissue” that results from chronic inflammation and the death of liver cells. Dying cells are replaced by those that are regenerating, a process that produces abnormal areas of tough, fibrous tissue called nodules. As more nodules form, the liver begins to literally harden.
Cirrhosis is a situation in which the liver does not function properly, typically because of long-term damage. This damage is often inflicted during repeated alcohol binging and suffered by alcoholics. Like Alzheimer’s, cirrhosis reveals itself very slowly, typically over months or even years. It may result in patients being weak and tired and experiencing swelling of the calves and feet. They may also exhibit yellow skin and bruise easily. One of the most dangerous symptoms of cirrhosis is the accumulation of abdominal fluid, which may become very rapidly infected. Other possible outcomes include liver cancer and bleeding from the esophagus.
Much media attention is paid to the issue of alcohol versus cannabis for recreational use. It is fitting that cannabis offers not only a healthier euphoriant than whiskey or vodka, but also one that can help repair the damage imposed on the body, especially the liver, by an overabundance of the alcohol molecule — especially over the long term. A variety of cannabinoids battle inflammation, which is the root cause of many diseases, including cancer, arthritis, fibromyalgia, and liver disease.
Endocannabinoid System and Cirrhosis
Many theorize that conditions like cirrhosis and other diseases, especially those related to inflammation, are the result of an endocannabinoid deficiency, or basically being malnourished in terms of cannabinoids and terpenes. Why? It turns out that patients with active cirrhosis feature CB2 receptors in their liver cells, whereas those not suffering from the disease lack these receptors. CB1 and CB2 receptors are those targeted by cannabinoids like THC and CBD. It is only through the binding of these special molecules with the appropriate receptors that medical benefit is experienced by patients.
Is this expression of cannabinoid receptors, which is intended to reduce the fibrosis process, the diseased liver’s way — via the endocannabinoid system and its governance of the immune system — to be prepared to accept phytocannabinoids (those derived from plants like cannabis) with the goal of restoring health and homeostasis? Researchers have learned just enough to understand that this mechanism is very similar to how cannabinoids take control of cancer cells, basically reprogramming them to cease spreading or even self-destruct.
It is interesting to observe how these CB2 receptors are located in the liver cells of patients with active cirrhosis, but not in those people not suffering it. This observation appears to indicate that the endocannabinoid system plays a protective role in a variety of liver diseases and overall immune system function.
Fibrosis and Consumption Volumes
Some studies have shown that the volume of cannabis consumed by a patient or lifestyle user determines the efficacy gained. For example, a 2004 analysis study in France regarding the development of fibrosis in hepatitis C patients found a “high progression rate” for fibrosis in those who daily consumed both cannabis and 30 grams of alcohol. For those who consumed cannabis moderately, however, no effect was found on the development of fibrosis (it neither increased or decreased).
A 2005 study conducted at Hebrew University Medical School concluded that endocannabinoids — the body’s own internally-produced cannabinoids that are intimately involved in regulation of the immune system and nervous system — help control things like vascular changes and the modulation of inflammation. In addition, it found these endocannabinoids to be critical to proper neurological function and helpful for those suffering from liver diseases like fibrosis and cirrhosis.
“Endocannabinoids appear to be involved in several aspects of acute and chronic liver disease.”
Like many similar efforts, these researchers called for further studies to better understand the role of both phytocannabinoids and endocannabinoids.A 2011 study published in the journal Cell Death and Disease revealed that CBD causes malignant cells in liver fibrosis to commit suicide, a process called “induced apoptosis.” The study concluded: “Collectively, these results, coupled with the excellent safety and tolerability profile of cannabidiol in humans, strongly suggest that it may have great therapeutic potential…” The researchers suggested that CBD may be an effective treatment for:
“…diabetic complications, and perhaps other cardiovascular disorders, by attenuating oxidative/nitrosative stress, inflammation, cell death, and fibrosis.”
A study released in 2013 in the journal Clinical Infectious Disease revealed that, counter to other studies, like the 2004 French research cited above, regular cannabis consumption does not accelerate the progression of liver disease, specifically fibrosis. This comprehensive human study involved nearly 700 participants and almost 2,000 person years of follow-up. Researchers concluded:“In this prospective analysis, we found no evidence for an association between marijuana smoking and significant liver fibrosis progression in HIV/HCV coinfection.”
- Thread starter
- #258
Thank you for that reassuring vote of confidence Derbybud.
I’ve told her it’s likely not liver cancer so she won’t have to shove anything up her butt. She’s happy with that determination. Lol! A high CBD regimen may be the perfect thing, and I have both Candida and Harlequin on hand to start the search for the right formulation.
Time to let the crew at the study hall know.
- Thread starter
- #259
continuing.....
Practical applications of cannabinoids and terpenes for chronic illnesses
Presentation by Mara Gordon at CannaCosta2015
Cannabinoids
The ECS is the reason cannabis functions as it does for as many different disease states.
B-caryophyllene, found in black pepper and other sources, may qualify as a cannabinoid, because it activates the CB2 receptors.
- It's not only cannabis that will stimulate the ECS, it's just that cannabis does so in so many ways as to set it apart from other sources of cannabinoids.
The euphoria caused by THC is a side benefit of all the other wonderful things the cannabinoid is doing for your healing body.
CBD doesn't offer any reported psychoactivity, but it does sometimes cause anxiety and sleepiness, which could be called psychoactivity of a different sort.
Terpenes are what you smell.
- They're involved in the entourage effect, the synergistic interplay of cannabinoids, terpenes, flavonoids, etc, the many components of cannabis sativa.
- Together they're greater than the sum of their parts.
- Full-plant extractions create very different physiological results than isolates.
Choose the terpenes you use carefully when developing medicines for particular disease states. All chemovars are not made alike.
For example, pinene is a good bronchial dialator, an anti-inflammatory, AIDS in memory function and is a good anti-bacterial, but it can also cause anxiety and allergic reaction in sensitive persons. Pine needles have high concentrations of pinene.
Limonene is very, very uplifting, is good for acid reflux, anxiety, and depression.
Linalool anti-convulsants, analgesic, and anti-anxiety. Lavender is high in linalool.
Beta-Caryophyllene has anti-inflammatory effects, is an analgesic, and will protect the cells lining the digestive tract. It's found in black pepper.
Myrcene contributes to the sedative effects of strong indicas, making it a powerful sleep aid, as well as a good muscle relaxer. It's also found in hops.
Eating a mango prior to ingesting cannabis demonstrates the importance of the entourage effect. The myrcene in the mango increases the absorbtion of the cannabinoids, thus improving bioavailibility. Myrcene has a very relaxing effect.
- When choosing your cannabis you're usually looking for something to slow you down or something to energize you. Slowing you down is what myrcene does.
- Myrcene is typically highest in the chemovars we refer to as indicas.
Sativas are used with PTSD, ADHD, Tourette's, some autism.
Indicas are preferred for chronic diseases like cancer, chronic pain, sleep disorder, etc.
Examples:
ACDC is an extremely high indica dominant chemovar bred specifically for high CBD It has little psychoactive effect for most people and is used (in conjunction with THC-rich chemovars) for epilepsy, cancer, and inflammatory disease.
Blue Dream is an extremely high THC sativa dominant chemovar that carried the Myrcene from an indica ?????? It's one of the most popular sativa dominant chemovars in the adult use market yet has ??????????? pain relief properties. Can't read the graphic and she didn't mention them.
Granddaddy Purple (GDP) is a high THC indica strain that is very relaxing and calming. Many patients choose it as a sleep aid.
The purpose of the ECS is to create homeostasis by balancing the CNS and the immune system. Disease is the lack of homeostasis.
- Cannabinoids and receptors in the ECS will do whatever they can to create a homeostatic environment.
THC has more medical applications in current clinical work (this was presented in 2015, and things have progressed) Without THC you're leaving the vast majority of diseases in most sick people without treatment.
Why is happiness and euphoria listed as a negative side effect? Reefer Madness, that's why.
THCa is becoming recognized as an important medicinal component.
- THCa is an anti-inflammatory, anti-prolific, and anti-epileptic. It's an important tool in the medicine box.
- Aunt Zelda's treats a lot of seizure disorder patients, either from epilepsy or some other condition like glioblastomas or metastatic cancers that've settled in the brain or other parts of the body.
Decarboxylation frees the carbon molecules from the acid cannabinoids so they can activate the receptors. With the carbon molecules attached they won't fit the receptors.
In treating epilepsy and CBD becomes less effective or isn't effective THCa is a viable substitute. You always need a small amount of THC.
CBD is being studies as an anti-psychotic, anti-epileptic, as useful in extreme inflammatory response.
- It's good for inflammation and pain.
- CBD will be effective in keeping cancer from returning. After cancer is in remission the maintenance dose can be dropped to low THC, high CBD (can be very high) so they can live more normal lives.
How It Works: An Overview
Activation of CB1, CB2, [and GPR55?] receptor sites promotes homeostasis in all other body systems
THC has more mechanisms of action in medical applications of cannabis than other cannabinoids or terpenes. It is the most potent activator of CB1 and CB2 receptor sites. It also has anti-inflammatory properties.
THCa is an anti-inflammatory, antti-proliferative, and anti-epileptic.
THCV reduces the parinoia side effects of THC through the entourage effect. It's being studied for use in diabetes. It can act as an appetite suppressant.
CBD is being studied as an anti-psychotic and anti-epileptic, and is proven to have extreme anti-inflammatory properties more potent than hydrocortisone. It also has antibacterial and anti fungal properties. The US has (Had) a patent on CBD as an anti-inflammatory and neuro protector.
CBG, when combined with THC, is a powerful pain suppressant (Entourage effect)
CBN, when combined with THC, is a sleep agent (Entourage effect)
CBC is a potent anti-bacterial, anti-fungal, and analgesic.
CBDV is another non-psychoactive cannabinoid that shows promise with epilepsy.
There are somewhere between 200 and 500 terpenes found in cannabis and new cannabinoids are being discovered al the time.
CB1 receptors primarily in CNS, CB2 receptors primarily in the immune cells of the lymphatic system.
- With disease states the eCBRs will appear where needed.
How it works: Cancer
THC: Super-activation of CB1 and CB2 receptor sites by THC leading to apoptosis (programmed cell death) of cancer cells.
Dr. Sean McCallaster (sp?) has been researching the ID-1 gene and has discovered that CBD restricts the translation of the ID-1 gene in many cancers, blocking the proliferation and metastasis of many cancers.
- High levels of ID-1 are found in brain, liver, lung, skin, and thyroid gland cancer cells. It is also expressed in fetal cells and in the umbilical vein endothelial cells.
Cannabidiol is indicated as a major component in the cancer protocol for
* Non small cell lung cancer
* Gastric cancer
* Breast cancer
* Prostate cancer
* Melanoma
* Glioblastoma
* Hepatocarcinoma
* Anaplastic thyroid tumor
* Metastasis of certain cancers
The ID-1 gene is responsible for tumor growth and metastasis. CBD doesn't activate the eCBRs, but rather affects other body systems to block proliferation and metastasis.
Try higher CBD and lower THC formulations for cancers involving the ID-1 gene.
** The last patient on the list is a 3-yr old female.
What does success mean? Because of the frustrations and stigmas attached to cannabis many cancer patients wait until it's very advanced or without hope before they seek a cannabinoid therapy. When we can reverse this trend we won't have as many people getting that desperately sick to begin with.
The patient determines the goals of the therapy. Are we treating symptoms or treating disease?
- After reviewing the patient history you work out the dose goal and the most desirable terpene and cannabinoid profile.
Give up the need to find a mg/kg formula for all canna is patients. It won't happen. Look at that picture. It pretty much says it all.
The closer correlation is with age; the younger the patient, the higher the dose.
Questions for the patient:
- What's the diagnosis?
- What's the current cannabis use and history of use?
- What pharmaceuticals and nutraceuticals are being used? Be aware of CP450 pathway pharma drugs. CBD may interfere with their metabolism allowing them to build to intolerable and dangerous levels in the system.
- Patient's age?
- What is your objective? What are you hoping to get from the cannabinoid therapy? What are you trying to accomplish?
Pick up at 16:11. Can't see anymore tonight to continue. Lol! This seems to be a pattern with me. I'm hoping to find something on cirrhosis in here.
I found my notes from a similar presentation in Prague the same year and made some additions.
In a gram of high THC CCO you can realistically expect to get between 500 and 750 mg of THC.
Practical applications of cannabinoids and terpenes for chronic illnesses
Presentation by Mara Gordon at CannaCosta2015
Cannabinoids
The ECS is the reason cannabis functions as it does for as many different disease states.
B-caryophyllene, found in black pepper and other sources, may qualify as a cannabinoid, because it activates the CB2 receptors.
- It's not only cannabis that will stimulate the ECS, it's just that cannabis does so in so many ways as to set it apart from other sources of cannabinoids.
The euphoria caused by THC is a side benefit of all the other wonderful things the cannabinoid is doing for your healing body.
CBD doesn't offer any reported psychoactivity, but it does sometimes cause anxiety and sleepiness, which could be called psychoactivity of a different sort.
Terpenes are what you smell.
- They're involved in the entourage effect, the synergistic interplay of cannabinoids, terpenes, flavonoids, etc, the many components of cannabis sativa.
- Together they're greater than the sum of their parts.
- Full-plant extractions create very different physiological results than isolates.
Choose the terpenes you use carefully when developing medicines for particular disease states. All chemovars are not made alike.
For example, pinene is a good bronchial dialator, an anti-inflammatory, AIDS in memory function and is a good anti-bacterial, but it can also cause anxiety and allergic reaction in sensitive persons. Pine needles have high concentrations of pinene.
Limonene is very, very uplifting, is good for acid reflux, anxiety, and depression.
Linalool anti-convulsants, analgesic, and anti-anxiety. Lavender is high in linalool.
Beta-Caryophyllene has anti-inflammatory effects, is an analgesic, and will protect the cells lining the digestive tract. It's found in black pepper.
Myrcene contributes to the sedative effects of strong indicas, making it a powerful sleep aid, as well as a good muscle relaxer. It's also found in hops.
Eating a mango prior to ingesting cannabis demonstrates the importance of the entourage effect. The myrcene in the mango increases the absorbtion of the cannabinoids, thus improving bioavailibility. Myrcene has a very relaxing effect.
- When choosing your cannabis you're usually looking for something to slow you down or something to energize you. Slowing you down is what myrcene does.
- Myrcene is typically highest in the chemovars we refer to as indicas.
Sativas are used with PTSD, ADHD, Tourette's, some autism.
Indicas are preferred for chronic diseases like cancer, chronic pain, sleep disorder, etc.
Examples:
ACDC is an extremely high indica dominant chemovar bred specifically for high CBD It has little psychoactive effect for most people and is used (in conjunction with THC-rich chemovars) for epilepsy, cancer, and inflammatory disease.
Blue Dream is an extremely high THC sativa dominant chemovar that carried the Myrcene from an indica ?????? It's one of the most popular sativa dominant chemovars in the adult use market yet has ??????????? pain relief properties. Can't read the graphic and she didn't mention them.
Granddaddy Purple (GDP) is a high THC indica strain that is very relaxing and calming. Many patients choose it as a sleep aid.
The purpose of the ECS is to create homeostasis by balancing the CNS and the immune system. Disease is the lack of homeostasis.
- Cannabinoids and receptors in the ECS will do whatever they can to create a homeostatic environment.
THC has more medical applications in current clinical work (this was presented in 2015, and things have progressed) Without THC you're leaving the vast majority of diseases in most sick people without treatment.
Why is happiness and euphoria listed as a negative side effect? Reefer Madness, that's why.
THCa is becoming recognized as an important medicinal component.
- THCa is an anti-inflammatory, anti-prolific, and anti-epileptic. It's an important tool in the medicine box.
- Aunt Zelda's treats a lot of seizure disorder patients, either from epilepsy or some other condition like glioblastomas or metastatic cancers that've settled in the brain or other parts of the body.
Decarboxylation frees the carbon molecules from the acid cannabinoids so they can activate the receptors. With the carbon molecules attached they won't fit the receptors.
In treating epilepsy and CBD becomes less effective or isn't effective THCa is a viable substitute. You always need a small amount of THC.
CBD is being studies as an anti-psychotic, anti-epileptic, as useful in extreme inflammatory response.
- It's good for inflammation and pain.
- CBD will be effective in keeping cancer from returning. After cancer is in remission the maintenance dose can be dropped to low THC, high CBD (can be very high) so they can live more normal lives.
How It Works: An Overview
Activation of CB1, CB2, [and GPR55?] receptor sites promotes homeostasis in all other body systems
THC has more mechanisms of action in medical applications of cannabis than other cannabinoids or terpenes. It is the most potent activator of CB1 and CB2 receptor sites. It also has anti-inflammatory properties.
THCa is an anti-inflammatory, antti-proliferative, and anti-epileptic.
THCV reduces the parinoia side effects of THC through the entourage effect. It's being studied for use in diabetes. It can act as an appetite suppressant.
CBD is being studied as an anti-psychotic and anti-epileptic, and is proven to have extreme anti-inflammatory properties more potent than hydrocortisone. It also has antibacterial and anti fungal properties. The US has (Had) a patent on CBD as an anti-inflammatory and neuro protector.
CBG, when combined with THC, is a powerful pain suppressant (Entourage effect)
CBN, when combined with THC, is a sleep agent (Entourage effect)
CBC is a potent anti-bacterial, anti-fungal, and analgesic.
CBDV is another non-psychoactive cannabinoid that shows promise with epilepsy.
There are somewhere between 200 and 500 terpenes found in cannabis and new cannabinoids are being discovered al the time.
CB1 receptors primarily in CNS, CB2 receptors primarily in the immune cells of the lymphatic system.
- With disease states the eCBRs will appear where needed.
How it works: Cancer
THC: Super-activation of CB1 and CB2 receptor sites by THC leading to apoptosis (programmed cell death) of cancer cells.
Dr. Sean McCallaster (sp?) has been researching the ID-1 gene and has discovered that CBD restricts the translation of the ID-1 gene in many cancers, blocking the proliferation and metastasis of many cancers.
- High levels of ID-1 are found in brain, liver, lung, skin, and thyroid gland cancer cells. It is also expressed in fetal cells and in the umbilical vein endothelial cells.
Cannabidiol is indicated as a major component in the cancer protocol for
* Non small cell lung cancer
* Gastric cancer
* Breast cancer
* Prostate cancer
* Melanoma
* Glioblastoma
* Hepatocarcinoma
* Anaplastic thyroid tumor
* Metastasis of certain cancers
The ID-1 gene is responsible for tumor growth and metastasis. CBD doesn't activate the eCBRs, but rather affects other body systems to block proliferation and metastasis.
Try higher CBD and lower THC formulations for cancers involving the ID-1 gene.
** The last patient on the list is a 3-yr old female.
What does success mean? Because of the frustrations and stigmas attached to cannabis many cancer patients wait until it's very advanced or without hope before they seek a cannabinoid therapy. When we can reverse this trend we won't have as many people getting that desperately sick to begin with.
The patient determines the goals of the therapy. Are we treating symptoms or treating disease?
- After reviewing the patient history you work out the dose goal and the most desirable terpene and cannabinoid profile.
Give up the need to find a mg/kg formula for all canna is patients. It won't happen. Look at that picture. It pretty much says it all.
The closer correlation is with age; the younger the patient, the higher the dose.
Questions for the patient:
- What's the diagnosis?
- What's the current cannabis use and history of use?
- What pharmaceuticals and nutraceuticals are being used? Be aware of CP450 pathway pharma drugs. CBD may interfere with their metabolism allowing them to build to intolerable and dangerous levels in the system.
- Patient's age?
- What is your objective? What are you hoping to get from the cannabinoid therapy? What are you trying to accomplish?
Pick up at 16:11. Can't see anymore tonight to continue. Lol! This seems to be a pattern with me. I'm hoping to find something on cirrhosis in here.
I found my notes from a similar presentation in Prague the same year and made some additions.
In a gram of high THC CCO you can realistically expect to get between 500 and 750 mg of THC.
- Thread starter
- #260
Boy..... I worked for nearly an hour to get about five minutes of video info worked out.