overlord
Well-Known Member
Boy..... I worked for nearly an hour to get about five minutes of video info worked out.
SweetSue's Class Notes
- Thread starter SweetSue
- Start date
- Thread starter
- #262
SweetSue said:
I found the notes from a presentation in Prague the same year, and cirrhosis wasn't covered in that one. Lots more info to go, but nothing that's gonna help me in the daughter's case.
What I've heard so far though reinforces the decision to go with high CBD. Now.... to find an indica-dom with rediculously high CBD.
- Thread starter
- #263
Here's a start. All of them inaccessible to me, sold as clones, I believe. ToMorris I'll chase that down. I'm headed to Cali. Anything is possible. At least it's a start in the right direction.
5 of the Most Popular High CBD /Low THC Strains, from marijuanabreak.com
1 – ACDC (The Marijuana Strain That Leaves You Feeling Thunderstruck)
This strain is a 50/50 hybrid and has one of the highest CBD: THC ratios around. You can get up to 20% CBD versions of ACDC, and while some contain up to 6% of THC, it is possible to get one with as little as 0.42%. As it is still above the 0.3% threshold, you won’t find ACDC in CBD oil form.
Once you consume ACDC, you’ll experience a strong euphoric feeling which makes you calm and happy. It is ideal for daytime use as it tends to make users more focused on their work and it also increases your sociability.
ACDC is generally used to treat anxiety, inflammation, migraines, nausea, neuropathy, arthritis and bipolar disorder. It is also a favorite for people with chronic pain, and it is even a good choice if you’re looking to mitigate the effects of chemotherapy treatment.
2 – Charlotte’s Web (The World’s Most Famous Marijuana Strain)
This world famous strain is indica dominant (60%) and was the focus of a bid to legalize high CBD strains. It helped reduce the seizures of Charlotte Figi, and it has a CBD content as high as 20%. Charlotte’s Web is extremely low in THC which means it can be sold as a food supplement.
Obviously, there is no ‘high’ associated with this strain, and it provides users with no cerebral effect. In fact, if it weren’t for its pain relieving ability, you wouldn’t even realize you’ve taken anything. Charlotte’s Web is typically consumed in CBD oil form rather than being smoked.
As well as its known effectiveness when treating pediatric seizure disorders such as Dravet’s Syndrome, Charlotte’s Web is used to help with migraines, fatigue, fibromyalgia, muscle spasms, and arthritis.
4 – Harle-Tsu (The Painkilling Marijuana Strain)
This indica dominant (60%) strain is a cross of Sour Tsunami and Harlequin strains and contains up to 22% CBD against less than 1% THC. It is a relatively rare bud, but we imagine that won’t be the case for long given its popularity.
The Harle-Tsu high is rather mellow, and instead of providing you with a body or cerebral high, this strain works well as a painkiller. You will feel something of a buzz behind the eyes at first and then your body will feel completely free and relaxed.
You should feel energized and motivated with Harle-Tsu which means it is excellent for daytime use. It works well to treat conditions such as PMS, PTSD, migraines, depression, inflammation, and insomnia.
5 of the Most Popular High CBD /Low THC Strains, from marijuanabreak.com
1 – ACDC (The Marijuana Strain That Leaves You Feeling Thunderstruck)
This strain is a 50/50 hybrid and has one of the highest CBD: THC ratios around. You can get up to 20% CBD versions of ACDC, and while some contain up to 6% of THC, it is possible to get one with as little as 0.42%. As it is still above the 0.3% threshold, you won’t find ACDC in CBD oil form.
Once you consume ACDC, you’ll experience a strong euphoric feeling which makes you calm and happy. It is ideal for daytime use as it tends to make users more focused on their work and it also increases your sociability.
ACDC is generally used to treat anxiety, inflammation, migraines, nausea, neuropathy, arthritis and bipolar disorder. It is also a favorite for people with chronic pain, and it is even a good choice if you’re looking to mitigate the effects of chemotherapy treatment.
2 – Charlotte’s Web (The World’s Most Famous Marijuana Strain)
This world famous strain is indica dominant (60%) and was the focus of a bid to legalize high CBD strains. It helped reduce the seizures of Charlotte Figi, and it has a CBD content as high as 20%. Charlotte’s Web is extremely low in THC which means it can be sold as a food supplement.
Obviously, there is no ‘high’ associated with this strain, and it provides users with no cerebral effect. In fact, if it weren’t for its pain relieving ability, you wouldn’t even realize you’ve taken anything. Charlotte’s Web is typically consumed in CBD oil form rather than being smoked.
As well as its known effectiveness when treating pediatric seizure disorders such as Dravet’s Syndrome, Charlotte’s Web is used to help with migraines, fatigue, fibromyalgia, muscle spasms, and arthritis.
4 – Harle-Tsu (The Painkilling Marijuana Strain)
This indica dominant (60%) strain is a cross of Sour Tsunami and Harlequin strains and contains up to 22% CBD against less than 1% THC. It is a relatively rare bud, but we imagine that won’t be the case for long given its popularity.
The Harle-Tsu high is rather mellow, and instead of providing you with a body or cerebral high, this strain works well as a painkiller. You will feel something of a buzz behind the eyes at first and then your body will feel completely free and relaxed.
You should feel energized and motivated with Harle-Tsu which means it is excellent for daytime use. It works well to treat conditions such as PMS, PTSD, migraines, depression, inflammation, and insomnia.
- Thread starter
- #264
How ironic is it that I have two excellent chemovars for CBD values, but they were chosen to increase my own levels, so they're sativas? Lol!
2 AM. I gotta stop and go to bed.
2 AM. I gotta stop and go to bed.
- Thread starter
- #265
continuing.....
Practical applications of cannabinoids and terpenes for chronic illnesses
Presentation by Mara Gordon at CannaCosta2015
Cannabinoids
The ECS is the reason cannabis functions as it does for as many different disease states.
B-caryophyllene, found in black pepper and other sources, may qualify as a cannabinoid, because it activates the CB2 receptors.
- It's not only cannabis that will stimulate the ECS, it's just that cannabis does so in so many ways as to set it apart from other sources of cannabinoids.
The euphoria caused by THC is a side benefit of all the other wonderful things the cannabinoid is doing for your healing body.
CBD doesn't offer any reported psychoactivity, but it does sometimes cause anxiety and sleepiness, which could be called psychoactivity of a different sort.
Terpenes are what you smell.
- They're involved in the entourage effect, the synergistic interplay of cannabinoids, terpenes, flavonoids, etc, the many components of cannabis sativa.
- Together they're greater than the sum of their parts.
- Full-plant extractions create very different physiological results than isolates.
Choose the terpenes you use carefully when developing medicines for particular disease states. All chemovars are not made alike.
For example, pinene is a good bronchial dialator, an anti-inflammatory, AIDS in memory function and is a good anti-bacterial, but it can also cause anxiety and allergic reaction in sensitive persons. Pine needles have high concentrations of pinene.
Limonene is very, very uplifting, is good for acid reflux, anxiety, and depression.
Linalool anti-convulsants, analgesic, and anti-anxiety. Lavender is high in linalool.
Beta-Caryophyllene has anti-inflammatory effects, is an analgesic, and will protect the cells lining the digestive tract. It's found in black pepper.
Myrcene contributes to the sedative effects of strong indicas, making it a powerful sleep aid, as well as a good muscle relaxer. It's also found in hops.
Eating a mango prior to ingesting cannabis demonstrates the importance of the entourage effect. The myrcene in the mango increases the absorbtion of the cannabinoids, thus improving bioavailibility. Myrcene has a very relaxing effect.
- When choosing your cannabis you're usually looking for something to slow you down or something to energize you. Slowing you down is what myrcene does.
- Myrcene is typically highest in the chemovars we refer to as indicas.
Sativas are used with PTSD, ADHD, Tourette's, some autism.
Indicas are preferred for chronic diseases like cancer, chronic pain, sleep disorder, etc.
Examples:
ACDC is an extremely high indica dominant chemovar bred specifically for high CBD It has little psychoactive effect for most people and is used (in conjunction with THC-rich chemovars) for epilepsy, cancer, and inflammatory disease.
Blue Dream is an extremely high THC sativa dominant chemovar that carried the Myrcene from an indica ?????? It's one of the most popular sativa dominant chemovars in the adult use market yet has ??????????? pain relief properties. Can't read the graphic and she didn't mention them.
Granddaddy Purple (GDP) is a high THC indica strain that is very relaxing and calming. Many patients choose it as a sleep aid.
The purpose of the ECS is to create homeostasis by balancing the CNS and the immune system. Disease is the lack of homeostasis.
- Cannabinoids and receptors in the ECS will do whatever they can to create a homeostatic environment.
THC has more medical applications in current clinical work (this was presented in 2015, and things have progressed) Without THC you're leaving the vast majority of diseases in most sick people without treatment.
Why is happiness and euphoria listed as a negative side effect? Reefer Madness, that's why.
THCa is becoming recognized as an important medicinal component.
- THCa is an anti-inflammatory, anti-prolific, and anti-epileptic. It's an important tool in the medicine box.
- Aunt Zelda's treats a lot of seizure disorder patients, either from epilepsy or some other condition like glioblastomas or metastatic cancers that've settled in the brain or other parts of the body.
Decarboxylation frees the carbon molecules from the acid cannabinoids so they can activate the receptors. With the carbon molecules attached they won't fit the receptors.
In treating epilepsy and CBD becomes less effective or isn't effective THCa is a viable substitute. You always need a small amount of THC.
CBD is being studies as an anti-psychotic, anti-epileptic, as useful in extreme inflammatory response.
- It's good for inflammation and pain.
- CBD will be effective in keeping cancer from returning. After cancer is in remission the maintenance dose can be dropped to low THC, high CBD (can be very high) so they can live more normal lives.
How It Works: An Overview
Activation of CB1, CB2, [and GPR55?] receptor sites promotes homeostasis in all other body systems
THC has more mechanisms of action in medical applications of cannabis than other cannabinoids or terpenes. It is the most potent activator of CB1 and CB2 receptor sites. It also has anti-inflammatory properties.
THCa is an anti-inflammatory, antti-proliferative, and anti-epileptic.
THCV reduces the parinoia side effects of THC through the entourage effect. It's being studied for use in diabetes. It can act as an appetite suppressant.
CBD is being studied as an anti-psychotic and anti-epileptic, and is proven to have extreme anti-inflammatory properties more potent than hydrocortisone. It also has antibacterial and anti fungal properties. The US has (Had) a patent on CBD as an anti-inflammatory and neuro protector.
CBG, when combined with THC, is a powerful pain suppressant (Entourage effect)
CBN, when combined with THC, is a sleep agent (Entourage effect)
CBC is a potent anti-bacterial, anti-fungal, and analgesic.
CBDV is another non-psychoactive cannabinoid that shows promise with epilepsy.
There are somewhere between 200 and 500 terpenes found in cannabis and new cannabinoids are being discovered al the time.
CB1 receptors primarily in CNS, CB2 receptors primarily in the immune cells of the lymphatic system.
- With disease states the eCBRs will appear where needed.
How it works: Cancer
THC: Super-activation of CB1 and CB2 receptor sites by THC leading to apoptosis (programmed cell death) of cancer cells.
Dr. Sean McCallaster (sp?) has been researching the ID-1 gene and has discovered that CBD restricts the translation of the ID-1 gene in many cancers, blocking the proliferation and metastasis of many cancers.
- High levels of ID-1 are found in brain, liver, lung, skin, and thyroid gland cancer cells. It is also expressed in fetal cells and in the umbilical vein endothelial cells.
Cannabidiol is indicated as a major component in the cancer protocol for
* Non small cell lung cancer
* Gastric cancer
* Breast cancer
* Prostate cancer
* Melanoma
* Glioblastoma
* Hepatocarcinoma
* Anaplastic thyroid tumor
* Metastasis of certain cancers
The ID-1 gene is responsible for tumor growth and metastasis. CBD doesn't activate the eCBRs, but rather affects other body systems to block proliferation and metastasis.
Try higher CBD and lower THC formulations for cancers involving the ID-1 gene.
** The last patient on the list is a 3-yr old female.
What does success mean? Because of the frustrations and stigmas attached to cannabis many cancer patients wait until it's very advanced or without hope before they seek a cannabinoid therapy. When we can reverse this trend we won't have as many people getting that desperately sick to begin with.
The patient determines the goals of the therapy. Are we treating symptoms or treating disease?
- After reviewing the patient history you work out the dose goal and the most desirable terpene and cannabinoid profile.
Give up the need to find a mg/kg formula for all canna is patients. It won't happen. Look at that picture. It pretty much says it all.
The closer correlation is with age; the younger the patient, the higher the dose. In the chart pictured the 88-yr old woman is only taking 75 mg of THC and 30 mg of CBD. The 3-yr old child is taking substantially more.
While the 75 mg of THC doesn't look like much, Marinol is marketed in doses of 2.5 mg, 5 mg, and 10 mg.
- For some patients, that 2.5 mg dose is too much.
- If you took 75 mg of the isolate a day you wouldn't be able to function. When you take a hit from a joint you're lucky to get 10% of that.
- For some - possibly most people - 75 mg of THC is a large dose.
The takeaway on this: More isn't always better, and age is what's most important when determining dose.
The second patient listed was triple negative, which means she was not hormone receptive, so they were looking at using a higher CBD and lower THC with her, and ended up with a 1:1, dosed at 100:100 (Sour Diesel:ACDC)
- She couldn't tolerate a dose higher than the 100mg each.
Start low, titrate very slowly. You're looking for a particular, very individual sweet spot. It can be easy to overshoot if you're not being slow and thoughtful.
She followed the example of Luis Pauling titrating his patients with Vit C.
The two women represented at the bottom of the list were on maintenance doses.
- The 35-yr old was super sensitive. Anything higher than the listed dose was intolerable for her, making her life unbearable.
You determine the patient's goals when setting a treatment plan.
- Are they interested in using cannabis to treat the cancer, or just to treat symptoms and side effects of conventional treatments?
- If wanting to kill cancer cells, then proceed. If not, just get the patient to comfortable.
Questions for the patient:
- What's the diagnosis?
- What's the current cannabis use and history of use?
- What pharmaceuticals and nutraceuticals are being used? Be aware of CP450 pathway pharma drugs. CBD may interfere with their metabolism allowing them to build to intolerable and dangerous levels in the system.
- Patient's age?
- What is your objective? What are you hoping to get from the cannabinoid therapy? What are you trying to accomplish?
In a gram of high THC CCO you can realistically expect to get between 500 and 750 mg of THC.
The actions in epilepsy of THC
Epilepsy is difficult because the diagnoses is a catch-all for seizure disorders.
- Seizures have many triggers, and you have to first determine what's triggering and treat that.
- If it's gut issues THCa is invaluable for healing the gut.
All healing is mind/body/spirit. Treat the whole patient.
- What are you doing to improve nutrition?
- What exercise and movement practice is being followed?
- What are you doing to align your spirit?
- What are you doing to calm and quiet the mind?
The last patient listed was taking 10.3 mg of THC to her 250 mg of CBD.
- In a CBD-only state her therapy would be illegal.
- The restrictive levels of THC being written into the laws are ineffective therapeutically for many, if not most disease states.
Mara believes hemp is wonderful. Let's save the world with it. Make medicine with whole-plant cannabis extracts.
As pertains to psychoactivity; when a person's in severe pain, a little freedom from that is not a bad thing.
- With the right dose you're still fully functional, not incapacitated by intoxication.
Medical doses vs recreational doses
- A medical dose is to relieve the pain.
- A recreational dose is for the pure fun of euphoria.
The eyes are complaining. Lol! Pick up at 24:41.
Practical applications of cannabinoids and terpenes for chronic illnesses
Presentation by Mara Gordon at CannaCosta2015
Cannabinoids
The ECS is the reason cannabis functions as it does for as many different disease states.
B-caryophyllene, found in black pepper and other sources, may qualify as a cannabinoid, because it activates the CB2 receptors.
- It's not only cannabis that will stimulate the ECS, it's just that cannabis does so in so many ways as to set it apart from other sources of cannabinoids.
The euphoria caused by THC is a side benefit of all the other wonderful things the cannabinoid is doing for your healing body.
CBD doesn't offer any reported psychoactivity, but it does sometimes cause anxiety and sleepiness, which could be called psychoactivity of a different sort.
Terpenes are what you smell.
- They're involved in the entourage effect, the synergistic interplay of cannabinoids, terpenes, flavonoids, etc, the many components of cannabis sativa.
- Together they're greater than the sum of their parts.
- Full-plant extractions create very different physiological results than isolates.
Choose the terpenes you use carefully when developing medicines for particular disease states. All chemovars are not made alike.
For example, pinene is a good bronchial dialator, an anti-inflammatory, AIDS in memory function and is a good anti-bacterial, but it can also cause anxiety and allergic reaction in sensitive persons. Pine needles have high concentrations of pinene.
Limonene is very, very uplifting, is good for acid reflux, anxiety, and depression.
Linalool anti-convulsants, analgesic, and anti-anxiety. Lavender is high in linalool.
Beta-Caryophyllene has anti-inflammatory effects, is an analgesic, and will protect the cells lining the digestive tract. It's found in black pepper.
Myrcene contributes to the sedative effects of strong indicas, making it a powerful sleep aid, as well as a good muscle relaxer. It's also found in hops.
Eating a mango prior to ingesting cannabis demonstrates the importance of the entourage effect. The myrcene in the mango increases the absorbtion of the cannabinoids, thus improving bioavailibility. Myrcene has a very relaxing effect.
- When choosing your cannabis you're usually looking for something to slow you down or something to energize you. Slowing you down is what myrcene does.
- Myrcene is typically highest in the chemovars we refer to as indicas.
Sativas are used with PTSD, ADHD, Tourette's, some autism.
Indicas are preferred for chronic diseases like cancer, chronic pain, sleep disorder, etc.
Examples:
ACDC is an extremely high indica dominant chemovar bred specifically for high CBD It has little psychoactive effect for most people and is used (in conjunction with THC-rich chemovars) for epilepsy, cancer, and inflammatory disease.
Blue Dream is an extremely high THC sativa dominant chemovar that carried the Myrcene from an indica ?????? It's one of the most popular sativa dominant chemovars in the adult use market yet has ??????????? pain relief properties. Can't read the graphic and she didn't mention them.
Granddaddy Purple (GDP) is a high THC indica strain that is very relaxing and calming. Many patients choose it as a sleep aid.
The purpose of the ECS is to create homeostasis by balancing the CNS and the immune system. Disease is the lack of homeostasis.
- Cannabinoids and receptors in the ECS will do whatever they can to create a homeostatic environment.
THC has more medical applications in current clinical work (this was presented in 2015, and things have progressed) Without THC you're leaving the vast majority of diseases in most sick people without treatment.
Why is happiness and euphoria listed as a negative side effect? Reefer Madness, that's why.
THCa is becoming recognized as an important medicinal component.
- THCa is an anti-inflammatory, anti-prolific, and anti-epileptic. It's an important tool in the medicine box.
- Aunt Zelda's treats a lot of seizure disorder patients, either from epilepsy or some other condition like glioblastomas or metastatic cancers that've settled in the brain or other parts of the body.
Decarboxylation frees the carbon molecules from the acid cannabinoids so they can activate the receptors. With the carbon molecules attached they won't fit the receptors.
In treating epilepsy and CBD becomes less effective or isn't effective THCa is a viable substitute. You always need a small amount of THC.
CBD is being studies as an anti-psychotic, anti-epileptic, as useful in extreme inflammatory response.
- It's good for inflammation and pain.
- CBD will be effective in keeping cancer from returning. After cancer is in remission the maintenance dose can be dropped to low THC, high CBD (can be very high) so they can live more normal lives.
How It Works: An Overview
Activation of CB1, CB2, [and GPR55?] receptor sites promotes homeostasis in all other body systems
THC has more mechanisms of action in medical applications of cannabis than other cannabinoids or terpenes. It is the most potent activator of CB1 and CB2 receptor sites. It also has anti-inflammatory properties.
THCa is an anti-inflammatory, antti-proliferative, and anti-epileptic.
THCV reduces the parinoia side effects of THC through the entourage effect. It's being studied for use in diabetes. It can act as an appetite suppressant.
CBD is being studied as an anti-psychotic and anti-epileptic, and is proven to have extreme anti-inflammatory properties more potent than hydrocortisone. It also has antibacterial and anti fungal properties. The US has (Had) a patent on CBD as an anti-inflammatory and neuro protector.
CBG, when combined with THC, is a powerful pain suppressant (Entourage effect)
CBN, when combined with THC, is a sleep agent (Entourage effect)
CBC is a potent anti-bacterial, anti-fungal, and analgesic.
CBDV is another non-psychoactive cannabinoid that shows promise with epilepsy.
There are somewhere between 200 and 500 terpenes found in cannabis and new cannabinoids are being discovered al the time.
CB1 receptors primarily in CNS, CB2 receptors primarily in the immune cells of the lymphatic system.
- With disease states the eCBRs will appear where needed.
How it works: Cancer
THC: Super-activation of CB1 and CB2 receptor sites by THC leading to apoptosis (programmed cell death) of cancer cells.
Dr. Sean McCallaster (sp?) has been researching the ID-1 gene and has discovered that CBD restricts the translation of the ID-1 gene in many cancers, blocking the proliferation and metastasis of many cancers.
- High levels of ID-1 are found in brain, liver, lung, skin, and thyroid gland cancer cells. It is also expressed in fetal cells and in the umbilical vein endothelial cells.
Cannabidiol is indicated as a major component in the cancer protocol for
* Non small cell lung cancer
* Gastric cancer
* Breast cancer
* Prostate cancer
* Melanoma
* Glioblastoma
* Hepatocarcinoma
* Anaplastic thyroid tumor
* Metastasis of certain cancers
The ID-1 gene is responsible for tumor growth and metastasis. CBD doesn't activate the eCBRs, but rather affects other body systems to block proliferation and metastasis.
Try higher CBD and lower THC formulations for cancers involving the ID-1 gene.
** The last patient on the list is a 3-yr old female.
What does success mean? Because of the frustrations and stigmas attached to cannabis many cancer patients wait until it's very advanced or without hope before they seek a cannabinoid therapy. When we can reverse this trend we won't have as many people getting that desperately sick to begin with.
The patient determines the goals of the therapy. Are we treating symptoms or treating disease?
- After reviewing the patient history you work out the dose goal and the most desirable terpene and cannabinoid profile.
Give up the need to find a mg/kg formula for all canna is patients. It won't happen. Look at that picture. It pretty much says it all.
The closer correlation is with age; the younger the patient, the higher the dose. In the chart pictured the 88-yr old woman is only taking 75 mg of THC and 30 mg of CBD. The 3-yr old child is taking substantially more.
While the 75 mg of THC doesn't look like much, Marinol is marketed in doses of 2.5 mg, 5 mg, and 10 mg.
- For some patients, that 2.5 mg dose is too much.
- If you took 75 mg of the isolate a day you wouldn't be able to function. When you take a hit from a joint you're lucky to get 10% of that.
- For some - possibly most people - 75 mg of THC is a large dose.
The takeaway on this: More isn't always better, and age is what's most important when determining dose.
The second patient listed was triple negative, which means she was not hormone receptive, so they were looking at using a higher CBD and lower THC with her, and ended up with a 1:1, dosed at 100:100 (Sour Diesel:ACDC)
- She couldn't tolerate a dose higher than the 100mg each.
Start low, titrate very slowly. You're looking for a particular, very individual sweet spot. It can be easy to overshoot if you're not being slow and thoughtful.
She followed the example of Luis Pauling titrating his patients with Vit C.
The two women represented at the bottom of the list were on maintenance doses.
- The 35-yr old was super sensitive. Anything higher than the listed dose was intolerable for her, making her life unbearable.
You determine the patient's goals when setting a treatment plan.
- Are they interested in using cannabis to treat the cancer, or just to treat symptoms and side effects of conventional treatments?
- If wanting to kill cancer cells, then proceed. If not, just get the patient to comfortable.
Questions for the patient:
- What's the diagnosis?
- What's the current cannabis use and history of use?
- What pharmaceuticals and nutraceuticals are being used? Be aware of CP450 pathway pharma drugs. CBD may interfere with their metabolism allowing them to build to intolerable and dangerous levels in the system.
- Patient's age?
- What is your objective? What are you hoping to get from the cannabinoid therapy? What are you trying to accomplish?
In a gram of high THC CCO you can realistically expect to get between 500 and 750 mg of THC.
The actions in epilepsy of THC
Epilepsy is difficult because the diagnoses is a catch-all for seizure disorders.
- Seizures have many triggers, and you have to first determine what's triggering and treat that.
- If it's gut issues THCa is invaluable for healing the gut.
All healing is mind/body/spirit. Treat the whole patient.
- What are you doing to improve nutrition?
- What exercise and movement practice is being followed?
- What are you doing to align your spirit?
- What are you doing to calm and quiet the mind?
The last patient listed was taking 10.3 mg of THC to her 250 mg of CBD.
- In a CBD-only state her therapy would be illegal.
- The restrictive levels of THC being written into the laws are ineffective therapeutically for many, if not most disease states.
Mara believes hemp is wonderful. Let's save the world with it. Make medicine with whole-plant cannabis extracts.
As pertains to psychoactivity; when a person's in severe pain, a little freedom from that is not a bad thing.
- With the right dose you're still fully functional, not incapacitated by intoxication.
Medical doses vs recreational doses
- A medical dose is to relieve the pain.
- A recreational dose is for the pure fun of euphoria.
The eyes are complaining. Lol! Pick up at 24:41.
- Thread starter
- #266
continuing.....
Practical applications of cannabinoids and terpenes for chronic illnesses
Presentation by Mara Gordon at CannaCosta2015
Cannabinoids
The ECS is the reason cannabis functions as it does for as many different disease states.
B-caryophyllene, found in black pepper and other sources, may qualify as a cannabinoid, because it activates the CB2 receptors.
- It's not only cannabis that will stimulate the ECS, it's just that cannabis does so in so many ways as to set it apart from other sources of cannabinoids.
The euphoria caused by THC is a side benefit of all the other wonderful things the cannabinoid is doing for your healing body.
CBD doesn't offer any reported psychoactivity, but it does sometimes cause anxiety and sleepiness, which could be called psychoactivity of a different sort.
Terpenes are what you smell.
- They're involved in the entourage effect, the synergistic interplay of cannabinoids, terpenes, flavonoids, etc, the many components of cannabis sativa.
- Together they're greater than the sum of their parts.
- Full-plant extractions create very different physiological results than isolates.
Choose the terpenes you use carefully when developing medicines for particular disease states. All chemovars are not made alike.
For example, pinene is a good bronchial dialator, an anti-inflammatory, AIDS in memory function and is a good anti-bacterial, but it can also cause anxiety and allergic reaction in sensitive persons. Pine needles have high concentrations of pinene.
Limonene is very, very uplifting, is good for acid reflux, anxiety, and depression.
Linalool anti-convulsants, analgesic, and anti-anxiety. Lavender is high in linalool.
Beta-Caryophyllene has anti-inflammatory effects, is an analgesic, and will protect the cells lining the digestive tract. It's found in black pepper.
Myrcene contributes to the sedative effects of strong indicas, making it a powerful sleep aid, as well as a good muscle relaxer. It's also found in hops.
Eating a mango prior to ingesting cannabis demonstrates the importance of the entourage effect. The myrcene in the mango increases the absorbtion of the cannabinoids, thus improving bioavailibility. Myrcene has a very relaxing effect.
- When choosing your cannabis you're usually looking for something to slow you down or something to energize you. Slowing you down is what myrcene does.
- Myrcene is typically highest in the chemovars we refer to as indicas.
Sativas are used with PTSD, ADHD, Tourette's, some autism.
Indicas are preferred for chronic diseases like cancer, chronic pain, sleep disorder, etc.
Examples:
ACDC is an extremely high indica dominant chemovar bred specifically for high CBD It has little psychoactive effect for most people and is used (in conjunction with THC-rich chemovars) for epilepsy, cancer, and inflammatory disease.
Blue Dream is an extremely high THC sativa dominant chemovar that carried the Myrcene from an indica ?????? It's one of the most popular sativa dominant chemovars in the adult use market yet has ??????????? pain relief properties. Can't read the graphic and she didn't mention them.
Granddaddy Purple (GDP) is a high THC indica strain that is very relaxing and calming. Many patients choose it as a sleep aid.
The purpose of the ECS is to create homeostasis by balancing the CNS and the immune system. Disease is the lack of homeostasis.
- Cannabinoids and receptors in the ECS will do whatever they can to create a homeostatic environment.
THC has more medical applications in current clinical work (this was presented in 2015, and things have progressed) Without THC you're leaving the vast majority of diseases in most sick people without treatment.
Why is happiness and euphoria listed as a negative side effect? Reefer Madness, that's why.
THCa is becoming recognized as an important medicinal component.
- THCa is an anti-inflammatory, anti-prolific, and anti-epileptic. It's an important tool in the medicine box.
- Aunt Zelda's treats a lot of seizure disorder patients, either from epilepsy or some other condition like glioblastomas or metastatic cancers that've settled in the brain or other parts of the body.
Decarboxylation frees the carbon molecules from the acid cannabinoids so they can activate the receptors. With the carbon molecules attached they won't fit the receptors.
In treating epilepsy and CBD becomes less effective or isn't effective THCa is a viable substitute. You always need a small amount of THC.
CBD is being studies as an anti-psychotic, anti-epileptic, as useful in extreme inflammatory response.
- It's good for inflammation and pain.
- CBD will be effective in keeping cancer from returning. After cancer is in remission the maintenance dose can be dropped to low THC, high CBD (can be very high) so they can live more normal lives.
How It Works: An Overview
Activation of CB1, CB2, [and GPR55?] receptor sites promotes homeostasis in all other body systems
THC has more mechanisms of action in medical applications of cannabis than other cannabinoids or terpenes. It is the most potent activator of CB1 and CB2 receptor sites. It also has anti-inflammatory properties.
THCa is an anti-inflammatory, antti-proliferative, and anti-epileptic.
THCV reduces the parinoia side effects of THC through the entourage effect. It's being studied for use in diabetes. It can act as an appetite suppressant.
CBD is being studied as an anti-psychotic and anti-epileptic, and is proven to have extreme anti-inflammatory properties more potent than hydrocortisone. It also has antibacterial and anti fungal properties. The US has (Had) a patent on CBD as an anti-inflammatory and neuro protector.
CBG, when combined with THC, is a powerful pain suppressant (Entourage effect)
CBN, when combined with THC, is a sleep agent (Entourage effect)
CBC is a potent anti-bacterial, anti-fungal, and analgesic.
CBDV is another non-psychoactive cannabinoid that shows promise with epilepsy.
There are somewhere between 200 and 500 terpenes found in cannabis and new cannabinoids are being discovered al the time.
CB1 receptors primarily in CNS, CB2 receptors primarily in the immune cells of the lymphatic system.
- With disease states the eCBRs will appear where needed.
How it works: Cancer
THC: Super-activation of CB1 and CB2 receptor sites by THC leading to apoptosis (programmed cell death) of cancer cells.
Dr. Sean McCallaster (sp?) has been researching the ID-1 gene and has discovered that CBD restricts the translation of the ID-1 gene in many cancers, blocking the proliferation and metastasis of many cancers.
- High levels of ID-1 are found in brain, liver, lung, skin, and thyroid gland cancer cells. It is also expressed in fetal cells and in the umbilical vein endothelial cells.
Cannabidiol is indicated as a major component in the cancer protocol for
* Non small cell lung cancer
* Gastric cancer
* Breast cancer
* Prostate cancer
* Melanoma
* Glioblastoma
* Hepatocarcinoma
* Anaplastic thyroid tumor
* Metastasis of certain cancers
The ID-1 gene is responsible for tumor growth and metastasis. CBD doesn't activate the eCBRs, but rather affects other body systems to block proliferation and metastasis.
Try higher CBD and lower THC formulations for cancers involving the ID-1 gene.
** The last patient on the list is a 3-yr old female.
What does success mean? Because of the frustrations and stigmas attached to cannabis many cancer patients wait until it's very advanced or without hope before they seek a cannabinoid therapy. When we can reverse this trend we won't have as many people getting that desperately sick to begin with.
The patient determines the goals of the therapy. Are we treating symptoms or treating disease?
- After reviewing the patient history you work out the dose goal and the most desirable terpene and cannabinoid profile.
Give up the need to find a mg/kg formula for all canna is patients. It won't happen. Look at that picture. It pretty much says it all.
The closer correlation is with age; the younger the patient, the higher the dose. In the chart pictured the 88-yr old woman is only taking 75 mg of THC and 30 mg of CBD. The 3-yr old child is taking substantially more.
While the 75 mg of THC doesn't look like much, Marinol is marketed in doses of 2.5 mg, 5 mg, and 10 mg.
- For some patients, that 2.5 mg dose is too much.
- If you took 75 mg of the isolate a day you wouldn't be able to function. When you take a hit from a joint you're lucky to get 10% of that.
- For some - possibly most people - 75 mg of THC is a large dose.
The takeaway on this: More isn't always better, and age is what's most important when determining dose.
The second patient listed was triple negative, which means she was not hormone receptive, so they were looking at using a higher CBD and lower THC with her, and ended up with a 1:1, dosed at 100:100 (Sour Diesel:ACDC)
- She couldn't tolerate a dose higher than the 100mg each.
Start low, titrate very slowly. You're looking for a particular, very individual sweet spot. It can be easy to overshoot if you're not being slow and thoughtful.
She followed the example of Luis Pauling titrating his patients with Vit C.
The two women represented at the bottom of the list were on maintenance doses.
- The 35-yr old was super sensitive. Anything higher than the listed dose was intolerable for her, making her life unbearable.
You determine the patient's goals when setting a treatment plan.
- Are they interested in using cannabis to treat the cancer, or just to treat symptoms and side effects of conventional treatments?
- If wanting to kill cancer cells, then proceed. If not, just get the patient to comfortable.
Questions for the patient:
- What's the diagnosis?
- What's the current cannabis use and history of use?
- What pharmaceuticals and nutraceuticals are being used? Be aware of CP450 pathway pharma drugs. CBD may interfere with their metabolism allowing them to build to intolerable and dangerous levels in the system.
- Patient's age?
- What is your objective? What are you hoping to get from the cannabinoid therapy? What are you trying to accomplish?
In a gram of high THC CCO you can realistically expect to get between 500 and 750 mg of THC.
The actions in epilepsy of THC
How it works: Epilepsy
THC: Activation of CB1 receptors shorts out calcium ion pump on pre-synaptic neuron. This potentially stops grand mail seizures, with hydrocortisone 1like anti-inflammatory mechanism.
CBD: Has 30-50 times the anti-inflammatory properties of hydrocortisone, and appears to dramatically reduce seizure activity. It's also a major neuro-protective agent.
THCa:Similar to CBD m charisma. More studies needed. Typical use is after acclimation of patient to CBD resulting in increased seizure activity. THCa will often replace CBD when it stops working and vice-versa.
Example:
* 7-yr old female (35kg) -10.3:250 (ACDC)
Epilepsy is difficult because the diagnoses is a catch-all for seizure disorders.
- Seizures have many triggers, and you have to first determine what's triggering and treat that.
- If it's gut issues THCa is invaluable for healing the gut.
All healing is mind/body/spirit. Treat the whole patient.
- What are you doing to improve nutrition?
- What exercise and movement practice is being followed?
- What are you doing to align your spirit?
- What are you doing to calm and quiet the mind?
The last patient listed was taking 10.3 mg of THC to her 250 mg of CBD.
- In a CBD-only state her therapy would be illegal.
- The restrictive levels of THC being written into the laws are ineffective therapeutically for many, if not most disease states.
Mara believes hemp is wonderful. Let's save the world with it. Make medicine with whole-plant cannabis extracts.
How it works: Intractable Nerve Pain
THC:
5 Mechanisims involved in pain reduction with CB1 and CB2activation by THC
1. Retards electrochemical reactions at peripheral pain r captors.
2. Interrupts pain signal at dorsal root ganglia.
3. Interrupts pain signal at neuron.
4. Activation of CB2 at leukocyte provides major anti-inflammatory response.
5.Psychoactive euphoric effects and short p-term memory reduction reduces stress response to pain.
CBD:
Anti-inflammatory mechanism provides 39-50 times hydrocortisone relief without shutting down adrenal gland
Patient: 78-yr old female - 15 mg THCa, 5 mg THC, 15 mg CBD (OG2xSour, Swiss Gold)
As pertains to psychoactivity; when a person's in severe pain, a little freedom from that is not a bad thing.
- With the right dose you're still fully functional, not incapacitated by intoxication.
Medical doses vs recreational doses
- A medical dose is to relieve the pain.
- A recreational dose is for the pure fun of euphoria.
Working out the regimen: Patient was a 78-yr old woman
The first medication they chose for the patient was made with Swiss Gold with 6.9 mg CBD and 0.7 mg THC per ml.
- Target dose was 15 mg if CBD, split into 3 doses.
- The total tincture used was 2.174 gr per day, administered in three doses of 0.725 gr each.
The second medication chosen was made from OG2xSour, with 37 mg of THCa and 9.3 mg THC per ml.
- The target dose was 15 mg of THCa per day in a single dose of 0.405 g of tincture that also supplies 3.8 mg of THC.
Her total THC dose is only 5.3 mg daily, and she reports she's sleeping like a baby for the first time in over 20 years of sleeping fitfully, and only after total exhaustion.
How it works: Insomnia
THC: Many indica dominant strains of cannabis contain terpenes such as beta myrcene and other cannabinoids like CBN that will cause somnolence at the correct dose. (importance i
Of Entourage Effect)
* Activation of CB1 receptor sites by THC at pre synaptic neuron slows neural activity at the synaptic cleft (Homeostasis)
* Activation of CB1 and CB2 sites by THC causes vasodilation of blood vessels by causing relaxation (Homeostasis)
* Anti-anxiety action of THC at correct dose aids sleep.
CBD: Mechanisims of action not completely understood as sleep agent. Studies have been done for sleep and for wake-inducing properties.
Patient: 60-yr old male (82kg) 25:0 (Granddaddy Purple)
Go with indica chemovars, higher in myrcene. Avoid the chemovars high in sativa terpenes of pinene and limonene. Use them for daytime.
- Sativas are appropriate for night meds with some PTSD patients, but not really for anyone else.
THC slows down the neural responses, creating a sense of ease so you can let go and sleep.
CBD will wake some people up and others to sleep. The patient discussed above had no CBD in his meds for insomnia because it made him hyperactive
Go with purples for night meds. Be careful with them during the day. Use only if you have experience and know how to dose it without putting the patient to sleep all day.
How it works: Hypertension
THC:
* Activation of CB1 and CB302 receptor sites by THC
- Causes vasodilation of blood vessels, lowering blood pressure
- Causes relief of stress by blocking production of acetylcholine
- Slows down neural activity in the neural cleft
Treatment of hypertension with cannabis is controversial, because it works for some patients and not for others.
Patient: 57-yr old male 30 mg THC/day 13 mg CBD/day in infused olive oil.
Aunt Zelda's tests at every stage of processing. They weigh their medicines down to 0.000. In this way they're building a data base that can more easily predict outcomes for individual patients.
This graphic shows how they compounded a medicine to replace the Cotton Candy Diesel that was doing a marvelous job, but was unavailable for purchase.
- You look for chemovars that come closest in cannabinoid and terpene profiles.
- This process is simplified if you already have lab results for what you're mixing.
- Consistency in dosing is the goal, so the patient knows that a dose of medicine will create an expected outcome.
How it works: Chron's Disease, Irritable Bowel Syndrome
THC: Activation of CB1 and CB2 r crept or sites in the gut relieves mobility and inhibits se creations causing inflammation.
CBD: Reduction of inflammation leads to relief of many IBS symptoms. Anti-bacterial properties relieves opportunistic abscesses often seen in Chron's.
Patient: 54-yr old female 30:15 (Pepe la Pu:ACDC) Note: also vaporizes for breakthrough.
Include THCa in any treatment plan for Chron's or IBS.
Aunt Zelda's tries to standardize their infused oils to 10 mg/ml. Infused oils allow for micro dosing with control.
- With CCO your cannabinoid counts are so high that it's easy to overshoot.
- When treating cancer or bowel disorders you want to avoid the extracts with alcohol. Nutrition is a very important part of the treatment.
THC blessedly interrupts your short-term memory. This is a godsend to someone with PTSD, caught in fight-or-flight.
Citocholine is available for OTC sale. It will calm the brain, relieving some of the distress patients may get with THC's euphoria.
- Start at 250 mg. you can go as high as 200mg.
- If the patient is on high doses of THC, introducing citocholine into the treat,net plan can mak the difference between success and failure of the regimen.
The patient is treating PTSD, not what she originally went to Aunt Zelda's tear the initial interview it was obvious that she was really dealing with PTSD.
- She's also super-sensitive to her body.
- That hyper-sensitivity allowed them to dial in a more pr case low dose that successfully keeps her on a healing path.
* With a super-sensitive patient the tendency is they'll stop when they get uncomfortable, so you need to be particularly focused on getting to the OTD.
CONCLUSIONS
* Cannabis is more than the sum of its parts.
* Endo and exocannabiniods play a significant role in treating ALL DISEASES
* It's important to select the right chemovars.
* It's possible to dose correctly and consistently.
* Individualized treatment plans are necessary.
* Separating the THC and CBD doses does influence results in a positive way.
* All cannabis medicines should be lab tested to guarantee consistent patient outcomes.
Without THC, most diseases wouldn't be treatable with cannabis.
If you chose the wrong chemovar nothing bad will happen, but you won't get the results you were working for.
- Get the chemovar matched to the patient and you'll get success with lower doses.
The entourage effect favors full-plant medicines.
If your medicines are lab tested by a reputable fascilitate with proper equipment and training you can compound medicines for individual patient regimens.
When you're using a THC dominant medicine and a CBD dominant medicine together in the treatment plan it will help to keep doses lower if they're seperated by at least 2 hours.
All the notes are taken. Now it's just a matter of formatting. Time to take a break woman.
Practical applications of cannabinoids and terpenes for chronic illnesses
Presentation by Mara Gordon at CannaCosta2015
Cannabinoids
The ECS is the reason cannabis functions as it does for as many different disease states.
B-caryophyllene, found in black pepper and other sources, may qualify as a cannabinoid, because it activates the CB2 receptors.
- It's not only cannabis that will stimulate the ECS, it's just that cannabis does so in so many ways as to set it apart from other sources of cannabinoids.
The euphoria caused by THC is a side benefit of all the other wonderful things the cannabinoid is doing for your healing body.
CBD doesn't offer any reported psychoactivity, but it does sometimes cause anxiety and sleepiness, which could be called psychoactivity of a different sort.
Terpenes are what you smell.
- They're involved in the entourage effect, the synergistic interplay of cannabinoids, terpenes, flavonoids, etc, the many components of cannabis sativa.
- Together they're greater than the sum of their parts.
- Full-plant extractions create very different physiological results than isolates.
Choose the terpenes you use carefully when developing medicines for particular disease states. All chemovars are not made alike.
For example, pinene is a good bronchial dialator, an anti-inflammatory, AIDS in memory function and is a good anti-bacterial, but it can also cause anxiety and allergic reaction in sensitive persons. Pine needles have high concentrations of pinene.
Limonene is very, very uplifting, is good for acid reflux, anxiety, and depression.
Linalool anti-convulsants, analgesic, and anti-anxiety. Lavender is high in linalool.
Beta-Caryophyllene has anti-inflammatory effects, is an analgesic, and will protect the cells lining the digestive tract. It's found in black pepper.
Myrcene contributes to the sedative effects of strong indicas, making it a powerful sleep aid, as well as a good muscle relaxer. It's also found in hops.
Eating a mango prior to ingesting cannabis demonstrates the importance of the entourage effect. The myrcene in the mango increases the absorbtion of the cannabinoids, thus improving bioavailibility. Myrcene has a very relaxing effect.
- When choosing your cannabis you're usually looking for something to slow you down or something to energize you. Slowing you down is what myrcene does.
- Myrcene is typically highest in the chemovars we refer to as indicas.
Sativas are used with PTSD, ADHD, Tourette's, some autism.
Indicas are preferred for chronic diseases like cancer, chronic pain, sleep disorder, etc.
Examples:
ACDC is an extremely high indica dominant chemovar bred specifically for high CBD It has little psychoactive effect for most people and is used (in conjunction with THC-rich chemovars) for epilepsy, cancer, and inflammatory disease.
Blue Dream is an extremely high THC sativa dominant chemovar that carried the Myrcene from an indica ?????? It's one of the most popular sativa dominant chemovars in the adult use market yet has ??????????? pain relief properties. Can't read the graphic and she didn't mention them.
Granddaddy Purple (GDP) is a high THC indica strain that is very relaxing and calming. Many patients choose it as a sleep aid.
The purpose of the ECS is to create homeostasis by balancing the CNS and the immune system. Disease is the lack of homeostasis.
- Cannabinoids and receptors in the ECS will do whatever they can to create a homeostatic environment.
THC has more medical applications in current clinical work (this was presented in 2015, and things have progressed) Without THC you're leaving the vast majority of diseases in most sick people without treatment.
Why is happiness and euphoria listed as a negative side effect? Reefer Madness, that's why.
THCa is becoming recognized as an important medicinal component.
- THCa is an anti-inflammatory, anti-prolific, and anti-epileptic. It's an important tool in the medicine box.
- Aunt Zelda's treats a lot of seizure disorder patients, either from epilepsy or some other condition like glioblastomas or metastatic cancers that've settled in the brain or other parts of the body.
Decarboxylation frees the carbon molecules from the acid cannabinoids so they can activate the receptors. With the carbon molecules attached they won't fit the receptors.
In treating epilepsy and CBD becomes less effective or isn't effective THCa is a viable substitute. You always need a small amount of THC.
CBD is being studies as an anti-psychotic, anti-epileptic, as useful in extreme inflammatory response.
- It's good for inflammation and pain.
- CBD will be effective in keeping cancer from returning. After cancer is in remission the maintenance dose can be dropped to low THC, high CBD (can be very high) so they can live more normal lives.
How It Works: An Overview
Activation of CB1, CB2, [and GPR55?] receptor sites promotes homeostasis in all other body systems
THC has more mechanisms of action in medical applications of cannabis than other cannabinoids or terpenes. It is the most potent activator of CB1 and CB2 receptor sites. It also has anti-inflammatory properties.
THCa is an anti-inflammatory, antti-proliferative, and anti-epileptic.
THCV reduces the parinoia side effects of THC through the entourage effect. It's being studied for use in diabetes. It can act as an appetite suppressant.
CBD is being studied as an anti-psychotic and anti-epileptic, and is proven to have extreme anti-inflammatory properties more potent than hydrocortisone. It also has antibacterial and anti fungal properties. The US has (Had) a patent on CBD as an anti-inflammatory and neuro protector.
CBG, when combined with THC, is a powerful pain suppressant (Entourage effect)
CBN, when combined with THC, is a sleep agent (Entourage effect)
CBC is a potent anti-bacterial, anti-fungal, and analgesic.
CBDV is another non-psychoactive cannabinoid that shows promise with epilepsy.
There are somewhere between 200 and 500 terpenes found in cannabis and new cannabinoids are being discovered al the time.
CB1 receptors primarily in CNS, CB2 receptors primarily in the immune cells of the lymphatic system.
- With disease states the eCBRs will appear where needed.
How it works: Cancer
THC: Super-activation of CB1 and CB2 receptor sites by THC leading to apoptosis (programmed cell death) of cancer cells.
Dr. Sean McCallaster (sp?) has been researching the ID-1 gene and has discovered that CBD restricts the translation of the ID-1 gene in many cancers, blocking the proliferation and metastasis of many cancers.
- High levels of ID-1 are found in brain, liver, lung, skin, and thyroid gland cancer cells. It is also expressed in fetal cells and in the umbilical vein endothelial cells.
Cannabidiol is indicated as a major component in the cancer protocol for
* Non small cell lung cancer
* Gastric cancer
* Breast cancer
* Prostate cancer
* Melanoma
* Glioblastoma
* Hepatocarcinoma
* Anaplastic thyroid tumor
* Metastasis of certain cancers
The ID-1 gene is responsible for tumor growth and metastasis. CBD doesn't activate the eCBRs, but rather affects other body systems to block proliferation and metastasis.
Try higher CBD and lower THC formulations for cancers involving the ID-1 gene.
** The last patient on the list is a 3-yr old female.
What does success mean? Because of the frustrations and stigmas attached to cannabis many cancer patients wait until it's very advanced or without hope before they seek a cannabinoid therapy. When we can reverse this trend we won't have as many people getting that desperately sick to begin with.
The patient determines the goals of the therapy. Are we treating symptoms or treating disease?
- After reviewing the patient history you work out the dose goal and the most desirable terpene and cannabinoid profile.
Give up the need to find a mg/kg formula for all canna is patients. It won't happen. Look at that picture. It pretty much says it all.
The closer correlation is with age; the younger the patient, the higher the dose. In the chart pictured the 88-yr old woman is only taking 75 mg of THC and 30 mg of CBD. The 3-yr old child is taking substantially more.
While the 75 mg of THC doesn't look like much, Marinol is marketed in doses of 2.5 mg, 5 mg, and 10 mg.
- For some patients, that 2.5 mg dose is too much.
- If you took 75 mg of the isolate a day you wouldn't be able to function. When you take a hit from a joint you're lucky to get 10% of that.
- For some - possibly most people - 75 mg of THC is a large dose.
The takeaway on this: More isn't always better, and age is what's most important when determining dose.
The second patient listed was triple negative, which means she was not hormone receptive, so they were looking at using a higher CBD and lower THC with her, and ended up with a 1:1, dosed at 100:100 (Sour Diesel:ACDC)
- She couldn't tolerate a dose higher than the 100mg each.
Start low, titrate very slowly. You're looking for a particular, very individual sweet spot. It can be easy to overshoot if you're not being slow and thoughtful.
She followed the example of Luis Pauling titrating his patients with Vit C.
The two women represented at the bottom of the list were on maintenance doses.
- The 35-yr old was super sensitive. Anything higher than the listed dose was intolerable for her, making her life unbearable.
You determine the patient's goals when setting a treatment plan.
- Are they interested in using cannabis to treat the cancer, or just to treat symptoms and side effects of conventional treatments?
- If wanting to kill cancer cells, then proceed. If not, just get the patient to comfortable.
Questions for the patient:
- What's the diagnosis?
- What's the current cannabis use and history of use?
- What pharmaceuticals and nutraceuticals are being used? Be aware of CP450 pathway pharma drugs. CBD may interfere with their metabolism allowing them to build to intolerable and dangerous levels in the system.
- Patient's age?
- What is your objective? What are you hoping to get from the cannabinoid therapy? What are you trying to accomplish?
In a gram of high THC CCO you can realistically expect to get between 500 and 750 mg of THC.
The actions in epilepsy of THC
How it works: Epilepsy
THC: Activation of CB1 receptors shorts out calcium ion pump on pre-synaptic neuron. This potentially stops grand mail seizures, with hydrocortisone 1like anti-inflammatory mechanism.
CBD: Has 30-50 times the anti-inflammatory properties of hydrocortisone, and appears to dramatically reduce seizure activity. It's also a major neuro-protective agent.
THCa:Similar to CBD m charisma. More studies needed. Typical use is after acclimation of patient to CBD resulting in increased seizure activity. THCa will often replace CBD when it stops working and vice-versa.
Example:
* 7-yr old female (35kg) -10.3:250 (ACDC)
Epilepsy is difficult because the diagnoses is a catch-all for seizure disorders.
- Seizures have many triggers, and you have to first determine what's triggering and treat that.
- If it's gut issues THCa is invaluable for healing the gut.
All healing is mind/body/spirit. Treat the whole patient.
- What are you doing to improve nutrition?
- What exercise and movement practice is being followed?
- What are you doing to align your spirit?
- What are you doing to calm and quiet the mind?
The last patient listed was taking 10.3 mg of THC to her 250 mg of CBD.
- In a CBD-only state her therapy would be illegal.
- The restrictive levels of THC being written into the laws are ineffective therapeutically for many, if not most disease states.
Mara believes hemp is wonderful. Let's save the world with it. Make medicine with whole-plant cannabis extracts.
How it works: Intractable Nerve Pain
THC:
5 Mechanisims involved in pain reduction with CB1 and CB2activation by THC
1. Retards electrochemical reactions at peripheral pain r captors.
2. Interrupts pain signal at dorsal root ganglia.
3. Interrupts pain signal at neuron.
4. Activation of CB2 at leukocyte provides major anti-inflammatory response.
5.Psychoactive euphoric effects and short p-term memory reduction reduces stress response to pain.
CBD:
Anti-inflammatory mechanism provides 39-50 times hydrocortisone relief without shutting down adrenal gland
Patient: 78-yr old female - 15 mg THCa, 5 mg THC, 15 mg CBD (OG2xSour, Swiss Gold)
As pertains to psychoactivity; when a person's in severe pain, a little freedom from that is not a bad thing.
- With the right dose you're still fully functional, not incapacitated by intoxication.
Medical doses vs recreational doses
- A medical dose is to relieve the pain.
- A recreational dose is for the pure fun of euphoria.
Working out the regimen: Patient was a 78-yr old woman
The first medication they chose for the patient was made with Swiss Gold with 6.9 mg CBD and 0.7 mg THC per ml.
- Target dose was 15 mg if CBD, split into 3 doses.
- The total tincture used was 2.174 gr per day, administered in three doses of 0.725 gr each.
The second medication chosen was made from OG2xSour, with 37 mg of THCa and 9.3 mg THC per ml.
- The target dose was 15 mg of THCa per day in a single dose of 0.405 g of tincture that also supplies 3.8 mg of THC.
Her total THC dose is only 5.3 mg daily, and she reports she's sleeping like a baby for the first time in over 20 years of sleeping fitfully, and only after total exhaustion.
How it works: Insomnia
THC: Many indica dominant strains of cannabis contain terpenes such as beta myrcene and other cannabinoids like CBN that will cause somnolence at the correct dose. (importance i
Of Entourage Effect)
* Activation of CB1 receptor sites by THC at pre synaptic neuron slows neural activity at the synaptic cleft (Homeostasis)
* Activation of CB1 and CB2 sites by THC causes vasodilation of blood vessels by causing relaxation (Homeostasis)
* Anti-anxiety action of THC at correct dose aids sleep.
CBD: Mechanisims of action not completely understood as sleep agent. Studies have been done for sleep and for wake-inducing properties.
Patient: 60-yr old male (82kg) 25:0 (Granddaddy Purple)
Go with indica chemovars, higher in myrcene. Avoid the chemovars high in sativa terpenes of pinene and limonene. Use them for daytime.
- Sativas are appropriate for night meds with some PTSD patients, but not really for anyone else.
THC slows down the neural responses, creating a sense of ease so you can let go and sleep.
CBD will wake some people up and others to sleep. The patient discussed above had no CBD in his meds for insomnia because it made him hyperactive
Go with purples for night meds. Be careful with them during the day. Use only if you have experience and know how to dose it without putting the patient to sleep all day.
How it works: Hypertension
THC:
* Activation of CB1 and CB302 receptor sites by THC
- Causes vasodilation of blood vessels, lowering blood pressure
- Causes relief of stress by blocking production of acetylcholine
- Slows down neural activity in the neural cleft
Treatment of hypertension with cannabis is controversial, because it works for some patients and not for others.
Patient: 57-yr old male 30 mg THC/day 13 mg CBD/day in infused olive oil.
Aunt Zelda's tests at every stage of processing. They weigh their medicines down to 0.000. In this way they're building a data base that can more easily predict outcomes for individual patients.
This graphic shows how they compounded a medicine to replace the Cotton Candy Diesel that was doing a marvelous job, but was unavailable for purchase.
- You look for chemovars that come closest in cannabinoid and terpene profiles.
- This process is simplified if you already have lab results for what you're mixing.
- Consistency in dosing is the goal, so the patient knows that a dose of medicine will create an expected outcome.
How it works: Chron's Disease, Irritable Bowel Syndrome
THC: Activation of CB1 and CB2 r crept or sites in the gut relieves mobility and inhibits se creations causing inflammation.
CBD: Reduction of inflammation leads to relief of many IBS symptoms. Anti-bacterial properties relieves opportunistic abscesses often seen in Chron's.
Patient: 54-yr old female 30:15 (Pepe la Pu:ACDC) Note: also vaporizes for breakthrough.
Include THCa in any treatment plan for Chron's or IBS.
Aunt Zelda's tries to standardize their infused oils to 10 mg/ml. Infused oils allow for micro dosing with control.
- With CCO your cannabinoid counts are so high that it's easy to overshoot.
- When treating cancer or bowel disorders you want to avoid the extracts with alcohol. Nutrition is a very important part of the treatment.
THC blessedly interrupts your short-term memory. This is a godsend to someone with PTSD, caught in fight-or-flight.
Citocholine is available for OTC sale. It will calm the brain, relieving some of the distress patients may get with THC's euphoria.
- Start at 250 mg. you can go as high as 200mg.
- If the patient is on high doses of THC, introducing citocholine into the treat,net plan can mak the difference between success and failure of the regimen.
The patient is treating PTSD, not what she originally went to Aunt Zelda's tear the initial interview it was obvious that she was really dealing with PTSD.
- She's also super-sensitive to her body.
- That hyper-sensitivity allowed them to dial in a more pr case low dose that successfully keeps her on a healing path.
* With a super-sensitive patient the tendency is they'll stop when they get uncomfortable, so you need to be particularly focused on getting to the OTD.
CONCLUSIONS
* Cannabis is more than the sum of its parts.
* Endo and exocannabiniods play a significant role in treating ALL DISEASES
* It's important to select the right chemovars.
* It's possible to dose correctly and consistently.
* Individualized treatment plans are necessary.
* Separating the THC and CBD doses does influence results in a positive way.
* All cannabis medicines should be lab tested to guarantee consistent patient outcomes.
Without THC, most diseases wouldn't be treatable with cannabis.
If you chose the wrong chemovar nothing bad will happen, but you won't get the results you were working for.
- Get the chemovar matched to the patient and you'll get success with lower doses.
The entourage effect favors full-plant medicines.
If your medicines are lab tested by a reputable fascilitate with proper equipment and training you can compound medicines for individual patient regimens.
When you're using a THC dominant medicine and a CBD dominant medicine together in the treatment plan it will help to keep doses lower if they're seperated by at least 2 hours.
All the notes are taken. Now it's just a matter of formatting. Time to take a break woman.
- Thread starter
- #267
Terpene Spotlight: Ocimene
Jill/ August 29, 2017
Ocimene is another terpene found in many strains of cannabis. While more research needs to be done before we can truly understand this terpene, it has some interesting characteristics.
It might help differentiate indicas from sativas. Many of the cannabis strains with the uplifting effects we attribute to sativas have myrcene as the dominant terpene. While that usually means that strain is an indica, researchers found that if ocimene or terpinolene is the second most abundant terpene, the strain will behave like a sativa.
Is there one particular strain that always makes you cough? You might want to check the lab report for elevated levels of ocimene. When smoked or vaped, it can help clear out any congestion you have in your airway.1
Therapeutic Uses of Ocimene
- A potential treatment for inflammation.
- It inhibits enzymes related to type 2 diabetes and hypertension.
- Shows promise as an anticonvulsant.
- Strikes terror in the heart of aphids.
- Has antibacterial properties.
- An effective decongestant.
Every strain is either a sativa or a hybrid. We’d be very interested if you know of any indicas that contain high levels of this terpene.
- Arjan’s Ultra Haze #1
- Avalanche
- Chernobyl
- Durban Poison
- Gold Country Afgoo
- Golden Goat
- Himalayan Gold
- Lemon Sour Diesel
- OG Kush
- Space Queen
- Strawberry Cough
- Basil
- Kumquats
- Mango
- Mint
- Orchids
- Oregano
- Parsley
- Pepper
- Tarragon
This particular terpene isn’t a big part of our product line, partially because the best way to get its benefits is by smoking or vaping. Like many other cannabis terpenes, it’s also a great insecticide. It has a green, woody flavor with floral and vegetal notes. It makes huge contributions to the scent of orchids.
How to Eat More Ocimene
Ocimene is found in tarragon, an herb so delicious that James Beard once said,
“I believe that if ever I had to practice cannibalism, I might manage if there were enough tarragon around.”
Terpene Spotlight: Terpinolene
Jill/ September 12, 2017
Terpinolene is a somewhat elusive terpene — at least when it comes to cannabis. Most strains don’t have any at all and those that do tend to have very low quantities. Fortunately, Jack Herer consistently shows high levels of this terpene and it’s a popular, and thus easy to find, strain.
While people have been using tea tree oil (which is naturally high in terpinolene) for its antimicrobial properties for centuries, we also found several interesting studies that show that this terpene has significant medical potential. However, not everything is as straightforward as tea tree oil: research shows that terpinolene has sedative effects on mice, but it only seems to be present in sativas or sativa-heavy hybrids. Clearly, we still have a lot to learn about this terpene and how it might affect us.
Therapeutic Uses of Terpinolene
- Offers some protection against heart disease.
- Inhaling this terpene sedates mice.
- Shows antimicrobial and antifungal properties.
- Prevents brain tumor cells from replicating themselves.
- Shows antioxidant properties.
- Potentially slows the growth of cancer.
- Jack Herer
- Pineapple Kush
- Pineapple Jack
- J1
- Apples
- Cumin
- Cypress
- Lilacs
- Pines
- Rosemary
- Sage
- Tea Tree Oil
This terpene has a piney fragrance with floral undertones and a sweet citrus flavor. While it’s not a big factor in any of our products, our Happy Belly tincture does feature sage. Without more research, it’s hard to say how or even if it can help improve digestion. Until we learn more, we’re happy to use an ingredient that could provide antioxidant and antimicrobial benefits.
How to Eat More Terpinolene
Cannabis research, especially terpene research, is still in the early stages. We simply don’t know the best way to use these compounds. That being said, terpenes are found in every plant and their strong scents and flavors contribute heavily to the way we enjoy foods. We don’t know if eating more terpenes will improve your health, but they are definitely a welcome addition to any meal.
- Thread starter
- #268
We can add Carnival to the list of chemovars high in both of those wonderful terpenes.
- Thread starter
- #269
Guaiol's fragrance is floral, woody, rose-like
- other chemovars high in Guaiol:
Alpha humulene, also known as alpha caryophyllene, has an earthy/woody scent. It’s found in hops, so it’s responsible for the distinctive smell of beer.
- other chemovars high in Guaiol:
- Barbara Bud
- Blue Kush
- Chocolope
- Jean Guy
- Liberty Haze
- White Widow
Alpha humulene, also known as alpha caryophyllene, has an earthy/woody scent. It’s found in hops, so it’s responsible for the distinctive smell of beer.
- Thread starter
- #270
- Thread starter
- #271
Carnival has Beta-Ocimene. I think that's different from the ocimene I found information on. That was a quick chase-down anyway. A more in-depth evaluation of the terpene profile will be in order. There are a couple other projects that are waiting to be completed.
- Thread starter
- #272
Notes: CBD 101 with Martin Lee of Project CBD
A Green Flower Media class
9:15 CBD and THC work best together.
- There's no single ratio or dose that'll work for everyone. Cannabis insists on being an individualized medication.
Liver, cardiovascular, and metabolic treatments now currently treated with CBD wouldn't be possible without THC
At 10:45 I have a note that simply says "brain cancer" with no information. I'll catch up to that when I do the next pass
11:32 A greater ratio of CBD to THC will lessen and eliminate the euphoric effects of THC.
- You can customize to your level of comfort with THC.
- THC is a necessary component for a complete and effective canna med.
13:10 Determining the ratio that suits you.
- How sensitive are you to both compounds?
- How experienced are you with cannabis?
Always start with low dose THC.
Time for bed. Goodnight moon.
A Green Flower Media class
9:15 CBD and THC work best together.
- There's no single ratio or dose that'll work for everyone. Cannabis insists on being an individualized medication.
Liver, cardiovascular, and metabolic treatments now currently treated with CBD wouldn't be possible without THC
At 10:45 I have a note that simply says "brain cancer" with no information. I'll catch up to that when I do the next pass
11:32 A greater ratio of CBD to THC will lessen and eliminate the euphoric effects of THC.
- You can customize to your level of comfort with THC.
- THC is a necessary component for a complete and effective canna med.
13:10 Determining the ratio that suits you.
- How sensitive are you to both compounds?
- How experienced are you with cannabis?
Always start with low dose THC.
Time for bed. Goodnight moon.
- Thread starter
- #273
continuing.....
Notes: CBD 101 with Martin Lee of Project CBD
A Green Flower Media class
Cannabis has been a friend to man since before the written word.
I love the way he talks.
Cannabis has a rich history as a medicine, going back thousands of years, including the U.S.
- In the latter part of the 19th century cannabis tinctures were and important, essential part of the medicine cabinet.
- Prohibition forced cannabis underground where it turned into a recreational drug.
- We're relearning ancient methods for using cannabis therapeutically.
Today it's not as simple as lighting up a joint.
- We have potent cannabis oils of every conceivable formulation.
- Many people are confused about what to do with all this choice.
How can we best use cannabis oils with varied ratios for maximum therapeutic benefit?
About CBD
Cannabidiol (CBD) is a plant cannabinoid.
This is not technically true. In the growing plant you have CBDa. CBD is a decarbed molecule, either by natural or man-made forces of time and temperature.
CBD is not psychoactive in the way THC is. You'll get a sense of well-being, but no euphoria commonly associated with THC.
Discovered in 1940 by Roger Adams, an American scientist.
- The molecular structure wasn't known until Raphael Meschoulem elucidated it in 1963.
- The following year he did the same for THC.
Interest in CBD didn't take off for years, because the focus was on THC.
- All the research money in the 1960s spent on cannabis research was with the intent to prove it was a dangerous drug, and it was that evil THC that got people stoned.
In 1980 there was a study in Brazil that demonstrated the dramatic therapeutic results available using CBD to treat seizures.
- The study was about a dozen patients, and was wildly successful.
- Nothing came of it for decades.
In 1988 NIH funded a study identified THC and CBD as potent neuroprotectors and anti-oxidants.
- The Federal government holds a patent on plant cannabinoids as neural protectors, filed in 2003.
Both THC and CBD are known to induce neurogenesis, the creation of new brain cells, in adult mammals.
- As close as 30 years ago the idea of neurogenesis in adult mammals was heresy. We knew better.
CBD has been studied as a molecule fairly extensively around the world.
Properties of single-molecule CBD
- Anti-tumor
- Anti-spasmodic
- Anti-convulsant
- Antidepressant
- Antipsychotic
- Anti-addictive
- Anxiolytic (anxiety-reducing)
- Antibiotic
- Analgesic (pain reliever)
Whole plant CBD is different in many ways from single-molecule CBD.
CBD and THC work best together.
- To gain the greatest therapeutic benefit of both molecules, use them in combination.
Benefits of whole-plant cannabinoid medicines
- CBD potentiates THC's pain modulation abilities.
- CBD enhances cannabis's efficacy for neuropathic pain, auto-immune diseases, cancer, and other conditions. These conditions respond better with CBD in the formulation.
Once CBD gained recognition and appreciation (starting in 2009 in N. Cali) it became obvious that CBD broadened the range of conditions treatable with cannabis.
- Conditions that didn't necessarily respond positively to high-THC formulations.
- Liver, cardiovascular, and metabolic disorders now currently treated with CBD wouldn't be possible without THC.
In a study published in 2010 by the California Pacific Medical Center it was shown that CBD will magnify THC's inhibitory effect on brain cancer.
- The study showed that THC and CBD alone have individual anti-cancer properties, but combined they had a synergistic effect on glioblastomas.
CBD doesn't get you high the way THC does.
- Though many enjoy euphoria, many others don't.
A greater ratio of CBD to THC will lessen and eliminate the euphoric effects of THC.
- You can now customize to your level of comfort with THC.
-There's no single ratio, dose, or product that'll work for everyone. Cannabis insists on being an individualized medication.
- Cannabis patients have the option of using cannabis without the euphoria.
- However, THC is a necessary component for a complete and effective canna med.
- A low-THC medicine won't get you high, but it also might not be effective medically.
- A medicine with both major Cannabinoids will be the most effective.
Determining the ratio that suits you.
- How sensitive are you to both compounds, in particular THC.
- How experienced are you with cannabis?
You control euphoria with ratio and dose.
- Always start with low dose THC when starting new patients with little or no experience.
The starting goal of a new cannabinoid therapy with a cannabis naive patient is to administer consistent, measurable doses of a CBD-rich medicine with as much THC in the formulation as the patient can comfortably handle.
"Dosage is everything." - Paracelsus
A personalized medicine focuses on the person, not the condition, because you're treating a person, not a condition.
- It's not so much finding the perfect ratio or dose for the disease state being treated, but rather finding what's appropriate and comfortable for this patient.
- Some will do well with a balanced ratio, others will find it too euphoric.
- Instead of gearing the medicine for the disease, make it reflect the patient.
What's the patient history with cannabis? How comfortable is the patient with cannabis, and in particular, THC?
The emerging patterns
At Project CBD they've begun to see patterns arising with cannabis therapeutics.
- Anxiety is treated best with higher CBD with low THC.
- Depression, spasms, pediatric seizure disorders respond best, at least initially, to low THC, high CBD products.
- Cancer, neurological disease, and gut issues do best with a 1:1 ratio.
- Chronic pain, neuropathic pain is best managed by a 1:1 ratio.
GW Pharmaceuticals proved that a balanced ratio manages chronic pain best.
- Chronic pain, neuropathic pain... the type of pain opioids don't treat well at all.
- Extensive clinical trials in Europe have proven that a balanced ratio can help someone struggling with chronic pain to live a better life, if they're comfortable with the euphoria that may occur with a 1:1
- Any chemovar will potentially help with auto-immune diseases (when your immune system attacks your cells inappropriately)
- THC activation or eCB2 receptors can regulate (dial down) an overactive immune response.
There are now CBD-rich products available in all the ways you can find THC-rich products.
What to look for in a CBD product
- clear labeling of quantity, ratio of major cannabinoids, and dose
- evidence and documentation of lab testing to be free of pollutants (molds, solvent residues, other contaminants)
- purity (no artificial additives) *be alert to thinning agents*
- look for sustainably-grown, high-resin content plants instead of industrial hemp
- avoid products extracted with solvents (butane, hexane, hydrocarbons)
- look for super-critical CO2 extractions or high-grade ethanol extractions
In the wild cannabis expresses close to an even ratio of the major cannabinoids.
- When prohibition percerted the market breeders went for high THC, overlooking CBD.
- Most plants available have high THC, and minimal CBD. That's quickly changing.
Low-resin industrial hemp has about 3.2% CBD by dry weight. By contrast, you can now find cannabis with levels up to 20%.
You can get CBD from industrial hemp but
- You need huge amounts of hemp to extract a little bit of CBD.
- Cannabis is a bioaccumulator, a florid way of saying that it'll suck toxins and heavy metals out of the soil it grows in.
- Although this makes hemp a valuable plant to clean polluted lands, it's not so cool when you're extracting oils for medicine. You end up with concentrations that can become problematic.
Hemp is defined as a cannabis sativa having 0.3% or less THC value.
- Martin believes, and I agree, that this definition exists solely to perpetuate prohibition.
- Grow a CBD-rich plant with a higher than 0.3% THC value and you're now breaking the law and dealing in a federally-controlled substance.
***When this class was originally broadcast CBD was federally illegal and not permitted to be shipped across state lines. Has this changed? I don't believe it has. ***
There are still problems with quality control, a consequence of prohibition.
- Since this class originally aired there's been an increase in quality control on the producer level as more states become legal, but there's still much to be done.
Of concern is the use of polypropylene glycol being used in vape pens.
- It's been approved for ingestion, but not for inhallation, yet everyone acts like this isn't an issue.
- When overheated - as would be done in a vaporizer - polypropylene glycol breaks down into a carcinogen.
- People reaching for a CBD pen are sick, and don't need carcinogens added to the formula.
- Many come flavored as well. No one tested those flavors as inhaled meds.
- The few things that have been tested turned out to be nasty.
Avoid flavored vape pens unless there's evidence that the flavoring agents were tested for inhalation.
It's not likely that they were tested.
Pick up at 28:55. This class runs 1
01. It'll take a while to get all in. Lol!
Notes: CBD 101 with Martin Lee of Project CBD
A Green Flower Media class
Cannabis has been a friend to man since before the written word.
I love the way he talks.
Cannabis has a rich history as a medicine, going back thousands of years, including the U.S.
- In the latter part of the 19th century cannabis tinctures were and important, essential part of the medicine cabinet.
- Prohibition forced cannabis underground where it turned into a recreational drug.
- We're relearning ancient methods for using cannabis therapeutically.
Today it's not as simple as lighting up a joint.
- We have potent cannabis oils of every conceivable formulation.
- Many people are confused about what to do with all this choice.
How can we best use cannabis oils with varied ratios for maximum therapeutic benefit?
About CBD
Cannabidiol (CBD) is a plant cannabinoid.
This is not technically true. In the growing plant you have CBDa. CBD is a decarbed molecule, either by natural or man-made forces of time and temperature.
CBD is not psychoactive in the way THC is. You'll get a sense of well-being, but no euphoria commonly associated with THC.
Discovered in 1940 by Roger Adams, an American scientist.
- The molecular structure wasn't known until Raphael Meschoulem elucidated it in 1963.
- The following year he did the same for THC.
Interest in CBD didn't take off for years, because the focus was on THC.
- All the research money in the 1960s spent on cannabis research was with the intent to prove it was a dangerous drug, and it was that evil THC that got people stoned.
In 1980 there was a study in Brazil that demonstrated the dramatic therapeutic results available using CBD to treat seizures.
- The study was about a dozen patients, and was wildly successful.
- Nothing came of it for decades.
In 1988 NIH funded a study identified THC and CBD as potent neuroprotectors and anti-oxidants.
- The Federal government holds a patent on plant cannabinoids as neural protectors, filed in 2003.
Both THC and CBD are known to induce neurogenesis, the creation of new brain cells, in adult mammals.
- As close as 30 years ago the idea of neurogenesis in adult mammals was heresy. We knew better.
CBD has been studied as a molecule fairly extensively around the world.
Properties of single-molecule CBD
- Anti-tumor
- Anti-spasmodic
- Anti-convulsant
- Antidepressant
- Antipsychotic
- Anti-addictive
- Anxiolytic (anxiety-reducing)
- Antibiotic
- Analgesic (pain reliever)
Whole plant CBD is different in many ways from single-molecule CBD.
CBD and THC work best together.
- To gain the greatest therapeutic benefit of both molecules, use them in combination.
Benefits of whole-plant cannabinoid medicines
- CBD potentiates THC's pain modulation abilities.
- CBD enhances cannabis's efficacy for neuropathic pain, auto-immune diseases, cancer, and other conditions. These conditions respond better with CBD in the formulation.
Once CBD gained recognition and appreciation (starting in 2009 in N. Cali) it became obvious that CBD broadened the range of conditions treatable with cannabis.
- Conditions that didn't necessarily respond positively to high-THC formulations.
- Liver, cardiovascular, and metabolic disorders now currently treated with CBD wouldn't be possible without THC.
In a study published in 2010 by the California Pacific Medical Center it was shown that CBD will magnify THC's inhibitory effect on brain cancer.
- The study showed that THC and CBD alone have individual anti-cancer properties, but combined they had a synergistic effect on glioblastomas.
CBD doesn't get you high the way THC does.
- Though many enjoy euphoria, many others don't.
A greater ratio of CBD to THC will lessen and eliminate the euphoric effects of THC.
- You can now customize to your level of comfort with THC.
-There's no single ratio, dose, or product that'll work for everyone. Cannabis insists on being an individualized medication.
- Cannabis patients have the option of using cannabis without the euphoria.
- However, THC is a necessary component for a complete and effective canna med.
- A low-THC medicine won't get you high, but it also might not be effective medically.
- A medicine with both major Cannabinoids will be the most effective.
Determining the ratio that suits you.
- How sensitive are you to both compounds, in particular THC.
- How experienced are you with cannabis?
You control euphoria with ratio and dose.
- Always start with low dose THC when starting new patients with little or no experience.
The starting goal of a new cannabinoid therapy with a cannabis naive patient is to administer consistent, measurable doses of a CBD-rich medicine with as much THC in the formulation as the patient can comfortably handle.
"Dosage is everything." - Paracelsus
A personalized medicine focuses on the person, not the condition, because you're treating a person, not a condition.
- It's not so much finding the perfect ratio or dose for the disease state being treated, but rather finding what's appropriate and comfortable for this patient.
- Some will do well with a balanced ratio, others will find it too euphoric.
- Instead of gearing the medicine for the disease, make it reflect the patient.
What's the patient history with cannabis? How comfortable is the patient with cannabis, and in particular, THC?
The emerging patterns
At Project CBD they've begun to see patterns arising with cannabis therapeutics.
- Anxiety is treated best with higher CBD with low THC.
- Depression, spasms, pediatric seizure disorders respond best, at least initially, to low THC, high CBD products.
- Cancer, neurological disease, and gut issues do best with a 1:1 ratio.
- Chronic pain, neuropathic pain is best managed by a 1:1 ratio.
GW Pharmaceuticals proved that a balanced ratio manages chronic pain best.
- Chronic pain, neuropathic pain... the type of pain opioids don't treat well at all.
- Extensive clinical trials in Europe have proven that a balanced ratio can help someone struggling with chronic pain to live a better life, if they're comfortable with the euphoria that may occur with a 1:1
- Any chemovar will potentially help with auto-immune diseases (when your immune system attacks your cells inappropriately)
- THC activation or eCB2 receptors can regulate (dial down) an overactive immune response.
There are now CBD-rich products available in all the ways you can find THC-rich products.
What to look for in a CBD product
- clear labeling of quantity, ratio of major cannabinoids, and dose
- evidence and documentation of lab testing to be free of pollutants (molds, solvent residues, other contaminants)
- purity (no artificial additives) *be alert to thinning agents*
- look for sustainably-grown, high-resin content plants instead of industrial hemp
- avoid products extracted with solvents (butane, hexane, hydrocarbons)
- look for super-critical CO2 extractions or high-grade ethanol extractions
In the wild cannabis expresses close to an even ratio of the major cannabinoids.
- When prohibition percerted the market breeders went for high THC, overlooking CBD.
- Most plants available have high THC, and minimal CBD. That's quickly changing.
Low-resin industrial hemp has about 3.2% CBD by dry weight. By contrast, you can now find cannabis with levels up to 20%.
You can get CBD from industrial hemp but
- You need huge amounts of hemp to extract a little bit of CBD.
- Cannabis is a bioaccumulator, a florid way of saying that it'll suck toxins and heavy metals out of the soil it grows in.
- Although this makes hemp a valuable plant to clean polluted lands, it's not so cool when you're extracting oils for medicine. You end up with concentrations that can become problematic.
Hemp is defined as a cannabis sativa having 0.3% or less THC value.
- Martin believes, and I agree, that this definition exists solely to perpetuate prohibition.
- Grow a CBD-rich plant with a higher than 0.3% THC value and you're now breaking the law and dealing in a federally-controlled substance.
***When this class was originally broadcast CBD was federally illegal and not permitted to be shipped across state lines. Has this changed? I don't believe it has. ***
There are still problems with quality control, a consequence of prohibition.
- Since this class originally aired there's been an increase in quality control on the producer level as more states become legal, but there's still much to be done.
Of concern is the use of polypropylene glycol being used in vape pens.
- It's been approved for ingestion, but not for inhallation, yet everyone acts like this isn't an issue.
- When overheated - as would be done in a vaporizer - polypropylene glycol breaks down into a carcinogen.
- People reaching for a CBD pen are sick, and don't need carcinogens added to the formula.
- Many come flavored as well. No one tested those flavors as inhaled meds.
- The few things that have been tested turned out to be nasty.
Avoid flavored vape pens unless there's evidence that the flavoring agents were tested for inhalation.
It's not likely that they were tested.
Pick up at 28:55. This class runs 1
01. It'll take a while to get all in. Lol! - Thread starter
- #274
Notes from Green Flower Media AMA with Martin Lee of Project CBD
Next week expect Project CBD to release a new major report on the cannabinoid.
Pain terps: Myrcene and B-caryophyllene
Energizing terps: Limonene
Find one with b-caryophyllene and limonene in the top 3-4 terps listed - let's say Carnival
- and you have an energizing pain reliever.
Clinical trials for Sativax demonstrated that a 1:1 works best for most cases of chronic pain.
- The peak for pain management appeared to be 20 mg each/day dosed across the day.
- Once you went higher than 20 mg the efficacy of the cannabinoid treatment began to diminish.
Childhood trauma can adversely effect gene expression leading to methylation of the gene that expresses eCB receptors.
- This sets the child up for a lifetime of poor health.
- The ECS is a dynamic system, and demethylation is achievable with some simple nutritional adjustments.
- Olive oil is an excellent demethylator.
CBDa is more easily absorbed by the body - it's more bioavailable - than CBD.
- If this carries across systems then it can be expected that in a topical CBDa might be more easily absorbed by the skin.
Both major cannabinoids are alerting or stimulating at low doses, and make you tired at high doses.
If you take CBD at night you don't want to take a small dose, you want to take a big one.
Some people take cannabis and they feel fine. Others take it and get anxious.
- Anyone who takes too much cannabis, in particular too much THC, will get anxious.
Pick up at 29:18. Can't see anymore tonight. Lol!
Next week expect Project CBD to release a new major report on the cannabinoid.
Pain terps: Myrcene and B-caryophyllene
Energizing terps: Limonene
Find one with b-caryophyllene and limonene in the top 3-4 terps listed - let's say Carnival
- and you have an energizing pain reliever.Clinical trials for Sativax demonstrated that a 1:1 works best for most cases of chronic pain.
- The peak for pain management appeared to be 20 mg each/day dosed across the day.
- Once you went higher than 20 mg the efficacy of the cannabinoid treatment began to diminish.
Childhood trauma can adversely effect gene expression leading to methylation of the gene that expresses eCB receptors.
- This sets the child up for a lifetime of poor health.
- The ECS is a dynamic system, and demethylation is achievable with some simple nutritional adjustments.
- Olive oil is an excellent demethylator.
CBDa is more easily absorbed by the body - it's more bioavailable - than CBD.
- If this carries across systems then it can be expected that in a topical CBDa might be more easily absorbed by the skin.
Both major cannabinoids are alerting or stimulating at low doses, and make you tired at high doses.
If you take CBD at night you don't want to take a small dose, you want to take a big one.
Some people take cannabis and they feel fine. Others take it and get anxious.
- Anyone who takes too much cannabis, in particular too much THC, will get anxious.
Pick up at 29:18. Can't see anymore tonight. Lol!
- Thread starter
- #275
continuing.....
Notes from Green Flower Media AMA with Martin Lee of Project CBD
Next week expect Project CBD to release a new major report on the cannabinoid.
Pain terps: Myrcene and B-caryophyllene
Energizing terps: Limonene
Find one with b-caryophyllene and limonene in the top 3-4 terps listed - let's say Carnival - and you have an energizing pain reliever.
Clinical trials for Sativax demonstrated that a 1:1 works best for most cases of chronic pain.
- The peak for pain management appeared to be 20 mg each/day dosed across the day.
- Once you went higher than 20 mg the efficacy of the cannabinoid treatment began to diminish.
Childhood trauma can adversely effect gene expression leading to methylation of the gene that expresses eCB receptors.
- This sets the child up for a lifetime of poor health.
- The ECS is a dynamic system, and demethylation is achievable with some simple nutritional adjustments.
- Olive oil is an excellent demethylator.
CBDa is more easily absorbed by the body - it's more bioavailable - than CBD.
- If this carries across systems then it can be expected that in a topical CBDa might be more easily absorbed by the skin.
Both major cannabinoids are alerting or stimulating at low doses, and make you tired at high doses.
If you take CBD at night you don't want to take a small dose, you want to take a big one.
Some people take cannabis and they feel fine. Others take it and get anxious.
- Anyone who takes too much cannabis, in particular too much THC, will get anxious.
Know what you're taking and track it.
There's been a push for many years to find a way to make cannabinoids water soluable. CBD products are being introduced as wate-infused meds brought about by nano technology.
- When you see an isolate product it's worth remembering that CBD as an isolate is never as effective as CBD from whole-plant extractions.
- The marketing thrust is that by making CBD water-soluable you won't need as much in the dose.
- Yeah.... but you lose the entourage effect and the benefit of all the other components.
Is using nano technology making an improvement on something that was working fine as a whole-plant component already? If it ain't broke.......
In general, the more options you have for cannabinoid therapies, the better.
- Isolates have a place in the therapeutic tool box. Whole plant is a stronger medicine.
When CBD interacts with medications using the CP450 system can be difficult to predict what effect it'll have.
- It may either increase the levels of these drugs, or decrease them.
- We still know very little about what's going on.
Some drugs are "pro" drugs, which means you take an inactive form that's metabolized by the liver enzymes into the active form.
- CBD will delay the metabolism of these drugs, so you don't get the effects.
Cannabinoids will induce or inhibit. You'll end up with either too much or too little of the drug in question.
- Monitor the blood regularly for pharma drug levels.
CBD with Warfarin requires more frequent blood monitoring.
- Warfarin will build up to dangerous levels and thin the blood beyond acceptable levels.
Within the P450 system there are dozens and dozens of different enzymes that CBD and THC will interact with to either suppress or enhance.
- Each subgroup of liver enzymes will effect particular pharma drugs.
- Cannabinoids do interact with many pharmaceuticals.
Drug interactions aren't often seen with flower use.
- Problems arise with isolates at very high doses.
- An oil extract may be a little more problamatic.
Epidialex is pure CBD. When used with other seizure drugs there will be interactions, some of them dangerous to the patient.
- In trials they discovered that when used they had to carefully monitor and adjust the levels of the other anti-seizure drugs being used.
When we think of drug interactions the knee-jerk reaction is that this is a bad thing, but some interactions can potentiate, allowing a reduction in dose.
- CBD interacts with chemotherapy agents and opiates, as well as many other drugs in a way that allows doctors to reduce the levels of toxic drugs being administered.
Using CBD or THC in conjunction with chemotherapeutic drugs offers a cancer-killing efficacy not attainable in a regimen using either only chemo or only cannabinoids.
- This applies to radiation treatment too. Studies of a combined regimen with glioblastomas found that Cannabinoids and chemo work best together.
CBD does well as a treatment for prostate cancer.
- I'd assume a high-CBD whole-plant medicine.
Smoking is more efficiently bio-available than ingesting.
- Find the delivery system that suits you, determined by your needs.
- Why are you using cannabis, and what's your expectation?
- Track your usage.
A 1:1 ratio has been shown to be effective for chronic pain or spasticity.
- Your comfort with euphoria is key to being able to tolerate a 1:1 ratio.
- Increasing the CBD component in the formula will allow you to take THC without euphoric concerns.
- A 10:1 CBD:THC ratio will both increase the efficacy of the medicine but will eliminate the euphoric concerns. CBD is easier to tolerate in higher numbers than THC.
Sometimes we don't understand why cannabis works, or why a certain product will work when others won't, or an administrative method will be more effective for a patient than the suggested one, but if it works, keep using it. Unlike most other medicines, cannabis is safe.
Pick up at 49:14. I'm goin' to bed. The cobs are wearing me out again.
Notes from Green Flower Media AMA with Martin Lee of Project CBD
Next week expect Project CBD to release a new major report on the cannabinoid.
Pain terps: Myrcene and B-caryophyllene
Energizing terps: Limonene
Find one with b-caryophyllene and limonene in the top 3-4 terps listed - let's say Carnival
- and you have an energizing pain reliever.Clinical trials for Sativax demonstrated that a 1:1 works best for most cases of chronic pain.
- The peak for pain management appeared to be 20 mg each/day dosed across the day.
- Once you went higher than 20 mg the efficacy of the cannabinoid treatment began to diminish.
Childhood trauma can adversely effect gene expression leading to methylation of the gene that expresses eCB receptors.
- This sets the child up for a lifetime of poor health.
- The ECS is a dynamic system, and demethylation is achievable with some simple nutritional adjustments.
- Olive oil is an excellent demethylator.
CBDa is more easily absorbed by the body - it's more bioavailable - than CBD.
- If this carries across systems then it can be expected that in a topical CBDa might be more easily absorbed by the skin.
Both major cannabinoids are alerting or stimulating at low doses, and make you tired at high doses.
If you take CBD at night you don't want to take a small dose, you want to take a big one.
Some people take cannabis and they feel fine. Others take it and get anxious.
- Anyone who takes too much cannabis, in particular too much THC, will get anxious.
Know what you're taking and track it.
There's been a push for many years to find a way to make cannabinoids water soluable. CBD products are being introduced as wate-infused meds brought about by nano technology.
- When you see an isolate product it's worth remembering that CBD as an isolate is never as effective as CBD from whole-plant extractions.
- The marketing thrust is that by making CBD water-soluable you won't need as much in the dose.
- Yeah.... but you lose the entourage effect and the benefit of all the other components.
Is using nano technology making an improvement on something that was working fine as a whole-plant component already? If it ain't broke.......
In general, the more options you have for cannabinoid therapies, the better.
- Isolates have a place in the therapeutic tool box. Whole plant is a stronger medicine.
When CBD interacts with medications using the CP450 system can be difficult to predict what effect it'll have.
- It may either increase the levels of these drugs, or decrease them.
- We still know very little about what's going on.
Some drugs are "pro" drugs, which means you take an inactive form that's metabolized by the liver enzymes into the active form.
- CBD will delay the metabolism of these drugs, so you don't get the effects.
Cannabinoids will induce or inhibit. You'll end up with either too much or too little of the drug in question.
- Monitor the blood regularly for pharma drug levels.
CBD with Warfarin requires more frequent blood monitoring.
- Warfarin will build up to dangerous levels and thin the blood beyond acceptable levels.
Within the P450 system there are dozens and dozens of different enzymes that CBD and THC will interact with to either suppress or enhance.
- Each subgroup of liver enzymes will effect particular pharma drugs.
- Cannabinoids do interact with many pharmaceuticals.
Drug interactions aren't often seen with flower use.
- Problems arise with isolates at very high doses.
- An oil extract may be a little more problamatic.
Epidialex is pure CBD. When used with other seizure drugs there will be interactions, some of them dangerous to the patient.
- In trials they discovered that when used they had to carefully monitor and adjust the levels of the other anti-seizure drugs being used.
When we think of drug interactions the knee-jerk reaction is that this is a bad thing, but some interactions can potentiate, allowing a reduction in dose.
- CBD interacts with chemotherapy agents and opiates, as well as many other drugs in a way that allows doctors to reduce the levels of toxic drugs being administered.
Using CBD or THC in conjunction with chemotherapeutic drugs offers a cancer-killing efficacy not attainable in a regimen using either only chemo or only cannabinoids.
- This applies to radiation treatment too. Studies of a combined regimen with glioblastomas found that Cannabinoids and chemo work best together.
CBD does well as a treatment for prostate cancer.
- I'd assume a high-CBD whole-plant medicine.
Smoking is more efficiently bio-available than ingesting.
- Find the delivery system that suits you, determined by your needs.
- Why are you using cannabis, and what's your expectation?
- Track your usage.
A 1:1 ratio has been shown to be effective for chronic pain or spasticity.
- Your comfort with euphoria is key to being able to tolerate a 1:1 ratio.
- Increasing the CBD component in the formula will allow you to take THC without euphoric concerns.
- A 10:1 CBD:THC ratio will both increase the efficacy of the medicine but will eliminate the euphoric concerns. CBD is easier to tolerate in higher numbers than THC.
Sometimes we don't understand why cannabis works, or why a certain product will work when others won't, or an administrative method will be more effective for a patient than the suggested one, but if it works, keep using it. Unlike most other medicines, cannabis is safe.
Pick up at 49:14. I'm goin' to bed. The cobs are wearing me out again.
- Thread starter
- #276
completed
Notes from Green Flower Media AMA with Martin Lee of Project CBD
Next week expect Project CBD to release a new major report on the cannabinoid.
Pain terps: Myrcene and B-caryophyllene
Energizing terps: Limonene
Find one with b-caryophyllene and limonene in the top 3-4 terps listed - let's say Carnival - and you have an energizing pain reliever.
Clinical trials for Sativax demonstrated that a 1:1 works best for most cases of chronic pain.
- The peak for pain management appeared to be 20 mg each/day dosed across the day.
- Once you went higher than 20 mg the efficacy of the cannabinoid treatment began to diminish.
Childhood trauma can adversely effect gene expression leading to methylation of the gene that expresses eCB receptors.
- This sets the child up for a lifetime of poor health.
- The ECS is a dynamic system, and demethylation is achievable with some simple nutritional adjustments.
- Olive oil is an excellent demethylator.
CBDa is more easily absorbed by the body - it's more bioavailable - than CBD.
- If this carries across systems then it can be expected that in a topical CBDa might be more easily absorbed by the skin.
Both major cannabinoids are alerting or stimulating at low doses, and make you tired at high doses.
If you take CBD at night you don't want to take a small dose, you want to take a big one.
Some people take cannabis and they feel fine. Others take it and get anxious.
- Anyone who takes too much cannabis, in particular too much THC, will get anxious.
Know what you're taking and track it.
There's been a push for many years to find a way to make cannabinoids water soluable. CBD products are being introduced as wate-infused meds brought about by nano technology.
- When you see an isolate product it's worth remembering that CBD as an isolate is never as effective as CBD from whole-plant extractions.
- The marketing thrust is that by making CBD water-soluable you won't need as much in the dose.
- Yeah.... but you lose the entourage effect and the benefit of all the other components.
Is using nano technology making an improvement on something that was working fine as a whole-plant component already? If it ain't broke.......
In general, the more options you have for cannabinoid therapies, the better.
- Isolates have a place in the therapeutic tool box. Whole plant is a stronger medicine.
When CBD interacts with medications using the CP450 system can be difficult to predict what effect it'll have.
- It may either increase the levels of these drugs, or decrease them.
- We still know very little about what's going on.
Some drugs are "pro" drugs, which means you take an inactive form that's metabolized by the liver enzymes into the active form.
- CBD will delay the metabolism of these drugs, so you don't get the effects.
Cannabinoids will induce or inhibit. You'll end up with either too much or too little of the drug in question.
- Monitor the blood regularly for pharma drug levels.
CBD with Warfarin requires more frequent blood monitoring.
- Warfarin will build up to dangerous levels and thin the blood beyond acceptable levels.
Within the P450 system there are dozens and dozens of different enzymes that CBD and THC will interact with to either suppress or enhance.
- Each subgroup of liver enzymes will effect particular pharma drugs.
- Cannabinoids do interact with many pharmaceuticals.
Drug interactions aren't often seen with flower use.
- Problems arise with isolates at very high doses.
- An oil extract may be a little more problamatic.
Epidialex is pure CBD. When used with other seizure drugs there will be interactions, some of them dangerous to the patient.
- In trials they discovered that when used they had to carefully monitor and adjust the levels of the other anti-seizure drugs being used.
When we think of drug interactions the knee-jerk reaction is that this is a bad thing, but some interactions can potentiate, allowing a reduction in dose.
- CBD interacts with chemotherapy agents and opiates, as well as many other drugs in a way that allows doctors to reduce the levels of toxic drugs being administered.
Using CBD or THC in conjunction with chemotherapeutic drugs offers a cancer-killing efficacy not attainable in a regimen using either only chemo or only cannabinoids.
- This applies to radiation treatment too. Studies of a combined regimen with glioblastomas found that Cannabinoids and chemo work best together.
CBD does well as a treatment for prostate cancer.
- I'd assume a high-CBD whole-plant medicine.
Smoking is more efficiently bio-available than ingesting.
- Find the delivery system that suits you, determined by your needs.
- Why are you using cannabis, and what's your expectation?
- Track your usage.
A 1:1 ratio has been shown to be effective for chronic pain or spasticity.
- Your comfort with euphoria is key to being able to tolerate a 1:1 ratio.
- Increasing the CBD component in the formula will allow you to take THC without euphoric concerns.
- A 10:1 CBD:THC ratio will increase the efficacy of the medicine but will eliminate the euphoric concerns. CBD is easier to tolerate in higher numbers than THC.
Sometimes we don't understand why cannabis works, or why a certain product will work when others won't, or an administrative method will be more effective for a patient than the suggested one, but if it works, keep using it. Unlike most other medicines, cannabis is safe.
Demographics studies have demonstrated that a population that uses cannabis regularly is leaner than a population that doesn't.
- This defies the stoner with munchies stereotype.
- THC will stimulate appetite. CBD will supress appetite, to some extent.
- Cannabis as an herb can have bi-directional effects, in that if you're too heavy it'll help you lose weight, and if you're too thin it'll help the body put on more weight. It balances the system.
- Cannabis is an adaptogen, it helps the system adapt to what it needs.
THCV is showing efficacy in weight loss.
- Some African chemovars are found to be rich in THCV, a minor cannabinoid in most plants.
It's unfortunate that the unregulated CBD industry has so many problems with verification that what the label says matches what's in the bottle.
- There are companies claiming to be offering full-spectrum medicines that turn out to be CBD isolates.
There was a case of a school bus driver who claimed to be using a CBD-only product that tested positive for cannabis.
- When being drug tested they're looking for the metabolites of the cannabinoids, not the cannabinoids themselves.
- There aren't any labs checking for CBD metabolites.
- In this case is was probably a label problem, or he's lying.
- THC metabolites can hang around for up to 90 days.
- Industrial hemp goes through a lot of processing to get to market, and anything can happen in that chain of events.
info@projectcbd.org for any questions about CBD.
Full-spectrum CBD oil has been effective with Chron's disease.
-Isolates you need very high concentrations at very precise doses. Go too high or too low and you lose effectiveness.
- A full spectrum oil has a much broader therapeutic window at a much lower dose.
- Patients need access to a wide range of choices.
- CBD isolates are improving in quality, and you can take them in high doses, but be aware of drug interactions when you deal with high doses.
What's really important is that the oil come from a resin-rich plant, one producing copious amounts of essential oils. That isn't often industrial hemp, is it?
- There's really no difference between 0.3% THC and 0.5% THC, but the latter will get you arrested in most of the world.
- A resin-rich plant will require less processing.
You'll want to avoid oils made from low-resin hemp, grown for fiber and seed.
- These oils typically come from Europe or China.
- Resin-rich hemp is being grown in Colorado, Kentucky, Oregon, Tennessee, and California.
- Breeders are coming up with plants that're high in resin, high in CBD, low enough in THC to pass muster as industrial hemp.
These breeding advances are destroying the restrictions of the laws.
WooHoo! One down!
Notes from Green Flower Media AMA with Martin Lee of Project CBD
Next week expect Project CBD to release a new major report on the cannabinoid.
Pain terps: Myrcene and B-caryophyllene
Energizing terps: Limonene
Find one with b-caryophyllene and limonene in the top 3-4 terps listed - let's say Carnival
- and you have an energizing pain reliever.Clinical trials for Sativax demonstrated that a 1:1 works best for most cases of chronic pain.
- The peak for pain management appeared to be 20 mg each/day dosed across the day.
- Once you went higher than 20 mg the efficacy of the cannabinoid treatment began to diminish.
Childhood trauma can adversely effect gene expression leading to methylation of the gene that expresses eCB receptors.
- This sets the child up for a lifetime of poor health.
- The ECS is a dynamic system, and demethylation is achievable with some simple nutritional adjustments.
- Olive oil is an excellent demethylator.
CBDa is more easily absorbed by the body - it's more bioavailable - than CBD.
- If this carries across systems then it can be expected that in a topical CBDa might be more easily absorbed by the skin.
Both major cannabinoids are alerting or stimulating at low doses, and make you tired at high doses.
If you take CBD at night you don't want to take a small dose, you want to take a big one.
Some people take cannabis and they feel fine. Others take it and get anxious.
- Anyone who takes too much cannabis, in particular too much THC, will get anxious.
Know what you're taking and track it.
There's been a push for many years to find a way to make cannabinoids water soluable. CBD products are being introduced as wate-infused meds brought about by nano technology.
- When you see an isolate product it's worth remembering that CBD as an isolate is never as effective as CBD from whole-plant extractions.
- The marketing thrust is that by making CBD water-soluable you won't need as much in the dose.
- Yeah.... but you lose the entourage effect and the benefit of all the other components.
Is using nano technology making an improvement on something that was working fine as a whole-plant component already? If it ain't broke.......
In general, the more options you have for cannabinoid therapies, the better.
- Isolates have a place in the therapeutic tool box. Whole plant is a stronger medicine.
When CBD interacts with medications using the CP450 system can be difficult to predict what effect it'll have.
- It may either increase the levels of these drugs, or decrease them.
- We still know very little about what's going on.
Some drugs are "pro" drugs, which means you take an inactive form that's metabolized by the liver enzymes into the active form.
- CBD will delay the metabolism of these drugs, so you don't get the effects.
Cannabinoids will induce or inhibit. You'll end up with either too much or too little of the drug in question.
- Monitor the blood regularly for pharma drug levels.
CBD with Warfarin requires more frequent blood monitoring.
- Warfarin will build up to dangerous levels and thin the blood beyond acceptable levels.
Within the P450 system there are dozens and dozens of different enzymes that CBD and THC will interact with to either suppress or enhance.
- Each subgroup of liver enzymes will effect particular pharma drugs.
- Cannabinoids do interact with many pharmaceuticals.
Drug interactions aren't often seen with flower use.
- Problems arise with isolates at very high doses.
- An oil extract may be a little more problamatic.
Epidialex is pure CBD. When used with other seizure drugs there will be interactions, some of them dangerous to the patient.
- In trials they discovered that when used they had to carefully monitor and adjust the levels of the other anti-seizure drugs being used.
When we think of drug interactions the knee-jerk reaction is that this is a bad thing, but some interactions can potentiate, allowing a reduction in dose.
- CBD interacts with chemotherapy agents and opiates, as well as many other drugs in a way that allows doctors to reduce the levels of toxic drugs being administered.
Using CBD or THC in conjunction with chemotherapeutic drugs offers a cancer-killing efficacy not attainable in a regimen using either only chemo or only cannabinoids.
- This applies to radiation treatment too. Studies of a combined regimen with glioblastomas found that Cannabinoids and chemo work best together.
CBD does well as a treatment for prostate cancer.
- I'd assume a high-CBD whole-plant medicine.
Smoking is more efficiently bio-available than ingesting.
- Find the delivery system that suits you, determined by your needs.
- Why are you using cannabis, and what's your expectation?
- Track your usage.
A 1:1 ratio has been shown to be effective for chronic pain or spasticity.
- Your comfort with euphoria is key to being able to tolerate a 1:1 ratio.
- Increasing the CBD component in the formula will allow you to take THC without euphoric concerns.
- A 10:1 CBD:THC ratio will increase the efficacy of the medicine but will eliminate the euphoric concerns. CBD is easier to tolerate in higher numbers than THC.
Sometimes we don't understand why cannabis works, or why a certain product will work when others won't, or an administrative method will be more effective for a patient than the suggested one, but if it works, keep using it. Unlike most other medicines, cannabis is safe.
Demographics studies have demonstrated that a population that uses cannabis regularly is leaner than a population that doesn't.
- This defies the stoner with munchies stereotype.
- THC will stimulate appetite. CBD will supress appetite, to some extent.
- Cannabis as an herb can have bi-directional effects, in that if you're too heavy it'll help you lose weight, and if you're too thin it'll help the body put on more weight. It balances the system.
- Cannabis is an adaptogen, it helps the system adapt to what it needs.
THCV is showing efficacy in weight loss.
- Some African chemovars are found to be rich in THCV, a minor cannabinoid in most plants.
It's unfortunate that the unregulated CBD industry has so many problems with verification that what the label says matches what's in the bottle.
- There are companies claiming to be offering full-spectrum medicines that turn out to be CBD isolates.
There was a case of a school bus driver who claimed to be using a CBD-only product that tested positive for cannabis.
- When being drug tested they're looking for the metabolites of the cannabinoids, not the cannabinoids themselves.
- There aren't any labs checking for CBD metabolites.
- In this case is was probably a label problem, or he's lying.
- THC metabolites can hang around for up to 90 days.
- Industrial hemp goes through a lot of processing to get to market, and anything can happen in that chain of events.
info@projectcbd.org for any questions about CBD.
Full-spectrum CBD oil has been effective with Chron's disease.
-Isolates you need very high concentrations at very precise doses. Go too high or too low and you lose effectiveness.
- A full spectrum oil has a much broader therapeutic window at a much lower dose.
- Patients need access to a wide range of choices.
- CBD isolates are improving in quality, and you can take them in high doses, but be aware of drug interactions when you deal with high doses.
What's really important is that the oil come from a resin-rich plant, one producing copious amounts of essential oils. That isn't often industrial hemp, is it?
- There's really no difference between 0.3% THC and 0.5% THC, but the latter will get you arrested in most of the world.
- A resin-rich plant will require less processing.
You'll want to avoid oils made from low-resin hemp, grown for fiber and seed.
- These oils typically come from Europe or China.
- Resin-rich hemp is being grown in Colorado, Kentucky, Oregon, Tennessee, and California.
- Breeders are coming up with plants that're high in resin, high in CBD, low enough in THC to pass muster as industrial hemp.
These breeding advances are destroying the restrictions of the laws.
WooHoo! One down!
- Thread starter
- #277
continuing.....
Notes: CBD 101 with Martin Lee of Project CBD
A Green Flower Media class
Cannabis has been a friend to man since before the written word.
Cannabis has a rich history as a medicine, going back thousands of years, including the U.S.
- In the latter part of the 19th century cannabis tinctures were and important, essential part of the medicine cabinet.
- Prohibition forced cannabis underground where it turned into a recreational drug.
- We're relearning ancient methods for using cannabis therapeutically.
Today it's not as simple as lighting up a joint.
- We have potent cannabis oils of every conceivable formulation.
- Many people are confused about what to do with all this choice.
How can we best use cannabis oils with varied ratios for maximum therapeutic benefit?
About CBD
Cannabidiol (CBD) is a plant cannabinoid.
This is not technically true. In the growing plant you have CBDa. CBD is a decarbed molecule, either by natural or man-made forces of time and temperature.
CBD is not psychoactive in the way THC is. You'll get a sense of well-being, but no euphoria commonly associated with THC.
Discovered in 1940 by Roger Adams, an American scientist.
- The molecular structure wasn't known until Raphael Meschoulem elucidated it in 1963.
- The following year he did the same for THC.
Interest in CBD didn't take off for years, because the focus was on THC.
- All the research money in the 1960s spent on cannabis research was with the intent to prove it was a dangerous drug, and it was that evil THC that got people stoned.
In 1980 there was a study in Brazil that demonstrated the dramatic therapeutic results available using CBD to treat seizures.
- The study was about a dozen patients, and was wildly successful.
- Nothing came of it for decades.
In 1988 NIH funded a study identified THC and CBD as potent neuroprotectors and anti-oxidants.
- The Federal government holds a patent on plant cannabinoids as neural protectors, filed in 2003.
Both THC and CBD are known to induce neurogenesis, the creation of new brain cells, in adult mammals.
- As close as 30 years ago the idea of neurogenesis in adult mammals was heresy. We knew better.
CBD has been studied as a molecule fairly extensively around the world.
Properties of single-molecule CBD
- Anti-tumor
- Anti-spasmodic
- Anti-convulsant
- Antidepressant
- Antipsychotic
- Anti-addictive
- Anxiolytic (anxiety-reducing)
- Antibiotic
- Analgesic (pain reliever)
Whole plant CBD is different in many ways from single-molecule CBD.
CBD and THC work best together.
- To gain the greatest therapeutic benefit of both molecules, use them in combination.
Benefits of whole-plant cannabinoid medicines
- CBD potentiates THC's pain modulation abilities.
- CBD enhances cannabis's efficacy for neuropathic pain, auto-immune diseases, cancer, and other conditions. These conditions respond better with CBD in the formulation.
Once CBD gained recognition and appreciation (starting in 2009 in N. Cali) it became obvious that CBD broadened the range of conditions treatable with cannabis.
- Conditions that didn't necessarily respond positively to high-THC formulations.
- Liver, cardiovascular, and metabolic disorders now currently treated with CBD wouldn't be possible without THC.
In a study published in 2010 by the California Pacific Medical Center it was shown that CBD will magnify THC's inhibitory effect on brain cancer.
- The study showed that THC and CBD alone have individual anti-cancer properties, but combined they had a synergistic effect on glioblastomas.
CBD doesn't get you high the way THC does.
- Though many enjoy euphoria, many others don't.
A greater ratio of CBD to THC will lessen and eliminate the euphoric effects of THC.
- You can now customize to your level of comfort with THC.
-There's no single ratio, dose, or product that'll work for everyone. Cannabis insists on being an individualized medication.
- Cannabis patients have the option of using cannabis without the euphoria.
- However, THC is a necessary component for a complete and effective canna med.
- A low-THC medicine won't get you high, but it also might not be effective medically.
- A medicine with both major Cannabinoids will be the most effective.
Determining the ratio that suits you.
- How sensitive are you to both compounds, in particular THC.
- How experienced are you with cannabis?
You control euphoria with ratio and dose.
- Always start with low dose THC when starting new patients with little or no experience.
The starting goal of a new cannabinoid therapy with a cannabis naive patient is to administer consistent, measurable doses of a CBD-rich medicine with as much THC in the formulation as the patient can comfortably handle.
"Dosage is everything." - Paracelsus
A personalized medicine focuses on the person, not the condition, because you're treating a person, not a condition.
- It's not so much finding the perfect ratio or dose for the disease state being treated, but rather finding what's appropriate and comfortable for this patient.
- Some will do well with a balanced ratio, others will find it too euphoric.
- Instead of gearing the medicine for the disease, make it reflect the patient.
What's the patient history with cannabis? How comfortable is the patient with cannabis, and in particular, THC?
The emerging patterns
At Project CBD they've begun to see patterns arising with cannabis therapeutics.
- Anxiety is treated best with higher CBD with low THC.
- Depression, spasms, pediatric seizure disorders respond best, at least initially, to low THC, high CBD products.
- Cancer, neurological disease, and gut issues do best with a 1:1 ratio.
- Chronic pain, neuropathic pain is best managed by a 1:1 ratio.
GW Pharmaceuticals proved that a balanced ratio manages chronic pain best.
- Chronic pain, neuropathic pain... the type of pain opioids don't treat well at all.
- Extensive clinical trials in Europe have proven that a balanced ratio can help someone struggling with chronic pain to live a better life, if they're comfortable with the euphoria that may occur with a 1:1
- Any chemovar will potentially help with auto-immune diseases (when your immune system attacks your cells inappropriately)
- THC activation or eCB2 receptors can regulate (dial down) an overactive immune response.
There are now CBD-rich products available in all the ways you can find THC-rich products.
What to look for in a CBD product
- clear labeling of quantity, ratio of major cannabinoids, and dose
- evidence and documentation of lab testing to be free of pollutants (molds, solvent residues, other contaminants)
- purity (no artificial additives) *be alert to thinning agents*
- look for sustainably-grown, high-resin content plants instead of industrial hemp
- avoid products extracted with solvents (butane, hexane, hydrocarbons)
- look for super-critical CO2 extractions or high-grade ethanol extractions
In the wild cannabis expresses close to an even ratio of the major cannabinoids.
- When prohibition percerted the market breeders went for high THC, overlooking CBD.
- Most plants available have high THC, and minimal CBD. That's quickly changing.
Low-resin industrial hemp has about 3.2% CBD by dry weight. By contrast, you can now find cannabis with levels up to 20%.
You can get CBD from industrial hemp but
- You need huge amounts of hemp to extract a little bit of CBD.
- Cannabis is a bioaccumulator, a florid way of saying that it'll suck toxins and heavy metals out of the soil it grows in.
- Although this makes hemp a valuable plant to clean polluted lands, it's not so cool when you're extracting oils for medicine. You end up with concentrations that can become problematic.
Hemp is defined as a cannabis sativa having 0.3% or less THC value.
- Martin believes, and I agree, that this definition exists solely to perpetuate prohibition.
- Grow a CBD-rich plant with a higher than 0.3% THC value and you're now breaking the law and dealing in a federally-controlled substance.
***When this class was originally broadcast CBD was federally illegal and not permitted to be shipped across state lines. Has this changed? I don't believe it has. ***
There are still problems with quality control, a consequence of prohibition.
- Since this class originally aired there's been an increase in quality control on the producer level as more states become legal, but there's still much to be done.
Of concern is the use of polypropylene glycol being used in vape pens.
- It's been approved for ingestion, but not for inhallation, yet everyone acts like this isn't an issue.
- When overheated - as would be done in a vaporizer - polypropylene glycol breaks down into a carcinogen.
- People reaching for a CBD pen are sick, and don't need carcinogens added to the formula.
- Many come flavored as well. No one tested those flavors as inhaled meds.
- The few things that have been tested turned out to be nasty.
Avoid flavored vape pens unless there's evidence that the flavoring agents were tested for inhalation.
It's not likely that they were tested. What was tested wasn't pretty. Be safe and avoid them.
Pick up at 28:55.
Pharmaceutical CBD products will be legal (I believe they are already???)
- Epidialex has been clinically tested.
- CBD isolate will be legal, but the effectiveness of isolates lacks the synergy of whole-plant CBD products.
An isolate has a very limited therapeutic window.
- You need precise doses, and high doses to be effective.
- Get the dose a little too high or low with an isolate and you get no effect.
- Whole plant meds are more effective for longer times with smaller doses. No exact dose is necessary for effectiveness.
CBD will interact with over 60% of prescribed pharma drugs.
- The interactions problems aren't a concern with whole plant extractions.
- Isolates are another matter. High doses of an isolate will cause some drugs to build up in the body, sometimes to dangerous levels.
- CBD interfere with the metabolism of these drugs.
- If your drugs say "avoid grapefruit juice" you want to have this levels checked more frequently if you're using a CBD isolate.
The take home message:
Cannabis is personalized medicine. At least initially it's about the person, not the condition. You're treating a person.
There's no single ratio, dosage, strength, or product that's right for everyone.
THC and CBD are the "Power Couple" of cannabinoid medicine, working best together.
Whole plant CBD is superior medicine, safer and more effective than single-molecule CBD.
Q & A Session
1. When would you suggest someone start with a CBD-dominant medication?
Without generalizing too much - cannabis is individualized medicine - what they're seeing in California is that the determining factor is experience with cannabis.
- A good starting point is a low-dose THC, high-CBD medicine. This will be tolerated by just about anyone.
- This works well for those with bad experiences in their history or patients with no experience
What kind of health challenge are you dealing with?
- Many disease states benefit from THC in the mix. You start low and slowly increase.
- As a patient becomes more relaxed with euphoria they may discover that they prefer a little THC for the experience.
- Some patients will always be more comfortable without any euphoric experience, and for them, low THC, high CBD will be the preferred formulation.
2. Are there conditions you're seeing that respond better to high CBD medications?
That's a tricky one. Take epilepsy, for instance.
- There's been dramatic footage of children responding well to CBD and having their seizures stop or lessen in frequency and power.
- That doesn't mean all children with seizure disorder can use a CBD-only medication and get these results. Some need THC.
- It's not the seizure that's the focus, but what's the underlying cause? With epilepsy you treat the cause, and some causes require THC.
- Genetic testing by Medicinal Genomics shows that there's a coding problem with the sodium channels in the bodies of children with certain types of seizure disorders. These conditions respond to CBD.
- The genetic mechanism is key to the treatment of seizure disorders with cannabis.
- Genetic testing can tell if a child will respond to CBD medications.
- Some children can have an adverse effect from CBD. Start low, go slow.
3. Are there other ailments where CBD-dominant medicines are working as well as other options?
There's a wide tableau of conditions that can be treated with CBD.
- CBD interacts with the EVS, which regulates all other body systems.
It comes down to what the patient is comfortable with.
- During the day many are most comfortable with a high CBD medicine that doesn't interfer with social functionality.
- At night many switch to a higher THC value
A person might be using differently formulated medications at different parts of the day.
Glioblastoma seems to respond best to high THC medicine.
Neuroblastoma - more common in children - seems to respond best to a high CBD medicine.
4. What's the best way to find the right ratios and profiles to make cannabis a personalized medicine?
First off, it depends on where you are. Is it even available to you, and if so, in what forms and products?
- You have to deal with what you can access.
- Flower is accessible in most of the country.
- You can smoke it or make cannabis flowers into edibles with little effort.
- The medical cannabis movement started with high THC meds.
Where are you psychologically?
- How experienced and comfortable with cannabis are you?
- What kind of guidance do you have?
- What's your support group look like?
- How open is your community?
You can start with a hemp product at low doses, slowly increasing.
- Begin to add in other products to get a more varied cannabinoid profile, as more options present themselves.
Done for the night. Pick up at 44:54.
Notes: CBD 101 with Martin Lee of Project CBD
A Green Flower Media class
Cannabis has been a friend to man since before the written word.
Cannabis has a rich history as a medicine, going back thousands of years, including the U.S.
- In the latter part of the 19th century cannabis tinctures were and important, essential part of the medicine cabinet.
- Prohibition forced cannabis underground where it turned into a recreational drug.
- We're relearning ancient methods for using cannabis therapeutically.
Today it's not as simple as lighting up a joint.
- We have potent cannabis oils of every conceivable formulation.
- Many people are confused about what to do with all this choice.
How can we best use cannabis oils with varied ratios for maximum therapeutic benefit?
About CBD
Cannabidiol (CBD) is a plant cannabinoid.
This is not technically true. In the growing plant you have CBDa. CBD is a decarbed molecule, either by natural or man-made forces of time and temperature.
CBD is not psychoactive in the way THC is. You'll get a sense of well-being, but no euphoria commonly associated with THC.
Discovered in 1940 by Roger Adams, an American scientist.
- The molecular structure wasn't known until Raphael Meschoulem elucidated it in 1963.
- The following year he did the same for THC.
Interest in CBD didn't take off for years, because the focus was on THC.
- All the research money in the 1960s spent on cannabis research was with the intent to prove it was a dangerous drug, and it was that evil THC that got people stoned.
In 1980 there was a study in Brazil that demonstrated the dramatic therapeutic results available using CBD to treat seizures.
- The study was about a dozen patients, and was wildly successful.
- Nothing came of it for decades.
In 1988 NIH funded a study identified THC and CBD as potent neuroprotectors and anti-oxidants.
- The Federal government holds a patent on plant cannabinoids as neural protectors, filed in 2003.
Both THC and CBD are known to induce neurogenesis, the creation of new brain cells, in adult mammals.
- As close as 30 years ago the idea of neurogenesis in adult mammals was heresy. We knew better.
CBD has been studied as a molecule fairly extensively around the world.
Properties of single-molecule CBD
- Anti-tumor
- Anti-spasmodic
- Anti-convulsant
- Antidepressant
- Antipsychotic
- Anti-addictive
- Anxiolytic (anxiety-reducing)
- Antibiotic
- Analgesic (pain reliever)
Whole plant CBD is different in many ways from single-molecule CBD.
CBD and THC work best together.
- To gain the greatest therapeutic benefit of both molecules, use them in combination.
Benefits of whole-plant cannabinoid medicines
- CBD potentiates THC's pain modulation abilities.
- CBD enhances cannabis's efficacy for neuropathic pain, auto-immune diseases, cancer, and other conditions. These conditions respond better with CBD in the formulation.
Once CBD gained recognition and appreciation (starting in 2009 in N. Cali) it became obvious that CBD broadened the range of conditions treatable with cannabis.
- Conditions that didn't necessarily respond positively to high-THC formulations.
- Liver, cardiovascular, and metabolic disorders now currently treated with CBD wouldn't be possible without THC.
In a study published in 2010 by the California Pacific Medical Center it was shown that CBD will magnify THC's inhibitory effect on brain cancer.
- The study showed that THC and CBD alone have individual anti-cancer properties, but combined they had a synergistic effect on glioblastomas.
CBD doesn't get you high the way THC does.
- Though many enjoy euphoria, many others don't.
A greater ratio of CBD to THC will lessen and eliminate the euphoric effects of THC.
- You can now customize to your level of comfort with THC.
-There's no single ratio, dose, or product that'll work for everyone. Cannabis insists on being an individualized medication.
- Cannabis patients have the option of using cannabis without the euphoria.
- However, THC is a necessary component for a complete and effective canna med.
- A low-THC medicine won't get you high, but it also might not be effective medically.
- A medicine with both major Cannabinoids will be the most effective.
Determining the ratio that suits you.
- How sensitive are you to both compounds, in particular THC.
- How experienced are you with cannabis?
You control euphoria with ratio and dose.
- Always start with low dose THC when starting new patients with little or no experience.
The starting goal of a new cannabinoid therapy with a cannabis naive patient is to administer consistent, measurable doses of a CBD-rich medicine with as much THC in the formulation as the patient can comfortably handle.
"Dosage is everything." - Paracelsus
A personalized medicine focuses on the person, not the condition, because you're treating a person, not a condition.
- It's not so much finding the perfect ratio or dose for the disease state being treated, but rather finding what's appropriate and comfortable for this patient.
- Some will do well with a balanced ratio, others will find it too euphoric.
- Instead of gearing the medicine for the disease, make it reflect the patient.
What's the patient history with cannabis? How comfortable is the patient with cannabis, and in particular, THC?
The emerging patterns
At Project CBD they've begun to see patterns arising with cannabis therapeutics.
- Anxiety is treated best with higher CBD with low THC.
- Depression, spasms, pediatric seizure disorders respond best, at least initially, to low THC, high CBD products.
- Cancer, neurological disease, and gut issues do best with a 1:1 ratio.
- Chronic pain, neuropathic pain is best managed by a 1:1 ratio.
GW Pharmaceuticals proved that a balanced ratio manages chronic pain best.
- Chronic pain, neuropathic pain... the type of pain opioids don't treat well at all.
- Extensive clinical trials in Europe have proven that a balanced ratio can help someone struggling with chronic pain to live a better life, if they're comfortable with the euphoria that may occur with a 1:1
- Any chemovar will potentially help with auto-immune diseases (when your immune system attacks your cells inappropriately)
- THC activation or eCB2 receptors can regulate (dial down) an overactive immune response.
There are now CBD-rich products available in all the ways you can find THC-rich products.
What to look for in a CBD product
- clear labeling of quantity, ratio of major cannabinoids, and dose
- evidence and documentation of lab testing to be free of pollutants (molds, solvent residues, other contaminants)
- purity (no artificial additives) *be alert to thinning agents*
- look for sustainably-grown, high-resin content plants instead of industrial hemp
- avoid products extracted with solvents (butane, hexane, hydrocarbons)
- look for super-critical CO2 extractions or high-grade ethanol extractions
In the wild cannabis expresses close to an even ratio of the major cannabinoids.
- When prohibition percerted the market breeders went for high THC, overlooking CBD.
- Most plants available have high THC, and minimal CBD. That's quickly changing.
Low-resin industrial hemp has about 3.2% CBD by dry weight. By contrast, you can now find cannabis with levels up to 20%.
You can get CBD from industrial hemp but
- You need huge amounts of hemp to extract a little bit of CBD.
- Cannabis is a bioaccumulator, a florid way of saying that it'll suck toxins and heavy metals out of the soil it grows in.
- Although this makes hemp a valuable plant to clean polluted lands, it's not so cool when you're extracting oils for medicine. You end up with concentrations that can become problematic.
Hemp is defined as a cannabis sativa having 0.3% or less THC value.
- Martin believes, and I agree, that this definition exists solely to perpetuate prohibition.
- Grow a CBD-rich plant with a higher than 0.3% THC value and you're now breaking the law and dealing in a federally-controlled substance.
***When this class was originally broadcast CBD was federally illegal and not permitted to be shipped across state lines. Has this changed? I don't believe it has. ***
There are still problems with quality control, a consequence of prohibition.
- Since this class originally aired there's been an increase in quality control on the producer level as more states become legal, but there's still much to be done.
Of concern is the use of polypropylene glycol being used in vape pens.
- It's been approved for ingestion, but not for inhallation, yet everyone acts like this isn't an issue.
- When overheated - as would be done in a vaporizer - polypropylene glycol breaks down into a carcinogen.
- People reaching for a CBD pen are sick, and don't need carcinogens added to the formula.
- Many come flavored as well. No one tested those flavors as inhaled meds.
- The few things that have been tested turned out to be nasty.
Avoid flavored vape pens unless there's evidence that the flavoring agents were tested for inhalation.
It's not likely that they were tested. What was tested wasn't pretty. Be safe and avoid them.
Pick up at 28:55.
Pharmaceutical CBD products will be legal (I believe they are already???)
- Epidialex has been clinically tested.
- CBD isolate will be legal, but the effectiveness of isolates lacks the synergy of whole-plant CBD products.
An isolate has a very limited therapeutic window.
- You need precise doses, and high doses to be effective.
- Get the dose a little too high or low with an isolate and you get no effect.
- Whole plant meds are more effective for longer times with smaller doses. No exact dose is necessary for effectiveness.
CBD will interact with over 60% of prescribed pharma drugs.
- The interactions problems aren't a concern with whole plant extractions.
- Isolates are another matter. High doses of an isolate will cause some drugs to build up in the body, sometimes to dangerous levels.
- CBD interfere with the metabolism of these drugs.
- If your drugs say "avoid grapefruit juice" you want to have this levels checked more frequently if you're using a CBD isolate.
The take home message:
Cannabis is personalized medicine. At least initially it's about the person, not the condition. You're treating a person.
There's no single ratio, dosage, strength, or product that's right for everyone.
THC and CBD are the "Power Couple" of cannabinoid medicine, working best together.
Whole plant CBD is superior medicine, safer and more effective than single-molecule CBD.
Q & A Session
1. When would you suggest someone start with a CBD-dominant medication?
Without generalizing too much - cannabis is individualized medicine - what they're seeing in California is that the determining factor is experience with cannabis.
- A good starting point is a low-dose THC, high-CBD medicine. This will be tolerated by just about anyone.
- This works well for those with bad experiences in their history or patients with no experience
What kind of health challenge are you dealing with?
- Many disease states benefit from THC in the mix. You start low and slowly increase.
- As a patient becomes more relaxed with euphoria they may discover that they prefer a little THC for the experience.
- Some patients will always be more comfortable without any euphoric experience, and for them, low THC, high CBD will be the preferred formulation.
2. Are there conditions you're seeing that respond better to high CBD medications?
That's a tricky one. Take epilepsy, for instance.
- There's been dramatic footage of children responding well to CBD and having their seizures stop or lessen in frequency and power.
- That doesn't mean all children with seizure disorder can use a CBD-only medication and get these results. Some need THC.
- It's not the seizure that's the focus, but what's the underlying cause? With epilepsy you treat the cause, and some causes require THC.
- Genetic testing by Medicinal Genomics shows that there's a coding problem with the sodium channels in the bodies of children with certain types of seizure disorders. These conditions respond to CBD.
- The genetic mechanism is key to the treatment of seizure disorders with cannabis.
- Genetic testing can tell if a child will respond to CBD medications.
- Some children can have an adverse effect from CBD. Start low, go slow.
3. Are there other ailments where CBD-dominant medicines are working as well as other options?
There's a wide tableau of conditions that can be treated with CBD.
- CBD interacts with the EVS, which regulates all other body systems.
It comes down to what the patient is comfortable with.
- During the day many are most comfortable with a high CBD medicine that doesn't interfer with social functionality.
- At night many switch to a higher THC value
A person might be using differently formulated medications at different parts of the day.
Glioblastoma seems to respond best to high THC medicine.
Neuroblastoma - more common in children - seems to respond best to a high CBD medicine.
4. What's the best way to find the right ratios and profiles to make cannabis a personalized medicine?
First off, it depends on where you are. Is it even available to you, and if so, in what forms and products?
- You have to deal with what you can access.
- Flower is accessible in most of the country.
- You can smoke it or make cannabis flowers into edibles with little effort.
- The medical cannabis movement started with high THC meds.
Where are you psychologically?
- How experienced and comfortable with cannabis are you?
- What kind of guidance do you have?
- What's your support group look like?
- How open is your community?
You can start with a hemp product at low doses, slowly increasing.
- Begin to add in other products to get a more varied cannabinoid profile, as more options present themselves.
Done for the night. Pick up at 44:54.
- Thread starter
- #278
Non-Psychoactive Cannabis & Carrot Juice Recipe - by Alexis Jones
How to Make Non-Psychoactive Cannabis & Carrot Juice
Total time: Approx. 5 minutes or less depending on your blender strength
Servings: 2-3
Difficulty level: Beginner
Vegan and gluten free!
What You Will Need:
7-10 raw cannabis leaves, freshly picked (within 2-3 days)
2 cups coconut water
2 cups chopped organic carrots
1 slice of organic lemon, skin included, no seeds
thin slice of organic ginger, no skin
6 ice cubes
cannabis and carrots
Steps To Making Cannabis & Carrot Juice As A Dietary Supplement
* Start by slicing carrots until you have about 2 cups worth.
* Cut one slice of lemon and remove any seeds.
* Remove skin from the outside of a small piece of fresh ginger.
* Cut a thin slice from this ginger and add it into the blender with the other ingredients (Note: You may want to grate the ginger if your blender is not strong enough to break it up evenly.)
* Fill blender with 2 cups coconut water.
* Add in the remaining solid ingredients.
* Mix manually (in spurts) being careful not to overheat the cannabis inside the blender.
The use of carrots (and especially carrot juice) as a therapeutic agent is an ancient practice. Carrots are rich with biotin, calcium, magnesium, potassium, phosphorus, organic sodium and more. However, many people do not know that most of these nutrients are concentrated just beneath the skin of a carrot, so try not to peel off its skin if you are looking to eat healthy. It’s recommended that you simply brush the carrot’s skin (with water) until the the dirt is cleaned off.
“Carrot juice can pull heavy metals from fatty tissue where they reside, bind them up, and discharge them from the system.” – American Journal of Clinical Nutrition, October 1985
Dr. William L Courtney gave me his personal recommendation for this juice, which is 10 parts carrot to one part cannabis (leaves and buds). After giving this a try a few times, I’d be inclined to agree. It’s the perfect drink for those who already love carrots in their soup, dipped in dressing, and diced into salads.
This process will require a good amount of blending. It’s important that you are careful to blend slowly, in spurts, so as not to overheat the cannabis leaves. Even a tiny bit of heat results in the raw cannabis further converting from THC-A (cannabinoid acid) to THC. Not a good thing if you want to stay sober after you consume your drink. What you want to do is keep the temperatures low, juice the whole cannabis plant, and in doing so, you will receive the full range of benefits that cannabinoids have to offer, engaging what is known as the entourage effect.
The cannabis leaves and buds called for in the recipe provide the body with much needed cannabinoid acids, specifically THC-A and CBD-A. These acids found in cannabis have been shown to help reduce or eliminate epileptic seizures, treat certain forms of cancer, and assist in the management of many other ailments. In general, cannabis is a complete protein and a great natural source of healthy omega 3 and 6 fatty acids.
One obstacle patients may face when juicing cannabis with carrots is having to deal with the vast amounts of the fiber after mixing. This fiber creates a foam at the top of your drink that most some people may consider too thick to drink with ease. Regardless, if you can get past the unpleasant texture, studies show you may be doing your body justice. After all, juice derived from carrots contains more Vitamin A than nearly any other juice. Vitamin A helps the liver flush out toxins from the body, making this a great recipe for detoxing your body.
In fact, according to the American Journal of Clinical Nutrition (October 1985), “carrot juice can pull heavy metals from fatty tissue where they reside, bind them up, and discharge them from the system.”
How to Make Non-Psychoactive Cannabis & Carrot Juice
Total time: Approx. 5 minutes or less depending on your blender strength
Servings: 2-3
Difficulty level: Beginner
Vegan and gluten free!
What You Will Need:
7-10 raw cannabis leaves, freshly picked (within 2-3 days)
2 cups coconut water
2 cups chopped organic carrots
1 slice of organic lemon, skin included, no seeds
thin slice of organic ginger, no skin
6 ice cubes
cannabis and carrots
Steps To Making Cannabis & Carrot Juice As A Dietary Supplement
* Start by slicing carrots until you have about 2 cups worth.
* Cut one slice of lemon and remove any seeds.
* Remove skin from the outside of a small piece of fresh ginger.
* Cut a thin slice from this ginger and add it into the blender with the other ingredients (Note: You may want to grate the ginger if your blender is not strong enough to break it up evenly.)
* Fill blender with 2 cups coconut water.
* Add in the remaining solid ingredients.
* Mix manually (in spurts) being careful not to overheat the cannabis inside the blender.
The use of carrots (and especially carrot juice) as a therapeutic agent is an ancient practice. Carrots are rich with biotin, calcium, magnesium, potassium, phosphorus, organic sodium and more. However, many people do not know that most of these nutrients are concentrated just beneath the skin of a carrot, so try not to peel off its skin if you are looking to eat healthy. It’s recommended that you simply brush the carrot’s skin (with water) until the the dirt is cleaned off.
“Carrot juice can pull heavy metals from fatty tissue where they reside, bind them up, and discharge them from the system.” – American Journal of Clinical Nutrition, October 1985
Dr. William L Courtney gave me his personal recommendation for this juice, which is 10 parts carrot to one part cannabis (leaves and buds). After giving this a try a few times, I’d be inclined to agree. It’s the perfect drink for those who already love carrots in their soup, dipped in dressing, and diced into salads.
This process will require a good amount of blending. It’s important that you are careful to blend slowly, in spurts, so as not to overheat the cannabis leaves. Even a tiny bit of heat results in the raw cannabis further converting from THC-A (cannabinoid acid) to THC. Not a good thing if you want to stay sober after you consume your drink. What you want to do is keep the temperatures low, juice the whole cannabis plant, and in doing so, you will receive the full range of benefits that cannabinoids have to offer, engaging what is known as the entourage effect.
The cannabis leaves and buds called for in the recipe provide the body with much needed cannabinoid acids, specifically THC-A and CBD-A. These acids found in cannabis have been shown to help reduce or eliminate epileptic seizures, treat certain forms of cancer, and assist in the management of many other ailments. In general, cannabis is a complete protein and a great natural source of healthy omega 3 and 6 fatty acids.
One obstacle patients may face when juicing cannabis with carrots is having to deal with the vast amounts of the fiber after mixing. This fiber creates a foam at the top of your drink that most some people may consider too thick to drink with ease. Regardless, if you can get past the unpleasant texture, studies show you may be doing your body justice. After all, juice derived from carrots contains more Vitamin A than nearly any other juice. Vitamin A helps the liver flush out toxins from the body, making this a great recipe for detoxing your body.
In fact, according to the American Journal of Clinical Nutrition (October 1985), “carrot juice can pull heavy metals from fatty tissue where they reside, bind them up, and discharge them from the system.”
- Thread starter
- #279
How-To Make A Cannabis Infused Blueberry Banana Smoothie - by Alexis Jones
According to Dr. Courtney, the pioneer for juicing cannabis and founder of Origins of Cannabis International Foundation, cannabis is a dietary essential. When we decarboxylate or heat the cannabinoids found in cannabis, we lose ~99% of the health benefits when the THC-A is converted into THC. The THC-A found in raw cannabis is filled with essential amino acids and other astounding properties that directly influence our immune systems, tapping into a wide range of therapeutic and reparative benefits.
Raw Cannabis, Blueberry Banana Smoothie Recipe
For today’s medical marijuana how-to article, I am sharing my personal blueberry banana smoothie recipe. Adding fruits to smoothies helps cover the bitter taste of cannabis (it has a very sharp taste similar to a wheat grass shot) and boosts the smoothies nutrient levels. As you may or may now know, most fruits are naturally low in fat, sodium, and calories. None have cholesterol.
Consult your caregiver or physician about your sugar intake before making this recipe, especially if you suffer from cancer or any other sugar-feeding disease.
As a general rule of thumb when cooking with cannabis, the fresher the leaves, the better. If you have access to live plants, make the juice fresh each morning. Just be sure to consume the leaves within three days of being cut and cleaned. You also only want to use flowers when the glands are clear and turning cloudy/milky white, but not yet amber.
Be sure to rinse your leaves with water to remove any excess residue before getting started. Treat the leaves as you would any other vegetable by storing them in the fridge when not in use, to extend their shelf-life.
Ingredients You Will Need: recipe
* 1 frozen banana
* 2 large frozen strawberries
* 1 cup frozen whole blueberries
* 1/2 cup regular almond milk
* 1/2 cup coconut water
* 1 tbsp chia seed
* 1 tbsp flax seed
* 1 tbsp hemp seed
* 15 fresh cannabis leaves and two - four 2in. fresh cannabis buds (If you do not have access to this much cannabis, feel free to add spinach in replacement.)
Editor’s Note: I aim to use fifteen fresh leaves a day plus two to four 2in fresh raw buds, the recommended dose for the chronically ill patients by Dr. Courtney. I suffer from Late Stage Lyme disease, a chronic autoimmune disorder. If Lyme disease is not caught early, many people suffer long term symptoms. Juicing cannabis has helped me tremendously to keep my symptoms at bay. My doctors have approved my consumption of natural sugars, however, it is advised that consult your doctor before making this at home, especially if you have any health concerns.
Tips To Making A Delicious Cannabis Smoothie
Frozen fruit isn’t mandatory. I prefer to use frozen fruit to help the drink stay colder longer. You may want to cut up the banana before freezing it if you make your own.
Depending on the strength of your blender, chopping up a whole banana can become troublesome and you’ll end up with a couple surprise banana chunks. A Blendtec is strong enough so I did not cut mine up, but it is not necessary for you to purchase that blender! It just may take longer to get the consistency you desire.
I recommended drinking the smoothie within fifteen minutes or less because chia gels, thickening the material of your smoothie. Depending on your tastes, you can always omit the chia or wait until it gels up, if you prefer it that way.
The hemp and flax seed both add a rich, nutty flavor. If you wish to cut back on those, know you are losing protein and healthy omegas. You can train your taste buds so don’t be afraid to go outside your comfort zone or ramp up slowly. Another option you may want to consider is almond milk, as this will increase the creaminess of the smoothie more than half a cup of almond milk + half a cup of coconut water (as called out in the recipe above).
The motor of the blender does release some heat, so you will want to keep the cannabis as far away from the blade as possible, so as not to decarboxylate the cannabinoids, increasing the psychoactive effects while decreasing the amount of THC-A present. I blend all the other ingredients first, only adding the cannabis after all other ingredients are completely blended. Blend the cannabis on pulse until the smoothie is your desired thickness.
Dr. Sulak, a well known MD in Maine that treats thousands of patients with cannabis, suggested that people should consider only blending smoothies using quick pulses, to avoid creating heat from the friction.
Final Thoughts And Friendly Advice
This cannabis-infused blueberry banana smoothie recipe will make ~21 ounces and comes to ~422 calories. Until the USDA considers cannabis a food, we are unable to give the exact calorie count. The calorie count listed includes all of the ingredients except cannabis.
The great thing about making cannabis-infused smoothies is that there is no one, perfect way to do it. Also, you really can not mess up too bad. Even if you don’t like the flavor of your infused creation, you can always add more of something sweet (like strawberries) to the mix and re-blend with a few quick pulses.
According to Dr. Courtney, the pioneer for juicing cannabis and founder of Origins of Cannabis International Foundation, cannabis is a dietary essential. When we decarboxylate or heat the cannabinoids found in cannabis, we lose ~99% of the health benefits when the THC-A is converted into THC. The THC-A found in raw cannabis is filled with essential amino acids and other astounding properties that directly influence our immune systems, tapping into a wide range of therapeutic and reparative benefits.
Raw Cannabis, Blueberry Banana Smoothie Recipe
For today’s medical marijuana how-to article, I am sharing my personal blueberry banana smoothie recipe. Adding fruits to smoothies helps cover the bitter taste of cannabis (it has a very sharp taste similar to a wheat grass shot) and boosts the smoothies nutrient levels. As you may or may now know, most fruits are naturally low in fat, sodium, and calories. None have cholesterol.
Consult your caregiver or physician about your sugar intake before making this recipe, especially if you suffer from cancer or any other sugar-feeding disease.
As a general rule of thumb when cooking with cannabis, the fresher the leaves, the better. If you have access to live plants, make the juice fresh each morning. Just be sure to consume the leaves within three days of being cut and cleaned. You also only want to use flowers when the glands are clear and turning cloudy/milky white, but not yet amber.
Be sure to rinse your leaves with water to remove any excess residue before getting started. Treat the leaves as you would any other vegetable by storing them in the fridge when not in use, to extend their shelf-life.
Ingredients You Will Need: recipe
* 1 frozen banana
* 2 large frozen strawberries
* 1 cup frozen whole blueberries
* 1/2 cup regular almond milk
* 1/2 cup coconut water
* 1 tbsp chia seed
* 1 tbsp flax seed
* 1 tbsp hemp seed
* 15 fresh cannabis leaves and two - four 2in. fresh cannabis buds (If you do not have access to this much cannabis, feel free to add spinach in replacement.)
Editor’s Note: I aim to use fifteen fresh leaves a day plus two to four 2in fresh raw buds, the recommended dose for the chronically ill patients by Dr. Courtney. I suffer from Late Stage Lyme disease, a chronic autoimmune disorder. If Lyme disease is not caught early, many people suffer long term symptoms. Juicing cannabis has helped me tremendously to keep my symptoms at bay. My doctors have approved my consumption of natural sugars, however, it is advised that consult your doctor before making this at home, especially if you have any health concerns.
Tips To Making A Delicious Cannabis Smoothie
Frozen fruit isn’t mandatory. I prefer to use frozen fruit to help the drink stay colder longer. You may want to cut up the banana before freezing it if you make your own.
Depending on the strength of your blender, chopping up a whole banana can become troublesome and you’ll end up with a couple surprise banana chunks. A Blendtec is strong enough so I did not cut mine up, but it is not necessary for you to purchase that blender! It just may take longer to get the consistency you desire.
I recommended drinking the smoothie within fifteen minutes or less because chia gels, thickening the material of your smoothie. Depending on your tastes, you can always omit the chia or wait until it gels up, if you prefer it that way.
The hemp and flax seed both add a rich, nutty flavor. If you wish to cut back on those, know you are losing protein and healthy omegas. You can train your taste buds so don’t be afraid to go outside your comfort zone or ramp up slowly. Another option you may want to consider is almond milk, as this will increase the creaminess of the smoothie more than half a cup of almond milk + half a cup of coconut water (as called out in the recipe above).
The motor of the blender does release some heat, so you will want to keep the cannabis as far away from the blade as possible, so as not to decarboxylate the cannabinoids, increasing the psychoactive effects while decreasing the amount of THC-A present. I blend all the other ingredients first, only adding the cannabis after all other ingredients are completely blended. Blend the cannabis on pulse until the smoothie is your desired thickness.
Dr. Sulak, a well known MD in Maine that treats thousands of patients with cannabis, suggested that people should consider only blending smoothies using quick pulses, to avoid creating heat from the friction.
Final Thoughts And Friendly Advice
This cannabis-infused blueberry banana smoothie recipe will make ~21 ounces and comes to ~422 calories. Until the USDA considers cannabis a food, we are unable to give the exact calorie count. The calorie count listed includes all of the ingredients except cannabis.
The great thing about making cannabis-infused smoothies is that there is no one, perfect way to do it. Also, you really can not mess up too bad. Even if you don’t like the flavor of your infused creation, you can always add more of something sweet (like strawberries) to the mix and re-blend with a few quick pulses.
- Thread starter
- #280
5 Steps To Making A Non-Psychotropic Cannabis-Infused Strawberry Banana Smoothie - by Alexis Jones
Total time: Approx. 5 minutes or less depending on your blender strength
Servings: 2-3
Difficulty level: Beginner
Vegan and gluten free!
What You Will Need:
* 7-10 raw cannabis leaves, freshly picked (within 2-3 days)
* 1 cup original hemp milk
* 1/4 cup of shelled hemp seed
* 1 large frozen banana
* 7 large frozen strawberries
* 1 tablespoon of honey (optional)
* Sprinkle coconut sugar on top at the end (optional)
Steps To Making Cannabis Strawberry & Banana Juice As A Dietary Supplement
Start by slicing up your frozen banana depending on your blender strength.
Fill blender with 1 cup hemp milk.
Add in the solid fruit and then top with cannabis leaves.
Finish with hemp seed, honey, and/or coconut sugar (optional).
Mix manually, in short spurts, being careful not to overheat the cannabis inside the blender (doing so will activate some of the plants cannabinoids).
The cannabis plant produces fresh leaves and buds that are a complete protein and a great natural source of healthy omega 3 and 6 fatty acids. It’s important to use fresh leaves and fresh buds, picked right off of a living plant (or properly fresh frozen). Old buds, cured for people to smoke or vaporize, are not suitable for creating a non-pyschotropic juice (eg. no high).
One large banana has over 400mg of potassium and 3 grams of fiber. On average, a banana also delivers more than 20% of your daily value of Vitamin C and B6. Bananas also strengthen the good flora in the gut and ease digestion. Bananas have also been linked with keeping blood pressure in check and boost the metabolism. It’s recommended that you allow your bananas to develop brown spots on the skin before consuming to allow the antioxidant count to reach its highest point.
strawberry banana smoothie
Strawberries are also high in potassium, lowering blood pressure and decreasing chances of strokes. Strawberries are antioxidant powerhouses linked to decreasing tumor growth and inflammation. The folate count makes them an ideal food choice for pregnant women and those suffering from depression.
One cup of hemp milk contains 3 grams of protein, 900mg Omega 3 ALA’s, and is lactose and cholesterol free.
Blend Slowly And Carefully; Do Not Overheat It
This process will require a healthy amount of blending. However, it is important that you are careful to blend the ingredients slowly, in spurts, so as not to overheat the cannabis leaves. Even a tiny bit of heat results in the raw cannabis further converting from THC-A (cannabinoid acid) to THC. Not a good thing if you want to stay sober after you consume your infused beverage.
What you want to do is keep the temperatures low, juice the whole cannabis plant, and in doing so, you will receive the full range of benefits that cannabinoids have to offer, engaging what is known as the entourage effect. The cannabis leaves and buds that the recipe calls for provide the body with much needed cannabinoid acids, specifically THC-A and CBD-A. These acids found in cannabis have been shown to help reduce or eliminate epileptic seizures, treat certain forms of cancer, and assist in the management of many other ailments.
Warning: Patients consuming beta-blockers that are wary about consuming too much potassium, may want to avoid a drink as high in potassium as this.
smoothie
Comments
gentle Jim
posted 3 years ago
I have been making raw cannabis shakes for 3 years for my severe back pain and sciatic nerve pain. The raw leaves and fresh raw bud work great for me and have little or no psychoactive effect. It's great for during the day when I'm busy. I use a probiotic yogurt and teaspoon of Montmorency cherry concentrate for arthritics . as a side effect I have lost weight, I needed that. And it was because I didn't feel hungry. I also stopped having issues with my diverticulitis. I use smoked indicas for quick relief short term but the shakes have been best and lasted for up to 12 hours for me.
God bless all who work to stop the drug war.
Gentle Jim
Total time: Approx. 5 minutes or less depending on your blender strength
Servings: 2-3
Difficulty level: Beginner
Vegan and gluten free!
What You Will Need:
* 7-10 raw cannabis leaves, freshly picked (within 2-3 days)
* 1 cup original hemp milk
* 1/4 cup of shelled hemp seed
* 1 large frozen banana
* 7 large frozen strawberries
* 1 tablespoon of honey (optional)
* Sprinkle coconut sugar on top at the end (optional)
Steps To Making Cannabis Strawberry & Banana Juice As A Dietary Supplement
Start by slicing up your frozen banana depending on your blender strength.
Fill blender with 1 cup hemp milk.
Add in the solid fruit and then top with cannabis leaves.
Finish with hemp seed, honey, and/or coconut sugar (optional).
Mix manually, in short spurts, being careful not to overheat the cannabis inside the blender (doing so will activate some of the plants cannabinoids).
The cannabis plant produces fresh leaves and buds that are a complete protein and a great natural source of healthy omega 3 and 6 fatty acids. It’s important to use fresh leaves and fresh buds, picked right off of a living plant (or properly fresh frozen). Old buds, cured for people to smoke or vaporize, are not suitable for creating a non-pyschotropic juice (eg. no high).
One large banana has over 400mg of potassium and 3 grams of fiber. On average, a banana also delivers more than 20% of your daily value of Vitamin C and B6. Bananas also strengthen the good flora in the gut and ease digestion. Bananas have also been linked with keeping blood pressure in check and boost the metabolism. It’s recommended that you allow your bananas to develop brown spots on the skin before consuming to allow the antioxidant count to reach its highest point.
strawberry banana smoothie
Strawberries are also high in potassium, lowering blood pressure and decreasing chances of strokes. Strawberries are antioxidant powerhouses linked to decreasing tumor growth and inflammation. The folate count makes them an ideal food choice for pregnant women and those suffering from depression.
One cup of hemp milk contains 3 grams of protein, 900mg Omega 3 ALA’s, and is lactose and cholesterol free.
Blend Slowly And Carefully; Do Not Overheat It
This process will require a healthy amount of blending. However, it is important that you are careful to blend the ingredients slowly, in spurts, so as not to overheat the cannabis leaves. Even a tiny bit of heat results in the raw cannabis further converting from THC-A (cannabinoid acid) to THC. Not a good thing if you want to stay sober after you consume your infused beverage.
What you want to do is keep the temperatures low, juice the whole cannabis plant, and in doing so, you will receive the full range of benefits that cannabinoids have to offer, engaging what is known as the entourage effect. The cannabis leaves and buds that the recipe calls for provide the body with much needed cannabinoid acids, specifically THC-A and CBD-A. These acids found in cannabis have been shown to help reduce or eliminate epileptic seizures, treat certain forms of cancer, and assist in the management of many other ailments.
Warning: Patients consuming beta-blockers that are wary about consuming too much potassium, may want to avoid a drink as high in potassium as this.
smoothie
Comments
gentle Jim
posted 3 years ago
I have been making raw cannabis shakes for 3 years for my severe back pain and sciatic nerve pain. The raw leaves and fresh raw bud work great for me and have little or no psychoactive effect. It's great for during the day when I'm busy. I use a probiotic yogurt and teaspoon of Montmorency cherry concentrate for arthritics . as a side effect I have lost weight, I needed that. And it was because I didn't feel hungry. I also stopped having issues with my diverticulitis. I use smoked indicas for quick relief short term but the shakes have been best and lasted for up to 12 hours for me.
God bless all who work to stop the drug war.
Gentle Jim