SweetSue's Cannabis Oil Study Hall

SweetSue said:
The desire I feel indicates you may be closer to that sparkling creature than you might believe. The one who ran away was obviously a little misguided. How sweet that a canine companion fills your need for loving and being loved. At least enough to tide you over until...

Hopelessly romantic over here. :laughtwo: We're here to love and be loved. When we allow that to happen the soul sings a mighty song of appreciation. You ever notice how healthy newlyweds are? They have their ECS on high gear. There is no power in the universe more potent, more creative and more sustaining to health than love.

What types of foods inspire you? Move past sweets. Corrine has a wealth of ideas. Green Flower Media has attracted the interest and involvement of a couple decent cannabis chefs. For my money no one beats Corrine for sheer authenticity. She makes you feel like you're standing there giggling with her.

Cannafan, one of our talented membership, has a thread on cannafoods that's well worth digging up. The resources are immense. :cheesygrinsmiley: Pick a direction and we can play.
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Newlyweds the honeymoon is over the next day :)

Yeah the one that ran away got invloved with a misguided druggie.

The dog is my friend a mans best friend is a dog.

Ok i will look into corrine and see what she has for me.

I have longed for mary jane and she has pleased me a lot, but i want her sisters too :)

A Licenced Medicinal Cannabis User
 
AngryBird said:
We have lots of recipes. see my Nest link post #1 and then here: I love cooking and I can "easyfy" any recipe for you if needed :)
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Thank you AngryBird i will have a look and see.

You like cooking that is appealing to many. Hash Brownies?

By the way the only AngryBirds i have dealt with have always flowen into pillars i hope you can fly straight.

A Licenced Medicinal Cannabis User
 
chadillac5580 said:
Does anyone have a rough bioavailability percentage for tacking CCO? I can't seem to find any info.

Sent from my 1975 Radio Shack walkie talkie.
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Current science suggests a rate of around 13% through the oral mucosa. This is the reference attached to those numbers.


Karschner et al. (2011) Clin. Chem. 57:66–75

We believe we're getting much better numbers with biobomb adaptations, but we have no hard evidence that I know of to back that up.
 
SweetSue said:


Current science suggests a rate of around 13% through the oral mucosa. This is the reference attached to those numbers.


Karschner et al. (2011) Clin. Chem. 57:66—75

We believe we're getting much better numbers with biobomb adaptations, but we have no hard evidence that I know of to back that up.
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Could a biobomb be made without lecithin? Would mixing olive oil/CCO or coconut oil/CCO offer better bioavailability?

Sent from my 1975 Radio Shack walkie talkie.
 
Ooh, that sounds like a good one. Thanks for the heads' up, Sue. It's definitely one that I'll be checking out.

:thanks:

SweetSue said:
My favorite cannacook, Corinne, over at Wake + Bake Cookbook, is releasing her latest e-book in May. She's taking preorders. This is one I'm ordering as soon as I have the funds to send off her way. The pre-order is half price, so for a mere $10 you can laugh your way through some of the best recipes for oils, tinctures and the like you're likely to find when she gets it posted. She's named this one "Dazed + Infused." :laughtwo: I love this woman's wicked sense of humor.

Dazed + Infused includes tutorials for:

8 Natural/Organic Cannabis Cooking Oils
5 Potent Tinctures
6 Topical Infusions
10+ Popular Dispensary Candy + Baked Recipes (with healthy, organic and sugar-free options)
3 Homemade Cannabis Drinks (Including Homemade Canna-soda)
4 Easy-to-Dose Medicines (Cough Drops, High Quil, and Suppositories)

Here's a link to her page on the book. Corrine brings a unique humor and artistry to the table. I thrill to find an email from her. I think you'll enjoy her too.

Dazed + Infused
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I have a banana most mornings when I wake up. They're not too heavy but they hit the spot when you need a quick fix. I also like them because they're quiet to eat -- I sometimes get hungry in the middle of the night and the banana tree is nearby so it's easy and it's quiet -- perfect nighttime snack, in my opinion.


SaraLinni said:
Thank you for munchie support!

I'm determined to just turn this into an opportunity to stuff myself with healthy foods - though I will have to focus on not overdoing it at each meal. I'm so used to have a stomach that screams NO MORE at me. It's strange not to feel that. Pre portioned snacks will be very handy.

Also - I need to drink more water. This cannabis made me thirsty as well

The worst of it comes in the morning - just that weird, almost hung over feeling and the ravenous pit in my belly. This morning a banana took care of it, so I'll just be prepared.
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I made sure this morning to drink a LOT of water before I ate anything more. That really helped me feel better all day, I think. I also pushed my luck with some decaf coffee. My mom makes it a lot, and it just smelled too dang good.

I actually felt it a little, but the oil pushed everything away. :cheertwo: I think I might just be in love with this stuff.

Today I also have been taking the oil every 3 hours. Keep the input steady.

I haven't quite had the hunger today. No junk food at all. Not sure if it's the water, the 3 hour schedule, or just a coincidence. I actually got full before I could finish my lunch, and haven't eaten for 3 hours. Hehe

Speaking of steak, last night my mom made a steak and shrimp dinner for me and my dad. I ate it all :) It was very good.

My parents don't know I'm using cannabis. I have a feeling they think I'm pregnant - sluggish, overeating and giving up coffee.
 
chadillac5580 said:
Could a biobomb be made without lecithin? Would mixing olive oil/CCO or coconut oil/CCO offer better bioavailability?

Sent from my 1975 Radio Shack walkie talkie.
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Our biobomb recipe was adapted from the canna-budwig protocol. Lecithin is key ingredient that makes it bio-available, so it can't be left out. There may be substitutes but I think they require other adjustments also. I don't know much detail about budwig protocol itself.
 
chadillac5580 said:
Could a biobomb be made without lecithin? Would mixing olive oil/CCO or coconut oil/CCO offer better bioavailability?

Sent from my 1975 Radio Shack walkie talkie.
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As KR pointed out, the lecithin is primary to the BioBomb. However, coconut oil itself makes the cannabinoids more bioavailable. You can also
* have a small snack with fat about 15-30 minutes before the dose
* include either apigenin or amentoflavone to further enhance bioavailability
* have some mango in advance (30-45 min before a dose) to clear the receptors

All of these steps can give you an upper hand with bioavaibility Chad. Lecithin is simply one tool in a crowded box of options.

Cajun would be real proud of all this talk of bioavaibility. :battingeyelashes: :Love:
 
KingstonRabbi said:
Our biobomb recipe was adapted from the canna-budwig protocol. Lecithin is key ingredient that makes it bio-available, so it can't be left out. There may be substitutes but I think they require other adjustments also. I don't know much detail about budwig protocol itself.
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I've tried with liquid sunflower lecithin, but for some reason it increases my anxiety and tics. I was wondering if a carrier oil with the CCO would increase bioavailability compared to swallowing the CCO alone?

Sent from my 1975 Radio Shack walkie talkie.
 
chadillac5580 said:
I've tried with liquid sunflower lecithin, but for some reason it increases my anxiety and tics. I was wondering if a carrier oil with the CCO would increase bioavailability compared to swallowing the CCO alone?

Sent from my 1975 Radio Shack walkie talkie.
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Absolutely it will Chad. The body has a difficult time digesting cannabinoids, so taken through the gut in any way, shape, or form you're compelled to use a carrier oil. Taken sublingually a carrier oil enhances absorbtion, plus it adds values offered by the chosen oil. No way to lose.

Cajun says it'll enhance tacking too, but I personally know of no one doing that. In tacking you need the oil to stick to the gums.

Forgive me if there's someone here that I should be aware of. I get a little self-absorbed sometimes. :battingeyelashes: :Love:
 
Dear sweetsue,

as you already know my father has liver cancer, and in parallel to his therapy in hospital (TACE) he uses Cannabis oil, or rather BioBomb. After four weeks slowly increasing the dose, he managed to take his maximal daily dose (4 x 65 mg CCO) or rather 4 times BioBomb capsules. But each morning he has nausea and sometime vomit, too...and this is just in the morning after waking up...Is this normal?

Thank you!!!
 
libra said:
Dear sweetsue,

as you already know my father has liver cancer, and in parallel to his therapy in hospital (TACE) he uses Cannabis oil, or rather BioBomb. After four weeks slowly increasing the dose, he managed to take his maximal daily dose (4 x 65 mg CCO) or rather 4 times BioBomb capsules. But each morning he has nausea and sometime vomit, too...and this is just in the morning after waking up...Is this normal?

Thank you!!!
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I'm sorry to hear he's having this difficulty libra. I have a few questions, and I'm hoping others have some questions as well. This can be tricky to do in a virtual world, so I ask that you be as thorough as possible when you respond to any of these queries.

- How long has the vomiting been going on?
- How severe is the vomiting? Has it increased, leveled off? Showing any signs of beginning to decrease?
- How much correlation to the most recent dose increase and the onset of the vomiting?
- What chance is there that the vomiting is being triggered by chemo drugs?
- Any recent changes in pharma meds?
- Where did you get the oil you're using?
* My very first thought with gastric disturbances is to suspect chemicals in the meds you weren't expecting. A compromised immune system is further strained by even small quantities of solvents left behind.
- What food is in his stomach when he gets that final dose of the day? Have you considered a small snack if he wakes in the night to get something in the gut?


That's it for my immediate questions. Now for suggestions. Keep in mind we are not trained professionals. We're brainstorming neighbors with more insight into the ECS and cannabinoid therapies than you're likely to find in the local coffee shop. :cheesygrinsmiley:

Gut reaction: cut back slightly on the cannabinoid load. See if this helps. For now, let go of any concern this causes. I realize this is intended to be life-giving meds and your mentality, as is most of ours, is to get as many cannabinoids in as you can. The reality is that cannabis effects every patient differently, and sometimes changes how it expresses within the same patient.

Cannabis is biphasic. This means that taken in the wrong dose it can cause the very symptom it was being used to treat. Always begin by backing off some to see if the condition stabilizes.

Phytocannabinoids keep adapting to the internal atmosphere the same way the endocannabinoids do. Something may have changed in your father that we aren't aware of.

You got my curiosity up and I found an article at Leafly that I'm going to post after this.

I am not suggesting that your father has this condition that the medical community hasn't properly pegged yet.

The information contained within the article may explain some of what's going on. It was an important enough perspective that I wanted the crew to investigate and explore. I didn't want you to panic libra. :battingeyelashes: :Love:

Take heart, we'll find a solution for you.
 
Sue i'm joining in on this one. Because Cannabis oil is something special and I also want to learn more about it and raise awareness off Cannabis oil.

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This is a wonderful insight into how the ECS interacts within the system, as pertains to nausea. It's from Leafly. Any bolding and highlighting was done by me.

*****​

HEALTH
What is Cannabinoid Hyperemesis Syndrome?
BAILEY RAHN


I used cannabis for nausea without realizing it might actually have been the cause of it. Cannabinoid hyperemesis syndrome (also known as cannabis hyperemesis syndrome, or CHS) is a recently discovered, poorly understood condition theoretically caused by heavy, long-term cannabis use. Its acute "hyperemetic" phase is characterized by vomiting, nausea, severe gastrointestinal discomfort, and compulsive bathing, although it may be preceded by a period of milder symptoms like morning nausea, consistent urges to vomit, and abdominal pain.

When I read about this condition in a 2011 study from Temple University, I nearly fell out of my chair. I've been using cannabis medicinally for the last five years to treat morning sickness, nausea, and intestinal pain. A conversation with an ex came to mind. He used to antagonistically pose theories that cannabis might be what's causing the problems, to which I would respond with a heated and defensive, "Cannabis is the only thing that helps, why the hell would it be causing it?!"


Fast-forward one year to a discussion with my budtender who recently experienced the acute phase of the condition. As per her doctor's recommendation, she set cannabis aside and within a few weeks, she made a full recovery. My friend's symptoms were so much more severe than mine, it never occurred to me that I might be experiencing early stages of the same condition.

In fact, it took a long, hard look at the research for me to admit that the condition might even exist at all.
Research on Cannabinoid Hyperemesis Syndrome

The earliest focused study on the cannabinoid hyperemesis phenomenon appears to be in 2004, when Australian researchers noticed a commonality among patients experiencing cyclical vomiting symptoms: chronic cannabis use. Seven out of ten subjects who abstained from cannabis resolved their cyclical vomiting symptoms; the other three participants refused to abstain and their symptoms continued.

Small case studies surfaced in the years following, demonstrating similar patterns:
In 2009, a 22-year old cannabis consumer exhibited CHS symptoms in a U.K. case study. His symptoms resolved following cannabis cessation.
Two more cases in 2009 that matched CHS criteria were recorded. Severe symptoms improved following 24 to 48 hours after cannabis cessation.
A 42-year old chronic cannabis user was CHS symptom-free 3 months after his diagnosis, according to a 2014 U.K. case study.


The appearance of cannabinoid hyperemesis syndrome in medical literature is rare for two reasons: (a) the condition has only recently been acknowledged and named, and (b) CHS — as a result — is likely to have been misdiagnosed as cyclical vomiting syndrome (CVS). Though rarely seen in study papers, personal stories are beginning to bubble up in media reports and by word-of-mouth.

I asked a number of doctors to share any cannabinoid hyperemesis syndrome patient information they had on hand, but it seemed that cannabis doctors were the only ones even privy to the condition at all. With 33 million Americans consuming cannabis, we can only hope that researchers and medical professionals will start to explore the many questions tied to this condition.

What are Cannabinoid Hyperemesis Syndrome Signs and Symptoms?

Among patients diagnosed with cannabinoid hyperemesis syndrome, most tend to be "young adults with a long history of cannabis use," according to the 2011 Temple study.

"In nearly all cases there is a delay of several years in the onset of symptoms preceded by chronic marijuana abuse. Daily marijuana use is characteristic and often reported as exceeding three to five times per day."

As previously mentioned, researchers have proposed CHS be characterized by three phases.

1. Prodromal Phase

Typically months or years before exhibiting severe cyclical vomiting symptoms, the patient experiences:
Morning sickness
Abdominal pain and discomfort
Nausea and fear of vomiting

Appetite is typically unaffected during this phase, but researchers note that consumers tend to administer more cannabis as a nausea remedy.


2. Hyperemetic Phase

The acute phase of the illness is characterized by an intensification of effects and unique behaviors:
Persistent nausea and vomiting that can last for hours at a time
Frequent retching, up to five times an hour
Abdominal pain
Weight loss
Dehydration
Habitual bathing and/or showering

Why the compulsive bathing and showering? Hot temperatures are known to relieve the nausea and vomiting associated with CHS. The reasons why are not well developed, but researchers propose that "hot bathing may act by correcting the cannabis-induced equilibrium of the thermoregulatory system of the hypothalamus."


A 2014 review offers further explanation:
"The brain may react to changes in core body temperature due to the dose-dependent hypothermic effects of [THC]. Alternatively, the bathing behaviour may be a result of direct CB1 receptor activation in the hypothalamus by [THC] or another active compound and may not necessarily be a response to changes in core body temperature."

3. Recovery Phase

After halting cannabis use (the only cannabinoid hyperemesis syndrome "treatment" option), patients typically recover in a matter of days, weeks, or months. Nausea ceases, appetite resumes, body weight is regained, and bathing/showering regimen returns to normal.

Why Would Cannabis Cause the Symptoms that Characterize CHS?

Though it will take a lot more research to evolve theory to fact, scientists at Temple University have a few leads on why cannabis might cause nausea and vomiting, upsetting what we've come to expect from our favorite anti-nausea remedy.

Cannabis may help us feel less nauseous by activating specific parts of the central nervous system, but what else might be happening in the gut itself? According to study authors from Temple University, activation of CB1 receptors (primarily by THC) may result in the following gastrointestinal actions:

Inhibition of gastric acid secretion
Lower esophageal sphincter relaxation
Altered intestinal motility
Visceral pain
Inflammation
Reduces gastric motility
Delays gastric emptying

These mechanisms are all ingredients in a theory that is yet to be baked, but it presents an interesting paradox — that THC, when consumed heavily and over a long period of time, may exert anti-emetic properties on the brain, but cause nausea via its effect on the gut.


The study also mentions a tangle of interactions between two secondary cannabinoids found in cannabis, CBD and CBG. They write:

"In animals the effect of CBD on toxin-induced vomiting displays a biphasic response with low doses producing an anti-emetic effect whereas higher doses enhance vomiting. Cannabigerol (CBG) is a non-psychotropic cannabinoid that behaves as an antagonist at both the CB1 and 5-HT1A receptors. This antagonism reverses the anti-emetic actions of low-dose CBD, which likely occurs at the 5-HT1A receptor. The pro-emetic properties of CBD (at higher doses) and CBG may play a role in the severe nausea and vomiting observed in patients with Cannabinoid Hyperemesis Syndrome."

To reiterate, these are theories, not proven or substantiated results. These ideas pull from a patchwork of cannabis research — some from animal models and others from human trials. For this reason, it's important to take this report and related case studies with a grain of salt.

Medical Professionals are Still Skeptical on Cannabinoid Hyperemesis Syndrome

The proposals and theories put forth by researchers are compelling, but some medical professionals remain skeptical.

Authors of a 2006 review out of Australia criticize the original 2004 research that defined cannabinoid hyperemesis syndrome for poor study design and for misattributing increases in cannabis use to liberalized laws.

"Cannabis has been consumed for many centuries and is currently used by millions of people in many countries," the authors wrote. "It is hard to believe that a distinctive syndrome caused by cannabis has never been noted before by users or clinicians."


I spoke to a doctor from Green Leaf Health Care here in Seattle, wondering what his take on the research was. He, too, showed a degree of skepticism and offered another possible explanation.

"I have an additional theory which is that cannabis grown with chemicals is affecting people in various ways, [and] this may be one of them," he said. "I've traveled through India and Asia extensively and know heavy long-term users without ever having issues regarding hyperemesis. Perhaps long term use and concentrated levels could produce these issues in certain susceptible individuals; however, I feel like it's more of a chemical issue."

The fact of the matter is, we don't have enough research to show if or why cannabis is the cause of these symptoms. What we do know is that there are people out there who benefit from cutting back on their intake or ceasing altogether. It may be purely coincidence that my cutting back coincided with a gastrointestinal recovery. We can't know why halting cannabis use helped my friend, or why she gets sick when she tries to resume. All we know is there's a possibility of connection, and that successfully bridging such a connection holds important implications for those who use cannabis every day.

* * * * *​

Lots of information to digest there guys. Have fun. I need to force myself out of curiosity mode and into nutritionist mode. One can't live on brownies alone. :cheesygrinsmiley:
 
rikvasen said:
Sue i'm joining in on this one. Because Cannabis oil is something special and I also want to learn more about it and raise awareness off Cannabis oil.

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How delightful to have you join us rikvasen. Make yourself at home and fire up your brainstorming capabilities. The rules are anything is on the table. Brainstorming requires us to be in full opportunistic mode. You're gonna like it here. :cheesygrinsmiley:
 
Oldbear said:
High dose of cannabis compounds is able to reverse cancer, it follows that there is a dose level that will prevent cancer from forming.

I wonder .........
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High doses of cannabis kills cancer cells because your ECS is deficient. A healthy ECS is fully capable of killing any cancer cells that arise within the system. Cannabis is reserve troops. The goal is to re-establish homeostasis to the point that cannabis becomes necessary for recreational or spiritual purposes only.

We all have cancer cells. Cancer is a common expression of cells. Your ECS is evolved to deal with this dilemma at the outset. The more you're inclined to laugh the easier it is for your ECS to hear the disparate signals.
 
SweetSue said:
How delightful to have you join us rikvasen. Make yourself at home and fire up your brainstorming capabilities. The rules are anything is on the table. Brainstorming requires us to be in full opportunistic mode. You're gonna like it here. :cheesygrinsmiley:
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Thanks Sue. I've already read a part of your last post about the CHS. I am pretty curious about it, I've not read it all yet so I don't know if it was already there yes or no, but if Cannabis caused it, to me it is like a overdose of medicine. But ofcourse Cannabis is fully natural so the recovery of CHS should be pretty fast if you step back from Cannabis for a while. So will CHS be a serious problem? The sympthomes are not that bad but pretty annoying and the recovery is pretty fast, so that's something i'm curious about. Then again I've by far not read everything so maybe the answer is already in it and I've just not read it yet.

By the way I will probably also going to make Cannabis oil, just need to know what I need for it and how I make it. Here in the Netherlands they do sell complete sets for under a 100 euro's including a manual on making cannabis oil which is interesting.

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