So many points of view when it comes to defoliation and thinning, pruning. I'm sure suggestions will rain on you if you ask the community about proper defol.
I for one take out every single grow tip and fan at every first node on all side branching. I leave anywhere from 2-5inch of cleared out body Stem/branch of the main. The inside of the plant is the critical area where poor airflow, lack of light and humidity retention will seed and sprout fungi spores; not now but later in fall.
You could probably take all fan leaves now and it wouldn't affect your plant, its not the same once they flower hard, they stop making big fan leaf so caution later on.
Anyway hope you keep having a healthy grow cycle, strong healthy plants don’t get sick.