I have not seen much progression in my symptoms since I was diagnosed 5 years ago . I started cannabis within the first year and so far so good.
Have experimented with many different delivery modes. Smoking/vaping/ CCO tacking, edibles, and infused oils. I am currently helping myself and 2 others with MS and several people (including my wife) for pain. We also treated my wife's Lyme disease with CCO. That got rid of it even after 4 rounds of doxyicycline failed. I have a CBD infused olive oil that is helping with arthritis pain in her hip.
I also have a friend with a form of Parkinson's disease and she is helped with blended concentrates. She has also done well with 2:1 THC/CBD. You can either try to find a strain with that percentage (not many out there...Medicann's Blue Blood comes to mind) but you can blend your own together.
For fast onset, vaping (or smoking) will get the meds into the system fast, but not always in the amounts you might need. Here is what works for me:
I use infuse olive oil made with sativa dom strains for daytime. I also have olive oil for night time made with indica dom. This helps for sleep. I won't lie, I enjoy relaxing after work so I don't mind smoking, but for longer lasting effect, you need the infused oils or cco. My one friend I help, prefers coconut oil. The other person I make brownies for and he uses them for sleep.
The advantage of the olive oil infusion, is it is easier to make then the cco, I for myself and (especially the people with pain) it is easier to micro dose. Most people can't be going to work impaired. Micro dosing allows you to find the right dose that alleviates the pain with out the impairment. One of my friends has gone from 100mg oxi per day and replaced it with 1/4t infused oil 3x per day and is only taking 20mg of oxy at night. Her goal is to get off that too.
As for me, It helps with the pain and allows me to sleep well.
Each person is an individual and will have slightly different needs and effects. You will need to find the right dose with a little trial and error to find the correct dose.
Sorry if I rambled bit there. Let me know if there is something more specific I can answer.