Derbybud Does CBD Strains In Coco & More

Pennywise said:
Yep, the Brooklyn can be a great producer with over sized colas
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Sounds like a really good strain. Just takes a little while for an auto is all. Hell I was to take the summer off anyhow so something in the tent hopefully on auto pilot will be a plus. Wife wanted me to take off till we get back from vacation in October. That's why I flipped the clones so quick as she wanted me to be done and take a break.
 
Derbybud said:
Yes I have. Shed informed me it should not get in my blood system with using grape seed oil.
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Indeed. Topicals don't penetrate into the blood stream. Transdermal patches do but that's not what we're makin'!
 
Kismet said:
I am excited to run these autos with you guys. Y'all are my hero's . Derb.Penny.Newt .Shed.Phobos.Ecg. And a lot more when i was lurking
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Flattered to be on that list...thanks! I'm looking forward to having some successful autos again.
 
Pterostychus said:
only thing is they dont test for THC in blood but on metabolites in urine ...
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The kidneys can't metabolize what's not in the blood. I don't understand your point.
 
InTheShed said:
The kidneys can't metabolize what's not in the blood. I don't understand your point.
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my point is every complex molecule in our body that doesnt belong gets broken down by enzymes in the liver and the metabolites go via the blood to the kidneys that excretes all waste products in the blood, i am not convinced topicals dont get in the blood as said here
 
Pterostychus said:
my point is every complex molecule in our body that doesnt belong gets broken down by enzymes in the liver and the metabolites go via the blood to the kidneys that excretes all waste products in the blood, i am not convinced topicals dont get in the blood as said here
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That's okay. Without scientific evidence showing that a molecule the size of THC can pass through the dermis and into the bloodstream on an oil-based carrier (rather than DMSO et al.), or without a positive urine test from someone using solely topical oil, I'm sticking with everything I have read on the subject.
 
2.1.5. Transcutaneous
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Another route of cannabinoid exposure that avoids first-pass metabolism and improves THC bioavailability is topical administration [43]. Cannabinoids are highly hydrophobic, making transport across the aqueous layer of the skin the rate-limiting step in the diffusion process [44][45]. In vitro diffusion studies may underestimate in vivo transdermal flux [43]. After application of a dermal patch, mean steady-state plasma concentration of Δ8-THC was 4.4 ng/ml within 1.4 h, and was maintained for at least 48 h. Permeabilities of CBD and CBN were found to be 10-fold higher than for Δ8-THC. In vivostudies of transdermal drug delivery in guinea pigs noted the presence of significant amounts of plasma metabolites after topical application of THC [46]. Additional research is planned with combinations of cannabinoids in EtOH to increase drug absorption.

Transdermal delivery of cannabinoids is hoped to reduce negative side effects seen with inhalation dosing [47]. Transdermal delivery also bypasses first-pass metabolism of cannabinoids. These properties could improve the utility of transdermal cannabinoid medications. Applying a transdermal patch several hours before chemotherapy, and wearing it for several days, would be a convenient means for treating associated nausea and vomiting. Also, wearing a patch for a week to stimulate appetite could be a good alternative to twice a day oral dosing of dronabinol.

The drug-abuse potential of cannabinoid transdermal patches is expected to be low because of slow delivery of THC to the brain. However, extraction of cannabinoids from the patch for administration by a more-rapid method has not been evaluated
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We've had this conversation before, remember? "After application of a dermal patch..."

The information you posted proves my original point.
 
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