Nobby,
Read this. It points out 2 very important points that I'm not aware of any professionals debating.
1. This can be VERY dose dependent. 1 size may not fit all.
2. Cleaning your receptors is mandatory for most. Not all do it, they're wasting medicine. Period.
Researchers treated/examined (1) prostate cancer cells (lines PC3 and PrC) and (2) cells from patients with benign prostatic hyperplasia (BPH, a condition that results in an increased number of prostate cells that are not cancerous):
histologically (i.e. using a microscope): stained cells in order to visualize cannabinoid (CB1 and CB2) receptors, and
by treating individual cells for (1) 48 hours with 2.5, 5.0 or 10 µM of either anandamide, 2-AG, or methanandamide (endocannabinoids, i.e. cannabinoids found naturally within the body) or (2) for 30 minutes with 10 or 20 µM of rimonabant (a CB1 receptor antagonist; an agent that prevents CB1 receptor stimulation) followed by treatment with the endocannabinoids.
Here is what they found:
more CB1 and CB2 receptors found in aggressive prostate cancer cells than in less aggressive prostate cancer cells or BPH cells
after treatment with endocannabinoids, cell survival was decreased in a statistically significant manner (i.e. in this case, there was a less than 5% chance that these results occurred merely by chance, rather than as a direct result of treatment)
the higher the dose of endocannabinoid used, the greater the decrease in cell number (i.e. "dose dependence" was exhibited)- effect greatest for PC3 cells > BPH > PrC
although expected among PC3, PrC, or BPH cells when treated with 5 µM of endocannabinoids, the cell's growth cycle was not inhibited in comparison to those that were untreated (dose used may not have been high enough)
when treated with 20 µM of the cannabinoid receptor antagonist, cell survival was not decreased— when treating the same cells with endocannabinoids, cell survival still was not decreased (likely as a result of the CB1 receptors being blocked)
when 10 µM of cannabinoid receptor antagonist was used followed by treatment with cannabinoids, cell survival then began to decrease in PC3 cells (i.e. not enough CB1 receptors were blocked by the antagonist in order to prevent the protective effects of the endocannabinoids)
between PC3 than in PrC cells, number of cells going through programmed-cell death was higher in cell lines treated with endocannabinoids than in those not being treated with endocannabinoids, with a stronger effect for PC3 cells
between PrC and BPH cells, after 48-treatment with 5 µM of endocannabinoids, there was an increase in caspase-3 (enzyme that helps to activate programmed cell death) and a decrease in Bcl-2 (a protein that helps to prevent programmed cell death)
The authors note,
"These results suggest that the effect of endocannabinoids on [prostate cancer] cells... may be caused by the activation of the apoptotic pathway... The great advantage that the use of endocannabinoids may bring to the battle against prostate cancer is that it has been demonstrated that the receptors for these molecules are substantially overexpressed in cancerous prostatic cells when compared to normal, healthy prostate tissues... Based on these results, we suggest that endocannabinoids may be a beneficial option for the treatment of prostate cancer that has become nonresponsive to common therapies."
You can order online as some mentioned, but it's buyer beware as Jimbo mentioned.
I don't know off hand of I'm allowed to post a link or a pm, but I'll give it a shot.
Might get deleted?
Try Caregivers for Life in Colorado. Great product. It's their Phoenix Tears oil. I know most everyone over there.
Sorry Mods if this was a no-no.
Oh so true!
to you Nobby, thoughts and prayers are all around you.
Hi gekkoca....I'm glad you found us.