Suppositories aren't working, I've tried for several weeks.
As against capsules as I am, I'm shelving the flaxseed oil & replacing with coconut oil.
Taking a medium chained fat like coconut oil gets the meds to the portal vein better.
I don't use coconut oil due to this, but it's perfect for the liver.
On that, EVERYONE should be eating MCF's 30 mins prior to tacking. It keeps the enzymes produced by the liver & digestive tract busy while the oil does it's thing. These enzymes are what keep our bodies from letting non polar substances like the oil from doing their thing.
The specific carrier oil source that you choose, directly dictates where in the body, your CO is absorbed. The digestive advantages of MCFAs over long-chain fatty acids are due to the differences in the way our bodies metabolize these fats. Because the MCFA molecules are smaller, they require less energy and fewer enzymes to break them down for digestion. They are digested and absorbed quickly and with minimal effort. Unlike other fatty acids, MCFAs are absorbed directly from the intestines into the portal vein and sent straight to the liver. (Longer fatty acids are absorbed into the lymphatic system) that's why we don't use coconut oil.
Normally you want to keep the cannabinoids away from the liver. The liver metabolizes the CO, causing the majority of the D9-THC to convert to the more psychoactive 11-OH-THC. 11-OH-THC produces a molecule many times more psychoactive but with most all medical benefits deactivated.Just because a cannabinoid has found it's way to the liver does not however mean that it will remain there to successfully treat any disease there.
The enzymes that metabolise cannabinoids are mainly found in the liver. A cannabinoid entering the liver is more likely to connect with an enzyme and be metabolised than to connect with a cancerous cell. This makes liver cancer a trickier one to treat without additional supplements.
Certain plant molecules are metabolised by the same enzymes that metabolise most THC molecules. The enzyme is called CYP2C9 and the molecules are apigenin and amentoflavone. Apinenin can be found in tablets and certain foods and amentoflavone is available in supplements for weightlifters such as Amentomax. These molecules, as well as having additional benefits, will give the enzymes "busy work" allowing the cannabinoids greater opportunity to circulate, connect with and destroy mutated cells both in the liver and throughout the body.
This enzyme busying effect is called competitive inhibiton. A well known example of this is the grapefruit effect. A molecule in grapefruit called bergamottin competitively inhibits an enzyme called CYP3A4 that metabolises many pharmaceuticals causing a risk of build up and overdose. Bergamottin from the grapefruit slows drug removal by 50-80% making it a moderate inhibitor.
I don't use caps usually. Been there done that. But, for the liver (portal vein) it's works better. My liver is reducing now due to the constant pressure from the oil. Hopefully. won't be long.
Olive oil & grape seed oil are the best as Motoco mentioned.
Big hugs and power your way!
Now I'm really worried. 
I sure don't like the sound of that most recent post Motoco, but you have to take care of yourselves. Holler out if you need help. We're here for you like you've been here for us. I assume you'd tell us if you need help....or just a break. Or to lay low!!!
All the very best! Nobby.
