- Thread starter
- #341
@Preston9mm, follow this link to Project CBD's list of research on cannabis and autism.
Autism: Project CBD
Autism: Project CBD
SweetSue's Class Notes
- Thread starter SweetSue
- Start date
You're the best!Let me go looking Preston, and see what I can find. I can tell you that magnesium is an overlooked necessity for autism, a little known fact. There are oral sprays that are instant absorbtion. Please advise your friends about this.
My thread on PTSD has information on this. The nurse practitioner who taught the class discovered the mag link quite by accident.
Be back later with more Preston.
- Thread starter
- #343
Hey @Preston9mm, I found an article from Newsweek, published in Feb of this year that's a must read for your parent friends.
Is Marijuana The World's Most Effective Medicine For Autism
Is Marijuana The World's Most Effective Medicine For Autism
- Thread starter
- #344
J Autism Dev Disord. 2013 Nov; 43(11):2686-95. doi: 10.1007/s10803-013-1824-9.
Cannabinoid receptor type 2, but not type 1, is up-regulated in peripheral blood mononuclear cells of children affected by autistic disorders.
Siniscalco D1, Sapone A, Giordano C, Cirillo A, de Magistris L, Rossi F, Fasano A, Bradstreet JJ, Maione S, Antonucci N.
Author information
Abstract
Autistic disorders (ADs) are heterogeneous neurodevelopmental disorders arised by the interaction of genes and environmental factors. Dysfunctions in social interaction and communication skills, repetitive and stereotypic verbal and non-verbal behaviours are common features of ADs. There are no defined mechanisms of pathogenesis, rendering curative therapy very difficult. Indeed, the treatments for autism presently available can be divided into behavioural, nutritional and medical approaches, although no defined standard approach exists. Autistic children display immune system dysregulation and show an altered immune response of peripheral blood mononuclear cells (PBMCs). In this study, we investigated the involvement of cannabinoid system in PBMCs from autistic children compared to age-matched normal healthy developing controls (age ranging 3-9 years; mean age: 6.06 ± 1.52 vs. 6.14 ± 1.39 in autistic children and healthy subjects, respectively). The mRNA level for cannabinoid receptor type 2 (CB2) was significantly increased in AD-PBMCs as compared to healthy subjects (mean ± SE of arbitrary units: 0.34 ± 0.03 vs. 0.23 ± 0.02 in autistic children and healthy subjects, respectively), whereas CB1 and fatty acid amide hydrolase mRNA levels were unchanged. mRNA levels of N-acylphosphatidylethanolamine-hydrolyzing phospholipase D gene were slightly decreased. Protein levels of CB-2 were also significantly increased in autistic children (mean ± SE of arbitrary units: 33.5 ± 1.32 vs. 6.70 ± 1.25 in autistic children and healthy subjects, respectively). Our data indicate CB2 receptor as potential therapeutic target for the pharmacological management of the autism care.
PMID: 23585028 DOI: 10.1007/s10803-013-1824-9
[Indexed for MEDLINE]
"Our data indicate CB2 receptor as potential therapeutic target for the pharmacological management of the autism care."
The relevance of this: if you're targeting the CB2 receptors you're targeting the immune cells and you want olive oil as the carrier to get cannabinoids absorbed into the lymphatic system first.
CB2 receptors in the periphery = EVOO as a carrier
Now.... for anything other than liver disease you want EVOO. You want as much time for those cannabinoids to be circulating as possible, so you're gonna use some competitive inhibition as well, intending to overwhelm the liver enzymes with amentoflavone and apigenin, taken 30 minutes before the cannabinoid dose.
Toss some mango in there for receptor demethylation, and wash it all down with a cup of green tea.
In case you're watching over my cosmic shoulder mon ami. Wouldn't want to forget the lessons of the shaman.
Cannabinoid receptor type 2, but not type 1, is up-regulated in peripheral blood mononuclear cells of children affected by autistic disorders.
Siniscalco D1, Sapone A, Giordano C, Cirillo A, de Magistris L, Rossi F, Fasano A, Bradstreet JJ, Maione S, Antonucci N.
Author information
Abstract
Autistic disorders (ADs) are heterogeneous neurodevelopmental disorders arised by the interaction of genes and environmental factors. Dysfunctions in social interaction and communication skills, repetitive and stereotypic verbal and non-verbal behaviours are common features of ADs. There are no defined mechanisms of pathogenesis, rendering curative therapy very difficult. Indeed, the treatments for autism presently available can be divided into behavioural, nutritional and medical approaches, although no defined standard approach exists. Autistic children display immune system dysregulation and show an altered immune response of peripheral blood mononuclear cells (PBMCs). In this study, we investigated the involvement of cannabinoid system in PBMCs from autistic children compared to age-matched normal healthy developing controls (age ranging 3-9 years; mean age: 6.06 ± 1.52 vs. 6.14 ± 1.39 in autistic children and healthy subjects, respectively). The mRNA level for cannabinoid receptor type 2 (CB2) was significantly increased in AD-PBMCs as compared to healthy subjects (mean ± SE of arbitrary units: 0.34 ± 0.03 vs. 0.23 ± 0.02 in autistic children and healthy subjects, respectively), whereas CB1 and fatty acid amide hydrolase mRNA levels were unchanged. mRNA levels of N-acylphosphatidylethanolamine-hydrolyzing phospholipase D gene were slightly decreased. Protein levels of CB-2 were also significantly increased in autistic children (mean ± SE of arbitrary units: 33.5 ± 1.32 vs. 6.70 ± 1.25 in autistic children and healthy subjects, respectively). Our data indicate CB2 receptor as potential therapeutic target for the pharmacological management of the autism care.
PMID: 23585028 DOI: 10.1007/s10803-013-1824-9
[Indexed for MEDLINE]
"Our data indicate CB2 receptor as potential therapeutic target for the pharmacological management of the autism care."
The relevance of this: if you're targeting the CB2 receptors you're targeting the immune cells and you want olive oil as the carrier to get cannabinoids absorbed into the lymphatic system first.
CB2 receptors in the periphery = EVOO as a carrier
Now.... for anything other than liver disease you want EVOO. You want as much time for those cannabinoids to be circulating as possible, so you're gonna use some competitive inhibition as well, intending to overwhelm the liver enzymes with amentoflavone and apigenin, taken 30 minutes before the cannabinoid dose.
Toss some mango in there for receptor demethylation, and wash it all down with a cup of green tea.
In case you're watching over my cosmic shoulder mon ami. Wouldn't want to forget the lessons of the shaman.
- Thread starter
- #345
Wow! That's some rabbit hole. Lol! I found myself reading Nathan Russo's famous research paper "A Tale of Two Cannabinoids."
Gotta stop and go to bed. Walking inn the morning with my friend.
Gotta stop and go to bed. Walking inn the morning with my friend.
- Thread starter
- #346
Send to
J Autism Dev Disord. 2013 Nov;43(11):2686-95. doi: 10.1007/s10803-013-1824-9.
Cannabinoid receptor type 2, but not type 1, is up-regulated in peripheral blood mononuclear cells of children affected by autistic disorders.
Siniscalco D1, Sapone A, Giordano C, Cirillo A, de Magistris L, Rossi F, Fasano A, Bradstreet JJ, Maione S, Antonucci N.
Author information
Abstract
Autistic disorders (ADs) are heterogeneous neurodevelopmental disorders arised by the interaction of genes and environmental factors. Dysfunctions in social interaction and communication skills, repetitive and stereotypic verbal and non-verbal behaviours are common features of ADs. There are no defined mechanisms of pathogenesis, rendering curative therapy very difficult. Indeed, the treatments for autism presently available can be divided into behavioural, nutritional and medical approaches, although no defined standard approach exists. Autistic children display immune system dysregulation and show an altered immune response of peripheral blood mononuclear cells (PBMCs). In this study, we investigated the involvement of cannabinoid system in PBMCs from autistic children compared to age-matched normal healthy developing controls (age ranging 3-9 years; mean age: 6.06 ± 1.52 vs. 6.14 ± 1.39 in autistic children and healthy subjects, respectively). The mRNA level for cannabinoid receptor type 2 (CB2) was significantly increased in AD-PBMCs as compared to healthy subjects (mean ± SE of arbitrary units: 0.34 ± 0.03 vs. 0.23 ± 0.02 in autistic children and healthy subjects, respectively), whereas CB1 and fatty acid amide hydrolase mRNA levels were unchanged. mRNA levels of N-acylphosphatidylethanolamine-hydrolyzing phospholipase D gene were slightly decreased. Protein levels of CB-2 were also significantly increased in autistic children (mean ± SE of arbitrary units: 33.5 ± 1.32 vs. 6.70 ± 1.25 in autistic children and healthy subjects, respectively). Our data indicate CB2 receptor as potential therapeutic target for the pharmacological management of the autism care.
PMID: 23585028 DOI: 10.1007/s10803-013-1824-9
[Indexed for MEDLINE]
"Our data indicate CB2 receptor as potential therapeutic target for the pharmacological management of the autism care."
The relevance of this: if you're targeting the CB2 receptors you're targeting the immune cells and you want olive oil as the carrier to get cannabinoids absorbed into the lymphatic system first.
CB2 receptors in the periphery = EVOO as a carrier
Now.... for anything other than liver disease you want EVOO. You want as much time for those cannabinoids to be circulating as possible, so you're gonna use some competitive inhibition as well, intending to overwhelm the liver enzymes with amentoflavone and apigenin, taken 30 minutes before the cannabinoid dose.
Toss some mango in there for receptor demethylation, and wash it all down with a cup of green tea.
In case you're watching over my cosmic shoulder mon ami. Wouldn't want to forget the lessons of the shaman.
The real significance here is to go with CBD for anything dealing with the immune system, and anything activating primarily eCB2Rs.
Goodnight.
- Thread starter
- #347
Anna Marie on coconut oil for topicals
WHY EXTRA VIRGIN OVER REFINED?
To be clear: Refined oils aren’t necessarily exposed to chemicals—some may be treated with only heat or clays to filter and purify the oil. But on the whole, virgin oils are the least processed of all available oils, maintain more of the natural components, and usually test higher for things like antioxidants and nutrients.
In a 2009 study, for example, researchers compared the antioxidant capacity of virgin coconut oil with oil that had been refined, bleached, and deodorized. They found that the virgin coconut oil had a higher antioxidant capacity than oil that had been significantly processed.
what is fractionated oil?
One thing about extra virgin coconut oil: it’s solid at room temperature. That’s why we warn you that our Coconut Body & Face Oil may solidify at cooler temperatures, and why our Coconut Honey Mask is more like butter than cream. It’s easy to soften it—a few minutes in hot water or warmed between your hands or fingers will do the trick.
For our facial oils, though, we needed a type of coconut oil that would do three things:
WHY WE USE FRACTIONATED COCONUT OIL
Fractionated coconut oil, also called “liquid coconut oil,” fit our requirements. Basically, it is a form of the oil that has had the long-chain fatty acids removed via hydrolysis and steam distillation. Just this one change makes the oil liquid at room temperature, and extends the product’s shelf life.
There are three basic types of fatty acids—short-chain, medium-chain, and long-chain. Long-chain fatty acids have more carbon atoms, which means they require higher temperatures to melt. Fats that are solid at room temperature have longer chain lengths—thus, coconut oil.
HOW DOES IT BECOME LIQUID?
One of the fatty acids that’s mostly removed in fractionation is lauric acid—a type of “healthy” saturated fat found in high quantities in coconut and palm kernel oils. It’s a great fat to have in skin care because it’s so moisturizing and cleansing. Removing it, though, gives us the liquid product we need to use in items like our Herbal Facial Oils.
WHAT'S LEFT?
Once the lauric acid and other long-chain fatty acids are gone, you’re still left with a lot of good stuff, including medium chain fatty acids like capric, caprylic, myristic and palmitic, all of which retain their super-moisturizing capabilities. You also still have the natural antioxidants, which protect from environmental stressors, and nutrients like vitamins A, C, and E, which help maintain a tighter, firmer look.
THE PERFECT CARRIER OIL
Fractionated coconut oil is completely soluble with other oils, which makes it the perfect carrier oil, capable of ushering other oils into the skin. It’s also extremely light, and absorbs quickly into the skin without clogging pores. You’re left with a soft, smooth feeling that won’t exacerbate oiliness or leave you feeling greasy
WHY EXTRA VIRGIN OVER REFINED?
To be clear: Refined oils aren’t necessarily exposed to chemicals—some may be treated with only heat or clays to filter and purify the oil. But on the whole, virgin oils are the least processed of all available oils, maintain more of the natural components, and usually test higher for things like antioxidants and nutrients.
In a 2009 study, for example, researchers compared the antioxidant capacity of virgin coconut oil with oil that had been refined, bleached, and deodorized. They found that the virgin coconut oil had a higher antioxidant capacity than oil that had been significantly processed.
what is fractionated oil?
One thing about extra virgin coconut oil: it’s solid at room temperature. That’s why we warn you that our Coconut Body & Face Oil may solidify at cooler temperatures, and why our Coconut Honey Mask is more like butter than cream. It’s easy to soften it—a few minutes in hot water or warmed between your hands or fingers will do the trick.
For our facial oils, though, we needed a type of coconut oil that would do three things:
- Mix well with the other oils in the product.
- Easily and quickly penetrate the skin.
- Moisturize without clogging pores.
WHY WE USE FRACTIONATED COCONUT OIL
Fractionated coconut oil, also called “liquid coconut oil,” fit our requirements. Basically, it is a form of the oil that has had the long-chain fatty acids removed via hydrolysis and steam distillation. Just this one change makes the oil liquid at room temperature, and extends the product’s shelf life.
There are three basic types of fatty acids—short-chain, medium-chain, and long-chain. Long-chain fatty acids have more carbon atoms, which means they require higher temperatures to melt. Fats that are solid at room temperature have longer chain lengths—thus, coconut oil.
HOW DOES IT BECOME LIQUID?
One of the fatty acids that’s mostly removed in fractionation is lauric acid—a type of “healthy” saturated fat found in high quantities in coconut and palm kernel oils. It’s a great fat to have in skin care because it’s so moisturizing and cleansing. Removing it, though, gives us the liquid product we need to use in items like our Herbal Facial Oils.
WHAT'S LEFT?
Once the lauric acid and other long-chain fatty acids are gone, you’re still left with a lot of good stuff, including medium chain fatty acids like capric, caprylic, myristic and palmitic, all of which retain their super-moisturizing capabilities. You also still have the natural antioxidants, which protect from environmental stressors, and nutrients like vitamins A, C, and E, which help maintain a tighter, firmer look.
THE PERFECT CARRIER OIL
Fractionated coconut oil is completely soluble with other oils, which makes it the perfect carrier oil, capable of ushering other oils into the skin. It’s also extremely light, and absorbs quickly into the skin without clogging pores. You’re left with a soft, smooth feeling that won’t exacerbate oiliness or leave you feeling greasy
- Thread starter
- #348
For later data collection:
Thoughts drive emotion.
Emotion drives biology.
Biology drives action.
Your thoughts create your reality.
Thoughts can be deliberate. It's your choice what emotion they trigger.
Now....find the papers that explain the ECS and how it influences the limbic and hormonal systems. Look for links that are associated with eCBR concentrations or lack thereof.
Your thoughts create the reality you experience. Perception is what this is all about. Your perception, your translation of the world around you and what you see ahead, determines the level of fear you allow to enter the formula.
Less fear = more momentum and broader experience filled with joyful expectation.
More fear = disease, be it mental, emotional, or physical, and a life filled with frustration, confusion, drama, and chaos.
All determined by the thoughts you choose, or allow to be expressed by default.
See...I can't for the life of me understand what's so difficult to understand here. This is simple biology, which is why I put it here instead of on the Path thread, although it'll find its way there too.
What you think is what you're feeling, what you're vibrating. In a universe where it's known that like attracts like, why wouldn't you choose to be as f'n happy as you could muster? Hell yeah, I'll continue to engage the universe in play every day for the rest of my long and joyful life. I can't see it being any other way.
Thoughts drive emotion.
Emotion drives biology.
Biology drives action.
Your thoughts create your reality.
Thoughts can be deliberate. It's your choice what emotion they trigger.
Now....find the papers that explain the ECS and how it influences the limbic and hormonal systems. Look for links that are associated with eCBR concentrations or lack thereof.
Your thoughts create the reality you experience. Perception is what this is all about. Your perception, your translation of the world around you and what you see ahead, determines the level of fear you allow to enter the formula.
Less fear = more momentum and broader experience filled with joyful expectation.
More fear = disease, be it mental, emotional, or physical, and a life filled with frustration, confusion, drama, and chaos.
All determined by the thoughts you choose, or allow to be expressed by default.
See...I can't for the life of me understand what's so difficult to understand here. This is simple biology, which is why I put it here instead of on the Path thread, although it'll find its way there too.
What you think is what you're feeling, what you're vibrating. In a universe where it's known that like attracts like, why wouldn't you choose to be as f'n happy as you could muster? Hell yeah, I'll continue to engage the universe in play every day for the rest of my long and joyful life. I can't see it being any other way.
- Thread starter
- #349
This looks like a good place to begin breaking it down. First, the source material: The Abstract
Revolution in GPCR signalling: opioid receptor heteromers as novel therapeutic targets: IUPHAR Review 10
Wakako Fujita, Ivone Gomes, and Lakshmi A Devi
Additional article information
Abstract
GPCRs can interact with each other to form homomers or heteromers. Homomers involve interactions with the same receptor type while heteromers involve interactions between two different GPCRs. These receptor–receptor interactions modulate not only the binding but also the signalling and trafficking properties of individual receptors.
Opioid receptor heteromerization has been extensively investigated with the objective of identifying novel therapeutic targets that are as potent as morphine but without the side effects associated with chronic morphine use. In this context, studies have described heteromerization between the different types of opioid receptors and between opioid receptors and a wide range of GPCRs including adrenoceptors, cannabinoid, 5-HT, metabotropic glutamate and sensory neuron-specific receptors.
Recent advances in the field involving the generation of heteromer-specific reagents (antibodies or ligands) or of membrane-permeable peptides that disrupt the heteromer interaction are helping to elucidate the GPCRs can interact with each other to form homomers or heteromers.
Homomers involve interactions with the same receptor type while heteromers involve interactions between two different GPCRs. These receptor–receptor interactions modulate not only the binding but also the signalling and trafficking properties of individual receptors.
Opioid receptor heteromerization has been extensively investigated with the objective of identifying novel therapeutic targets that are as potent as morphine but without the side effects associated with chronic morphine use. In this context, studies have described heteromerization between the different types of opioid receptors and between opioid receptors and a wide range of GPCRs including adrenoceptors, cannabinoid, 5-HT, metabotropic glutamate and sensory neuron-specific receptors.
Recent advances in the field involving the generation of heteromer-specific reagents (antibodies or ligands) or of membrane-permeable peptides that disrupt the heteromer interaction are helping to elucidate the physiological role of opioid receptor heteromers and the contribution of the partner receptor to the side effects associated with opioid use. For example, studies using membrane-permeable peptides targeting the heteromer interface have implicated μ and δ receptor heteromers in the development of tolerance to morphine, and heteromers of μ and gastrin-releasing peptide receptors in morphine-induced itch.
In addition, a number of ligands that selectively target opioid receptor heteromers exhibit potent antinociception with a decrease in the side effects commonly associated with morphine use. In this review, we summarize the latest findings regarding the biological and functional characteristics of opioid receptor heteromers both in vitro and in vivo.
From ProfOfPot:
CB1 & Opioid Receptors
The μ opioid receptor (μOR) is activated by opiates such as morphine and is largely responsible for their pain-blocking effects.
Multiple studies (see above) have shown that CB1 and μOR form a heteromer with unique properties. Activation of either receptor allows signaling, but activation of both receptors in the heteromer causes a decrease in signaling. This heteromer may also be involved in developing tolerance to the pain-blocking effects of opiates.
The CB1 receptor is expressed in the same cortical neurons as another opioid receptor subtype – the δ opioid receptor (δOR). The δOR is able to reduce anxiety and depressive-like behavior. Low δOR activity may be responsible for anxiety and depression in people with chronic pain.
Many interactions have been demonstrated between CB1 and δOR – they tend to inhibit each others function. If the CB1 receptor is missing, then δOR activity is higher, and vice versa. So it was not much surprise when it was discovered that these receptors interact directly by forming a heteromer.
This heteromer was increased in the brains of rats with neuropathic pain, which may contribute to low δOR signaling and anxiety. However, low doses of a CB1 agonist were able to increase δOR activity through a conformation change of the dimer.
I'm going walking at 7 AM, which means it's nite-nite time for me. I'll pick this up tomorrow. It's actually starting to make sense. Lol!
Revolution in GPCR signalling: opioid receptor heteromers as novel therapeutic targets: IUPHAR Review 10
Wakako Fujita, Ivone Gomes, and Lakshmi A Devi
Additional article information
Abstract
GPCRs can interact with each other to form homomers or heteromers. Homomers involve interactions with the same receptor type while heteromers involve interactions between two different GPCRs. These receptor–receptor interactions modulate not only the binding but also the signalling and trafficking properties of individual receptors.
Opioid receptor heteromerization has been extensively investigated with the objective of identifying novel therapeutic targets that are as potent as morphine but without the side effects associated with chronic morphine use. In this context, studies have described heteromerization between the different types of opioid receptors and between opioid receptors and a wide range of GPCRs including adrenoceptors, cannabinoid, 5-HT, metabotropic glutamate and sensory neuron-specific receptors.
Recent advances in the field involving the generation of heteromer-specific reagents (antibodies or ligands) or of membrane-permeable peptides that disrupt the heteromer interaction are helping to elucidate the GPCRs can interact with each other to form homomers or heteromers.
Homomers involve interactions with the same receptor type while heteromers involve interactions between two different GPCRs. These receptor–receptor interactions modulate not only the binding but also the signalling and trafficking properties of individual receptors.
Opioid receptor heteromerization has been extensively investigated with the objective of identifying novel therapeutic targets that are as potent as morphine but without the side effects associated with chronic morphine use. In this context, studies have described heteromerization between the different types of opioid receptors and between opioid receptors and a wide range of GPCRs including adrenoceptors, cannabinoid, 5-HT, metabotropic glutamate and sensory neuron-specific receptors.
Recent advances in the field involving the generation of heteromer-specific reagents (antibodies or ligands) or of membrane-permeable peptides that disrupt the heteromer interaction are helping to elucidate the physiological role of opioid receptor heteromers and the contribution of the partner receptor to the side effects associated with opioid use. For example, studies using membrane-permeable peptides targeting the heteromer interface have implicated μ and δ receptor heteromers in the development of tolerance to morphine, and heteromers of μ and gastrin-releasing peptide receptors in morphine-induced itch.
In addition, a number of ligands that selectively target opioid receptor heteromers exhibit potent antinociception with a decrease in the side effects commonly associated with morphine use. In this review, we summarize the latest findings regarding the biological and functional characteristics of opioid receptor heteromers both in vitro and in vivo.
From ProfOfPot:
CB1 & Opioid Receptors
The μ opioid receptor (μOR) is activated by opiates such as morphine and is largely responsible for their pain-blocking effects.
Multiple studies (see above) have shown that CB1 and μOR form a heteromer with unique properties. Activation of either receptor allows signaling, but activation of both receptors in the heteromer causes a decrease in signaling. This heteromer may also be involved in developing tolerance to the pain-blocking effects of opiates.
The CB1 receptor is expressed in the same cortical neurons as another opioid receptor subtype – the δ opioid receptor (δOR). The δOR is able to reduce anxiety and depressive-like behavior. Low δOR activity may be responsible for anxiety and depression in people with chronic pain.
Many interactions have been demonstrated between CB1 and δOR – they tend to inhibit each others function. If the CB1 receptor is missing, then δOR activity is higher, and vice versa. So it was not much surprise when it was discovered that these receptors interact directly by forming a heteromer.
This heteromer was increased in the brains of rats with neuropathic pain, which may contribute to low δOR signaling and anxiety. However, low doses of a CB1 agonist were able to increase δOR activity through a conformation change of the dimer.
I'm going walking at 7 AM, which means it's nite-nite time for me. I'll pick this up tomorrow. It's actually starting to make sense. Lol!
- Thread starter
- #350
"GPCRs can interact with each other to form homomers or heteromers. Homomers involve interactions with the same receptor type while heteromers involve interactions between two different GPCRs. These receptor–receptor interactions modulate not only the binding but also the signalling and trafficking properties of individual receptors."
What this says to me as someone who understands a little about cannabis, is that these interactions, very likely driven by the terpenes that accompany the phytocannabinoids, will determine which cannabinoid is needed to create the specific vibration the cell needs in the quest for homeostasis.
Does that make any sense m'lord?
Once again, headed to bed. Lol!
What this says to me as someone who understands a little about cannabis, is that these interactions, very likely driven by the terpenes that accompany the phytocannabinoids, will determine which cannabinoid is needed to create the specific vibration the cell needs in the quest for homeostasis.
Does that make any sense m'lord?
Once again, headed to bed. Lol!
overlord
Well-Known Member
Tennessee Tim
Well-Known Member
Great stuff Sue! Amazing, how we ignorant old hippies, stoned our way to survival with a resilience to so many things that afflict mankind! Learning a bit about the science involved, is like learning about the secret life of a super hero! You walk away with a yeah , I knew that! Thanks Sue, again, for your work to help us understand more of the known facts! I have been continuing to treat myself for RA, Digestive disorders, skin lesions, pre-cancers(skin) and anxiety/adhd ,with good results continuing! I use smoke, vape, topical rub (I make it with my oil,coconut oil and filtered fresh beeswax-I call it my magic bus relaxation rub), butter and other edibles.) My RA is still in remission, now verified by MD blood test! Over a full year of test (2) indicate (high normal range for the blood factors they test for. Even most of the swelling/disfigurement of certain knuckles on my hands have improved! I have not been on prescribed RA meds for almost three years! Best of all, I have been able to go back to work (part time),after being forced to retire a few years ago! I discovered accidentally and from reading your post, that just smoking it was not going to work as well as a multi pronged attack on certain serious afflictions! When I began to eat cannabis oils, butter, cookies and etc. even in very small doses at times or taking frequent week long breaks , I started to not just treat the discomforts, but the actual disorders themselves! I have always been convinced that using the natural occurring THC and CBD together is more effective for healing than CBD alone! Anyway,it is at least more relaxing and enjoyable to medicate! Missed talking to you the last year or so, love ya Sue!
- Thread starter
- #353
Tim.....
God, it's good to hear from you. 
I read your little testimony to a diversified regimen with interest, because I'm moving to New Orleans, and in doing so I'm leaving behind a senior group that I've been enjoying lunch with for the last few months. When I joined their group I was thinkin' I'd be living here for years, and I started giving away pain creams and oils. Now, all of a sudden I'm relocating to a dream situation, but that means I won't be here to guide them through proper use of a cannabis topical - which means encouraging them to use them more often.
One of the group has RA and her hands in particular are problematic for her. I've been telling her that continuious application of her oils and body butter will counter the effects of RA over time. When I see her on Friday I'm gonna read this to her in hopes that it sinks in that when I say "Use it every time anything goes 'Ouch!' " I mean it.
I've missed you too Tim. Back to work, eh? I stay busy around here. A job would just get in the way. Lol!
Tennessee Tim
Well-Known Member
Great to be back! I thank Teddy for his mercy and forgiving an old fool for my late night slips of the tongue! I will attempt to be more mindful, so I can stick around! I have huge gardens and acres of grass, a wood shop, small wooden sailing boat and plenty to stay busy with, but not the financial resources to live off of SS, so working for a paycheck 4 days a week IS IMPORTANT!. The little bit of money I make off of watermelons and etc. will not pay the bills! Encourage your friends to use the topical's, two or more times a day, a little dab will do ya! Yes, I may dab,vape or smoke and eat a little butter made from high quality oil. I use about an aspirin size pill of butter, made with 2 grams of oil per stick of butter. i have friends, who are treating themselves now for several conditions, with very small doses of butter, about the size of a BB once or twice a day! I do take frequent breaks from eating the cannabis for a week or so. I still have some pains but the severe pain and constant nature of the pains from the past are relieved now. BTW, the cookies are extremely popular with my senior friends,many just eat a quarter of a cookie and report their problems melt away! I am, because of my age, no longer eligible for Disability payments, but for now, I am not disabled anymore, just slowed down a bit. Cannabis topical's and edibles get most of the credit for this improvement, from me. Has my MD, who was anti cannabis, rethinking his previous opposition to Cannabis, I think! KEEP ON DOING WHAT YOUR DOING FOR ALL OF US, SWEET SUE, KNOWLEDGE IS POWERFUL!
- Thread starter
- #355
Powerful testimony Tim.
I haven't introduced my senior friends to edibles yet, but I'm planning to set up a meeting with some daughters who may be courageous enough to go through the trouble. The medical cannabis program wasn't put together with the interests of the seniors living off SS in mind. It'll be up to us to educate them and up to them to make the choices that offer relief. I was the one who offered the topicals to them. I'll have to find a way to keep them supplied if I can't get a family member to step in behind me. For them I'll do it, but I'll be cautious about being so generous to such a large group again. Live and learn, eh? Lol! The universe provides. It hasn't caused a hardship.
So much of what they're taking has dangerous side effects. I take nothing but cannabis. They noticed the difference early on, and you know me. Lol! Can't stay quiet about cannabis therapeutics.
Tim, I don't think I could be comfortable not doing what I do here. This is the most fun I've had in years.
Tennessee Tim
Well-Known Member
I know what you mean Sue, about supporting a large group! I have been, at times, stretched to provide edibles and topical's to my friends! Some of whom could not afford to pay for RX's or cannabis. The time involved in making the "remedies" can be difficult to find sometimes. But , what is exciting about cannabis treating many peoples health issues is that it seems to be effective for some maladies in very small doses! I know two friends {besides myself) who have some disorder of the digestive track that report improvements in their symptoms with doses of only a small pill of quality cannabis butter taken twice daily! I told them try an aspirin size but after a while they both told me they used from BB size to a small green pea size pill with ongoing success in relieving their issues. One , a life long friend, has some Colitus and regular bleeding from the rectum, before we began a treatment program. He also had anxiety attached to these issues ,as well. He reports to me he no longer has the bleeding and he is very happy about that! Also his Colitus is not bothering him any longer and he feels better, with less anxiety to boot! He also smokes pot a bit (but not regularly), but that never helped clear up these problems. I did recommend for him to eat 1/3-1/2 cannabis cookie(2 grams very good oil to one stick butter= 26 cookies) once or twice a week the first few weeks. He takes" breaks" eating the cannabis of 4-5 days every three or four weeks, as I told him I do. His condition improved rapidly, and after a couple months he was and still is greatly improved as mentioned(no bleeding/stomach aches etc.). He does see a MD and has had all the diagnostic test done, but no Pharmaceuticals that MD's prescribed had helped him more than minor relief of discomforts temporarily over the course of quite a few years or ever stopped the bleeding!. It never ceases to amaze me when someone finds the key to relieving their malady in cannabis! I think it may help them, but never do I expect the kind of results I see so often. Of course a few find a reason to not follow a regimen or when they are not completely healed with a few doses, give up. Your live with joy medicine, is also a very powerful tool, if one can overcome their anxiety enough to accept happiness, it will help them to heal themselves! Easier for me to teach, than to do that ! Wow, Sue! Just so much to tell you about my circle of seniors (Primarily) and their reasons for cannabis therapy and how it is working for them! When something strikes me as remarkable I will pass it on. So far, my associates/friends report effective therapy for Anxiety, Anger Management, Appetite, Colitus, Rectal Bleeding, RA , Parkinson's, Chronic pain, Crohn's Disease, Migraines, Nausea, Insomnia and Irritable Bowel Syndrome, that I can remember! Please forgive me for rambling!
Tennessee Tim
Well-Known Member
PS. Sue ,hope your "Dream" relocation to New Orleans goes smooth!
- Thread starter
- #358
Oh Tim, this energy stream is unlike any I’ve experienced, and at 64 I’m ripe for the change and all the wonder that lies ahead.
I learned a couple secrets over the time I’ve been dancing among you. I now know with unshakable certainty they we were designed/evolved to spontaneously heal, and it’s the blocking of the energy flow in the body caused by tension that’s getting in the way.
I’m ahead of the pack in my belief, and we lack empirical data to back it up, but the piece I found at profofpot on homomeres and heteromeres locked it in for me.
I also learned that expectation determines outcome. Now, most people read that and think “I should lift my expectations.” I read that and shift my expectations upwards. I trained myself through very methodical steps to default to joy. IMO this is the vibration that leads the ECS most consistently back to health and wholeness.
The most important lesson I’ve learned is that we don’t need cannabis at all. It’s tremendously helpful in aligning an overstressed ECS and the reserve troops are likely greeted with a systemic sigh of relief, but I believe it’s the expectation that’s doing the heavy work.
If you have strong intention that vibration will cause the proper signaling to occur, if only because your belief relieves enough tension for signaling to be carried out more efficiently.
Joy is the operational mode we were intended for. The further away from joy you allow yourself to roam the sicker you’ll become, first emotionally, then mentally, then, finally, physical illness becomes the norm as fear takes the upper hand.
It appears that part of my darma is to spread the word that joy heals, and offer steps to cultivate a healing internal conversation.
I know how to manifest my dreams Tim, and NOLA is the latest in a string of desires I’ve had drop right in front of me. Turns out that unbounded joy pulls more to entertain and delight. Like attracts like in this universe. I don’t even entertain thoughts that the move will be anything short of breathtakingly smooth sailing.
- Thread starter
- #359
Tim, I reformatted this for easier readibity. There was too much in there that was going to be overlooked because many of our members have difficulty with masses of characters and walk in by. I knew you’d be ok with this.
”I know what you mean Sue, about supporting a large group! I have been, at times, stretched to provide edibles and topical's to my friends! Some of whom could not afford to pay for RX's or cannabis.
The time involved in making the "remedies" can be difficult to find sometimes. But , what is exciting about cannabis treating many peoples health issues is that it seems to be effective for some maladies in very small doses!
I know two friends {besides myself) who have some disorder of the digestive track that report improvements in their symptoms with doses of only a small pill of quality cannabis butter taken twice daily! I told them try an aspirin size but after a while they both told me they used from BB size to a small green pea size pill with ongoing success in relieving their issues.
One , a life long friend, has some Colitus and regular bleeding from the rectum, before we began a treatment program. He also had anxiety attached to these issues as well. He reports to me he no longer has the bleeding and he is very happy about that!
Also his Colitus is not bothering him any longer and he feels better, with less anxiety to boot! He also smokes pot a bit (but not regularly), but that never helped clear up these problems. I did recommend for him to eat 1/3-1/2 cannabis cookie(2 grams very good oil to one stick butter= 26 cookies) once or twice a week the first few weeks.
He takes" breaks" eating the cannabis of 4-5 days every three or four weeks, as I told him I do. His condition improved rapidly, and after a couple months he was and still is greatly improved as mentioned(no bleeding/stomach aches etc.). He does see a MD and has had all the diagnostic test done, but no Pharmaceuticals that MD's prescribed had helped him more than minor relief of discomforts temporarily over the course of quite a few years or ever stopped the bleeding!.
It never ceases to amaze me when someone finds the key to relieving their malady in cannabis! I think it may help them, but never do I expect the kind of results I see so often. Of course a few find a reason to not follow a regimen or when they are not completely healed with a few doses, give up.
Your live with joy medicine, is also a very powerful tool, if one can overcome their anxiety enough to accept happiness, it will help them to heal themselves! Easier for me to teach, than to do that !
Wow, Sue! Just so much to tell you about my circle of seniors (Primarily) and their reasons for cannabis therapy and how it is working for them! When something strikes me as remarkable I will pass it on.
So far, my associates/friends report effective therapy for Anxiety, Anger Management, Appetite, Colitus, Rectal Bleeding, RA , Parkinson's, Chronic pain, Crohn's Disease, Migraines, Nausea, Insomnia and Irritable Bowel Syndrome, that I can remember! Please forgive me for rambling!” - Tennessee Tim
”I know what you mean Sue, about supporting a large group! I have been, at times, stretched to provide edibles and topical's to my friends! Some of whom could not afford to pay for RX's or cannabis.
The time involved in making the "remedies" can be difficult to find sometimes. But , what is exciting about cannabis treating many peoples health issues is that it seems to be effective for some maladies in very small doses!
I know two friends {besides myself) who have some disorder of the digestive track that report improvements in their symptoms with doses of only a small pill of quality cannabis butter taken twice daily! I told them try an aspirin size but after a while they both told me they used from BB size to a small green pea size pill with ongoing success in relieving their issues.
One , a life long friend, has some Colitus and regular bleeding from the rectum, before we began a treatment program. He also had anxiety attached to these issues as well. He reports to me he no longer has the bleeding and he is very happy about that!
Also his Colitus is not bothering him any longer and he feels better, with less anxiety to boot! He also smokes pot a bit (but not regularly), but that never helped clear up these problems. I did recommend for him to eat 1/3-1/2 cannabis cookie(2 grams very good oil to one stick butter= 26 cookies) once or twice a week the first few weeks.
He takes" breaks" eating the cannabis of 4-5 days every three or four weeks, as I told him I do. His condition improved rapidly, and after a couple months he was and still is greatly improved as mentioned(no bleeding/stomach aches etc.). He does see a MD and has had all the diagnostic test done, but no Pharmaceuticals that MD's prescribed had helped him more than minor relief of discomforts temporarily over the course of quite a few years or ever stopped the bleeding!.
It never ceases to amaze me when someone finds the key to relieving their malady in cannabis! I think it may help them, but never do I expect the kind of results I see so often. Of course a few find a reason to not follow a regimen or when they are not completely healed with a few doses, give up.
Your live with joy medicine, is also a very powerful tool, if one can overcome their anxiety enough to accept happiness, it will help them to heal themselves! Easier for me to teach, than to do that !
Wow, Sue! Just so much to tell you about my circle of seniors (Primarily) and their reasons for cannabis therapy and how it is working for them! When something strikes me as remarkable I will pass it on.
So far, my associates/friends report effective therapy for Anxiety, Anger Management, Appetite, Colitus, Rectal Bleeding, RA , Parkinson's, Chronic pain, Crohn's Disease, Migraines, Nausea, Insomnia and Irritable Bowel Syndrome, that I can remember! Please forgive me for rambling!” - Tennessee Tim
Tennessee Tim
Well-Known Member
Thanks for the assist Sue, it helps to be legible! I wish I could maintain more positivity/joy like you Sue! I agree it helps overcome our greatest pains and puts sorrow into perspective! My Dad was like you Sue! He overcame terminal cancer without radiation or chemotherapy in 1989, he went salmon fishing in Alaska instead of back to the hospital! He passed away in 2009 at two weeks shy of 94 years. Many golf games and fishing trips later!