Generally speaking gig's comments above I agree with. Differences in opinion may lay around the 10 plant plus comment however. For sake of argument, let's consider end size first. Now, if it were a commercial grower with 30+ plants lets say, and growing them indoors, vert lighting, 4 foot tall or more, then it's going to be a shit ton of work. Yet I still believe they will see a substantial yield increase.
However, if it were 100 2L hempys, veged 10 days then I totally agree it wouldn't be worth the effort, but I have no experience with hempys either, just a calculated guess.
I also agree that an aversion to work or a bad back may not be conducive to this.
The initial longer time to harvest I pay no mind to at all because I always have a new grow behind the current grow. But that's not the case with everyone.
As far as your plant being ready to defoliate, you can go for it. But be forewarned, if you're in a small cab/closet, you may overgrow it too.