Litmis, I also used the capsules as suppositories, with no problem. I don't own a mold.
A Base Treatment Regimen For Cancer
- Thread starter CajunCelt
- Start date
Arctic Bowl
Well-Known Member
Great evening to all, have a thought regarding DMSO and it's ability to cross the blood brain barrier and bring other things right along with it. Would it be viable to mix DMSO with CCO, topically applied this mixture ( not sure at what ratio) to a clean area of skin and have the THC/CBD cross over with the DMSO? From what we understand (not everything by any stretch) that not everything can or will cross over with DMSO dependent on many factors like molecular size etc. etc. but "if" this is a way to cross the blood brain barrier with CCO to aid the fight of cancer what are the do's and dont's. has it been tried?
Blessed Buds our friends and be well
Blessed Buds our friends and be well
Great evening to all, have a thought regarding DMSO and it's ability to cross the blood brain barrier and bring other things right along with it. Would it be viable to mix DMSO with CCO, topically applied this mixture ( not sure at what ratio) to a clean area of skin and have the THC/CBD cross over with the DMSO? From what we understand (not everything by any stretch) that not everything can or will cross over with DMSO dependent on many factors like molecular size etc. etc. but "if" this is a way to cross the blood brain barrier with CCO to aid the fight of cancer what are the do's and dont's. has it been tried?
Blessed Buds our friends and be well
From what I understand (a quick google), the endocannabonoid receptors are in various cell-wall membranes with their 'active' side facing 'out' into the blood stream. Having DMSO open a pathway through the cell walls, even if it worked, would put the cannabis cannabinoids on the wrong side of the cell wall to mate up with the endocannabinoid receptors.
Arctic Bowl
Well-Known Member
Thank you Rad
Trying to get this understood, by no means disagreeing or being disrespectful but we understood DMSO actually enters the bloodstream as well as cells where applied? When CCO is tacked it enters the bloodstream as we understand and are trying to understand why it wouldn't do the same with the DMSO if it truly crosses the blood brain barrier?
Blessed Buds our friend and be well
Thank you Rad
Trying to get this understood, by no means disagreeing or being disrespectful but we understood DMSO actually enters the bloodstream as well as cells where applied? When CCO is tacked it enters the bloodstream as we understand and are trying to understand why it wouldn't do the same with the DMSO if it truly crosses the blood brain barrier?
Blessed Buds our friend and be well
Glad you aren't trying to be disagreeable, I'm not either. It's an interesting question and a good thought experiment
I don't have access to the medical experimental databases since I retired from the univeristy computers. The experiments I have seen with DMSO and CB1 receptors have used DMSO to transport the target 'problem' inside the cells and the test substances testing the CB1 receptors ability to mediate the 'answer' inside the cells (under various inhibition and disinhibition scenarios.)
As I understand it, which is not well, DMSO crosses many barriers, topically it crosses the skin (epithelial tissue) and the blood brain barrier(also epithelial tissue.) The crossing seems to be bi-directional, (in) from the outer surface of the skin into cells, and (out) from inside cells into the bloodstream.
DMSO acts as a carrier, transporting other things with it through the tissue barriers.
Above are my assumptions about DMSO, please correct me if they are wrong or questionable.
Your question used the words blood brain barrier and topical, so I picture a pathway of DMSO and CCO travel of : topical application, epithelial cells, bloodstream, circulation, blood brain barrier, cerebral spinal fluid, nerve and brain cells. The DMSO isn't following a map so would probably also travel lymph pathways and enter other cells not on the targetted path.
Issue #1: Is CCO able to travel bidirectionally through cellular walls along with the DMSO? I don't know the answer. Is CCO hydrophobic? Is it structurally shaped right?
Issue #2: By crossing the blood brain barrier, is the DMSO going to the right place? This was the question I was trying to answer. Where and why will the DMSO release the CCO so that it binds to CB1 and other cannabinoid receptors.
Assumption about CCO treatment : The blood stream is the right place for CCO to go.
CB1 and other cannabinod receptors occur on various organs, immune cells, brain cells, and spinal cord cells. As CCO cirulates through the blood stream it has a potential to bind with CB1 and other cannabinoid receptors of immune cells circulating through the blood and cells adjacent to the blood wherever the blood flows. Cannabinoids can attach to CB1 receptors on the brain or spinal column cellular walls and do their stuff just fine while circulating through the blood stream.
On each lap around the bloodstream, some of the cannabinoids (about 10%) will pass through the liver and potentially be tranformed (THC to THCA?) and become more recreational than medicinal. The liver is cleaning the blood. As a byproduct, we get more stoned.
The potential problem I see with DMSO as a delivery vehicle is the question of how much of the cannabinoids will be released into the blood stream to do their job? Inside a cell, the cannabinoids can't do their job. Floating around in cerebral spinal fluid cannabinoids can't do their job. They need to attach to the CB1 and other cannabinoid receptors on the outer surface of the cells and blood brain barrier, not the inside surfaces.
May you and yours have a blessed New Year.
KingstonRabbi
Well-Known Member
Thanks Rad and Arctic Bowl. This is truly a mind-bending question on how to get a hydrophobic CCO molecule to travel through a mainly water-based solution (i.e. blood stream or lymph system) to the cell so it can bind to receptor. My understanding in that this is what the lecithin/longchained fatty acid mixture is for in biobomb recipe. I looked into this earlier and made my brain hurt. What happens at the cellular level involves too many terms I don't understand even when I have the definition. 
My gut feeling is that DMSO is overkill. It will transport just about anything you come in contact with and takes it everywhere, so I've steered clear of it. No science there, just caution that may or may not be warranted.
As far as crossing blood-brain barrier mangos do the trick well. And they smell and taste a lot better than DMSO.
My gut feeling is that DMSO is overkill. It will transport just about anything you come in contact with and takes it everywhere, so I've steered clear of it. No science there, just caution that may or may not be warranted.
As far as crossing blood-brain barrier mangos do the trick well. And they smell and taste a lot better than DMSO.
Arctic Bowl
Well-Known Member
Thank you again Rad much much much appreciated. We are "trying" to understand some of this cell "stuff" and are now like KingstonRabbi our heads are swimming. It's a tuff one to wrap our heads around and finding those like yourself that do understand this, somewhat genius like, we want to get a grasp on it but holly cow it's like trying to grab a greased pig. You can see it but holding on to it might not happen lol. Not even sure why it feels important but it does so the journey is beginning and now wish I would have studied science harder instead of just doing what it took to pass
Ever thought of giving cell class for dummies? We look up definitions to more words in articles we read and spend more time doing that then reading the articles, lol or feels that way anyhow. When you have to look up definitions for the definitions it's time consuming and then still might not know what it means
Thank you Rad
Blessed Buds our friend and be well, Happy New Years to you and yours.
Ever thought of giving cell class for dummies? We look up definitions to more words in articles we read and spend more time doing that then reading the articles, lol or feels that way anyhow. When you have to look up definitions for the definitions it's time consuming and then still might not know what it means
Thank you Rad
Blessed Buds our friend and be well, Happy New Years to you and yours.
Thank you again Rad much much much appreciated. We are "trying" to understand some of this cell "stuff" and are now like KingstonRabbi our heads are swimming. It's a tuff one to wrap our heads around and finding those like yourself that do understand this, somewhat genius like, we want to get a grasp on it but holly cow it's like trying to grab a greased pig. You can see it but holding on to it might not happen lol. Not even sure why it feels important but it does so the journey is beginning and now wish I would have studied science harder instead of just doing what it took to pass
Ever thought of giving cell class for dummies? We look up definitions to more words in articles we read and spend more time doing that then reading the articles, lol or feels that way anyhow. When you have to look up definitions for the definitions it's time consuming and then still might not know what it means
Thank you Rad
Blessed Buds our friend and be well, Happy New Years to you and yours.
I have no cellular expertise. My cellular science knowledge is based on reading Scientific American cover to cover throughout the 70s and early 80s
and speed reading studies about cannabis since my wife started using it medicinally 3 years ago. The actual chemistry is way over my head. 
Hello Cajuncelt!
My father has primary liver cancer. So we started with cannabis or rather biomix (coconut oil dilluted with Cannabis + Lecithin).
In case of liver we have to insure creative inhibtion and I am pretty confused, because I read that it is not goog to take Cannabis on "empty liver" and it recommended to take some fats (f.e. coconut oil) 30 to 40 minutes before biomix...but in case of liver this is not enough and we need also apigenin and ametoflavone.
But I found few posts where stands that in case of liver coconut oil is contraindicatory...and also aou posted that the coconut oil shoud be avoided.
Could you please explain me why and what is correct?
Currently my father has following protocol:
-1 teaspoon coconut oil
-apigenin 50 mg
-ametoflavonn 200 mg
-mango
Please help!!!
Thanks!!!!
My father has primary liver cancer. So we started with cannabis or rather biomix (coconut oil dilluted with Cannabis + Lecithin).
In case of liver we have to insure creative inhibtion and I am pretty confused, because I read that it is not goog to take Cannabis on "empty liver" and it recommended to take some fats (f.e. coconut oil) 30 to 40 minutes before biomix...but in case of liver this is not enough and we need also apigenin and ametoflavone.
But I found few posts where stands that in case of liver coconut oil is contraindicatory...and also aou posted that the coconut oil shoud be avoided.
Could you please explain me why and what is correct?
Currently my father has following protocol:
-1 teaspoon coconut oil
-apigenin 50 mg
-ametoflavonn 200 mg
-mango
Please help!!!
Thanks!!!!
Hello libra. Cajun's opening his new clinic right now, so he may be unavailable for a short time. Maybe we help clear this up.
First off, take a deep breath.... nice and slow........ There, feels a little better now, doesn't it? Alright now, about that confusion....
There's so much information on these pages, and in our desperation it can be easy to feel overwhelmed. When you feel like that, call out for help, and one of us will come running to assist. We'll help you take that breath and find clarity.
The coconut oil is what's called for with liver cancer. It's a medium-chained fatty acid, which means it will be sent to the liver for metabolization on the first pass through the system. With just about all other cancers, this is something we want to avoid, so we choose long-chained fatty acids like olive oil that will bypass the first pass through the liver, to be absorbed into the lymphatic system.
But with liver cancer, the cells we're targeting are in that same dangerous realm that will create the enzymes that metabolize the very component we need, the cancer-killing THC. Competitive inhibition through the use of amentoflavone or apigenin (or both) are absolutely necessary. Those enzymes will be so busy when the THC hits that they won't have enough time to get to the cannabinoids before a significant number can find attachment points on tumor cells.
The tablespoon of coconut oil, taken at the same time as the supplements, which are strong cancer fighters in their own right, will set the stage for successful administration of your cannabinoid therapy.
Your plan looks solid. Allow yourself the wash of gratitude that your instincts were good. We have a Study Hall where we congregate to explore cannabis oils and the development of effective protocols. There's a link at the bottom of my signature line. Please feel free to stop and engage us on your behalf. We're a happy crew and we may be able to help you take more than that one breath and find a way to feel more positive about your father's situation.
Right about now, if your father knew you were here, he'd be overwhelmed with pride. I allowed myself to feel that for him. I don't think he'll mind.
I jumped in here earlier to leave a quick response to a cry for help on my way to an engagement. I just finished reading the previous conversation. Gentleman, I'm a bit breathless and more than a little excited. All this curious brainstorming can only end up somewhere good.
That thought filled me with glee.
A couple thoughts:
* Getting past the BBB is part of the evolutionary design of cannabinoids. Lecithin and carrier oils speed that process up in ways I don't comprehend fully yet, but we're getting closer. That gives me great hope.
* The message Dr. William Courtney is putting forth offers his belief that the acid cannabinoids, those naturally occurring in the plant, have the ability to cross the cell membrane and act directly upon the inner cellular structures.
He's out there on his own edge, and he makes a strong argument.
* Rad made a strong point about the indiscriminate nature of this untested additive.
I love the way these discussions get the creative juices going. Thank you gentleman for being so engaging. Food for thought.
That thought filled me with glee.
A couple thoughts:
* Getting past the BBB is part of the evolutionary design of cannabinoids. Lecithin and carrier oils speed that process up in ways I don't comprehend fully yet, but we're getting closer. That gives me great hope.
* The message Dr. William Courtney is putting forth offers his belief that the acid cannabinoids, those naturally occurring in the plant, have the ability to cross the cell membrane and act directly upon the inner cellular structures.
He's out there on his own edge, and he makes a strong argument.
* Rad made a strong point about the indiscriminate nature of this untested additive.
I love the way these discussions get the creative juices going. Thank you gentleman for being so engaging. Food for thought.
Thank you so much for the answer and such encouraging words!
I was so confused and uncertain about coconut oil.
I will join your study hall and contribute with my experience.
Another question that I have is herxing. I know this is from case to case different…but I wonder if this can happen after two three weeks of consuming biomix…namely my father consumes biomix already three weeks. We started with small dose…and each day we increased little bit and right now he is on 200 mg/d, the goal is 300 mg/d…but now he has some new symptoms: flue, frequent urination, headache, mood swings…could it hexing???
I was so confused and uncertain about coconut oil.
I will join your study hall and contribute with my experience.
Another question that I have is herxing. I know this is from case to case different…but I wonder if this can happen after two three weeks of consuming biomix…namely my father consumes biomix already three weeks. We started with small dose…and each day we increased little bit and right now he is on 200 mg/d, the goal is 300 mg/d…but now he has some new symptoms: flue, frequent urination, headache, mood swings…could it hexing???
The symptoms certainly strongly suggest herxing. If this is the case you have more reason to be hopeful and maybe a little excited. It won't last long. Stay hydrated. This is of primary importance. All those broken down cells need washed out of the system. Drink more water.
I'll have you know I took a drink myself as I wrote that. It suggests that you've reached the point where the cannabinoids are having an appreciable effect. I don't know about you, but that made me wake right up and shout
Quietly though. I don't want to wake the neighbors. Lol! When are his next labs? You'll want to take a close look for changes.
Gonna make another try for bed.
- Thread starter
- #1,217
CajunCelt
New Member
I hope that he has herxing.
On 24th januray he has CT scan...
I will inform you about the results.
In between thanks!!!
Hi all. Popping in for a bit. Holiday & clinic hangover right now.
He's not herxing. Or at least, that's not the typical symptoms of herxing. Has he possibly started consuming a strong Sativa med?
Any other pharmaceuticals?
What and where did the term "biomix" come from? The dispensary?
Hey you hard-working man. Happy New Year. Having fun?
I've a quick question on the herxing call. All four symptoms he listed there were included in the list we'd posted earlier on herxing. I'm a bit confused. What did we miss?
Hi,
Biomix stands for cannabis oil mixed with carrier oil (in this case coconut oil) and lecithin. It´s not from drugstore, a friend of mine who has experience, prepared it for me, but to be true I do not know which strains he used exactly. I will ask. Each of these capsules has ca. 65 mg CCO.
In parallel or rather three weeks ago my father was in hospital and got his therapy TACE:
“Transcatheter arterial chemoembolization (also called transarterial chemoembolization or TACE) is a minimally invasive procedure performed in interventional radiology to restrict a tumor's blood supply. . Small embolic particles coated with chemotherapeutic drugs are injected selectively through a catheter into an artery directly supplying the tumor. These particles both block the blood supply and induce cytotoxicity, attacking the tumor in several ways.”
I think this therapy has also an influence, and I hope that cannabis or rather biomix can help. Do you have similar experience where people were treated with TACE and in parallel they had cannabis, too?
How does the herxing look like?
Biomix stands for cannabis oil mixed with carrier oil (in this case coconut oil) and lecithin. It´s not from drugstore, a friend of mine who has experience, prepared it for me, but to be true I do not know which strains he used exactly. I will ask. Each of these capsules has ca. 65 mg CCO.
In parallel or rather three weeks ago my father was in hospital and got his therapy TACE:
“Transcatheter arterial chemoembolization (also called transarterial chemoembolization or TACE) is a minimally invasive procedure performed in interventional radiology to restrict a tumor's blood supply. . Small embolic particles coated with chemotherapeutic drugs are injected selectively through a catheter into an artery directly supplying the tumor. These particles both block the blood supply and induce cytotoxicity, attacking the tumor in several ways.”
I think this therapy has also an influence, and I hope that cannabis or rather biomix can help. Do you have similar experience where people were treated with TACE and in parallel they had cannabis, too?
How does the herxing look like?
Knowledge is power. This is possibly the best description of the biological process I'll come across. I've been meaning to get this posted for way too long. May it help you understand what madness your cells decided to partake in, and then you can envision how your protocol will lead you to healing.
DEVELOPMENT OF CANCER AND CHARACTERISTICS OF CANCER CELLS
From "Natural Compounds in Cancer Therapy" by John Boik, copyright 2001
Imagine a healthy tissue containing thousands of cells. Every cell serves the greater good, which is the continuation of a person's life. Each cell is programmed so that when the cell is old or no longer needed, it dies a peaceful and timely death. This death is called apoptosis. All cells are in communication, which allows for the smooth repair and replacement of tissues and other aspects of cell behavior. Communication takes place either indirectly, via exchange of messager compounds such as hormones and growth factors, or directly, via cell-to-cell contact. Contact allows cells to respond to the "feel" of neighboring cells, via cell adhesion molecules, and to exchange messenger molecules through cell-to-cell portals called cell junctions. With the help of proper communication, appropriate cells proliferate when new cells are needed, and when enough new cells have been produced, cell division stops.
Cancer cells are the descendants of a normal cell in which something has gone wrong. In this normal cell, some kind of internal or external stress causes a mix-up in its genetic code (it's DNA). This event is said to "initiate" the cell to a precancerous state. After its DNA has been damaged, the cell withdrawals from close communication with its neighboring cells. Interrupted cell-to-cell communication is a common result of DNA damage or other forms of cellular damage. Separated from the regulatory controls of its community, it is now at the mercy of its environment. Let us say that the environment around this cell contains a promoting agent, which is a compound that stimulates cell proliferation. In response to the promoting agent, this precancerous cell divides to produce daughter cells, and these daughter cells divide to produce more daughter cells, and so on. All are proliferating only in response to the promoting agent. The promoting agent may be a chemical foreign to the body, or it could come from a natural process like inflammation. One day, the worst occurs. The genetic instabilities passed down through the generations finally result in one cell that becomes capable of self-stimulation, and on this day, an autonomous cancer cell is born. This cell no longer requires the the promoting agent to stimulate its proliferation. The role of the promoting agent is made obsolete by the cell's ability to make proteins such as growth factors that stimulate proliferation.
This original cancer cell divides to produce daughter cells, these cells also divide, and soon there is a population of cancer cells. As they divide they develop malignant characteristics, such as the ability to invade and metastasize. They also develop other characteristics that help assure survival, for example, the ability to evade the immune system, to mutate when faced with adverse conditions, and to induce the growth of new blood vessels through the process called angiogenesis. The development of these characteristics marks the third stage of carcinogenesis, the first two stages being initiation and promotion respectively. In this book, I use the term progression to refer to both the third stage of carcinogenesis proper and to the entire postpromotion period of the cancer's life. This correctly implies that progression is an ongoing, evolving process.
Compared to normal cells, cancer cells have lost touch with their neighboring cells, their community purpose, and even largely with one another. They are a race of self-serving, easily adaptable cells, whose proliferation continues at the slightest provocation. They use more than their fair share of resources, live longer than their fair share of time, and produce more than their share of offspring. In short, they exhibit the two deadly characteristics of cancer: uncontrolled proliferation and uncontrolled spread.
DEVELOPMENT OF CANCER AND CHARACTERISTICS OF CANCER CELLS
From "Natural Compounds in Cancer Therapy" by John Boik, copyright 2001
Imagine a healthy tissue containing thousands of cells. Every cell serves the greater good, which is the continuation of a person's life. Each cell is programmed so that when the cell is old or no longer needed, it dies a peaceful and timely death. This death is called apoptosis. All cells are in communication, which allows for the smooth repair and replacement of tissues and other aspects of cell behavior. Communication takes place either indirectly, via exchange of messager compounds such as hormones and growth factors, or directly, via cell-to-cell contact. Contact allows cells to respond to the "feel" of neighboring cells, via cell adhesion molecules, and to exchange messenger molecules through cell-to-cell portals called cell junctions. With the help of proper communication, appropriate cells proliferate when new cells are needed, and when enough new cells have been produced, cell division stops.
Cancer cells are the descendants of a normal cell in which something has gone wrong. In this normal cell, some kind of internal or external stress causes a mix-up in its genetic code (it's DNA). This event is said to "initiate" the cell to a precancerous state. After its DNA has been damaged, the cell withdrawals from close communication with its neighboring cells. Interrupted cell-to-cell communication is a common result of DNA damage or other forms of cellular damage. Separated from the regulatory controls of its community, it is now at the mercy of its environment. Let us say that the environment around this cell contains a promoting agent, which is a compound that stimulates cell proliferation. In response to the promoting agent, this precancerous cell divides to produce daughter cells, and these daughter cells divide to produce more daughter cells, and so on. All are proliferating only in response to the promoting agent. The promoting agent may be a chemical foreign to the body, or it could come from a natural process like inflammation. One day, the worst occurs. The genetic instabilities passed down through the generations finally result in one cell that becomes capable of self-stimulation, and on this day, an autonomous cancer cell is born. This cell no longer requires the the promoting agent to stimulate its proliferation. The role of the promoting agent is made obsolete by the cell's ability to make proteins such as growth factors that stimulate proliferation.
This original cancer cell divides to produce daughter cells, these cells also divide, and soon there is a population of cancer cells. As they divide they develop malignant characteristics, such as the ability to invade and metastasize. They also develop other characteristics that help assure survival, for example, the ability to evade the immune system, to mutate when faced with adverse conditions, and to induce the growth of new blood vessels through the process called angiogenesis. The development of these characteristics marks the third stage of carcinogenesis, the first two stages being initiation and promotion respectively. In this book, I use the term progression to refer to both the third stage of carcinogenesis proper and to the entire postpromotion period of the cancer's life. This correctly implies that progression is an ongoing, evolving process.
Compared to normal cells, cancer cells have lost touch with their neighboring cells, their community purpose, and even largely with one another. They are a race of self-serving, easily adaptable cells, whose proliferation continues at the slightest provocation. They use more than their fair share of resources, live longer than their fair share of time, and produce more than their share of offspring. In short, they exhibit the two deadly characteristics of cancer: uncontrolled proliferation and uncontrolled spread.