- Thread starter
- #121
Can you explain the difference between sublingual intake compared to ingestion as it relates to the liver? I thought the first pass conversion by the liver to 11-hydroxy THC was primarily responsible for the euphoria rather than a fast-track to the brain.
Sublingual administration is a faster pathway for delta-9 THC’s entry to the brain where it can activate the massive number of eCB1 receptors, causing euphoria. Once any of that unused delta-9 reaches the liver it would be converted to 11-hydroxy, which is 4 - 10 times more psychoactive.
When you inhale it’s the same type of high, just faster, since the cannabinoids go directly from the lungs to the brain before going on to the liver.
Any THCa or delta-9 THC through the gut that makes it to the liver will be converted into 11-hydroxy.
Did I clear that up for you Shed?
Has anybody tried making dust from a cob? I bet that would be good.
That‘s been the way I and many other members use our cobs all along. I keep a supply in the drawer at all times.
It’s along the same lines, since cobbing decarbs through the fermentation process. Cob dust is more intense.