Dear all,
I have decided to move toward rectal administration. My mum cannot tolerate anymore the side effects (being so high). I kindly ask if you could please answer the following questions, I have so many doubts:
1) I think I was not clear when I reported the prescription here. The twe listed were 2 types of cannabis not 2 types of oils. The type of cannabis are produced in The Netherlands and can be found here (
Google Translate ). I called the pharmacy, they told me the procedure they use to make the oil. They follow the paper of Citti et al, 2016 (
Medicinal cannabis: Principal cannabinoids concentration and their stability evaluated by a high performance liquid chromatography coupled to diode... - PubMed - NCBI). They use ethyl alcohol as a solvent. The final concentrations are:
THC: 311 mg/ml
CBD: 134 mg/ml
THC-A: 76 mg/ml
CBD-A: 84 mg/ml
Therefore, since each syringe is 5 ml (which is 5 grams since the density is about 1), I have 311 mg of TCB in it. And since each syringe has about 30 drops and I give her 4 drops per day (at once) she takes about 311/30*4=41 mg/l of THC per day in a single time before going to sleep. This gets her pretty high already. What do you think about it?
2) When you speak of "1 gram/day of cannabis oil" what do you mean? Do you mean 1 gram of THC? Or of oil (i.e. THC,CBD,THC-A,CBD-A, plus terpenes plus god knows what else is left after alcohol evaporation, maybe some water)?.
3) Given that the previous dose makes her pretty high, what dose should I use daily in the rectal suppositories?
4) Which type of suppositories and applicator do you suggest? We have never done this, we really appreciate any detailed suggestion/procedure.
5) Sue you say: Properly inserted the suppositories offer a sense of wellbeing, not overwhelming euphoria. What does it mean? Can you be more specific about the technique we should use?
6) how many mg of omega 3 should we use? You said 1000 IU a day, I have never heard of IU and google does not help. I will give it 40 mins before the cannabis together with 80 mg Apinenin, Is it ok once per day before sleeping?
Thank you again a lot
V
1) If I understand you correctly you have syringes with 5 ml of an excellently balanced oil for the treatment. Also, you're only dosing once a day? This part must change. I understand why you'd choose bedtime for this, to limit the euphoric concerns, but you're leaving the tumor cells free from the cannabinoid bombardment necessary to tear tumor cells apart or keep them from spreading.
We want continuious cannabinoid presence, and that's done best with suppositories, administered at least three to four times a day. KR knows more about the dosing schedule to treat cancer with the BioBombs.
2) One gram a day is one gram of oil, the oil you have mixed. In the syringe that's measured, as you know, in ml. With the BioBomb formulations we base it all on the ratio of carrier oil to cannabis oil, so a 10:1 mix would be 10 parts of carrier oil (olive oil if you can) for every 1 part of cannabis oil, and the liquid sunflower lecithin to top it off.
The interest in concentrated cannabis oils became big due to the relentless efforts of Rick Simpson. Without adequate support from the medical community he was left to his own devices to figure out what dose would most consistently bring a body back into homeostasis. He settled on one gram a day of CCO, or RSO as much of the world knows it. What we're learning as more clinical data funnels in from a more responsive medical community is that it takes much less than that 1 gram a day to effect natural healing and balance out damaged bodies.
The policy now is to start low and gently increase doses to fit the individual patient, hoping to have some imaging and lab work to drive the protocol.
3) My gut feeling is still to go with the 10:1 capsules and start with three doses a day. If she tolerates this well, go to four doses as quickly as possible. The BioBomb mix will potentiate the cannabinoids beyond what she's getting now. When you're ready to make another batch go to the 5:1.
One syringe, converted to BioBombs will make 55 capsules at the 10:1 strength. When you calculate that out you'll see it's only 5.65 mg of THC per capsule, but don't let that shake your confidence. You're increasing the bioavailability, and one of the reasons the oil she's prescribed is so high in cannabinoids is that the understanding is it'll go through the gut and only a small percentage will get into the system. BioBombs get into the system much more efficiently.
4) You can use a capsule as a suppository. Insert with the edging pointing away from the body for a more gentle insertion. If you insert too deeply it goes to the liver and euphoria ensues. We're trying to avoid that, so you don't want to insert any deeper than the first joint of the finger used to push the suppository in. Cajun has detailed instructions on this. Please read them carefully.
CajunCelt on suppositories
As to practical information, this can be messy, so have a towel nearby to mop up. Women detest being messy with our bodies, so anything to help her feel more comfortable will be greatly appreciated. It really is as simple as it sounds; lie on the side, lift the opposite cheek to expose the entry point, insert, and clench the cheeks together to help melt the capsule and contain any leaking. Wait patiently about 10-20 minutes and clean up. Panty liners come in handy for between doses. There will be a certain amount of leakage, be assured of this.
The empty capsule most often works its way out, making that panty liner even more valuable.
As an alternative, the oil can be pulled up into 1 ml syringes. This is actually much easier to deal with for some. I've been considering this option myself, if only to get the experience. In this case, insert the tip just into the opening and plunge slowly, so as not to squirt it too deep.
5) You're trying to keep the oil at the end of the colon, where it gets absorbed directly into the system, bypassing the first-pass through the liver. Applied in this manner the body responds with what I equate to a sigh of relief, a sense that all's well within me and the universe. It's really low-level euphoria, akin to what anandamide creates within you naturally.
Inserted more deeply the oil gets absorbed into the liver directly and you experience increased euphoria as the liver enzymes busily convert delta-9 THC to 11-hydroxy THC. This can't hurt your mother, but it's the euphoria she deals with now, and she's stated that it's a bit much. Get the insertion right and you have happy healing without disconcerting euphoria.
It's not difficult to get the depth of insertion correct. You want to be right inside the opening, one joint deep.
6) Sorry about that confusion. I was raised by a mother who used vitamins to the extreme, and they get listed as International Units (IU). Omega-3 fish oils are sold in mg. you want at least 1000 mg of omega-3s a day.
I hope I got it all V. If not, please ask again. You're doing really well. My best to your mother.
If you need 4 or 5 doses of each it's easier to do it all at once.
