Been Awhile everyone, I Hope all is well and it is great to see the dedication of many the individuals on here helping others with the info and research they post. I have a question on Swollen prostate and blood clots in urine. My brother was not prescribed a follow up medication for his blood and swollen prostate in the urine issue which was caused by a incompetent doctor who did not properly read the information given by a specialist. The issue now is ,the medicine that he initially was supposed to be prescribed 2 months ago will take apparently 4-6 months to start being effective.I was thinking about giving him some bio-bombs or suppositories to help reducing the swelling of the prostate and inflammation and possibly curing this issue. Would just like to know if anyone has had experience with the swollen prostate & cco combo? What method they recommend?.. Have a CBD blueberry headband 1:1 and cannatonic along with numerous Good Medical THC strains. Thanks!
A Base Treatment Regimen For Cancer
- Thread starter CajunCelt
- Start date
This must have been why you've been on my mind so much, because it started before I watched the video by the Australian medical advocacy group.
Hello friend.
Yeah.... we missed you too. 
I'd think this would be a great response to his discomfort. I have no experience with this condition, but I've been studying a lot about pain and the ECS, and in particular how cannabis fits into the mix. I'd start with the 1:1 and if that doesn't do it increase both in equal volume until he gets the relief he seeks. It may result in more healing than anticipated.
Whatever you do, please let us know the outcome. We offer a lot of advice around here, and I assume much gets used. What feedback we do get helps with the next case. I suspect we'll find its taking less cannabinoids than we thought it would take in most cases.
I've developed a special interest in pain management with cannabis that created a desire for more feedback. You were standing right there when it went full-blown. Lol!
Thanks a lot Sweetum's. Think i will try to see if he will do suppositories along with a 20-1 bio bombs 5-6 times a day , with apigenin and amentoflavone. Does either one of those have any side effects for ppl with high blood pressure , high sugar levels, heart medication that anyone is aware of?, 13 different pills in total...I know ,fair amount of medication. He is a regular smoker of Cannabis thou and has had plenty of experience with the party Life.
OtherMother
Active Member
Hi guys, I wanted to update you on our situation. We've had our little three year old girl who has acute myeloid leukaemia in the central nervous system on an oral cannabinoid regimen for about a month now, currently up to 300mg of CBD/day and 80mg of THC/day, spaced out over the day. We have had real problems getting liquid lecithin delivered for making a bio bomb, partly because of the awful weather in the UK these past few days. Having ordered nearly two weeks ago, it still hasn't arrived – I'm hoping tomorrow or Monday. Weird how easy by comparison to get full-spec cannabis oil even though it's illegal here. We're currently giving her the THC in coconut oil, having made up that batch before getting advice from your site last month. To try and mitigate we are giving her mango, green tea and olive oil each day to demethylate the receptors and giving her coconut oil in milk a half hour before each cannabis dose to try and distract the liver.
But meanwhile, we got bad news from the doctors today: the cancer cell count in her central nervous system is way up on two weeks ago when they last gave her a shot of cytarabine and hydrocortisone into the area. They say the disease is now effectively resistant to this treatment. On Monday they plan to give her a shot of the heavy duty stuff: these two drugs plus a shot of methotrexate. They hope that this will buy her a little time, and they might follow up with one or two similar doses in the coming weeks.
But basically they're saying we're close to having completely run out of conventional treatment options. She's also spent the last 36 hours throwing up about every 15 minutes for reasons no one has figured out – maybe viral but the doctors think probably related to the cancer – albeit they find no signs of increased cranial pressure or tumours in the brain.
I know we need to get the daily THC dose higher and switch to a bio-bomb in a more suitable carrier oil for oral ingestion. I know Rabbi previously suggested suppositories – lingual really doesn't feel like an option – and not forgetting Sue's hug regimen. Is there anything else you would recommend we try to turn this around? We're in a really tight corner here and I'm really worried she's not going to make it...
But meanwhile, we got bad news from the doctors today: the cancer cell count in her central nervous system is way up on two weeks ago when they last gave her a shot of cytarabine and hydrocortisone into the area. They say the disease is now effectively resistant to this treatment. On Monday they plan to give her a shot of the heavy duty stuff: these two drugs plus a shot of methotrexate. They hope that this will buy her a little time, and they might follow up with one or two similar doses in the coming weeks.
But basically they're saying we're close to having completely run out of conventional treatment options. She's also spent the last 36 hours throwing up about every 15 minutes for reasons no one has figured out – maybe viral but the doctors think probably related to the cancer – albeit they find no signs of increased cranial pressure or tumours in the brain.
I know we need to get the daily THC dose higher and switch to a bio-bomb in a more suitable carrier oil for oral ingestion. I know Rabbi previously suggested suppositories – lingual really doesn't feel like an option – and not forgetting Sue's hug regimen. Is there anything else you would recommend we try to turn this around? We're in a really tight corner here and I'm really worried she's not going to make it...
Bluenoser
Well-Known Member
OtherMother,
My heart goes out to you, what your going through is terrible, and should never happen in this world, it makes what I am going through look like a joke.
I hope you don't mind (I don't know what religion you are) but I would like to say a prayer for you, your family and your daughter. Hope that's OK.
Hang in there, the people here are absolutely awesome, and I trust the info and advice that they are giving out here.
God bless.
My heart goes out to you, what your going through is terrible, and should never happen in this world, it makes what I am going through look like a joke.
I hope you don't mind (I don't know what religion you are) but I would like to say a prayer for you, your family and your daughter. Hope that's OK.
Hang in there, the people here are absolutely awesome, and I trust the info and advice that they are giving out here.
God bless.
OtherMother
Active Member
Hi again
Oh one more query to add to the above. On suppositories, I'm doing the maths: KingstonRabbi you recommended size 3 gel caps, but so far as I can see they have a capacity of 0.3ml. I calculate that I'll need 1.5ml space per dose of cannabinoids - 0.5ml for THC and 1ml for CBD, since the CBD I've been using is a 10% oil. I don't know much about suppositories but I assume giving her five at once is not going to work. Can kids take bigger suppositories than size 3 or what's my best solution? Even 000s don't look like they hold enough capacity for one shot...
Oh one more query to add to the above. On suppositories, I'm doing the maths: KingstonRabbi you recommended size 3 gel caps, but so far as I can see they have a capacity of 0.3ml. I calculate that I'll need 1.5ml space per dose of cannabinoids - 0.5ml for THC and 1ml for CBD, since the CBD I've been using is a 10% oil. I don't know much about suppositories but I assume giving her five at once is not going to work. Can kids take bigger suppositories than size 3 or what's my best solution? Even 000s don't look like they hold enough capacity for one shot...
I'll let KR get back to you on the suppositories. I'm sorry to hear they've put her through such hell. Hang in there. At a time like this all we can do is send you loving energy.
My thoughts went to flipping the cannabinoid count with suppositories, regardless of how many you do. I'd only do one at a time and space them through the day to get the daily dose in.
Anyone else think this would be a good idea? My studies, and in particular my attention to Mara Gordon suggests that if one cannabinoid dominance isn't doing the job then flip the ratio and see how that goes.
You might want to contact Aunt Zelda's and see what they suggest. They have the clinical experience we don't.
OtherMother
Active Member
Awesome Thanks SweetSue. I watched a video with Mara Gordon on your recommendation and she had some interesting views I hadn't heard before. I'd love to hear anyone's feedback:
1. Your tolerance collapses after 72 hours without cannabinoids and you need to go back to very low doses when you resume treatment.
2. It's better to take THC and CBD separately at different times of the day – the interactions of these agonists and antagonists potentially weaken their anti-cancer effect if you do them simultaneously. I've read a paper before that showed that adolescents damage their brains with very high repeated doses of THC but that when they did it 50-50 with CBD there was no ill effect – feels like MG contradicted this?
3. If you take cannabinoids and opiates at the same time, their interaction makes the opiate effect much stronger. The answer is to take half the opiate dose.
4. It's age that matters for dosing, not weight.
5. The younger the patient, the higher the dose should broadly be – albeit everyone has very individual therapeutic dose and it varies with different cancers.
6. Once you get up to a dose of about 30mg-35mg of THC, you can start titrating up more aggressively.
7. If a cancer is in the CNS, which Heidi's is, you usually want to have a THC/CBD ratio that's much more THC. I dunno whether she would say leukaemia is an exception to this?
8. Avoid antioxidants: these prevent the cancer cells from oxidising, which is necessary in their destruction, so it undermines what you're trying to achieve. Examples she gave included vitamin C and blueberry extract (though some blueberries or whatever was okay if you don't go crazy).
9. Taking chemo drugs and cannabinoids at the same time tends to make them both work more effectively. I wondered about this. Someone else has told me that the necrotic effect of chemo drugs means they kill both healthy and cancerous cells, and that this prevents the body from having enough healthy cells to be able to heal itself. And therefore you are better off stopping chemo (and even maybe other conventional meds) and going all out on the cannabinoids. Any thoughts?
10. Tinctures are bad news because they either contain alcohol or glycerin which are both full of sugar, which as we know feeds cancer cells.
11. She was quite down on suppositories except for cancers of the colon etc, saying she hadn't seen them have anything like the success rate. Would she not have heard of biobombs or even had issues with them? The vid is I think a few months old, so maybes this area is just developing really fast?
Whoah wasn't quite meaning to get past about five, but oh well, I hope it's interesting.
OM
1. Your tolerance collapses after 72 hours without cannabinoids and you need to go back to very low doses when you resume treatment.
2. It's better to take THC and CBD separately at different times of the day – the interactions of these agonists and antagonists potentially weaken their anti-cancer effect if you do them simultaneously. I've read a paper before that showed that adolescents damage their brains with very high repeated doses of THC but that when they did it 50-50 with CBD there was no ill effect – feels like MG contradicted this?
3. If you take cannabinoids and opiates at the same time, their interaction makes the opiate effect much stronger. The answer is to take half the opiate dose.
4. It's age that matters for dosing, not weight.
5. The younger the patient, the higher the dose should broadly be – albeit everyone has very individual therapeutic dose and it varies with different cancers.
6. Once you get up to a dose of about 30mg-35mg of THC, you can start titrating up more aggressively.
7. If a cancer is in the CNS, which Heidi's is, you usually want to have a THC/CBD ratio that's much more THC. I dunno whether she would say leukaemia is an exception to this?
8. Avoid antioxidants: these prevent the cancer cells from oxidising, which is necessary in their destruction, so it undermines what you're trying to achieve. Examples she gave included vitamin C and blueberry extract (though some blueberries or whatever was okay if you don't go crazy).
9. Taking chemo drugs and cannabinoids at the same time tends to make them both work more effectively. I wondered about this. Someone else has told me that the necrotic effect of chemo drugs means they kill both healthy and cancerous cells, and that this prevents the body from having enough healthy cells to be able to heal itself. And therefore you are better off stopping chemo (and even maybe other conventional meds) and going all out on the cannabinoids. Any thoughts?
10. Tinctures are bad news because they either contain alcohol or glycerin which are both full of sugar, which as we know feeds cancer cells.
11. She was quite down on suppositories except for cancers of the colon etc, saying she hadn't seen them have anything like the success rate. Would she not have heard of biobombs or even had issues with them? The vid is I think a few months old, so maybes this area is just developing really fast?
Whoah wasn't quite meaning to get past about five, but oh well, I hope it's interesting.
OM
Hi - a couple of thoughts as I also went to Mara Gordon's for advice - a bit different for me as a woman in my 60's, not a young child. I first tried CBD oil - all I had at the time, and in nothing like the dose I then thought was required - while having chemo; I had my lowest (in fact, unexpectedly low) CA-125 cancer marker count at this time. With hindsight I realise that the CBD probably WAS an effective dose, and that it probably DID support chemo; the old idea of 1gm a day has been modified and my 200mg was probably a therapeutic dose for someone of my age. My oncologist was OK with CBD in support of chemo, but Mara Gordon's did warn that the cannabis and the chemo drugs might compete and checked this out for me - I purchased a consultation and this was a useful part of it.
Latterly I tried fasting whilst undergoing chemo - 1 or 2 days before, the day of chemo itself and 1 day after; the idea being that, as you say, chemo targets active cells and cancer cells cannot shut down, whereas a fast makes your healthy cells react as if to a time of low nutrition, and they cut back their activity to the minimum and so keep their heads below the parapet. I know this works - when I didn't fast, or was a bit sloppy about it, the side effects were much worse that when I did. I don't know whether this is doable with a young child, though.
Do take a look at the ketogenic diet for cancer - it mimics fasting but with the aim of starving out the cancer whilst allowing you to eat - mainly fats, a little bit of protein and a miniscule helping of carbs. Mara Gordon's people also recommend this. I have to say I find it hard, and am following an adapted version and trusting cannabis to do the real job. (I have now left chemo - it and the cancer had reached stalemate). Try the book "Keto for Cancer" by Miriam Kalamian. Not just a fad - the science holds up.
Lastly - CBD and THC together - my protocol from MGs is to keep them separate - but I am not sure if this is for the best either. It is convenient in that I can take THC at night and CBD in the day; but I think this is based on a theory, not a proven fact. (The more experienced people on here will have more information on it). There was a study done on mice which might be relevant - I will try and find it.
Latterly I tried fasting whilst undergoing chemo - 1 or 2 days before, the day of chemo itself and 1 day after; the idea being that, as you say, chemo targets active cells and cancer cells cannot shut down, whereas a fast makes your healthy cells react as if to a time of low nutrition, and they cut back their activity to the minimum and so keep their heads below the parapet. I know this works - when I didn't fast, or was a bit sloppy about it, the side effects were much worse that when I did. I don't know whether this is doable with a young child, though.
Do take a look at the ketogenic diet for cancer - it mimics fasting but with the aim of starving out the cancer whilst allowing you to eat - mainly fats, a little bit of protein and a miniscule helping of carbs. Mara Gordon's people also recommend this. I have to say I find it hard, and am following an adapted version and trusting cannabis to do the real job. (I have now left chemo - it and the cancer had reached stalemate). Try the book "Keto for Cancer" by Miriam Kalamian. Not just a fad - the science holds up.
Lastly - CBD and THC together - my protocol from MGs is to keep them separate - but I am not sure if this is for the best either. It is convenient in that I can take THC at night and CBD in the day; but I think this is based on a theory, not a proven fact. (The more experienced people on here will have more information on it). There was a study done on mice which might be relevant - I will try and find it.
Another thing - point 10 - tinctures and alcohol - surely the highly distilled alcohol used is sugar free?
And 9 - Stopping chemo. It depends why it is being used. It saved my life originally, but latterly I have felt I have been given it because routine medical has nothing else to give me and can't just step back and do nothing. Maybe I - we as patients - create this attitude because we demand and expect help. Any gains are very very temporary, in my case - but I think this is commonplace with a lot of cancers. So, it buys you time; but you have to make that difficult call for yourself; is it still helping or is it doing too much damage to be worth it? And have I something that will take its place?
And 9 - Stopping chemo. It depends why it is being used. It saved my life originally, but latterly I have felt I have been given it because routine medical has nothing else to give me and can't just step back and do nothing. Maybe I - we as patients - create this attitude because we demand and expect help. Any gains are very very temporary, in my case - but I think this is commonplace with a lot of cancers. So, it buys you time; but you have to make that difficult call for yourself; is it still helping or is it doing too much damage to be worth it? And have I something that will take its place?
In matters of cannabinoids and cancer treatment I pretty much defer to Mara. She's an engineer by nature and training, and has used that inclination to create a beautifully elegant data collection method. In my opinion she's made a profound impact on how we think about cannabinoid therapies.
Let me see what I can share:
Absolutely. We have a thread for helping each other through the sentization process that begins with a 72-hour abstinence of cannabis, followed by a gentle and thoughtful re-introduction of your cannabis medication. It typically results in the effective dose being cut in half.
THC is not a strong antagonist for the CB receptors, meaning it doesn't make a strong connection. CBD will "soften" the effects of THC, and Mara's contention is that she's seen an improvement in the efficiency of the meds when you seperate the doses of dominant cannabinoids by at least two hours. In her experience this keeps the doses lower.
When you work with the ECS a gentle approach will many times bring the same results, over a longer timeframe, but with less stress to the ECS. Get too much THC in particular in circulation and you run the risk of overwhelming the system and causing some receptors to go offline. Then you have to ramp up the doses to get the same effect. Cannabis is an out-for-pocket expense. Keeping doses down is always a popular option from the perspective of cost. Biobombs do this wonderfully
I'm personally not as concerned about this until we cross into cancer treatment, although I will confess that I use that two-hour window for my own meds. Mara has years of experience and data to back up her contentions. I'd follow that advice. Understand there are always both major cannabinoids in the medicines she's suggesting. Each dose uses a higher ratio of one or the other if the formulation wasn't evenly balanced by design. Many cancers are responding to a balanced ratio.
Absolutely. Cannabis has turned out to be the gateway drug to get away from opiates. My signature line has a link to my latest thread, on tapering off opioids with cannabis. Dr. Sulak insists that you should never take an opiate without a small dose of THC. Not only can you reduce the opiate dose, but you'll get better pain management with both together than you will with either alone.
Opiates shouldn't be used for longer than two weeks. All those safety studies were done for two weeks. Don't get me started.
Younger patients often take doses that would knock a grown adult on their ass. There's a theory that small children are still developing the ECS and don't have the same concentration of receptors adults do. Adults in the later years may have receptors cluttered or offline. At this point we don't know, but Mara's experience holds that it's age you want to pay attention to.
The process is the same with each patient - start sub-therapeutically and increase doses slowly and thoughtfully until the patient can't adapt and feel comforatble. Then you back off one level and stay there until you have a good reason to change it. With cancer patients you're watching the labs.
If the patient can tolerate those doses they've developed a tolerance. I remember Cajun telling me once that it took a rediculous amount of cannabis for him to get high when he was up to a gram a day in suppositories.
This is because there's a higher concentration of CB1 receptors in the CNS. I agree with her. Most of us are more comfortable suggesting at least a 2:1 dominance of THC for treating cancer, any cancer.
Again, I can see her point here. Try not to counteract the medicine. Lol! We're so well-trained to go for anti-oxidants aren't were? I wouldn't hesitate to eat some blueberries or whatever. Don't eat them for any reason other than they taste good. Your cells really do know what they're doing. I do my best to not think of any food as dangerous, but make intelligent choices. When you brand a food with judgement it starts a snowball effect in your mind that gets confused by the cells. Choose good quality and tasty fuel and enjoy it.
Unfortunately, just about everything conventional medicine does for cancer supports spreading the cells, beginning with the biopsy. We recently learned that standard chemo treatment for breast cancer punches holes into the bloodstream that spreads disease. I suspect if they have the courage to go looking further than breast cancer we'll find these results repeated.
Chemo is an indiscriminate killer. They've been shrinking the field of collateral damage, but their success rate for long-term relief with good quality of life is pretty abysmal. Just my opinion. Cannabinoids cause tumor cell necrosis by a number of pathways without damaging neighboring cells. This is what your ECS is evolved to do under optimal conditions.
Taking a cannabinoid dose about 30 minutes before a radiation or chemo therapy can mitigate many of the nasty side effects of those treatments and protect healthy cells.
Have you ever tried a tincture yourself? Alcohol burns. She's correct about the blood sugar concern, and I'll give her this one. When treating cancer you're treating an inflammed gut, among other things, and sugar in any form that's not fruit can make things more difficult.
I sometimes wonder if Mara had someone she loved die trying to use suppositories. Her resistance to them doesn't fit with the rest of her energy, or at least that's how it feels to me. There are many clinicians that don't share her bias and have patient histories to support their recommendations. Cajun himself recommended them to his own patients, because they worked.
This community - because of Cajun - possibly supports suppositories more than others. We also went through the trouble to pay attention to his teachings on bioavailability and develop the formulations for the biobombs as an attempt to increase the efficacy of this medicine that can be expensive and difficult to procure.
That's my thoughts. Anyone else want to jump in?
Let me see what I can share:
Absolutely. We have a thread for helping each other through the sentization process that begins with a 72-hour abstinence of cannabis, followed by a gentle and thoughtful re-introduction of your cannabis medication. It typically results in the effective dose being cut in half.
OtherMother said:
THC is not a strong antagonist for the CB receptors, meaning it doesn't make a strong connection. CBD will "soften" the effects of THC, and Mara's contention is that she's seen an improvement in the efficiency of the meds when you seperate the doses of dominant cannabinoids by at least two hours. In her experience this keeps the doses lower.
When you work with the ECS a gentle approach will many times bring the same results, over a longer timeframe, but with less stress to the ECS. Get too much THC in particular in circulation and you run the risk of overwhelming the system and causing some receptors to go offline. Then you have to ramp up the doses to get the same effect. Cannabis is an out-for-pocket expense. Keeping doses down is always a popular option from the perspective of cost. Biobombs do this wonderfully
I'm personally not as concerned about this until we cross into cancer treatment, although I will confess that I use that two-hour window for my own meds. Mara has years of experience and data to back up her contentions. I'd follow that advice. Understand there are always both major cannabinoids in the medicines she's suggesting. Each dose uses a higher ratio of one or the other if the formulation wasn't evenly balanced by design. Many cancers are responding to a balanced ratio.
OtherMother said:
Absolutely. Cannabis has turned out to be the gateway drug to get away from opiates. My signature line has a link to my latest thread, on tapering off opioids with cannabis. Dr. Sulak insists that you should never take an opiate without a small dose of THC. Not only can you reduce the opiate dose, but you'll get better pain management with both together than you will with either alone.
Opiates shouldn't be used for longer than two weeks. All those safety studies were done for two weeks. Don't get me started.
OtherMother said:
Younger patients often take doses that would knock a grown adult on their ass. There's a theory that small children are still developing the ECS and don't have the same concentration of receptors adults do. Adults in the later years may have receptors cluttered or offline. At this point we don't know, but Mara's experience holds that it's age you want to pay attention to.
The process is the same with each patient - start sub-therapeutically and increase doses slowly and thoughtfully until the patient can't adapt and feel comforatble. Then you back off one level and stay there until you have a good reason to change it. With cancer patients you're watching the labs.
OtherMother said:
If the patient can tolerate those doses they've developed a tolerance. I remember Cajun telling me once that it took a rediculous amount of cannabis for him to get high when he was up to a gram a day in suppositories.
OtherMother said:
This is because there's a higher concentration of CB1 receptors in the CNS. I agree with her. Most of us are more comfortable suggesting at least a 2:1 dominance of THC for treating cancer, any cancer.
OtherMother said:
Again, I can see her point here. Try not to counteract the medicine. Lol! We're so well-trained to go for anti-oxidants aren't were? I wouldn't hesitate to eat some blueberries or whatever. Don't eat them for any reason other than they taste good. Your cells really do know what they're doing. I do my best to not think of any food as dangerous, but make intelligent choices. When you brand a food with judgement it starts a snowball effect in your mind that gets confused by the cells. Choose good quality and tasty fuel and enjoy it.
OtherMother said:
Unfortunately, just about everything conventional medicine does for cancer supports spreading the cells, beginning with the biopsy. We recently learned that standard chemo treatment for breast cancer punches holes into the bloodstream that spreads disease. I suspect if they have the courage to go looking further than breast cancer we'll find these results repeated.
Chemo is an indiscriminate killer. They've been shrinking the field of collateral damage, but their success rate for long-term relief with good quality of life is pretty abysmal. Just my opinion. Cannabinoids cause tumor cell necrosis by a number of pathways without damaging neighboring cells. This is what your ECS is evolved to do under optimal conditions.
Taking a cannabinoid dose about 30 minutes before a radiation or chemo therapy can mitigate many of the nasty side effects of those treatments and protect healthy cells.
OtherMother said:
Have you ever tried a tincture yourself? Alcohol burns. She's correct about the blood sugar concern, and I'll give her this one. When treating cancer you're treating an inflammed gut, among other things, and sugar in any form that's not fruit can make things more difficult.
OtherMother said:
I sometimes wonder if Mara had someone she loved die trying to use suppositories. Her resistance to them doesn't fit with the rest of her energy, or at least that's how it feels to me. There are many clinicians that don't share her bias and have patient histories to support their recommendations. Cajun himself recommended them to his own patients, because they worked.
This community - because of Cajun - possibly supports suppositories more than others. We also went through the trouble to pay attention to his teachings on bioavailability and develop the formulations for the biobombs as an attempt to increase the efficacy of this medicine that can be expensive and difficult to procure.
That's my thoughts. Anyone else want to jump in?
KingstonRabbi
Well-Known Member
I thought #3 capsules would be easier to use if you could formulate oil to right concentration, but if oil is already diluted then you'll have to use bigger caps, and only one at a time. I've recently discovered that there may be a limit to how much oil can be absorbed. I was using double doses for a while, which works fine once in a while, but after a day I noticed some oil with my BMs and after a couple days some leakage. If possible add CCO to increase potency and reduce volume of oil to be absorbed.
THC is the better cancer killer so I would increase ratio to at least 3 THC: 1 CBD. Also based on Mara's comments and my own experience I think it is better to take separate doses of CBD from THC. CBD made THC easier to tolerate when I took orally, but not an issue with suppositories. Some small amount of each in the other helps the entourage effect, but it makes sense that too much CBD could also interfere with THC.
Last thing: Apigenin, apigenin, apigenin. Cajun wrote that it was safe to take 1,500 mg of it per day. I was using 500 mg/day (100 mg) x 5 doses/day. The 80 mg per dose he recommended was the minimum. I've started taking 200 mg (4 capsules) per dose, plus using my phone's alarm to remind me to take bio bomb exactly 30 mins after, and today I'm working while on a 150 mg CCO dose. With 100 mg apigenin I could only tolerate 30-50 mg at work. I don't know what maximum safe dose is for 3 year old. Check with Dr. and use maximum safe dose to increase tolerance and effectiveness of cannabis oil.
OtherMother
Active Member
Fantastic guys thank you. I'm very much on the case with the apigenin KingstonRabbi. I bought some dried parsley yesterday which I understand is loaded with it and I'll add it to her smoothies. Noted on 80mg being the minimum. And also on the THC ratio and separating doses. On suppositories we could at least use them for the THC and if bigger caps are alright we can get the overall number a lot lower. I've only just finally got the bio bomb ready, having had to wait about three weeks for the liquid lecithin from the States.
Hey SweetSue, really interesting on loads of things, including opiates and tolerance. We'll see if we can get up to a disproportionate THC ratio. Right now we're still having to build up again because of her gastritis, which cost us a few days. Frustrating but we just have to keep pushing.
Still not sure what to do about chemo. I'm currently acquiescing to another round of chemo on Thursday. After that I don't know. What you/Mara say is quite persuasive. It's a big step and in the UK it has the added risk that the social workers may perceive it as harming a child and therefore step in to make it happen. Still, it may be a battle we have to fight. And I think you're right Nixie, it's a question of weighing harms and benefits. Right now, it's probably still a slight net benefit: my worry is it will make it harder for the cannabinoids to do their job and that the time gained actually ends up being time lost. Persuade that's the case and I think it has to stop.
When you say, Sue, that sugar in any form that's no fruit can make things difficult, two questions: does that mean avoid even complex carbs, and why do you say fruit/fructose is okay? I had assumed it was best to consume them sparingly...
On suppositories Sue, I guess it's the nature of the beast that specialists will have different views in an area with so much uncertainty. It sounds like you have a lot of anecdotal evidence to support your position. I know of a human trial taking place in Jamaica this year to test bioavailability via different routes, which should be interesting...
Nixie that's great advice about fasting, I'd never heard that before. Like you say I have no idea whether my three year old would accept that. On the upside, she's young enough that she needs general anaesthetics for her lumbar punctures, so she does at least fast for about six-eight hours on the day she gets chemo. I'll also read up on that ketogenic diet. My little girl's gastritis could be an issue for something that's mainly about fats, but maybe I can adapt it a bit.
By the way guys, compared to just using cannabis oil mixed with olive oil, as we have been, how much if at all do you recommend we drop the dose at the beginning when we move over to bio bombs??
Hey SweetSue, really interesting on loads of things, including opiates and tolerance. We'll see if we can get up to a disproportionate THC ratio. Right now we're still having to build up again because of her gastritis, which cost us a few days. Frustrating but we just have to keep pushing.
Still not sure what to do about chemo. I'm currently acquiescing to another round of chemo on Thursday. After that I don't know. What you/Mara say is quite persuasive. It's a big step and in the UK it has the added risk that the social workers may perceive it as harming a child and therefore step in to make it happen. Still, it may be a battle we have to fight. And I think you're right Nixie, it's a question of weighing harms and benefits. Right now, it's probably still a slight net benefit: my worry is it will make it harder for the cannabinoids to do their job and that the time gained actually ends up being time lost. Persuade that's the case and I think it has to stop.
When you say, Sue, that sugar in any form that's no fruit can make things difficult, two questions: does that mean avoid even complex carbs, and why do you say fruit/fructose is okay? I had assumed it was best to consume them sparingly...
On suppositories Sue, I guess it's the nature of the beast that specialists will have different views in an area with so much uncertainty. It sounds like you have a lot of anecdotal evidence to support your position. I know of a human trial taking place in Jamaica this year to test bioavailability via different routes, which should be interesting...
Nixie that's great advice about fasting, I'd never heard that before. Like you say I have no idea whether my three year old would accept that. On the upside, she's young enough that she needs general anaesthetics for her lumbar punctures, so she does at least fast for about six-eight hours on the day she gets chemo. I'll also read up on that ketogenic diet. My little girl's gastritis could be an issue for something that's mainly about fats, but maybe I can adapt it a bit.
By the way guys, compared to just using cannabis oil mixed with olive oil, as we have been, how much if at all do you recommend we drop the dose at the beginning when we move over to bio bombs??
When I was speaking of sugar it was of processed sugar, which has permeated our foods. Complex carbs are to be encouraged. I try to get sugars from quality foods, in my case, mostly fruits.
I'd like to hear KR's thoughts on the BioBomb doses. My thought was she's already tolerating the dose she's taking, so if it were me I'd be using that as my starting point.
You're always in our thoughts.
KingstonRabbi
Well-Known Member
Chemo is a hard call. I don't think it will interfere with cannabinoids, and the cannabinoids can make chemo more effective plus protect against some of the harm. Even knowing what I know now it would take a leap of faith to refuse chemo if I were actually facing that choice right now. Whatever choice you make is the right one. You're doing what's best for your daughter.
I wouldn't drop the dose when switching to bio bombs. It's like stepping up to the next dose level. If it turns out to be too much then you can back off the same way you would with a normal increased dose.
OtherMother
Active Member
Thanks guys. I've stuck with the bio bomb dose, she's sleeping quite a lot – maybe four hours out of eight. Going to persevere on the assumption it will ease off next day or two. Big change in peak effect: I'd say it's 1.5 -2.5 hours after, compared to more like 3-4 hours after previously. I take this to mean she's metabolising a lot less of the oil in the liver than before.
I note what you both say on chemo, still not sure which way to jump. There's a two week gap now so we can think it over and see if we can climb to therapeutic dose of oils in the meantime.
Phew.
I note what you both say on chemo, still not sure which way to jump. There's a two week gap now so we can think it over and see if we can climb to therapeutic dose of oils in the meantime.
Phew.
Guy Cavallero
Well-Known Member
You're an incredible dad @OtherMother. I don't have a lot to offer the experts other than that. You're on the right track and you've got the best team on earth.....
OtherMother
Active Member
Thank you I appreciate that GuyCavallero. Let's hope I can write something positive here in the next few weeks...
Hello everyone.
I finally got the ingredients needed to make biobomb. Made my first batch with a ratio of 20:1 , sitting in the ref atm.
Just wondering has anyone used biobombs with Vit B17 amigdalina pills?
I finally got the ingredients needed to make biobomb. Made my first batch with a ratio of 20:1 , sitting in the ref atm.
Just wondering has anyone used biobombs with Vit B17 amigdalina pills?