1. Could you handle the gelatin capsules by hand to fill the mixture ?
2. My mother cant take anything from mouth at the moment, and thus we can only do rectal suppositories.
My questions are more specific for her, and wondering what to do since gelatin capsules are also not readily available here, so we are currently using coconut oil as carrier in 1:1 ratio - 0.5 ml coconut oil and 0.5 ml cannabis oil in a 1 ml.
3. We have not got any data about THC content of current oil (It is indica strain which is supposed to have high THC but what we are locally getting here, those people are setting up a laboratory for the same.) CBD international claiming the THC content will be 80%, also they have recommended to use cocoa butter to create suppository and take the entire 1 gm equivalent in one go at night.
So basic questions now:
1. Whether we can give 1 ml in one go at night.
2. What should be the composition of cocoa butter : cannabis oil in case we want to make our own suppositories ?
3. Can you handle empty gelatin capsules by hand, can you send us a link from where you bought those ?
Will this work :
Now Foods, Healthy Foods, Double "00" Gelatin Caps, 750 Empty Capsules - iHerb.com
4. Is lechitin + virgin olive oil combination is better than cocoa butter as a carrier ?
Running against time here, with mother vomiting 10-15 times a day despite getting all kinds of anti-vomit meds in a cancer special hospital (Tata Memorial Hospital).
Regards,
Piyush
Good morning Piyush
It's recommended that you always have some food in the system before a dose of cannabinoids. They use a tremendous amount of energy, so at least a spoon of coconut oil about 15-30 minutes before dosing. Copious amounts of water are also called for. Keep her sipping water. Anytime she mentions thirst, give her more water. It's hard to get too much water in.
1. You can handle the capsules by hand, but you can easily make a simple jig by shoving the bottom sections of the capsules into a piece of bread. Some have made simple jigs with many items. You only need some way to keep them upright while you fill them.
2. Our formulations for biobombs won't work in formed suppositories, which is one of the reasons we went with capsules. That concentration has been successful in the past due to the overwhelming levels of cannabinoids, but giving it to the patient in one high dose a day is problematic for me.
Cannabinoids circulate, do their duty if possible, and then get eliminated from the system at large, either being eliminated or hiding in fat stores. For this reason we recommend 4-5 doses a day, splitting the daily dose up. In this way you create a more level endocannabinoid tone and lessen the risk that the system may feel overwhelmed enough to shut down some of the receptors we're targeting.
The regimen laid out by stayalive is excellent. I recommend you follow her lead there, and in making contact with Mara's crew. They aren't yet fans of the suppository route, so be prepared to be forceful on that point.
Now for the basic questions:
1. My recommendation would be to split the 1 gram up. Actually, I recommend you make biobombs at the 5:1 Mix and use those, ignoring the cannabinoid count. What I mean by that is you'll be using less than a gram a day at first, but you'll be healing in a way that would be comparable to that straight 1:1 suppository you were making. By including the liquid sunflower lecithin and refrigerating it for the suggested 24 hours the lecithin encapsulates the cannabinoids bonded to the carrier oil and increases the bioavailability dramatically.
Less concentrated oil needed to get better healing results. Here's the link to the BioBomb instructions:
https://www.420magazine.com/community/threads/biobombs-cannabis-oil-kick.356122/
4-5 suppository doses a day is where many settle for the most effective treatment. Most of us don't eat all of our day's food at one meal. We don't recommend you do that with your meds either.
2. See the BioBomb link above.
3. Those are the same capsules I use. I've already explained the handling of the capsules. If your doing them by hand try holding them with a tissue if your hands are sweaty. You're not holding them all that long, but sweaty hands can be a challenge.
4. The addition of lecithin will potentiate any cannabinoid med. The liquid sunflower lecithin is even more effective at this task, enough so that most of us don't even consider granular soy lecithin. However, lecithin added to the suppositories you're making now will make them unusable as suppositories. They won't hold the shape.
Carrier oils are another matter. If you're forming suppositories by hand, coconut is your choice, because it will hold its shape. If she was taking capsules by mouth I'd recommend olive oil, because as a long-chained fatty acid it gets absorbed into the system before the First-Pass through the liver, where the cannabinoids are metabolized. We don't want them metabolized before they have a chance to do their signalling.
If you're using biobombs as suppositories, use olive oil.
Since you're going the anal route with formed suppositories this isn't a concern. Use coconut oil. Be careful about placement. You want to be just inside the sphincter muscle. Don't worry about leakage. The sphincter is a strong muscle, and if any leaks you can wipe up. The oils will be concentrated enough she'll get cannabinoids in, no worries.
Now..... I realize you're up against a few walls with gathering supplies, so I want to assure you that the suppositories you're making for her now will work, just not as efficiently as our BioBomb recipe will. But cannabinoids are made to signal healing messages to the body, and any cannabinoids into her stressed system is a good thing.
If what you have is the best you can get, run with it. Believe with your whole being that there is something available for her here. Infuse every dose with the healing power of whatever deity you hold dear and anticipate that her cells know what they need to do to ramp up her natural healing potential.
We work with cannabinoids, molecules evolved to create an atmosphere of spontaneous healing in the body. This is what the body itself is evolved to do. Have every expectation that she will benefit from your actions. If nothing else you'll help her make her passage from this realm to the next with more dignity and much less pain.
I wish you every bit of luck the cosmos can throw your way. This is a wonderful thing you do for your mother. It takes great courage to make this effort. There are no guarantees, and we're all terminal cases in the end, encased in these bodies we travel around in, but there's no reason I can see to give up. When her time comes she'll pass, but it doesn't have to be cancer that forces her leaving your loving family behind. She's still young. I'm 63, and I know I still have another 30 years to play. I'd bet your mother feels the same way.
The first couple posts of this thread lay out the instructions for both demethylation and competitive inhibition. Post #50, on page 4 has Cajun's instructions for making the type of suppository you're using right now, with instructions for insertion. I highly recommend you follow his instructions for demethylation and competitive inhibition. KingstonRabbi strongly recommends 2 apigenin capsules before every dose. In his opinion it made all the difference in the effectiveness of the doses.
It's a bit overwhelming, but we're here to help you wade through it.
) I mean live your life, because that was the real point of treatment.
