Thanks Shed! Newts and I had some insta exchanges around that. Was total coincidence that we both cleansed at almost the same time.
I did about 55hrs of complete abstinence before introducing the Candida oil for 3 days and then introducing THC, first with oils and then a little vaping.
have a theory brewing that there’s a CBD:THC ratio that softens the mixed signals that cause Auto-immune response. May you find the ratio that brings you he relief you seek.
Thanks Sue - I’ve certainly modulated the immune overrespone somewhat over that last 18minths or so - through a variety of interventions. It’s very challenging to get clarity on it - such a complex thing with so many effecting elements. Still the case that any activity causes massive immune flare. It’s not clearly an auto-immune thing with me. The usual markers don’t show. Working theory is that the connective tissue disease and the trauma/stress on the system this causes is possibly what’s driving the immune over-response bc it thinks there’s something wrong - which there kind of is. So it’s not the usual auto-immune drivers. Early days for me knowing about the connective tissue thing so there’s lots to figure out and many things to instigate over the coming months that may alleviate things a lot.
At the moment I’m back to dosing through mostly sub-lingual and/or mucosal pathways. Sometimes I’m doing half and half sublingual-mucosal/ingestion. It’s tricky to gauge CBD bc it isn’t so obvious.
I can say that the bell-curve response they speak of with CBD is quite real. At low doses we both find it sends us pretty manic - happy mostly, but manic and prone to irritable flashes as it tapers. Having learnt about the bell-curve aspect to the biphasic properties of CBD I proposed we both double our dose, and it worked! A much smoother, far less intense response without manicness (is that a word? lol).
Something I’m wondering about, and I should post this in the oil thread perhaps, is what happens to CBD in the liver? We know that THC either gets metabolised to 11-hydroxy-THC or is excreted as waste (which is more likely on an empty stomach), but nowhere have I seen anything about CBD and first-pass metabolism.
Similarly, nothing gets written about CBD degrading to anything the way THC degrades to CBN. Maybe it’s the case that CBD is just very stable and doesn’t break down or convert to anything - or just that the research hasn’t been done yet.
I’ve been hoping to gauge the difference btw mucosal dosing and ingestion for CBD but I think to get a better read on it I’d have to stay off the THC for longer and I’m not prepared to do that right now. I haven’t found any literature about this aspect of CBD.
Anyhoo - I feel better for the cleanse and resensitising. It’s always a rocky second day for me with the abstinence. This time I felt
much better on the third day than the second. It can be rough for heavy or therapeutic users (and especially if you’re both!) but it’s so worth it. Newty just posted that even doing a THC only cleanse has massively reduced her needs
Thanks all for the supporting thoughts and words and presence.