Differential Effects Of Repeated Low Dose Treatment With The Cannabinoid

[Truth Seeker]

Abstract
Pain due to bone malignancies is one of the most difficult types of cancer pain to fully control and may further decrease the patients' quality of life. Animal models of chronic pain conditions resulting from peripheral inflammatory reactions or nerve injuries are responsive to treatment with cannabinoid agonists. However, the use of cannabinoid agonists in humans may be hampered by CNS related side effects and development of tolerance. In the present study, we investigated the effect of repeated low dose administration of the synthetic cannabinoid agonist WIN 55,212-2 on bone cancer pain and neuropathic pain in mice. In addition, we investigated the development of CNS related side effects and tolerance. We found that 0.5 mg/kg/day for 18 days reduced pain related behavior and expression of spinal glial fibrillary acidic protein in the bone cancer pain model but not in the neuropathic pain model. Furthermore, this treatment strategy was not found to induce measurable CNS related side effects or tolerance. Cancer cell viability assays and bone volume fraction assessed by micro computed tomography (microCT) demonstrated that these effects were not due to changes in cancer progression. The difference in WIN 55,212-2 efficacy between the bone cancer and neuropathic pain models may reflect the different pain generating mechanisms, which may be utilized in designing new therapeutic drugs.

Source: Differential effects of repeated low... [Pharmacol Biochem Behav. 2008] - PubMed - NCBI

 

[filce]

i just started with research on the net about medical marijuana and was wondering does it help patients with bone cancer . My grandfather was diagnosed with bone cancer 3 months ago and doctors just dont want to do anything cos it may harm him even more and now hes stuck with constant pain in the lower body bones , constant exhaustion and sleepiness .

My question here if someone can give me an advice , since in my country marijuana is not legal , what marijuana types are referable if it helps for bone cancer , cos i can get illegal marijuana and maybe make a hemp oil or whatever is the best way for extracting the chemicals ?

Any help is apriciated ty in advance .