Now im wondering if you cross a grapefruit with a blueberry are you necessarily getting a blue/grapefruit flavor? Or a random new flavor. I understand its alot more complicated then this on a molecular level. But do you think fruit flavors will pair well or its a hit or miss deal? Also is there any research that dictates if you must use 12/12 lighting or 18/6 while the plant is getting dusted or growing seeds?
I'll try to answer to the best of my knowledge, but others know a lot more than me...
On the results of crosses... I think it is a bit of a crap shoot. It all comes down to traits that are dominant versus recessive. Like autoflowering is a recessive trait, so as soon as you introduce a photoperiod parent, that trait dominates, until you get to later generations. I think there are also traits or characteristics that are the result of several genomes acting in concert, so it is not like a single gene makes it smell/taste like blueberry. If you do a cross, you might loose one aspect of blueberry, but pick up another trait from the grapefruit parent. So I guess the short answer is "hit or miss" but sure will be a lot of fun trying!
On the lighting hours... if you are crossing photoperiod plants, I think you would want to be at 12/12 as the seed maturing is part of the flowering process. If you are crossing autos, then it doesn't matter, as they are independent from light times.
As I said, just based on the limited knowledge I have.
EDIT to add: if you are running autos, I'd suggest 20/4. That appears to be the consensus for best yield and rest time.