A few weeks back I introduced for discussion the idea of supplementing cannabis oil mix with one or more terpenes of desirable property, after seeing a recipe that included beta carotene and limonene. A Base Treatment Regimen for Cancer
Today I'm revisiting the idea of adding terpenes after reading a discussion that claims it's possible to neutralise the psychoactive reaction to THC by simultaneously injesting one or two specific terpenes with an unusual property. The exciting upshot being that it allows immediate leap into full dose THC cannabis medication and eliminates the need to titrate up gradually in order to build tolerance to the THC. If borne out in practice, it would also be welcomed by those who have been forced to leave off THC oil because they found the effect of being stoned all too frightening.
Its basis is explained from a facebook discussion: about 5 or 6 years ago a STRONG CB2 receptor agonist was found in the oil of the Copaiba Tree in Brazil at around 50 - 55%. That compound is called beta-caryophyllene (BCP), it's bioavailable & non-toxic. BCP does occur in cannabis as a terpene (it is a sesquiterpene) but NOT at levels sufficient to overcome the high sensitivity of those having no prior exposure to cannabis. Copaiba Oil and BCP are completely legal.
The writer goes on to suggest dosage: For a slightly built adult (children even less) I recommend 6 - 8 drops of each of BCP and orange oil (d-limonene) at breakfast only with yoghurt or lecithin or milk etc., to emulsify - ranging for heavy set adult up to 8 drops of each twice per day. He later suggests that the orange oil alone may suffice, skip the BCP, for d-limonene is apparently likewise a CB2 receptor agonist.
For a scientific discussion: Beta-caryophyllene is a dietary cannabinoid. - PubMed - NCBI
BCP: Beta-Caryophyllene: The Dietary Cannabinoid That Could Make Synthetics Irrelevant - Leaf Science
source of orange oil: Natural Fractions - Products / Australian based manufacturers of Essential Oils & Food Ingredients
If in fact this pans out it could indeed be beneficial, if it in no way interferes with the THC, which is our greatest ally here. How will you determine efficacy?
Thanks for continuing to pursue this train of thought. Beta-caryophyllene is one I look for in a strain, though not for this effect. Made me smile to read that.