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Cajuncelt,
British Green kindly pointed me here. We have spoken before in another place and I'm so pleased to have found you again. I was hoping you could help me out please...
We have spoke before, but i’ll get you up to speed. My friend had 3/4 of his large intestine removed due to cancer, it has also spread to all, but one lymph nodes which have been removed. They have put him through 5 months of Chemo but cut his treatment short as he can’t take anymore. As you can imagine, his not doing to great and is suffering badly with chronic stomach pains and all the usual nasty chemo side affects.
I have 25oz of CBD Crews Critical Mass which i harvested around 6 weeks ago. My thoughts are to go with suppositories but I’m unsure of dosage amounts, how often and for how long?
I have unrefined organic cocoa butter for the suppositories but the label states “for external use only” which concerns me too?
If you can offer any assistance we would be most grateful
Best regards
Chewey
, Disclaimer: The tricks of the trade herein are for your entertainment only. You hereby acknowledge that any reliance upon any TRICKS or the information herein shall be at your sole risk .
Not sure when Cajun will be able to post again Sweets, So I will hijack this question,lol. Yes, you are correct 1gram of CCO to 20Grams (or mls what ever term you prefer), a couple little suggestions to save you some trial & error as what I went through. warm up the CCO with a 2-5 mls of food grade alcohol to thin it out you will find it much easier to thoroughly mix with the flax, I also found slowly& lowly(lol not sure if that is a word) warming up the lecithin (since it is so Damn sticky) so it will liquify then add to the 3 tbs(or 45 mls or grams)of flaxseed and mix, you may can also add a tad of alcohol to this if need to. When initially trying this I had problems with the flax and lecithin separating until I started adding a touch of food grade alcohol(I used absolute vodka), I would fill the caps up then after a little bit I would notice a very foamy substance on to the top of the capsule and the flax on the bottom making for a very inconsistent mix. I also like using a 60 ml syringe when getting ready to fill caps since it saves time from refilling. But hey each for their own . Someone may find a better way of doing this but this is what work for me . P.S the disclaimer was not meant for me to be a fool, I sincerely think it is a good idea, just like to lighten up the mood sometimes.
Tonight I'm perusing that book on Natural Compounds you recommended. Thank you so much for that. This book is beautiful! Wow!
Hi Chewey. I do remember you from aother place.
I'm sorry to read of the issue. I've been through the exact same colonectomy & think I can help. You have alot we can work with too.
I'm on a crazy schedule right now, but I'll jump back here asap. Shouldn't take too long.
Be cautioned.
It took an oncologist an entire night to get me through about 5 pertinent chapters.
Without an M.D., I'm not sure how helpful it will be, but there lots to be gleamed from.
You'll see that my " feeble" attempts as you put it, are actually based on many medical procedures. I frankly know how to calculate specific doses based on some of the calculations you'll see, but can't use, in the book. As a homeopathic clinician, I have the added benefit of the oncologists help through all this medical "stuff".
Don't quote the book unless you've been taught too.
Real quick:
I've read through most of the latest questions & suggest reading the thread more. I've posted lots on +E substitutes & the Canna Budwig protocol.
Bioavailability, the BioBomb, all of these are based on lipscomal encapsulation, the CannaBudwig Protocol.
That's pretty much what this thread is all about.
Bioavailability thru correct dosing, & the use of the listed supplements like apignen.
And, bioavailability thru lipscomal encapsulation used with a carrier oil & liquid, non GMO, non soy lecithin.
Powder won't work & soy sucks.
Follow panacea & I, use sunflower or chia.
Finally, competitive inhibitors...the apignen. Which ALONE is a cancer killer.
For carrier oils, use extra virgin oil oil, grapeseed oil, out others I've suggested.
Use coconut oil only for liver diseases at least as a carrier for the cco.
In other uses other than for cco, coconut oil is awesome in many ways.
The above thoughts are in reference to cancer & other chronic, terminal illnesses.
I wouldn't lose sleep over carrier oils of its not a chronic illness. I would suggest coconut oil.
I have to add that other supplements like garlic, tumeric, vitamin D3, selenium, and especially fish-based Omega 3's, melatonin, ect. all contribute to the cco by synergy at least 50 fold.
Powdered lecithin is out and liquid in. Got it. I'll make sure to track some down. Is there no way to liquefy the powdered, or is there something about the purchased liquid preparation that makes that much difference?
You know, the Omega 3 oil thing just gags me every time I come across it these days. Just as Dale entered dialysis in 2013 his cardiologist sat him down and told him the data on Omega 3 and heart disease was inconclusive and to stop taking the omega 3 because he was just throwing his money away. When you tell a man who's already taking over twenty pills a day that he can stop taking three of them he jumps at it.
Two years later, when the double bypass clogged back up within six months I remember thinking maybe that wasn't the best advice we were given by our medical team. Now I know how short-sighted it really was.
Real quick:
I've read through most of the latest questions & suggest reading the thread more. I've posted lots on +E substitutes & the Canna Budwig protocol.
Bioavailability, the BioBomb, all of these are based on lipscomal encapsulation, the CannaBudwig Protocol.
That's pretty much what this thread is all about.
Bioavailability thru correct dosing, & the use of the listed supplements like apignen.
And, bioavailability thru lipscomal encapsulation used with a carrier oil & liquid, non GMO, non soy lecithin.
Powder won't work & soy sucks.
Follow panacea & I, use sunflower or chia.
Finally, competitive inhibitors...the apignen. Which ALONE is a cancer killer.
For carrier oils, use extra virgin oil oil, grapeseed oil, out others I've suggested.
Use coconut oil only for liver diseases at least as a carrier for the cco.
In other uses other than for cco, coconut oil is awesome in many ways.
The above thoughts are in reference to cancer & other chronic, terminal illnesses.
I wouldn't lose sleep over carrier oils of its not a chronic illness. I would suggest coconut oil.
I have to add that other supplements like garlic, tumeric, vitamin D3, selenium, and especially fish-based Omega 3's, melatonin, ect. all contribute to the cco by synergy at least 50 fold.
Chewed, it warms my heart that we've been able to lighten that dark cloud. You have every reason to be hopeful. I'm sure you and Cajun can come up with a strong plan to enhance your friend's life. And yes, we all identify with the pain and frustration. That's a good part of what fuels the dedication.
Thank you Sweetsue.
Perhaps you can help me whilst i wait for Cajun? Whilst reading through this thread I discovered the post where Cajun talks about the following...
"But, the other (& a biggy) is are the receptors (the CB1 & CB2 mainly) absorbing the cannabinoids?
The receptors can easily become chemically inactivated. They are turned off.
This is called methylation.
Basically, methyl groups (cells) surround the receptor sites & shut them down."
I have tried to find out how to do this but i can't seem to find anything that i can understand. Are you able to throw some light on this as it seems to me, this is the first step. Is that correct?
Activate Cannaboid Receptors: Include demethylating agents such as green tea. These protect the CB1 receptors from shutdown due to methylation. Phenols, Phenylpropanoids and essential oils can clean cell receptors. Grapefruit juice cleans and clears the cannabinoid receptors. Mangos will be used for pre-dosing to avoid the"Grapefruit Affect" since I have heart medications that will have interactions with grapefruit.
Ok guys, I've been immersed in this for days and days and I have some thoughts to share.
Thoughts on Demethylation and the Methylation Cycle
"If the body is made up of bricks, then methylation is the laying of each individual brick. " - Patrick Quillin
Please keep in mind this is the most basic explanation for the wonderfully complex methylation cycle. Also, remember that aberrant methylation is caused by something, but that trigger may be impossible to determine, since it could be something environmental, something you ate when you were 12 or keep eating despite knowing better or even something as tragic as being isolated from your mother during the first week of your life. You are an incredibly complex and beautiful biological machine.
Your body is a constant cacophony of chemical reactions. We tend to think of them in isolated events, but the closer analogy would be buckets full of molecules awaiting movement and activity as assigned by the attending enzymes. An integral part of this activity is the passing of methyl groups, a carbon molecule bonded to three hydrogen molecules. These are akin to work orders for the enzymes, directing the expression or silencing of the gene to affect the change required to keep everything stable in this corner of the body/world.
Methylation is the exchange of the methyl groups so necessary for the chemical reactions that make you who you are. Methylation is what determines gene expression and protein function. It's what determines how you feel, think, see, look, are.
It turns out there's a quirk that seems to occur in the methylation cycle that's a precursor to cancer and continues as cancer grows. A genetic mutation causes an imbalance of proteins that causes an imbalance in the methylation cycle and the genes that regulate the cannabinoid receptors are overwhelmed by swarms of methyl groups, effectively silencing them. We call this hypermethylation. If the genes regulating the receptors are being silenced they can't communicate with the receptors, the cannabinoids can't attach and the work of eliminating that cancer cell can't take place. Instead, the cancer cell grows and replicates. The tumor advances.
The challenge then becomes getting these receptors cleaned so that the cannabinoids you worked so hard to acquire will have the best chance of helping your body return to health by eliminating the cancer cells. There are some surprisingly easy and tasty ways to do this.
* green tea: Not only good for demethylation but also an excellent antioxidant. We should all be drinking green tea, IMHO. My preference has become a mix of green tea and ginger tea with lemon, infused with probiotics. Multi-functional food. How like a multi-tasking woman.
* mangoes: Always best fresh, of course, but there're juices on the market worth looking at and in a pinch, baby food lines have started to include mangoes in their pureed fruit bags. I get excited when I find myself at the grocery as they decide to chop up some mangoes that are too ripe to leave on the stands any longer. Perfectly ripe and already chopped up.
My habit has become 4 oz of mango juice 30-40 minutes before dosing. I find juice so much easier to deal with in my own life. Unless I found chopped mango at the grocery. Sweet!
* green apples: Recent findings indicate that DNA demethylation is mediated by Tet (ten eleven translocation) enzymes, which convert 5-methylcytosine (5-mC) to 5-hydroxymethylcytosine (5-hmC). Sorry, sometimes technical is called for. It took me days to understand that sentence. I'm happy to say, I now understand it and so much more.
I have no idea, nor have I been able to find an explaination for why the green apples. Care to share Cajun?
It's been determined that vitamin C, which can be found in fruits such as apples and oranges, induces Tet-dependent DNA demethylation in mouse embryonic stem (ES) cells when present in cell culture media.
Yes, it's animal research but we are, after all, animals ourselves, so a certain amount of extrapolation can be safely applied. "An apple a day" makes much more sense now, doesn't it?
In 2007 a group of researchers discovered that the polyphenols in Annurca apples (a variety from southern Italy) have astounding demethylation properties. They aren't green apples, but if you can get them, I'd certainly add them in some way. I hear they're absolutely delicious.
* grapefruit juice: Be cautious if you're on certain cardiac meds that disallow grapefruit. There're other options.
* cinnamon: Take 1/8 tsp a day. It goes down easy with almond milk. I like it mixed with honey, but I've a notorious sweet tooth.
* dark chocolate (90%): To the uninitiated this tastes nasty the first time, but give your palate a chance to adjust to the difference. After the initial shock to the chocoholic in me this has become my favorite choice of chocolates. At least 1 oz a day. Doesn't that just make you happy?
* olive oil: I have no idea how much, but it's a sure bet that a tablespoon a day wouldn't hurt. Use it in cooking. Use it a lot. Dip bread into it for a quick snack. Infuse it with cannabis and make it even better for you.
In an interview with Project CBD, Mauro Maccarone, a scientist at the University of Teramo, Italy shared these thoughts:
Maccarone hypothesized that olive oil might counter some of the adverse effects of methylation.
"We found that olive oil, in particular the phenolic components of olive oil, can reactivate CB-1 expression. By adding olive oil to an animal's diet, we can restore a normal CB-1 receptor level that will protect cells against cancer," Maccarone explained.
"This is very interesting and very promising because it suggests that the normal daily impact of the right amount of olive oil could be protective and could give you a better chance of a healthy life."
**********
There you have it. A quick list of simple things you can add to your diet every day to help your body heal and make better use of this oil that feels like gold every time you look at it.
We work hard to grow the right strains, harvest and cure with loving care. We take great steps to insure that the oil we produce is clean and potent to our needs. It only makes sense to do all we can to help our bodies get the greatest number of cannabinoids working on our behalf. I hope this helps.
Go have some green tea.
Chewey, the below should get you started. This excerpt is from an early post by Cajun:
And the below is from Sue's excellent post on page 24:
I hope this helps, until others get here. Cajun did mention earlier to someone he was helping that he had a demethylation protocol.
Cajun do you have something with more detail than the above you can share with everyone?
Is this from this thread? I must have missed this, sorry about that and thank you very much. So much to take in but im chipping away at it.
Thanks again SlowToke