Hello all, my question is to CajunCelt or anyone else who may be able to help.
My 6 year old son Cody has a rare cancer in the biliary tree of his liver call Embryonal Rhabdomyosarcoma. We would like to use his NG tube to administer his CO oils and he has a target dosage of 330 MG of THC and 170MG CBD that we are trying to work him up to. We have a THC oil from Cannakids which is 877mg per 1gm syringe and for CBD syringes, it has 858mg of CBD.
My questions are these.
- What is the best carrier oil to dilute the oils to be able to go through his NG tube, to prevent having to try and get him to do it orally?
- We have had a lot of people tell us to use Organic extra virgin olive oil, MCT oil, Coconut oil, Hemp Seed Oil, etc...trying to figure out which one makes the most sense for him for both bioavailability and for ease of going down his tube without being clogged.
- Should we be giving him mango prior to giving him this to help his liver absorb more, if so is there a "dose" or certain amount you'd recommend?
- He is receiving chemo that all are affecting similar to grapefruit, I think its cytochrom p450 if I'm not mistaken that they mentioned to be worried about, what is your thoughts on THC and CBD during chemo? We have been told that the CBD affects it much more than THC, but want to know your opinions.
- What is the percentage of bio-availability taken:
- Orally
- Sublingually if thats any different
- Through NG/Tube
- Rectally
Sorry to have missed this. Let me see if I can answer these for you.
1) Coconut oil will be absorbed and sent directly to the liver, so this is the one I’d be choosing. Pay attention to the use of supplements that’ll occupy the liver enzymes to get the greatest efficacy.
2) Mango is high in myrcene, which helps the cannabinoids get through the Brain Blood Barrier. A suggested serving or an adult in advance of the cannabis oil dose is a cup. Your son can get away with a smaller dose.
3) It’s CBD that causes the concern, and the problem is that the cannabinoid will take priority in being transported into the cells, leaving the other drugs to build up. Some of those pharma drugs can cause serious side effects if the levels are permitted to get out of control.
It’s more of a concern with isolates, less of a concern with full-plant extractions that have the buffering effects of all that synergy going on. The solution is to alert the medical team and have them keep a close watch on the pharma drugs. You want to reduce those drugs to keep them from backing up, not the CBD.
4) It’s been difficult to pin down precise numbers on bioavailability without some good research to back it up. We tend to work with broader ideas of “what works best in this situation?”
Oral drugs run the gauntlet of the stomach, and their bioavailability shows it. It can vary wildly, depending on formulations, time of day, stress of the patient, when the patient last ate and what that meal entailed, and health of the gut system at large, to mention a few variables.
Oral administration can offer the deepest effects for the longest therapeutic window.
Tube feeding would be essentially the same effect as oral dosing. Using olive oil the cannabinoids will be absorbed into the lymphatic system first, making this a more valuable administration pathway, IMHO.
Sublingual administration is more directly to the brain. Quick onset, smaller therapeutic window. It’s an effective way to administer multiple doses that you’ll be needing to take near-immediate effect across the day. It’s more difficult to train a child to do this, but then children are quite adaptable.
The best way to get the highest cannabinoid load into the body is through anal suppositories. Inserted shallowly you can avoid the overwhelming euphoria a high-THC dose would have through the gut.
It depends on the patient and the condition being treated. Cannabis is incredibly individual when it comes to dosing.