I just did that a couple weeks ago to one of mine and it definitely stalled it out while it was making repairs. It just now is putting out new larger solar panels again. I did that heavy defoliation thinking I would be putting light and energy to future bud sites. I thought the big leaves were blocking too much light which is why I defoliated.but it seems to me that stripping a plant of all that foliage would force it to expend energy repairing the damaged areas and then re-foliating.