Olive oil extract update

SweetSue;2834254 said:

PsyCro;2833689 said:

Come on people, lets get some REAL info in here, enough hearsay already.

How Efficient are Cannabis Suppositories? | O'Shaughnessy's
More on Cannabis Suppositories | O'Shaughnessy's

If we take averages from above study:
- oral, 12.5g (10-15) = 9.5ng/ml (2.1-16.9)
- rectal, 3.75g (2.5-5) = 2.6ng/ml (1.1-4.1)
.. if i'm not mistaken, not a huge difference, but, information on how the study subjects 'felt' would also be great, along with exact methods of rectal administration.

Lets see some more ACTUAL absorption figures, and we just might figure out why exactly you might not be 'feeling' it.. that's what i'm trying to get to the bottom of.

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Human Cannabinoid Pharmacokenetics: (2007) We need more current data
Section 2.1.4 ".......The bioavailability of the rectal route was approximately twice that of the oral route due to higher absorption and lower first-pass metabolism."

And the link

Human Cannabinoid Pharmacokenetics

Many of the patient support pages I've been reading show a strong preference for rectal administration with high doses.

Isn't it as much about matching the plant to the patient as it is the delivery system?

John makes good points, one of the best is that there isn't any "correct" choice other than the one best suited to the patient. Obviously, tacking is working. Also, just as obvious, some disease requires a more aggressive approach. We may discover that the best results come from using multiple delivery systems and more refined mixing of strains to gain better synergy from the joining of terpenes and flavonoids.

We're out here on the edge, learning as we go while grant proposals are sitting on desks in research labs all across the country, just waiting. We're a team guys. Just looking for more understanding of what we're doing with people's lives and hopes.

Still looking for the research data I'm happy with on oral-mucosal bioavailability. Something more recent than 2007 would be nice.

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