An international team of researchers has provided new insights into how cannabis can offer significant relief with inflammation. Recently, the German federal government made a controversial decision to decriminalize the possession and purchase of small amounts of cannabis. Then Voting in favor of the Cannabis Act. Allowing many to access medicine for the first time legally. This move has been eagerly anticipated by many. Although concerns persist among some about the health risks associated with cannabis use.
Researchers from The University of Jena, in collaboration with colleagues. Have undertaken a novel study examining cannabis, a medicinal plant. Published in the journal Cell Chemical Biology, their research from the Institute of Pharmacy focused on understanding how specific compounds in cannabis combat inflammation. Previous studies had identified cannabis not only as an analgesic and antispasmodic but also as possessing anti-inflammatory properties.
Dr. Paul Mike Jordan, leading the study alongside Professor Oliver Werz, highlighted The reasoning behind cannabis’s anti-inflammatory effect has been largely unclear until now. Their findings revealed that CBD (cannabidiol) in particular exhibits potent effects. The researchers discovered that CBD activates an enzyme called 15-lipoxygenase-1, which stimulates the production of inflammation-resolving compounds. These compounds subsequently reduce inflammation by altering the behavior of immune cells involved in the process.
Dr. Jordan explained, “CBD essentially triggers a switch in these cells, shifting the inflammatory process from promotion to inhibition.” The team confirmed these results first in cell cultures and later in animal experiments involving mice.
The implications of these insights are significant, potentially paving the way for new therapeutic approaches to treat inflammatory diseases. The researchers emphasized CBD’s efficacy. Noting that existing cannabinoid preparations often include THC (tetrahydrocannabinol), which can lead to various side effects. By focusing on CBD alone, therapeutics could mitigate these issues.
The research was conducted within the Collaborative Research Centers “PolyTarget” and “ChemBioSys” at the University of Jena, Germany. While they received funding from the German Research Foundation.
