Jim Finnel
Fallen Cannabis Warrior & Ex News Moderator
Fride E, Shohami E.
Source
Department of Behavioral Sciences, College of Judea, Ariel, Israel. esty@cc.huji.ac.il
Abstract
Since the identification and cloning of the first cannabinoid (CB1) receptor and the subsequent discovery of the endogenous cannabinoid ligands (endocannabinoids), anandamide, 2-arachidonoyl glycerol (2-AG) and noladin ether, a intensive search for their function in health and disease has been launched. The endocannabinoids in the central nervous system bind Gi/o coupled CB1 receptors that modulate adenylyl cyclase, ion channels and extracellular signal-regulated kinases. The present review discusses the nature of endocannabinoid (anandamide and 2-AG) neurotransmission, the activity of cannabinoids and the possibility that some of these activities are mediated via a receptor, yet to be discovered, which is distinct from the brain specific CB1 receptor. Three physiological functions in which the endocannabinoids play a critical role are also discussed: embryonal implantation, feeding and appetite, and neuroprotection.
PMID: 12395075 [PubMed - indexed for MEDLINE]
Source: The endocannabinoid system: function in survival o... [Neuroreport. 2002] - PubMed result
Source
Department of Behavioral Sciences, College of Judea, Ariel, Israel. esty@cc.huji.ac.il
Abstract
Since the identification and cloning of the first cannabinoid (CB1) receptor and the subsequent discovery of the endogenous cannabinoid ligands (endocannabinoids), anandamide, 2-arachidonoyl glycerol (2-AG) and noladin ether, a intensive search for their function in health and disease has been launched. The endocannabinoids in the central nervous system bind Gi/o coupled CB1 receptors that modulate adenylyl cyclase, ion channels and extracellular signal-regulated kinases. The present review discusses the nature of endocannabinoid (anandamide and 2-AG) neurotransmission, the activity of cannabinoids and the possibility that some of these activities are mediated via a receptor, yet to be discovered, which is distinct from the brain specific CB1 receptor. Three physiological functions in which the endocannabinoids play a critical role are also discussed: embryonal implantation, feeding and appetite, and neuroprotection.
PMID: 12395075 [PubMed - indexed for MEDLINE]
Source: The endocannabinoid system: function in survival o... [Neuroreport. 2002] - PubMed result
