Jacob Bell
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Stimulation of Sphingomyelin Hydrolysis by Cannabidiol in Fibroblasts from a Niemann-pick Patient
Authors:
Burstein S
Hunter S A
Renzulli L
Biochemical and biophysical research communications
Publish Date: May 1984
ISSN: 0006-291X
Volume: 121
Issue: 1
Pages: 168-73
Medium: Print
Language: English
Citation (JAMA): Burstein S, Hunter S A, Renzulli L, et al. Stimulation of Sphingomyelin Hydrolysis by Cannabidiol in Fibroblasts from a Niemann-pick Patient.. Biochem. Biophys. Res. Commun. May 1984;121:168-73
Abstract
The hydrolysis of sphingomyelin in cells derived from a Niemann-Pick patient was studied using both a labelled precursor and measurement of endogenous levels. In vitro exposure of the cells to cannabidiol resulted in a large decrease in both the relative and absolute amounts of this lipid; the drug had a smaller effect on normal fibroblasts. Cannabidiol has been tested in the clinic as an antiepileptic agent with some success; our findings suggest that it may also be useful in relieving the symptoms associated with Niemann-Pick disease.
Mesh Headings (Keywords): Cannabidiol, Cannabinoids, Cells, Cultured, Fibroblasts, Humans, Hydrolysis, Lipid Metabolism, Niemann-Pick Diseases, Sphingomyelins
Check for Full Text / PubMed Unique Identifier (PMID): 6732800
This abstract is part of PubMed, a service of the U.S. National Library of Medicine. PubMed includes more than 17 million citations from MEDLINE and other life science journals for biomedical articles. See Copyright and Disclaimers.
Linked medical terms appearing on this page are added by Healia to help readers find more information and are not part of the original PubMed document.
The data herein was last updated on July 8th, 2008 and may not reflect the most current and accurate data available from NLM.
Source: Stimulation of Sphingomyelin Hydrolysis by Cannabidiol in Fibroblasts from a Niemann-pick Patient
Authors:
Burstein S
Hunter S A
Renzulli L
Biochemical and biophysical research communications
Publish Date: May 1984
ISSN: 0006-291X
Volume: 121
Issue: 1
Pages: 168-73
Medium: Print
Language: English
Citation (JAMA): Burstein S, Hunter S A, Renzulli L, et al. Stimulation of Sphingomyelin Hydrolysis by Cannabidiol in Fibroblasts from a Niemann-pick Patient.. Biochem. Biophys. Res. Commun. May 1984;121:168-73
Abstract
The hydrolysis of sphingomyelin in cells derived from a Niemann-Pick patient was studied using both a labelled precursor and measurement of endogenous levels. In vitro exposure of the cells to cannabidiol resulted in a large decrease in both the relative and absolute amounts of this lipid; the drug had a smaller effect on normal fibroblasts. Cannabidiol has been tested in the clinic as an antiepileptic agent with some success; our findings suggest that it may also be useful in relieving the symptoms associated with Niemann-Pick disease.
Mesh Headings (Keywords): Cannabidiol, Cannabinoids, Cells, Cultured, Fibroblasts, Humans, Hydrolysis, Lipid Metabolism, Niemann-Pick Diseases, Sphingomyelins
Check for Full Text / PubMed Unique Identifier (PMID): 6732800
This abstract is part of PubMed, a service of the U.S. National Library of Medicine. PubMed includes more than 17 million citations from MEDLINE and other life science journals for biomedical articles. See Copyright and Disclaimers.
Linked medical terms appearing on this page are added by Healia to help readers find more information and are not part of the original PubMed document.
The data herein was last updated on July 8th, 2008 and may not reflect the most current and accurate data available from NLM.
Source: Stimulation of Sphingomyelin Hydrolysis by Cannabidiol in Fibroblasts from a Niemann-pick Patient
