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Pot Inhibits Neurodegeneration In Animal Model Of MS, Study Says
London, United Kingdom: Cannabinoids and the cannabinoid receptor system
offer neuroprotection against allergic encephalo myelitis (EAE), an
animal model of Multiple Sclerosis (MS), according to findings published
in the July 22, 2003 issue of the journal Brain.
Scientists at London's Institute of Neurology determined that mice
deficient in the cannabinoid receptor CB1 developed "substantial
neurodegeneration" as a result of EAE Researchers also noted that
"exogenous CB1 agonists (agents that bind to the receptor, such as
THC)can provide significant neuroprotection from the consequences of
inflammatory CNS disease in an experimental ... model."
Authors concluded: "Therefore, in addition to symptom management,
cannabis may also slow down the neurodegenerative processes that
ultimately lead to chronic disability in multiple sclerosis and probably
other diseases."
Multiple sclerosis is believed to be a neurodegenerative disease that is
triggered by an inflammatory attack of the central nervous system.
Although several previous human studies have demonstrated that marijuana
may provide symptomatic relief to common symptoms of MS such as muscle
spasms, depression and incontinence, the U.K. study is one of the first
to indicate that cannabinoids may potentially stave the onset of the
disease.
A previous study published in the May 6, 2003 issue of the journal
NeuroReport similarly noted that "cannabinoids could provide
neuroprotection" and "modify neurodegeneration in Huntington's disease."
Abstracts of both studies,
"Cannabinoids inhibit neurodegeneration in models of multiple sclerosis"
and "Effects of cannabinoids in the rat model of Huntington's disease
generated by an intrastriatal injection of malonate," are available
online via the PubMed
search engine at: Home - PubMed - NCBI
London, United Kingdom: Cannabinoids and the cannabinoid receptor system
offer neuroprotection against allergic encephalo myelitis (EAE), an
animal model of Multiple Sclerosis (MS), according to findings published
in the July 22, 2003 issue of the journal Brain.
Scientists at London's Institute of Neurology determined that mice
deficient in the cannabinoid receptor CB1 developed "substantial
neurodegeneration" as a result of EAE Researchers also noted that
"exogenous CB1 agonists (agents that bind to the receptor, such as
THC)can provide significant neuroprotection from the consequences of
inflammatory CNS disease in an experimental ... model."
Authors concluded: "Therefore, in addition to symptom management,
cannabis may also slow down the neurodegenerative processes that
ultimately lead to chronic disability in multiple sclerosis and probably
other diseases."
Multiple sclerosis is believed to be a neurodegenerative disease that is
triggered by an inflammatory attack of the central nervous system.
Although several previous human studies have demonstrated that marijuana
may provide symptomatic relief to common symptoms of MS such as muscle
spasms, depression and incontinence, the U.K. study is one of the first
to indicate that cannabinoids may potentially stave the onset of the
disease.
A previous study published in the May 6, 2003 issue of the journal
NeuroReport similarly noted that "cannabinoids could provide
neuroprotection" and "modify neurodegeneration in Huntington's disease."
Abstracts of both studies,
"Cannabinoids inhibit neurodegeneration in models of multiple sclerosis"
and "Effects of cannabinoids in the rat model of Huntington's disease
generated by an intrastriatal injection of malonate," are available
online via the PubMed
search engine at: Home - PubMed - NCBI
