Jacob Bell
New Member
Author(s) Radwan MM, Elsohly MA, Slade D, Ahmed SA, Wilson L, El-Alfy AT, Khan IA, Ross SA
Institution National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, University, MS 38677, USA.
Source Phytochemistry 2008 Oct; 69(14):2627-33.
MeSH Analgesics
Animals
Anti-Infective Agents
Antimalarials
Antioxidants
Antiprotozoal Agents
Biological Products
Cannabis
Flavones
Mice
Molecular Structure
Abstract Six new non-cannabinoid constituents were isolated from a high potency Cannabis sativa L. variety, namely 5-acetoxy-6-geranyl-3-n-pentyl-1,4-benzoquinone (1), 4,5-dihydroxy-2,3,6-trimethoxy-9,10-dihydrophenanthrene (2), 4-hydroxy-2,3,6,7-tetramethoxy-9,10-dihydrophenanthrene (3), 4,7-dimethoxy-1,2,5-trihydroxyphenanthrene (4), cannflavin C (5) and beta-sitosteryl-3-O-beta-d-glucopyranoside-2'-O-palmitate (6). In addition, five known compounds, alpha-cannabispiranol (7), chrysoeriol (8), 6-prenylapigenin (9), cannflavin A (10) and beta-acetyl cannabispiranol (11) were identified, with 8 and 9 being reported for the first time from cannabis. Some isolates displayed weak to strong antimicrobial, antileishmanial, antimalarial and anti-oxidant activities. Compounds 2-4 were inactive as analgesics.
Language eng
Pub Type(s) Journal Article
Research Support, N.I.H., Extramural
PubMed ID 18774146
Source: Non-cannabinoid constituents from a high potency Cannabis sativa variety
Institution National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, University, MS 38677, USA.
Source Phytochemistry 2008 Oct; 69(14):2627-33.
MeSH Analgesics
Animals
Anti-Infective Agents
Antimalarials
Antioxidants
Antiprotozoal Agents
Biological Products
Cannabis
Flavones
Mice
Molecular Structure
Abstract Six new non-cannabinoid constituents were isolated from a high potency Cannabis sativa L. variety, namely 5-acetoxy-6-geranyl-3-n-pentyl-1,4-benzoquinone (1), 4,5-dihydroxy-2,3,6-trimethoxy-9,10-dihydrophenanthrene (2), 4-hydroxy-2,3,6,7-tetramethoxy-9,10-dihydrophenanthrene (3), 4,7-dimethoxy-1,2,5-trihydroxyphenanthrene (4), cannflavin C (5) and beta-sitosteryl-3-O-beta-d-glucopyranoside-2'-O-palmitate (6). In addition, five known compounds, alpha-cannabispiranol (7), chrysoeriol (8), 6-prenylapigenin (9), cannflavin A (10) and beta-acetyl cannabispiranol (11) were identified, with 8 and 9 being reported for the first time from cannabis. Some isolates displayed weak to strong antimicrobial, antileishmanial, antimalarial and anti-oxidant activities. Compounds 2-4 were inactive as analgesics.
Language eng
Pub Type(s) Journal Article
Research Support, N.I.H., Extramural
PubMed ID 18774146
Source: Non-cannabinoid constituents from a high potency Cannabis sativa variety
