New Study: Marijuana May Help Heal Broken Bones

[Jacob Redmond]

Israeli researchers have discovered that cannabis can be effectively used in healing broken bones and maybe other skeletal illnesses.

Scientists from the Tel Aviv University revealed that cannabis has a component which enhances the healing process of fractured bones. The study was published in the Journal of Bone and Mineral Research.

A curative component, called cannabidiol (CBD), sped up healing processes in the broken leg bones of trial rats with mid-femoral fractures. CBD is non-psychotropic and is also effective when isolated from tetrahydrocannabinol (THC), the main psychoactive component of cannabis.

"While there is still a lot of work to be done to develop appropriate therapies, it is clear that it is possible to detach a clinical therapy objective from the psychoactivity of cannabis. CBD, the principal agent in our study, is primarily anti-inflammatory and has no psychoactivity," said Dr. Yankel Gabet of Tel Aviv's Bone Research Laboratory, as cited by the Tel Aviv university website.
To illustrate these findings, scientists tested two different groups of rats - one was treated with both CBD and THC while the other one only with CBD.

"We found CBD alone to be sufficiently effective in enhancing fracture healing," Gabet explained.

"Other studies have also shown CBD to be a safe agent, which leads us to believe we should continue this line of study in clinical trials to assess its usefulness in improving human fracture healing," he added.

The researchers also found that human cannabinoid receptors stimulate bone growth. That means further studies of marijuana usage to treat osteoporosis and other skeletal diseases are to come.

"We only respond to cannabis because we are built with intrinsic compounds and receptors that can also be activated by compounds in the cannabis plant," Gabet said.

"The clinical potential of cannabinoid-related compounds is simply undeniable at this point," he added.

Medical cannabis also provides bone tissue with mineralization, so it protects bones from further injury, making them less fragile. "After being treated with CBD, the healed bone will be harder to break in the future," Gabet explained.

This is not the first study devoted to the health properties of marijuana. It has been linked to effective treatment of epilepsy, Multiple Sclerosis, Alzheimer's and Parkinson 's diseases. It is also used to soften the negative effects of chemotherapy in cancer patients, treat chronic pain, and help people struggling with post-traumatic stress disorder.

News Moderator: Jacob Redmond 420 MAGAZINE ®
Full Article: Marijuana may help heal broken bones ? new study ? RT News
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[NuttyProfessor]

AN AMAZING PLANT

 

[Hybrid Garden]

Israeli researchers have discovered that cannabis can be effectively used in healing broken bones and maybe other skeletal illnesses.

Really? I guess nobody bothered to read the study titled The putative cannabinoid receptor GPR55 affects osteoclast function in vitro and bone mass in vivo which was released back in 2009.

Extract

GPR55 is a G protein-coupled receptor recently shown to be activated by certain cannabinoids and by lysophosphatidylinositol (LPI). However, the physiological role of GPR55 remains unknown. Given the recent finding that the cannabinoid receptors CB1 and CB2 affect bone metabolism, we examined the role of GPR55 in bone biology. GPR55 was expressed in human and mouse osteoclasts and osteoblasts; expression was higher in human osteoclasts than in macrophage progenitors. Although the GPR55 agonists O-1602 and LPI inhibited mouse osteoclast formation in vitro, these ligands stimulated mouse and human osteoclast polarization and resorption in vitro and caused activation of Rho and ERK1/2. These stimulatory effects on osteoclast function were attenuated in osteoclasts generated from GPR55−/− macrophages and by the GPR55 antagonist cannabidiol (CBD). Furthermore, treatment of mice with this non-psychoactive constituent of cannabis significantly reduced bone resorption in vivo. Consistent with the ability of GPR55 to suppress osteoclast formation but stimulate osteoclast function, histomorphometric and microcomputed tomographic analysis of the long bones from male GPR55−/− mice revealed increased numbers of morphologically inactive osteoclasts but a significant increase in the volume and thickness of trabecular bone and the presence of unresorbed cartilage. These data reveal a role of GPR55 in bone physiology by regulating osteoclast number and function. In addition, this study also brings to light an effect of both the endogenous ligand, LPI, on osteoclasts and of the cannabis constituent, CBD, on osteoclasts and bone turnover in vivo.

"CBD" is actually a term used to describe a group of active metabolites ( with (-)-7-hydroxy-CBD and (-)-CBD-7-oic acid and their dimethylheptyl (DMH) homologs which act together being two main ones ) and samples of CBD which contain different levels of these active ingredients will produce different results. You could extract samples of CBD from 50 different plants and will end up with 50 different "types" of CBD.

What is the use of doing experiments of the medical uses of CBD when we don't even know what half the compounds in cannabis are, how they interact with each other or why the plants even produces them. Talk about putting the cart before the horse. I liken it to someone who drives a car and says, "I don't know how it works but it gets me from A to B and that's all that matters."

Lets be clear, Yankel Gabet, Senior Lecturer, PI Bone Laboratory at Tel Aviv University is not interested in highlighting the medical benefits of cannabis, rather his intentions are to chemically synthesize the CBD compound, patent it and make squillions by selling it to you pill form.