Mammary Excretion of Cannabidiol in Rabbits After Intravenous Administration

Jacob Bell

New Member
Yoo SD, Fincher TK, Holladay JW.
Source

Department of Basic Pharmaceutical Sciences, College of Pharmacy, University of South Carolina, Columbia 29208.
Abstract

The present study examined the distribution of cannabidiol into milk after an intravenous bolus injection (3 mg kg-1) to lactating rabbits. Drug concentrations in milk and serum were measured by HPLC. Cannabidiol was excreted into milk rapidly and the drug levels in milk increased over a 4-24-h period following the maternal injection. The mean milk to serum concentration ratio was 25.9, indicating a significant accumulation of the drug in milk.


Source: Mammary Excretion of Cannabidiol in Rabbits After Intravenous Administration
 
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