Julie Gardener
New Member
Effects Of Cannabinoids On L1210 Murine Leukemia. 1. Inhibition of DNA Synthesis
Tucker AN, Friedman MA.Res Commun Chem Pathol Pharmacol. 1977 Aug
Abstract
The effect of cannabinoid derivatives on thymidine-3H uptake in L1210 murine leukemia was determined. In experiments at 200 mg/kg 3 hrs after treatment, the order of activity was delta9-tetrahydrocannabinol less than cannabinol less than cannabidiol less than abnormal cannabidiol less than 11-hydroxy-delta9-tetrahydrocannabinol less than delta8-tetrahydrocannabinol. The inhibitory effect of delta8-tetrahydrocannabinol was 99%. When animals were dosed on consecutive days with delta9-tetrahydrocannabinol and killed on the third day, thymidine-3H incorporation was increased while delta8-tetrahydrocannabinol retained its inhibitory activity under the same conditions. Delta-9-tetrahydrocannabinol and delta8-tetrahydrocannabinol inhibited RNA and protein synthesis in a fashion analagous to the inhibition of DNA synthesis.
Source: Effects of cannabinoids on L1210 murine leukemia. ... [Res Commun Chem Pathol Pharmacol. 1977] - PubMed result
