Jacob Bell
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Tracy M. WestlakeCorresponding Author Contact Information, 1, Allyn C. Howlett1, Syed F. Ali2, Merle G. Paule2, Andrew C. Scallet2 and William Slikker, Jr.2
aDepartment of Pharmacological and Physiological Science, St. Louis University Medical Center, St. Louis, MO 63104U.S.A.
bDivision of Reproductive and Developmental Toxicology, National Center for Toxicological Research, Jefferson, AR 72079U.S.A.
Correspondence: T.M. Westlake, Department of Pharmacological and Physiological Science, St. Louis University Medical School, 1402 South Grand Boulevard, St. Louis, MO 63104, U.S.A.
Abstract
The effects of chronicΔ9-tetrahydrocannabinol (Δ9-THC) and marijuana administration on the properties of brain cannabinoid receptor populations of the rat and monkey, respectively, were examined in this study. It was determined that the properties of the cannabinoid receptors in the striatum, cerebral cortex, cerebellum, hippocampus, and brainstem/spinal cord of the rat do not appear to be irreversibly altered by chronic exposure toΔ9-THC. Similarly, the cannabinoid receptors in the caudate, prefrontal cortex, and cerebellum of the monkey do not appear to be irreversibly altered by chronic exposure to marijuana smoke.
Keywords: Cannabinoid receptor; Δ9-Tetrahydrocannabinol; CP-55, 940; Desacetyllevonantradol; Rat; Monkey
Source: ScienceDirect - Brain Research : Chronic exposure to Delta9-tetrahydrocannabinol fails to irreversibly alter brain cannabinoid receptors
aDepartment of Pharmacological and Physiological Science, St. Louis University Medical Center, St. Louis, MO 63104U.S.A.
bDivision of Reproductive and Developmental Toxicology, National Center for Toxicological Research, Jefferson, AR 72079U.S.A.
Correspondence: T.M. Westlake, Department of Pharmacological and Physiological Science, St. Louis University Medical School, 1402 South Grand Boulevard, St. Louis, MO 63104, U.S.A.
Abstract
The effects of chronicΔ9-tetrahydrocannabinol (Δ9-THC) and marijuana administration on the properties of brain cannabinoid receptor populations of the rat and monkey, respectively, were examined in this study. It was determined that the properties of the cannabinoid receptors in the striatum, cerebral cortex, cerebellum, hippocampus, and brainstem/spinal cord of the rat do not appear to be irreversibly altered by chronic exposure toΔ9-THC. Similarly, the cannabinoid receptors in the caudate, prefrontal cortex, and cerebellum of the monkey do not appear to be irreversibly altered by chronic exposure to marijuana smoke.
Keywords: Cannabinoid receptor; Δ9-Tetrahydrocannabinol; CP-55, 940; Desacetyllevonantradol; Rat; Monkey
Source: ScienceDirect - Brain Research : Chronic exposure to Delta9-tetrahydrocannabinol fails to irreversibly alter brain cannabinoid receptors
