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German scientists from the universities of Goettingen, Hamburg and Dresden reported of the treatment of a 15-year-old boy with treatment refractory TOURETTE Syndrome (TS) and attention deficit hyperactivity disorder (ADHD) leading to severe physical and psychosocial impairment. Administration of THC resulted in a considerable improvement of tics without adverse effects, allowing parallel stimulant treatment of comorbid ADHD. Along with THC treatment, intracortical inhibition, that is inhibition of signal transmission between nerve cells in the cortex of the brain, was increased.
Authors concluded that "our observation suggests that delta-9-THC might be a successful alternative in patients with severe TS refractory to classic treatment. Particularly in the case of stimulant-induced exacerbation of tics, delta-9-THC might enable successful treatment of comorbid ADHD. The enhancement of intracortical inhibition might be mediated by modulating release of several neurotransmitters including dopamine and gamma-aminobutyric acid."
Source: International Association for Cannabis as Medicine
Authors concluded that "our observation suggests that delta-9-THC might be a successful alternative in patients with severe TS refractory to classic treatment. Particularly in the case of stimulant-induced exacerbation of tics, delta-9-THC might enable successful treatment of comorbid ADHD. The enhancement of intracortical inhibition might be mediated by modulating release of several neurotransmitters including dopamine and gamma-aminobutyric acid."
Source: International Association for Cannabis as Medicine
