Jacob Bell
New Member
January 2003, Vol. 12, No. 1 , Pages 39-49 (doi:10.1517/13543784.12.1.39)
Giulia Di Carlo, Angelo A Izzo
Department of Experimental Pharmacology, University of Naples Federico II, via D. Montesano 49, 80131 Naples, Italy, Fax +39 081 678 403;
Δ9-Tetrahydrocannabinol (the active ingredient of marijuana), as well as endogenous and synthetic cannabinoids, exert many biological functions by activating two types of cannabinoid receptors, CB1 and CB2 receptors. CB1 receptors have been detected on enteric nerves, and pharmacological effects of their activation include gastroprotection, reduction of gastric and intestinal motility and reduction of intestinal secretion. The digestive tract also contains endogenous cannabinoids (i.e., the endocannabinoids anandamide and 2-aracidonylglycerol) and mechanisms for endocannabinoid inactivation (i.e., endocannabinoids uptake and enzymatic degradation). Cannabinoid receptors, endocannabinoids and the proteins involved in endocannabinoids inactivation are collectively referred as the 'endogenous cannabinoid system'. A pharmacological modulation of the endogenous cannabinoid system could provide new therapeutics for the treatment of a number of gastrointestinal diseases, including nausea and vomiting, gastric ulcers, irritable bowel syndrome, Crohn's disease, secretory diarrhoea, paralytic ileus and gastroesophageal reflux disease. Some cannabinoids are already in use clinically, for example, nabilone and Δ9-tetrahydrocannabinol are used as antiemetics.
Keywords
2-AG, ACEA, anandamide transport, anandamide, cannabinoid agonists/antagonists, cannabinoid receptors, cannabis, Crohn's disease, diarrhoea, emesis, endocannabinoids, FAAH, gastric secretion, gastric ulcer, GERD, inflammatory bowel disease, intestinal motility, intestinal secretion, intestine, irritable bowel syndrome, noladin ether, paralytic ileus, rimonabant, SR141716A, transient lower oesophageal sphincter relaxation, VDM11
Source: Cannabinoids for gastrointestinal diseases: potential therapeutic applications
Giulia Di Carlo, Angelo A Izzo
Department of Experimental Pharmacology, University of Naples Federico II, via D. Montesano 49, 80131 Naples, Italy, Fax +39 081 678 403;
Δ9-Tetrahydrocannabinol (the active ingredient of marijuana), as well as endogenous and synthetic cannabinoids, exert many biological functions by activating two types of cannabinoid receptors, CB1 and CB2 receptors. CB1 receptors have been detected on enteric nerves, and pharmacological effects of their activation include gastroprotection, reduction of gastric and intestinal motility and reduction of intestinal secretion. The digestive tract also contains endogenous cannabinoids (i.e., the endocannabinoids anandamide and 2-aracidonylglycerol) and mechanisms for endocannabinoid inactivation (i.e., endocannabinoids uptake and enzymatic degradation). Cannabinoid receptors, endocannabinoids and the proteins involved in endocannabinoids inactivation are collectively referred as the 'endogenous cannabinoid system'. A pharmacological modulation of the endogenous cannabinoid system could provide new therapeutics for the treatment of a number of gastrointestinal diseases, including nausea and vomiting, gastric ulcers, irritable bowel syndrome, Crohn's disease, secretory diarrhoea, paralytic ileus and gastroesophageal reflux disease. Some cannabinoids are already in use clinically, for example, nabilone and Δ9-tetrahydrocannabinol are used as antiemetics.
Keywords
2-AG, ACEA, anandamide transport, anandamide, cannabinoid agonists/antagonists, cannabinoid receptors, cannabis, Crohn's disease, diarrhoea, emesis, endocannabinoids, FAAH, gastric secretion, gastric ulcer, GERD, inflammatory bowel disease, intestinal motility, intestinal secretion, intestine, irritable bowel syndrome, noladin ether, paralytic ileus, rimonabant, SR141716A, transient lower oesophageal sphincter relaxation, VDM11
Source: Cannabinoids for gastrointestinal diseases: potential therapeutic applications
