Jacob Bell
New Member
Author(s) Ahmed SA, Ross SA, Slade D, Radwan MM, Zulfiqar F, Elsohly MA
Institution sross@olemiss.edu, melsohly@olemiss.edu.
Source J Nat Prod 2008 Feb 28.
Abstract Eleven new cannabinoid esters, together with three known cannabinoid acids and Delta (9)-tetrahydrocannabinol ( Delta (9)-THC ), were isolated from a high-potency variety of Cannabis sativa. The structures were determined by extensive spectroscopic analyses to be beta-fenchyl Delta (9)-tetrahydrocannabinolate ( 1), epi-bornyl Delta (9)-tetrahydrocannabinolate ( 2), alpha-terpenyl Delta (9)-tetrahydrocannabinolate ( 3), 4-terpenyl Delta (9)-tetrahydrocannabinolate ( 4), alpha-cadinyl Delta (9)-tetrahydrocannabinolate ( 5), gamma-eudesmyl Delta (9)-tetrahydrocannabinolate ( 6), gamma-eudesmyl cannabigerolate ( 7), 4-terpenyl cannabinolate ( 8), bornyl Delta (9)-tetrahydrocannabinolate ( 9), alpha-fenchyl Delta (9)-tetrahydrocannabinolate ( 10), alpha-cadinyl cannabigerolate ( 11), Delta (9)-tetrahydrocannabinol ( Delta (9)-THC ), Delta (9)-tetrahydrocannabinolic acid A ( Delta (9)-THCA ), cannabinolic acid A ( CBNA), and cannabigerolic acid ( CBGA). Compound 8 showed moderate antimicrobial activity against Candida albicans ATCC 90028 with an IC 50 value of 8.5 microg/mL. CB-1 receptor assay indicated that the esters, as well as the parent acids, are not active.
Language ENG
Pub Type(s) JOURNAL ARTICLE
PubMed ID 18303850
Source: Cannabinoid Ester Constituents from High-Potency Cannabis sativa
Institution sross@olemiss.edu, melsohly@olemiss.edu.
Source J Nat Prod 2008 Feb 28.
Abstract Eleven new cannabinoid esters, together with three known cannabinoid acids and Delta (9)-tetrahydrocannabinol ( Delta (9)-THC ), were isolated from a high-potency variety of Cannabis sativa. The structures were determined by extensive spectroscopic analyses to be beta-fenchyl Delta (9)-tetrahydrocannabinolate ( 1), epi-bornyl Delta (9)-tetrahydrocannabinolate ( 2), alpha-terpenyl Delta (9)-tetrahydrocannabinolate ( 3), 4-terpenyl Delta (9)-tetrahydrocannabinolate ( 4), alpha-cadinyl Delta (9)-tetrahydrocannabinolate ( 5), gamma-eudesmyl Delta (9)-tetrahydrocannabinolate ( 6), gamma-eudesmyl cannabigerolate ( 7), 4-terpenyl cannabinolate ( 8), bornyl Delta (9)-tetrahydrocannabinolate ( 9), alpha-fenchyl Delta (9)-tetrahydrocannabinolate ( 10), alpha-cadinyl cannabigerolate ( 11), Delta (9)-tetrahydrocannabinol ( Delta (9)-THC ), Delta (9)-tetrahydrocannabinolic acid A ( Delta (9)-THCA ), cannabinolic acid A ( CBNA), and cannabigerolic acid ( CBGA). Compound 8 showed moderate antimicrobial activity against Candida albicans ATCC 90028 with an IC 50 value of 8.5 microg/mL. CB-1 receptor assay indicated that the esters, as well as the parent acids, are not active.
Language ENG
Pub Type(s) JOURNAL ARTICLE
PubMed ID 18303850
Source: Cannabinoid Ester Constituents from High-Potency Cannabis sativa
