If 4x2 you mean by foot e.g 4' by 2' or even 120cm by 60cm
Then a 250w MH will cover an average of a 2' by 2' / 60cm by 60cm square area if housed in a half decent reflector preferable of a rectangler design this will give you an average 62.5 watts per square foot & thats pretty optimal
Most rectangler reflectors put down a simaler light foot print to shape of it !
So ultimately to make the most out of your grow area 2 x 250w MH will be required to cover total area with reflectors and ballasts to support the lights.
A cheaper option is the Blue spectrum 6500k cfls if gaint versions are aviable which are E40 bayonet fitting a 125w cfl will provide same coverage of 2' by 2' as the 250w MH at a cheaper cost of electricity & ample results for vegging/seedlings/clone/cuttings.
I use a 125w cfl E40 fitting in a 2' by 2' squared area this equates to aprox 31 watts per square foot and a tad shy of 2000 lumen per square foot & in the past have grown seedling/cuttings and vegged plants up to 8 weeks under that same 125w cfl with ample results with my own indica shorter growing strain from cutting to veg to an average height of 18 inches/45 cm in 8 weeks before entering the flowering tent, these results will varie from one strain to another tho.
Another question to the lighting equation is whether you wish to use HPS in the flowering phase & will still require 2 bulbs and reflectors to cover the area this means two ballasts & all of this comes at addittional cost !
Where as cfls do not require ballast as they are in built in the bulb itself saving $$$
If you wish to maintain a MH stance coupled with HPS for flowering, i believe you may find 150w version of each bulb aviable or even a dual spectrum version growlux & sunmaster springs to mind also depending of country of origin & whats aviable.
A 150 w will give you an average of 37.5 watts per square foot