Jacob Bell
New Member
R. D. SOFIA,
S. D. NALEPA,
J. J. HARAKAL and
H. B. VASSAR
Department of Pharmacology, Wallace Laboratories, Craubury, New Jersey
Abstract
Δ9-Tetrahydrocannabinol (THC) is an orally effective anti-edema and anaigesic agent. In the carrageenan edema test the potency of THC is 20 times that of aspirin and nearly twice that of hydrocortisone. The anti-edema activity of THC, at least in the carrageenan edema assay, appears to be mediated by stimulation of time pituitary-adrenal axis, since this activity was markedly attenuated in both adrenalectomized and hypophysectomized rats. Howeser, the compound is devoid of corticosteroid-like activity since it did not prolong the survival time of adrenalectomized rats nor did it favorably influence the rate of change of body weight in these animals. Furthermore, THC is an effective inhibitor of developing adjuvant-induced arthritis and suppresses further development of time established disease. The analgesic activity for THC is substantially greater than that for aspirin. The compound has no antipyretic activity at a dose producing profound anti-edema effects.
Footnotes
Received October 5, 1972.
Accepted May 8, 1973.
Source: Anti-Edema And Analgesic Properties Of Delta9-Tetrahydrocannabinol(THC)
S. D. NALEPA,
J. J. HARAKAL and
H. B. VASSAR
Department of Pharmacology, Wallace Laboratories, Craubury, New Jersey
Abstract
Δ9-Tetrahydrocannabinol (THC) is an orally effective anti-edema and anaigesic agent. In the carrageenan edema test the potency of THC is 20 times that of aspirin and nearly twice that of hydrocortisone. The anti-edema activity of THC, at least in the carrageenan edema assay, appears to be mediated by stimulation of time pituitary-adrenal axis, since this activity was markedly attenuated in both adrenalectomized and hypophysectomized rats. Howeser, the compound is devoid of corticosteroid-like activity since it did not prolong the survival time of adrenalectomized rats nor did it favorably influence the rate of change of body weight in these animals. Furthermore, THC is an effective inhibitor of developing adjuvant-induced arthritis and suppresses further development of time established disease. The analgesic activity for THC is substantially greater than that for aspirin. The compound has no antipyretic activity at a dose producing profound anti-edema effects.
Footnotes
Received October 5, 1972.
Accepted May 8, 1973.
Source: Anti-Edema And Analgesic Properties Of Delta9-Tetrahydrocannabinol(THC)
