Edison tested his light bulb a hundred times with a result of "it doesn't work." Until he found a way it did work.
If that is the case then you should not use 18/6. The Alaskan land strains naturally grow under 24 hour of light in the summer. Acapulco gold naturally grows near the equator so days are nearly 12 hours long year round. What is the optimum natural grow condition for Alaskan gold? Hybridization throws a wrench into thousands of years of adaptation. Not to mention humans brought those original seeds to those extremes in the first place
Yes,,,, but the goal is to achieve optimum DLI. Photosynthesis is a cycle consisting of (day light) exothermic photo reaction and the (night) calvin, synthesis reaction. As long as the plant has more CO2, water, and light than it can react, the limiting factor is ATP storage, produced from the light reaction. This is why leaves are generally less productive after 6 hours of light reducing DLI. The calvin cycle converts ATP into glucose that can be transported out of the leaf, making room for more ATP production and storage. The calvin cycle is partially active on the bottom side of leaves during the day but, it is the leaves primary action at night. So under the right conditions, with the right genetics, you could, in theory, optimize DLI with lighting time manipulation.