Tikkun Olam, in Israel, spearheads many studies which examine the application of its exclusive products for treating various diseases. Reducing pain, regulating appetite, inducing sleep, instilling a feeling of serenity and a variety of other positive effects reported by patients who have used medical grade Cannabis. Cannabis as medicine is a cheap, readily available and safe solution, because it is agreed that Cannabis is one of the safest medical products known to and produced by mankind. The ratio of the effective dosage to a lethal dosage is approximately 40,000:1. A very low presence of cannabinoid receptors in the brainstem indicates why especially high doses of Cannabis are not lethal - Herkenham et al., 1990