The drug-like effects experienced by cannabis users are caused by cannabinoids, the active chemicals that are present in the plant. The main active cannabinoid in cannabis is delta-9-tetrahydrocannabinol, more simply known as THC. THC affects specific parts of the brain with cannabinoid receptors, triggering a series of cellular reactions that leads to the quot;highquot; experienced by users. Some areas of the brain have many cannabinoid receptors, and others have few or none at all. The most can be found in areas of the brain that influence sensory and time perception, pleasure, concentrating, memory, and coordinated movement. Besides THC, another active cannabinoid is cannabidiol, a compound that may decrease inflammation and relieve pain without the quot;highquot; that comes from THC. - National Geographic