In Ancient China, the plant, known as Ma, was used for food, fuel, clothing, and medicine going back to 6,000 B.C. But the oldest existing reference to medical marijuana dates to 2737 B.C. when the Red Emperor Shen Nung is credited with writing The Herbal, a listing of medicinal properties of various herbs, including Ma, to alleviate rheumatism and gout pain. In 2 A.D. Hua T'o is recorded as having used Ma-yo, the female plant, and red wine as an anesthesia while he performed painful surgeries including organ grafts and loin incisions. Yeah, you'd probably want to be high for that.