Using it in flower can be done via applications to the medium rather than spray.
One would do well to consider a few things however.
First, Neem is very strong in both flavor and smell (used in toothpaste in India?!?!). You really want to try to finish it without use. I discontinue use in flower altogether. I feel the Neem incorporated in the plant from it's veg applications that I do via spray is sufficient to protect it during flower. When treating via soil or medium, I like to try to over flush during normal feedings towards the end of the life cycle in an attempt to flush out any remaining neem oil in the medium.
Second, spraying anything with water anywhere near my buds in flower is avoided at all times.
My routine....
Spray application: 2tsp neem oil +1tsp dawn dish soap (or whatever... I just like + use dawn) + 1gal water. Spray entire (especially up under leaves) plant with the mix until heavy and dripping wet.
Soil/medium application: This differs as roots uptake at a much lower rate. 4tsp Neem oil + 1tds dawn dish soap + 1gal water. Water as if feeding. Try to apply as evenly as possible to saturate the entire soil/medium mass fully.
Neem is an oil. Liquid soap is used to break up the oil and allow it to mix evenly with the water.
One would do well to consider a few things however.
First, Neem is very strong in both flavor and smell (used in toothpaste in India?!?!). You really want to try to finish it without use. I discontinue use in flower altogether. I feel the Neem incorporated in the plant from it's veg applications that I do via spray is sufficient to protect it during flower. When treating via soil or medium, I like to try to over flush during normal feedings towards the end of the life cycle in an attempt to flush out any remaining neem oil in the medium.
Second, spraying anything with water anywhere near my buds in flower is avoided at all times.
My routine....
Spray application: 2tsp neem oil +1tsp dawn dish soap (or whatever... I just like + use dawn) + 1gal water. Spray entire (especially up under leaves) plant with the mix until heavy and dripping wet.
Soil/medium application: This differs as roots uptake at a much lower rate. 4tsp Neem oil + 1tds dawn dish soap + 1gal water. Water as if feeding. Try to apply as evenly as possible to saturate the entire soil/medium mass fully.
Neem is an oil. Liquid soap is used to break up the oil and allow it to mix evenly with the water.