cajuncelt;2710660 said:The whole pharmacogenomics thing means that some people will be genetically predisposed to metabolise THC at different rates and so benefit to differing degrees.
Due to the low and varied bioavailability of oral THC formulations, alternative routes of drug administration, including oromucosal (through the mouth lining), sublingual (under the tongue), vaporization and inhalation, and rectal administration, have been developed by pharmaceutical companies to improve the amount of delivered cannabinoids in their products. All medical user should take note of their measures. This is an industry that would much prefer to produce a usable cannabis pill. That they don't is for good reason.
The future of successful Dosing “Competitive Inhibition”
Competitive inhibition, allows for greater circulation of cannabinoids through your system.
This is achieved when certain enzymes in your liver (CYP2C9) are occupied whilst the THC is going through. The metabolism of THC, into 11-OH-THC produces a molecule many times more psychoactive but with ‘key medical benefits deactivated’. It's counter intuitive but the amount of healing occurring cannot easily be judged by the height of the high. THC will be long gone by the time the effects of the 11-OH-THC have stopped being felt.
The enzymes that metabolise cannabinoids are mainly found in the liver. A cannabinoid entering the liver is more likely to connect with an enzyme and be metabolised than to connect with a cancerous cell. Slowing metabolism does not however result in a stronger high. Slowing metabolism of THC to 11-OH-THC means the more psychoactive metabolite's entry into the body is spread out over a longer period. Consequently a person is less likely be made uneasy by a strong more condensed wave of psychoactivity.
Beneficially certain plant molecules are metabolised by the same enzymes that metabolise most THC molecules. The enzyme is called CYP2C9 and the molecules are apigenin and amentoflavone. Apigenin can be found in tablets and certain foods and amentoflavone is available in supplement form. These molecules, as well as having additional benefits, will give the enzymes "busy work" allowing the cannabinoids greater opportunity to circulate, connect with and destroy mutated cells both in the liver and throughout the body.
Apigenin and Amentoflavone reduce "clearance" by >80%, a strong inhibitor. As one cannot overdose on cannabis we can safely harness this strong competitive inhibition. This will allow cannabinoids greater chance to heal and maximise the benefits of an often expensive and limited supply.
Reduce clearance by (more than)> 80%, means, a lot of THC is not converted to 11-OH-THC. And has a chance of attaching to the receptors.
Certain essential oils will increase bioavailability. Some inhibit the metabolism of CBD. . The phenolic oils clean methylated receptors and myrcene assists THC across the blood brain barrier. Eating 15ml of coconut oil approximately 30 minutes before taking oil by any method will make a big difference. Busy the enzymes themselves and bioavailability might improve >5x.
Remember, High is not proportionate to healing.